24217660 | Mdm2 SNP309 G-variant is associated with invasive growth of human urinary bladder cancer. | Pathobiology | 2014 | Hitzenbichler F | doi: 10.1159/000355976 |
12138177 | Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. | Mol Cell Biol | 2002 Aug | Ard PG | - |
26476535 | Interaction between p53 codon 72 and MDM2 309T>G polymorphisms and the risk of hepatocellular carcinoma. | Tumour Biol | 2016 Mar | Qiu M | doi: 10.1007/s13277-015-4222-4 |
15734740 | Relief of p53-mediated telomerase suppression by p73. | J Biol Chem | 2005 Apr 29 | Toh WH | - |
19541936 | NOLC1, an enhancer of nasopharyngeal carcinoma progression, is essential for TP53 to regulate MDM2 expression. | Am J Pathol | 2009 Jul | Hwang YC | doi: 10.2353/ajpath.2009.080931 |
17848574 | MDM2 chaperones the p53 tumor suppressor. | J Biol Chem | 2007 Nov 9 | Wawrzynow B | - |
24632578 | Combined effects of genetic variants of the PTEN, AKT1, MDM2 and p53 genes on the risk of nasopharyngeal carcinoma. | PLoS One | 2014 Mar 14 | Zhang X | doi: 10.1371/journal.pone.0092135 |
19379464 | Murine double-minute 2 homolog single nucleotide polymorphism 309 and the risk of gynecologic cancer. | Hum Cell | 2009 May | Ueda M | doi: 10.1111/j.1749-0774.2009.00068.x. |
20358297 | ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. | Mol Biol Rep | 2011 Jan | Akisik E | doi: 10.1007/s11033-010-0113-3 |
21667122 | Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroups. | Breast Cancer Res Treat | 2011 Nov | van den Broek AJ | doi: 10.1007/s10549-011-1615-y |
23210739 | Association of MDM2 and p53 polymorphisms with the advancement of cervical carcinoma. | DNA Cell Biol | 2013 Jan | Singhal P | doi: 10.1089/dna.2012.1718 |
26796597 | MDM2 gene amplification in esophageal carcinoma. | Oncol Rep | 2016 Apr | Michalk M | doi: 10.3892/or.2016.4578 |
25136862 | MicroRNA-410 suppresses migration and invasion by targeting MDM2 in gastric cancer. | PLoS One | 2014 Aug 19 | Shen J | doi: 10.1371/journal.pone.0104510 |
28741571 | RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance. | Trends Cancer | 2016 Apr | Liu Y | doi: 10.1016/j.trecan.2016.03.002 |
18487080 | Combined effects of MDM2 SNP 309 and p53 mutation on oral squamous cell carcinomas associated with areca quid chewing. | Oral Oncol | 2009 Jan | Huang SF | doi: 10.1016/j.oraloncology.2008.03.006 |
28692049 | Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53. | Oncogene | 2017 Nov 2 | Senturk JC | doi: 10.1038/onc.2017.229 |
29651441 | STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. | J Immunol Res | 2018 Jan 31 | Chen S | doi: 10.1155/2018/4564328 |
25176350 | Several fusion genes identified by whole transcriptome sequencing in a spindle cell sarcoma with rearrangements of chromosome arm 12q and MDM2 amplification. | Int J Oncol | 2014 Nov | Panagopoulos I | doi: 10.3892/ijo.2014.2605 |
12150820 | Alternative and aberrant splicing of MDM2 mRNA in human cancer. | Cancer Cell | 2002 Jul | Bartel F | - |
26431163 | Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors. | Oncotarget | 2015 Oct 20 | Li Y | doi: 10.18632/oncotarget.5891. |
26840476 | ASSOCIATION BETWEEN MURINE DOUBLE MINUTE 2 - T309G polymorphism and recurrence of hepatocellular carcinoma after surgical treatment. | Arq Gastroenterol | 2015 Dec | Teixeira UF | doi: 10.1590/S0004-28032015000400014. |
24361594 | DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner. | Biochim Biophys Acta | 2014 Jan | Qi M | doi: 10.1016/j.bbagrm.2013.12.003 |
20708156 | Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. | Cancer Cell | 2010 Aug 9 | Inuzuka H | doi: 10.1016/j.ccr.2010.06.015. |
21986500 | MDM2 regulates vascular endothelial growth factor mRNA stabilization in hypoxia. | Mol Cell Biol | 2011 Dec | Zhou S | doi: 10.1128/MCB.06085-11 |
18809412 | Intrinsically unstructured domains of Arf and Hdm2 form bimolecular oligomeric structures in vitro and in vivo. | J Mol Biol | 2008 Dec 5 | Sivakolundu SG | doi: 10.1016/j.jmb.2008.09.019 |
24240108 | HDM2 regulation by AURKA promotes cell survival in gastric cancer. | Clin Cancer Res | 2014 Jan 1 | Sehdev V | doi: 10.1158/1078-0432.CCR-13-1187 |
20849851 | Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells. | FEBS Lett | 2010 Oct 8 | Nardinocchi L | doi: 10.1016/j.febslet.2010.09.018 |
19946469 | Alterations in gene expression and sensitivity to genotoxic stress following HdmX or Hdm2 knockdown in human tumor cells harboring wild-type p53. | Aging (Albany NY) | 2009 Jan | Heminger K | - |
18607552 | MDM2 mRNA expression in the p53 pathway may predict the potential of invasion and liver metastasis in colorectal cancer. | Dis Colon Rectum | 2008 Sep | Kondo I | doi: 10.1007/s10350-008-9382-5 |
18572327 | Relationship of Ki67, TP53, MDM-2 and BCL-2 expressions with WHO 1973 and WHO/ISUP grades, tumor category and overall patient survival in urothelial tumors of the bladder. | Pathol Res Pract | 2008 | Gonul II | doi: 10.1016/j.prp.2008.03.011 |
22939400 | The MDM2 SNP309 G allele is not preferentially amplified in bone and soft tissue tumors. | Cancer Genet | 2012 Sep | Mertens F | doi: 10.1016/j.cancergen.2012.06.001. |
