EuRBPDB

Description

Ensembl ID: ENSG00000135624 (Gene tree)
Gene ID: 10574
Gene Symbol: CCT7
Alias: Ccth|Nip7-1
Full Name: chaperonin containing TCP1 subunit 7
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 19,603 bases
Position: chr2:73,233,420-73,253,022
Accession: 1622
RBP type: non-canonical RBP
Summary: This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000626868	CCT7-217	249	-	ENSP00000487267	83 (aa)	-	A0A0D9SG95
ENST00000464397	CCT7-206	583	-	-	- (aa)	-	-
ENST00000492253	CCT7-214	531	-	-	- (aa)	-	-
ENST00000409924	CCT7-204	567	-	ENSP00000386978	83 (aa)	-	F8WBP8
ENST00000258091	CCT7-201	1916	-	ENSP00000258091	543 (aa)	-	Q99832
ENST00000398422	CCT7-202	1234	-	ENSP00000381456	339 (aa)	-	Q99832
ENST00000473786	CCT7-210	811	-	-	- (aa)	-	-
ENST00000480489	CCT7-211	527	-	-	- (aa)	-	-
ENST00000471927	CCT7-208	556	-	-	- (aa)	-	-
ENST00000540468	CCT7-216	1674	-	ENSP00000442058	456 (aa)	-	Q99832
ENST00000539919	CCT7-215	2031	XM_011532478	ENSP00000437824	499 (aa)	XP_011530780	Q99832
ENST00000469844	CCT7-207	612	-	-	- (aa)	-	-
ENST00000461290	CCT7-205	1018	-	-	- (aa)	-	-
ENST00000473197	CCT7-209	595	-	-	- (aa)	-	-
ENST00000399032	CCT7-203	593	-	ENSP00000412996	98 (aa)	-	F8WAM2
ENST00000488856	CCT7-213	612	-	-	- (aa)	-	-
ENST00000482064	CCT7-212	567	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135624	Respiratory Function Tests	3.4240000E-005	-
ENSG00000135624	Respiratory Function Tests	1.7990000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135624	rs2303907	2	73243369	T	Educational attainment (MTAG)	30038396	[0.0058-0.0108] unit increase	0.0083	EFO_0004784
ENSG00000135624	rs2303907	2	73243369	T	General cognitive ability	29844566	z-score increase	6.035	EFO_0004337

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135624	CCT7	99	78.351	FBgn0037632	CCT7	96	76.527	Drosophila_melanogaster
ENSG00000135624	CCT7	98	66.667	YJL111W	CCT7	95	63.931	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	14532270.25416956.25467444.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	9819444.	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005832	chaperonin-containing T-complex	21873635.	IBA	Component
GO:0005832	chaperonin-containing T-complex	23011926.	IDA	Component
GO:0005832	chaperonin-containing T-complex	25467444.	TAS	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0006457	protein folding	-	TAS	Process
GO:0007339	binding of sperm to zona pellucida	-	IEA	Process
GO:0032212	positive regulation of telomere maintenance via telomerase	25467444.	IMP	Process
GO:0042802	identical protein binding	-	IEA	Function
GO:0044297	cell body	-	IEA	Component
GO:0050821	protein stabilization	25467444.	IMP	Process
GO:0051082	unfolded protein binding	-	IEA	Function
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:1901998	toxin transport	-	IEA	Process
GO:1904851	positive regulation of establishment of protein localization to telomere	25467444.	IMP	Process
GO:1904871	positive regulation of protein localization to Cajal body	25467444.	HMP	Process
GO:1904874	positive regulation of telomerase RNA localization to Cajal body	25467444.	HMP	Process