17846171 | A novel role for IGF-1R in p53-mediated apoptosis through translational modulation of the p53-Mdm2 feedback loop. | J Cell Biol | 2007 Sep 10 | Xiong L | - |
15448710 | MDM2 expression in EBV-infected nasopharyngeal carcinoma cells. | Lab Invest | 2004 Dec | Wu HC | - |
17827408 | MDM2 SNP309 and cancer risk: a combined analysis. | Carcinogenesis | 2007 Nov | Wilkening S | - |
25605253 | Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation. | Oncotarget | 2015 Sep 22 | Seo SK | doi: 10.18632/oncotarget.3100. |
22699518 | Sensitivity of MDM2 amplification and unexpected multiple faint alphoid 12 (alpha 12 satellite sequences) signals in atypical lipomatous tumor. | Mod Pathol | 2012 Oct | Kashima T | doi: 10.1038/modpathol.2012.90 |
17139261 | p53 mediates the negative regulation of MDM2 by orphan receptor TR3. | EMBO J | 2006 Dec 13 | Zhao BX | - |
18519749 | Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients. | Clin Cancer Res | 2008 Jun 1 | Cattelani S | doi: 10.1158/1078-0432.CCR-07-4725. |
16479015 | Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2. | Mol Cell Biol | 2006 Mar | Ding Y | - |
23786219 | A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. | J Med Chem | 2013 Jul 11 | Zhao Y | doi: 10.1021/jm4005708 |
22397410 | Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28-MDM2-p53 complexes and by preventing the ubiquitination and degradation of p53. | Biochem J | 2012 Jun 1 | Sun NK | doi: 10.1042/BJ20112223. |
27129219 | HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis. | J Biol Chem | 2016 Jun 10 | Chen Y | doi: 10.1074/jbc.M116.714147 |
23802716 | Synthesis, in vitro, and in cell studies of a new series of [indoline-3,2'-thiazolidine]-based p53 modulators. | J Med Chem | 2013 Jul 11 | Bertamino A | doi: 10.1021/jm400311n |
18504050 | Identification of HDM2 as a regulator of VEGF expression in cancer cells. | Life Sci | 2008 Jun 20 | Narasimhan M | doi: 10.1016/j.lfs.2008.04.004 |
19752772 | MDM2 SNP309 associates with accelerated pancreatic adenocarcinoma formation. | Pancreas | 2010 Jan | Grochola LF | doi: 10.1097/MPA.0b013e3181b9f105. |
20528739 | Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function. | Crit Rev Eukaryot Gene Expr | 2010 | Clegg HV | - |
18356162 | Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. | J Biol Chem | 2008 May 16 | Lopez-Pajares V | doi: 10.1074/jbc.M710030200 |
24413081 | Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase. | Oncogene | 2015 Jan 15 | Xu C | doi: 10.1038/onc.2013.557 |
23060298 | Gastrointestinal stromal tumors: clinical significance of p53 expression, MDM2 amplification, and KIT mutation status. | Appl Immunohistochem Mol Morphol | 2013 Jul | Wallander ML | doi: 10.1097/PAI.0b013e31826ea7c0. |
26138282 | Microsecond simulations of mdm2 and its complex with p53 yield insight into force field accuracy and conformational dynamics. | Proteins | 2015 Sep | Pantelopulos GA | doi: 10.1002/prot.24852 |
26070072 | Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment. | PLoS One | 2015 Jun 12 | Hoffman-Luca CG | doi: 10.1371/journal.pone.0128807 |
18234968 | The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability. | Mol Cancer Res | 2008 Jan | D'Arcy P | doi: 10.1158/1541-7786.MCR-07-0176. |
12208736 | The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2. | Cancer Res | 2002 Sep 1 | Leung KM | - |
16738062 | p19ras brings a new twist to the regulation of p73 by Mdm2. | Sci STKE | 2006 May 30 | Harms KL | - |
15720184 | MDM2 is a central node in the p53 pathway: 12 years and counting. | Curr Cancer Drug Targets | 2005 Feb | Bond GL | - |
16027727 | Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. | Oncogene | 2005 Nov 24 | Steinman HA | - |
20881839 | Automated brightfield dual-color in situ hybridization for detection of mouse double minute 2 gene amplification in sarcomas. | Appl Immunohistochem Mol Morphol | 2011 Jan | Zhang W | doi: 10.1097/PAI.0b013e3181ee8e14. |
22333590 | Mutational analysis of Mdm2 C-terminal tail suggests an evolutionarily conserved role of its length in Mdm2 activity toward p53 and indicates structural differences between Mdm2 homodimers and Mdm2/MdmX heterodimers. | Cell Cycle | 2012 Mar 1 | Dolezelova P | doi: 10.4161/cc.11.5.19445 |
26482041 | Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas. | Clin Cancer Res | 2016 Mar 1 | Verreault M | doi: 10.1158/1078-0432.CCR-15-1015 |
18086778 | MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies. | Cancer Epidemiol Biomarkers Prev | 2007 Dec | Hu Z | - |
25915849 | Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. | Oncogene | 2016 Jan 21 | Riley MF | doi: 10.1038/onc.2015.88 |
15943041 | A comparative study of P53/MDM2 genes alterations and P53/MDM2 proteins immunoreactivity in liver cirrhosis and hepatocellular carcinoma. | J Exp Clin Cancer Res | 2005 Mar | Jablkowski M | - |
22510592 | Combination of radiotherapy and adenovirus-mediated p53 gene therapy for MDM2-overexpressing hepatocellular carcinoma. | J Radiat Res | 2012 | Koom WS | - |
20431480 | Liposarcomas with mixed well-differentiated and pleomorphic features: a clinicopathologic study of 12 cases. | Am J Surg Pathol | 2010 Jun | Boland JM | doi: 10.1097/PAS.0b013e3181dbf2f7. |
20849854 | Overexpression of SCYL1-BP1 stabilizes functional p53 by suppressing MDM2-mediated ubiquitination. | FEBS Lett | 2010 Oct 22 | Yan J | doi: 10.1016/j.febslet.2010.09.019 |
22095636 | Murine double minute 2 regulates Hu antigen R stability in human liver and colon cancer through NEDDylation. | Hepatology | 2012 Apr | Embade N | doi: 10.1002/hep.24795 |
22200978 | RNA interference against MDM2 suppresses tumor growth and metastasis in pancreatic carcinoma SW1990HM cells. | Mol Cell Biochem | 2014 Feb | Shi W | doi: 10.1007/s11010-011-1208-4 |
23506010 | Pleomorphic fibroma and dermal atypical lipomatous tumor: are they related? | J Cutan Pathol | 2013 Apr | Al-Zaid T | doi: 10.1111/cup.12095. |
23438693 | Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA. | Cancer Lett | 2013 Jul 28 | Jung CH | doi: 10.1016/j.canlet.2013.02.035 |
23391506 | Stress response of glioblastoma cells mediated by miR-17-5p targeting PTEN and the passenger strand miR-17-3p targeting MDM2. | Oncotarget | 2012 Dec | Li H | - |
17671677 | Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. | Int J Oncol | 2007 Sep | Katayama A | - |
26802432 | Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer. | Int J Cancer | 2016 Jul 1 | Inoue K | doi: 10.1002/ijc.30003 |
21317535 | Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. | J Clin Invest | 2011 Mar | Zhao R | doi: 10.1172/JCI44111 |
26984736 | Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. | Am J Physiol Cell Physiol | 2016 Jun 1 | Sorensen BH | doi: 10.1152/ajpcell.00256.2015 |
27485527 | MicroRNA-610 is downregulated in glioma cells, and inhibits proliferation and motility by directly targeting MDM2. | Mol Med Rep | 2016 Sep | Yan Y | doi: 10.3892/mmr.2016.5559 |
27508976 | MDM2 and CDK4 Immunohistochemistry: Should It Be Used in Problematic Differentiated Lipomatous Tumors?: A New Perspective. | Am J Surg Pathol | 2016 Dec | Clay MR | - |
28592528 | HDM2 Promotes NEDDylation of Hepatitis B Virus HBx To Enhance Its Stability and Function. | J Virol | 2017 Jul 27 | Liu N | doi: 10.1128/JVI.00340-17 |
27264869 | Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. | Mol Cell | 2016 Jun 16 | Riscal R | doi: 10.1016/j.molcel.2016.04.033 |
27597521 | Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry. | Hum Pathol | 2017 Jan | Kammerer-Jacquet SF | doi: 10.1016/j.humpath.2016.08.009 |
26973248 | Scaffold protein FHL2 facilitates MDM2-mediated degradation of IER3 to regulate proliferation of cervical cancer cells. | Oncogene | 2016 Sep 29 | Jin H | doi: 10.1038/onc.2016.54 |
27036047 | Period2 downregulation inhibits glioma cell apoptosis by activating the MDM2-TP53 pathway. | Oncotarget | 2016 May 10 | Zhanfeng N | doi: 10.18632/oncotarget.8439. |
27550999 | Therapeutic Inhibition of the MDM2-p53 Interaction Prevents Recurrence of Adenoid Cystic Carcinomas. | Clin Cancer Res | 2017 Feb 15 | Nor F | doi: 10.1158/1078-0432.CCR-16-1235 |
28035066 | Estradiol shows anti-skin cancer activities through decreasing MDM2 expression. | Oncotarget | 2017 Jan 31 | Li L | doi: 10.18632/oncotarget.14275. |
28351930 | Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate. | Clin Cancer Res | 2017 Aug 1 | Kato S | doi: 10.1158/1078-0432.CCR-16-3133 |
29793321 | Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. | Biomed Pharmacother | 2018 Jan | Feng C | doi: 10.1016/j.biopha.2017.11.091 |
28892044 | A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. | Oncogene | 2018 Jan 4 | Comiskey DF Jr | doi: 10.1038/onc.2017.282 |
30544386 | Association between MDM2 SNP309 and endometrial cancer risk: A PRISMA-compliant meta-analysis. | Medicine (Baltimore) | 2018 Dec | Zou X | doi: 10.1097/MD.0000000000013273. |
29309298 | Clarifying the Distinction Between Malignant Peripheral Nerve Sheath Tumor and Dedifferentiated Liposarcoma: A Critical Reappraisal of the Diagnostic Utility of MDM2 and H3K27me3 Status. | Am J Surg Pathol | 2018 May | Makise N | doi: 10.1097/PAS.0000000000001014. |
30454706 | Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells. | Biochem Biophys Res Commun | 2018 Nov 30 | Chen G | doi: 10.1016/j.bbrc.2018.10.130 |
21761395 | Identification of spliced variants of the proto-oncogene HDM2 in colorectal cancer. | Cancer | 2012 Feb 15 | Yu Z | doi: 10.1002/cncr.26330 |
21656578 | Effects of MDM2 promoter polymorphisms and p53 codon 72 polymorphism on risk and age at onset of squamous cell carcinoma of the head and neck. | Mol Carcinog | 2011 Sep | Yu H | doi: 10.1002/mc.20806 |
16934800 | Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells. | Exp Cell Res | 2006 Oct 15 | Duan W | - |
25326024 | A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran. | Iran Biomed J | 2014 | Hashemi M | - |
24777531 | USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. | Nat Immunol | 2014 Jun | Zou Q | doi: 10.1038/ni.2885 |
26553387 | Clinical significance of TP53 (R72P) and MDM2 (T309G) polymorphisms in breast cancer patients. | Clin Transl Oncol | 2016 Jul | Yadav P | doi: 10.1007/s12094-015-1425-5 |
18577987 | Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics. | Br J Cancer | 2008 Jul 8 | Stoehr R | doi: 10.1038/sj.bjc.6604441 |
25431177 | Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon. | Int J Cancer | 2015 Jul 1 | Gansmo LB | doi: 10.1002/ijc.29358 |
24882579 | miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2. | Oncogene | 2015 Apr 9 | Jansson MD | doi: 10.1038/onc.2014.130 |
26945408 | Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals. | Medicine (Baltimore) | 2016 Mar | Zhuo X | doi: 10.1097/MD.0000000000002948. |
27573292 | Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression. | Oncol Rep | 2016 Oct | Zhang X | doi: 10.3892/or.2016.5018 |
21305319 | Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. | Hum Genet | 2011 Jun | Wu CC | doi: 10.1007/s00439-011-0957-1 |
21316605 | The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians. | Cancer Cell | 2011 Feb 15 | Knappskog S | doi: 10.1016/j.ccr.2010.12.019. |
22729912 | Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis. | Mol Biol Rep | 2012 Sep | Cheng H | doi: 10.1007/s11033-012-1800-z |
19492228 | Cigarette smoking, MDM2 SNP309, gene-environment interactions, and lung cancer risk: a meta-analysis. | J Toxicol Environ Health A | 2009 | Bai J | doi: 10.1080/15287390902840930. |
18332869 | Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells. | Oncogene | 2008 Jul 3 | Qiu W | doi: 10.1038/onc.2008.43 |
26229107 | The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer. | J Biol Chem | 2015 Sep 11 | Li H | doi: 10.1074/jbc.M115.658468 |
27171940 | The MDM2 T309G polymorphism and risk of lung cancer: an updated meta-analysis of 10,186 cases and 14,155 controls. | Panminerva Med | 2016 Dec | Tian X | - |
27194168 | The Role of MDM2 Amplification and Overexpression in Tumorigenesis. | Cold Spring Harb Perspect Med | 2016 Jun 1 | Oliner JD | doi: 10.1101/cshperspect.a026336. |
28158999 | MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk. | BMC Cancer | 2017 Feb 3 | Gansmo LB | doi: 10.1186/s12885-017-3094-y. |
28498468 | MicroRNA-379-5p plays a tumor-suppressive role in human bladder cancer growth and metastasis by directly targeting MDM2. | Oncol Rep | 2017 Jun | Wu D | doi: 10.3892/or.2017.5607 |
29480845 | Association of rs2279744 and rs117039649 promoter polymorphism with the risk of gynecological cancer: A meta-analysis of case-control studies. | Medicine (Baltimore) | 2018 Jan | Zhang J | doi: 10.1097/MD.0000000000009554. |
28667029 | Association of the Del1518 Promoter (rs3730485) Polymorphism in the MDM2 Gene with Breast Cancer in a Mexican Population. | Ann Clin Lab Sci | 2017 May | Gallegos-Arreola MP | - |
28784612 | Early-Stage Metastasis Requires Mdm2 and Not p53 Gain of Function. | Mol Cancer Res | 2017 Nov | Hauck PM | doi: 10.1158/1541-7786.MCR-17-0174 |
27624283 | MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer. | Sci Rep | 2016 Sep 14 | Helwa R | doi: 10.1038/srep33153. |
30244662 | The Study of MDM2 rs937283 Variant and Cancer Susceptibility in a Central Chinese Population. | Technol Cancer Res Treat | 2018 Jan 1 | Chen B | doi: 10.1177/1533033818801550. |
21444629 | Synergistic suppression of prostatic cancer cells by coexpression of both murine double minute 2 small interfering RNA and wild-type p53 gene in vitro and in vivo. | J Pharmacol Exp Ther | 2011 Jul | Ji K | doi: 10.1124/jpet.111.180364 |
25201199 | Splice variants of MDM2 in oncogenesis. | Subcell Biochem | 2014 | Rosso M | doi: 10.1007/978-94-017-9211-0_14. |
24236052 | MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9. | PLoS One | 2013 Nov 13 | Chen X | doi: 10.1371/journal.pone.0078794 |
20370686 | Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy. | Curr Cancer Drug Targets | 2010 May | Azmi AS | - |
21477265 | A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population. | Fundam Clin Pharmacol | 2012 Jun | Alshatwi AA | doi: 10.1111/j.1472-8206.2011.00939.x |
23045280 | Prognostic value of the hDMP1-ARF-Hdm2-p53 pathway in breast cancer. | Oncogene | 2013 Aug 29 | Maglic D | doi: 10.1038/onc.2012.423 |
26411689 | LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer. | Cell Rep | 2015 Oct 6 | Zhang A | doi: 10.1016/j.celrep.2015.08.069 |
22266832 | Impact of MDM2 polymorphism: increased risk of developing colorectal cancer and a poor prognosis in the Tunisian population. | Eur J Gastroenterol Hepatol | 2012 Mar | Chaar I | doi: 10.1097/MEG.0b013e32834bdf84. |
21877955 | Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia. | Genet Test Mol Biomarkers | 2012 Feb | Al-Hadyan KS | doi: 10.1089/gtmb.2011.0126 |
26350565 | The cholesterol metabolite 27-hydroxycholesterol regulates p53 activity and increases cell proliferation via MDM2 in breast cancer cells. | Mol Cell Biochem | 2015 Dec | Raza S | doi: 10.1007/s11010-015-2551-7 |
25479941 | Genetic association of single nucleotide polymorphisms in P53 pathway with gastric cancer risk in a Chinese Han population. | Med Oncol | 2015 Jan | Wu GC | doi: 10.1007/s12032-014-0401-1 |
23359199 | Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women. | Pol J Pathol | 2012 Dec | Zajac A | - |
20503107 | MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis. | Med Oncol | 2011 Dec | Fang F | doi: 10.1007/s12032-010-9577-1 |
18281248 | MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population. | Carcinogenesis | 2008 Apr | Lum SS | doi: 10.1093/carcin/bgn024 |
16825434 | Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells. | J Med Genet | 2007 Jan | Alazzouzi H | - |
25987086 | MDM2 (RS769412) G>A Polymorphism in Cigarette Smokers: a Clue for the Susceptibility to Smoking and Lung Cancer Risk. | Asian Pac J Cancer Prev | 2015 | Ahmad D | - |
22716509 | Murine double minute 2 promoter SNP309 polymorphism and prostate cancer risk: a meta-analysis. | Int J Urol | 2012 Oct | Liu G | doi: 10.1111/j.1442-2042.2012.03067.x |
24423195 | MDM2 SNP309 polymorphism contributes to endometrial cancer susceptibility: evidence from a meta-analysis. | J Exp Clin Cancer Res | 2013 Nov 3 | Peng Q | doi: 10.1186/1756-9966-32-85. |
19590949 | Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis. | Breast Cancer Res Treat | 2010 Feb | Economopoulos KP | doi: 10.1007/s10549-009-0467-1 |
19144119 | Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer. | BMC Cancer | 2009 Jan 13 | Sun YF | doi: 10.1186/1471-2407-9-13. |
18023538 | No association between SNP309 promoter polymorphism in the MDM2 and cervical cancer in a study from northeastern Brazil. | Cancer Detect Prev | 2007 | Meissner Rde V | - |
17094469 | MDM2 T309G polymorphism is associated with bladder cancer. | Anticancer Res | 2006 Sep-Oct | Onat OE | - |
16496380 | Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer. | Int J Cancer | 2006 Aug 1 | Lind H | - |
17957785 | Genetic polymorphisms of MDM2, cumulative cigarette smoking and nonsmall cell lung cancer risk. | Int J Cancer | 2008 Feb 15 | Liu G | - |
20875869 | Association between polymorphisms of TP53 and MDM2 and prostate cancer risk in southern Chinese. | Cancer Genet Cytogenet | 2010 Oct 15 | Xu B | doi: 10.1016/j.cancergencyto.2010.02.014. |
23624782 | Association of MDM2 SNP309 and TP53 Arg72Pro polymorphisms with risk of endometrial cancer. | Oncol Rep | 2013 Jul | Yoneda T | doi: 10.3892/or.2013.2433 |
24870800 | A functional SNP in the MDM2 promoter mediates E2F1 affinity to modulate cyclin D1 expression in tumor cell proliferation. | Asian Pac J Cancer Prev | 2014 | Yang ZH | - |
22744426 | Polymorphisms in TP53 and MDM2 contribute to higher risk of colorectal cancer in Chinese population: a hospital-based, case-control study. | Mol Biol Rep | 2012 Oct | Zhang Y | doi: 10.1007/s11033-012-1831-5 |
21479369 | Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. | Oncol Rep | 2011 Jun | Leu JD | doi: 10.3892/or.2011.1254 |
16434608 | No association between the MDM2 -309 T/G promoter polymorphism and breast cancer in African-Americans or Whites. | Cancer Epidemiol Biomarkers Prev | 2006 Jan | Millikan RC | - |
19062713 | [Impact of PI3K /Akt /mdm2 signaling pathway on the sensitivity of gastric cancer cell line SGC7901 to doxorubicin]. | Zhonghua Zhong Liu Za Zhi | 2008 Jul | Ai YW | - |
18317451 | Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt-dependent activation of Hdm2 and downregulation of p53. | Oncogene | 2008 Jun 26 | Shankar E | doi: 10.1038/onc.2008.39 |
23870475 | Expression and significance of p53 and mdm2 in patients with leukoplakia cancer. | Asian Pac J Trop Med | 2013 Oct | Cui JJ | doi: 10.1016/S1995-7645(13)60147-9. |
17620186 | P53 and MDM2 isoforms in blood from lung cancer patients. | Exp Lung Res | 2007 Jun-Jul | Gonzalez-Avila G | - |
26281353 | [Multifunctionality of MDM2 protein and its role in genomic instability of cancer cells]. | Postepy Biochem | 2015 | Maluszek M | - |
26625797 | Correlation between Patterns of Mdm2 SNIP 309 and Histopathological Severity of Helicobacter pylori Associated Gastritis in Thailand. | Asian Pac J Cancer Prev | 2015 | Tongtawee T | - |
25672611 | Association of p53 and mdm2 in the development and progression of non-small cell lung cancer. | Tumour Biol | 2015 Jul | Javid J | doi: 10.1007/s13277-015-3208-6 |
24293392 | MDM2 rs2279744 polymorphism and endometrial cancer: a meta-analysis. | Tumour Biol | 2014 Apr | Wang LH | doi: 10.1007/s13277-013-1413-8 |
18519798 | A novel functional polymorphism C1797G in the MDM2 promoter is associated with risk of bladder cancer in a Chinese population. | Clin Cancer Res | 2008 Jun 1 | Wang M | doi: 10.1158/1078-0432.CCR-07-5155. |
17538168 | MDM2 polymorphism, survival, and histology in early-stage non-small-cell lung cancer. | J Clin Oncol | 2007 Jun 1 | Heist RS | - |
21478269 | Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells. | Mol Cancer Res | 2011 May | Li D | doi: 10.1158/1541-7786.MCR-10-0534 |
19470936 | MDM2 and Ki-67 predict for distant metastasis and mortality in men treated with radiotherapy and androgen deprivation for prostate cancer: RTOG 92-02. | J Clin Oncol | 2009 Jul 1 | Khor LY | doi: 10.1200/JCO.2008.19.8267 |
23451111 | MDM2 SNP309 rs2279744 polymorphism and gastric cancer risk: a meta-analysis. | PLoS One | 2013 | Ma Y | doi: 10.1371/journal.pone.0056918 |
25227851 | Effects of p53 codon 72 and MDM2 SNP309 polymorphisms on gastric cancer risk among the Iranian population. | Asian Pac J Cancer Prev | 2014 | Moradi MT | - |
19751436 | Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients. | Helicobacter | 2009 Oct | Wang X | doi: 10.1111/j.1523-5378.2009.00712.x. |
19526525 | MDM2 SNP309 genotype influences survival of metastatic but not of localized neuroblastoma. | Pediatr Blood Cancer | 2009 Oct | Perfumo C | doi: 10.1002/pbc.22132. |
16152608 | Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. | Int J Cancer | 2006 Mar 1 | Hu Z | - |
18313915 | MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients. | Eur J Cancer | 2008 Mar | Phang BH | doi: 10.1016/j.ejca.2008.02.007 |
11859876 | Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer. | Breast Cancer Res Treat | 2002 Jan | Hori M | - |
22310835 | Possible implication of Mdm2 as a prognostic marker in invasive laryngeal carcinoma. | Eur Arch Otorhinolaryngol | 2012 Jul | Hassumi-Fukasawa MK | doi: 10.1007/s00405-012-1937-3 |
22558411 | MDM2 promoter SNP344T>A (rs1196333) status does not affect cancer risk. | PLoS One | 2012 | Knappskog S | doi: 10.1371/journal.pone.0036263 |
20822933 | Are cell cycle and apoptosis genes associated with prostate cancer risk in North Indian population? | Urol Oncol | 2012 Sep | Mandal RK | doi: 10.1016/j.urolonc.2010.05.006 |
21867960 | MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis. | J Genet Genomics | 2011 Aug 20 | Wo X | doi: 10.1016/j.jgg.2011.07.005 |
18953830 | [Genetic polymorphism in MDM2 is associated with susceptibility to colorectal cancer in a Chinese population]. | Zhonghua Zhong Liu Za Zhi | 2008 May | Liu JN | - |
19707196 | The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. | Br J Cancer | 2009 Oct 20 | Sinilnikova OM | doi: 10.1038/sj.bjc.6605279 |
12750288 | p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. | Cancer Res | 2003 May 15 | Phelps M | - |
16883576 | A downstream kinase of the mammalian target of rapamycin, p70S6K1, regulates human double minute 2 protein phosphorylation and stability. | J Cell Physiol | 2006 Nov | Fang J | - |
22938470 | Association between MDM2 promoter SNP309 T/G polymorphism and liver cancer risk - a meta-analysis. | Asian Pac J Cancer Prev | 2012 | Ma HB | - |
27569097 | MDM2 344T>A polymorphism; could it be a predictive marker of anthracycline resistance? | J BUON | 2016 May-Jun | Arfaoui A | - |
17638920 | Interaction of P53 Arg72Pro and MDM2 T309G polymorphisms and their associations with risk of gastric cardia cancer. | Carcinogenesis | 2007 Sep | Yang M | - |
21539745 | MDM2 antagonists boost antitumor effect of androgen withdrawal: implications for therapy of prostate cancer. | Mol Cancer | 2011 May 3 | Tovar C | doi: 10.1186/1476-4598-10-49. |
16478747 | Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. | J Natl Cancer Inst | 2006 Feb 15 | Menin C | - |
17719241 | Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women. | Ann Epidemiol | 2008 Jan | Singh V | - |
25110100 | Mathematical simulation of p53-Mdm2 protein biological system regulation. | Bull Exp Biol Med | 2014 Aug | Voropaeva OF | doi: 10.1007/s10517-014-2608-8 |
25241153 | Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. | Arch Dermatol Res | 2014 Nov | Oliveira Alves MG | doi: 10.1007/s00403-014-1500-8 |
25070969 | MDM2 oncogene, E3 ubiquitin protein ligase T309G polymorphism and risk of oesophageal or gastric cancer: meta-analysis of 15 studies. | J Int Med Res | 2014 Oct | Shen W | doi: 10.1177/0300060514527910 |
21770737 | MDM2 SNP309 polymorphism and colorectal cancer risk: a meta-analysis. | DNA Cell Biol | 2012 Mar | Cao X | doi: 10.1089/dna.2011.1338 |
19020940 | Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. | Ann Surg Oncol | 2009 Feb | Chen J | doi: 10.1245/s10434-008-0220-8 |
17909070 | Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium. | Cancer Res | 2007 Oct 1 | Schmidt MK | - |
25316267 | TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal women. | Med Oncol | 2014 Nov | Zajac A | doi: 10.1007/s12032-014-0286-z |
17013834 | Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer. | Mol Carcinog | 2007 Feb | Jun HJ | - |
23679294 | Association between MDM2 SNP309 T>G and risk of gastric cancer: a meta-analysis. | Asian Pac J Cancer Prev | 2013 | Tian X | - |
24823443 | HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator. | FEBS J | 2014 Jul | Bhattacharya S | doi: 10.1111/febs.12843 |
26977010 | MDM2 and PSMA Play Inhibitory Roles in Metastatic Breast Cancer Cells Through Regulation of Matrix Metalloproteinases. | Anticancer Res | 2016 Mar | Bradbury R | - |
18292944 | CARF (collaborator of ARF) interacts with HDM2: evidence for a novel regulatory feedback regulation of CARF-p53-HDM2-p21WAF1 pathway. | Int J Oncol | 2008 Mar | Hasan MK | - |
21547352 | MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis. | Hum Cell | 2011 Jun | Li Y | doi: 10.1007/s13577-011-0013-4 |
19941740 | Frequency and prognostic significance of murine double minute protein-2 overexpression and p53 gene mutations in childhood acute lymphoblastic leukemia. | Hematology | 2009 Dec | Hendy OM | doi: 10.1179/102453309X12473408860389. |
22487911 | MDM2 SNP285 does not antagonize the effect of SNP309 in lung cancer. | Int J Cancer | 2012 Dec 1 | Ryan BM | doi: 10.1002/ijc.27573 |
26320449 | MDM2 and TP53 Polymorphisms as Predictive Markers for Head and Neck Cancer in Northeast Indian Population: Effect of Gene-Gene and Gene-Environment Interactions. | Asian Pac J Cancer Prev | 2015 | Bhowmik A | - |
21706156 | MDM2 SNP309 and TP53 R72P associated with severe and febrile neutropenia in breast cancer patients treated with 5-FU/epirubicin/cyclophosphamide. | Breast Cancer Res Treat | 2012 Apr | Okishiro M | doi: 10.1007/s10549-011-1637-5 |
19411066 | Regulation of XIAP translation and induction by MDM2 following irradiation. | Cancer Cell | 2009 May 5 | Gu L | doi: 10.1016/j.ccr.2009.03.002. |
18234963 | TAp73 alpha increases p53 tumor suppressor activity in thyroid cancer cells via the inhibition of Mdm2-mediated degradation. | Mol Cancer Res | 2008 Jan | Malaguarnera R | doi: 10.1158/1541-7786.MCR-07-0005. |
19346994 | Clinicopathological correlations of cyclooxygenase-2, MDM2, and p53 expressions in surgically resectable pancreatic invasive ductal adenocarcinoma. | Pancreas | 2009 Jul | Hermanova M | doi: 10.1097/MPA.0b013e31819fef8b. |
21725850 | MDM2 SNP309 polymorphism and breast cancer risk: a meta-analysis. | Mol Biol Rep | 2012 Apr | Zhao E | doi: 10.1007/s11033-011-1119-1 |
21080085 | MDM2 is overexpressed and regulated by the eukaryotic translation initiation factor 4E (eIF4E) in human squamous cell carcinoma of esophagus. | Ann Surg Oncol | 2011 May | Hsu HS | doi: 10.1245/s10434-010-1428-y |
25074979 | MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. | Sci Signal | 2014 Jul 29 | Thirumurthi U | doi: 10.1126/scisignal.2005076. |
19193430 | Polymorphisms in TP53 and MDM2 combined are associated with high grade endometrial cancer. | Gynecol Oncol | 2009 Apr | Ashton KA | doi: 10.1016/j.ygyno.2008.12.036 |
23423487 | Effect of TP53 codon 72 and MDM2 SNP309 polymorphisms on survival of gastric cancer among patients who receiving 5-fluorouracil-based postoperative adjuvant chemotherapy. | Cancer Chemother Pharmacol | 2013 Apr | Wang S | doi: 10.1007/s00280-013-2103-3 |
18804411 | MDM2 SNP309 does not confer an increased risk to oral squamous cell carcinoma but may modulate the age of disease onset. | Oral Oncol | 2009 Jun | Hamid S | doi: 10.1016/j.oraloncology.2008.06.003 |
24289472 | The clinicopathological significance and relationship of Gli1, MDM2 and p53 expression in resectable pancreatic cancer. | Histopathology | 2014 Mar | Sheng W | doi: 10.1111/his.12273 |
18828900 | MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. | BMC Cancer | 2008 Oct 1 | Paulin FE | doi: 10.1186/1471-2407-8-281. |
19264476 | MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians. | Eur J Cancer | 2009 Jul | Gui XH | doi: 10.1016/j.ejca.2009.02.002 |
14522887 | Tumor promotion by Mdm2 splice variants unable to bind p53. | Cancer Res | 2003 Sep 15 | Fridman JS | - |
21229604 | Role of the MDM2 SNP309 polymorphism in the initiation and early age of onset of nasopharyngeal carcinoma. | Mol Carcinog | 2011 Feb | Sousa H | doi: 10.1002/mc.20689 |
18348658 | No association of MDM2 T309G polymorphism with susceptibility to Korean gastric cancer patients. | Neoplasma | 2008 | Cho YG | - |
22844496 | Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls. | PLoS One | 2012 | Zhuo W | doi: 10.1371/journal.pone.0041546 |
21051533 | TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. | Jpn J Clin Oncol | 2011 Feb | Joshi AM | doi: 10.1093/jjco/hyq200 |
24844868 | Current evidence on the relationship between murine double minute 2 T309G polymorphism and esophageal cancer susceptibility. | Dis Esophagus | 2015 Aug-Sep | Chen B | doi: 10.1111/dote.12240 |
26151241 | Overexpression of microRNA125a3p effectively inhibits the cell growth and invasion of lung cancer cells by regulating the mouse double minute 2 homolog/p53 signaling pathway. | Mol Med Rep | 2015 Oct | Li S | doi: 10.3892/mmr.2015.4038 |
16287156 | Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. | Hum Mutat | 2006 Jan | Zhang X | - |
26840028 | microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis. | Oncotarget | 2016 Feb 23 | Zhang C | doi: 10.18632/oncotarget.7088. |
26373042 | Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China). | J Nanosci Nanotechnol | 2015 Jul | Elingarami S | - |
27015167 | Murine Double Minute 2 SNP T309G Polymorphism and Urinary Tract Cancer Risk: A Meta-Analysis. | Medicine (Baltimore) | 2016 Mar | Ding H | doi: 10.1097/MD.0000000000002941. |
17116689 | Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. | Mol Cell Biol | 2007 Feb | Lindstrom MS | - |
22914606 | Relationship between MDM2 and p53 alterations in colorectal cancer and their involvement and prognostic value in the Tunisian population. | Appl Immunohistochem Mol Morphol | 2013 May | Chaar I | doi: 10.1097/PAI.0b013e31825f4e20. |
18547962 | MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk. | Oncology | 2008 | Krekac D | doi: 10.1159/000139135 |
19671680 | MDM2 controls the timely expression of cyclin A to regulate the cell cycle. | Mol Cancer Res | 2009 Aug | Frum R | doi: 10.1158/1541-7786.MCR-08-0334 |
17003841 | The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes. | Eur J Hum Genet | 2007 Jan | Ruijs MW | - |
11894120 | Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. | Int J Oncol | 2002 Apr | Wang H | - |
18355939 | EGFR, TTF-1 and Mdm2 expression in stage III non-small cell lung cancer: a positive association. | Lung Cancer | 2008 Oct | Berghmans T | doi: 10.1016/j.lungcan.2008.02.003 |
19955655 | TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. | J Clin Invest | 2010 Jan | Araki S | doi: 10.1172/JCI39194 |
25271042 | Effects of MDM2 promoter polymorphisms on the development of cervical neoplasia in a Southeastern Brazilian population. | Biomarkers | 2014 Dec | Vargas-Torres SL | doi: 10.3109/1354750X.2014.962614 |
20080680 | Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes. | Proc Natl Acad Sci U S A | 2010 Feb 2 | Sarafraz-Yazdi E | doi: 10.1073/pnas.0909364107 |
24377582 | Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk. | Asian Pac J Cancer Prev | 2014 Jan | Song B | - |
19764997 | Association of TP53 and MDM2 polymorphisms with survival in bladder cancer patients treated with chemoradiotherapy. | Cancer Sci | 2009 Dec | Shinohara A | doi: 10.1111/j.1349-7006.2009.01331.x |
25016295 | Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. | Gastroenterology | 2014 Oct | Wang W | doi: 10.1053/j.gastro.2014.07.001 |
25122426 | DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer. | J Thorac Oncol | 2014 Sep | Yang YC | doi: 10.1097/JTO.0000000000000240. |
16203772 | p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. | Clin Cancer Res | 2005 Oct 1 | Sotamaa K | - |
20219101 | Effect of MDM2 SNP309 and p53 codon 72 polymorphisms on lung cancer risk and survival among non-smoking Chinese women in Singapore. | BMC Cancer | 2010 Mar 10 | Chua HW | doi: 10.1186/1471-2407-10-88. |
14729628 | p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF. | Cancer Res | 2004 Jan 1 | Xia L | - |
17717065 | Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer. | Stem Cells | 2007 Dec | Pruitt SC | - |
12450795 | Transformation of normal human cells in the absence of telomerase activation. | Cancer Cell | 2002 Nov | Seger YR | - |
17387621 | The p53 Arg72Pro and MDM2 -309 polymorphisms and risk of breast cancer in the nurses' health studies. | Cancer Causes Control | 2007 Aug | Cox DG | - |
26514489 | Genetic Polymorphism of MDM2 SNP309 in Patients with Helicobacter Pylori-Associated Gastritis. | Asian Pac J Cancer Prev | 2015 | Tongtawee T | - |
17545525 | A polymorphism in HDM2 (SNP309) associates with early onset in superficial tumors, TP53 mutations, and poor outcome in invasive bladder cancer. | Clin Cancer Res | 2007 Jun 1 | Sanchez-Carbayo M | - |
19509552 | Association of p73 and MDM2 polymorphisms with the risk of epithelial ovarian cancer in Chinese women. | Int J Gynecol Cancer | 2009 May | Kang S | doi: 10.1111/IGC.0b013e3181a130ab. |
25842826 | [Association of polymorphic markers Arg72Pro of TP53 and T309g of MDM2 genes with non small cell lung cancer in Russians of Moscow region]. | Mol Biol (Mosk) | 2014 Jan-Feb | Loginov VI | - |
25280518 | Triptolide induces apoptosis of gastric cancer cells via inhibiting the overexpression of MDM2. | Med Oncol | 2014 Nov | Wang BY | doi: 10.1007/s12032-014-0270-7 |
25537146 | TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study. | Pathol Oncol Res | 2015 Jul | Abderrahmane R | doi: 10.1007/s12253-014-9867-6 |
21268124 | MDM2 SNP309 contributes to non-small cell lung cancer survival in Chinese. | Mol Carcinog | 2011 Jun | Dong J | doi: 10.1002/mc.20727 |
19448627 | p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. | Nat Cell Biol | 2009 Jun | Wang SP | doi: 10.1038/ncb1875 |
25649770 | Interaction between p53 mutation and a somatic HDMX biomarker better defines metastatic potential in breast cancer. | Cancer Res | 2015 Feb 15 | Grawenda AM | doi: 10.1158/0008-5472.CAN-14-2637 |
24792886 | Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies. | Tumour Biol | 2014 Aug | Zhao Y | doi: 10.1007/s13277-014-1886-0 |
20832750 | A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. | Cancer Cell | 2010 Sep 14 | Post SM | doi: 10.1016/j.ccr.2010.07.010. |
19874399 | Polymorphisms of p53 codon 72 and MDM2 promoter 309 and the risk of endometrial cancer. | Hum Cell | 2009 Nov | Nunobiki O | doi: 10.1111/j.1749-0774.2009.00075.x. |
25119589 | Association between murine double minute 2 T309G polymorphism and risk of liver cancer. | Tumour Biol | 2014 Nov | Tang T | doi: 10.1007/s13277-014-2432-9 |
27825169 | Inhibition of MDM2 Re-Sensitizes Rapamycin Resistant Renal Cancer Cells via the Activation of p53. | Cell Physiol Biochem | 2016 | Tian X | - |
24532430 | MDM2 SNP309 variation increases cervical cancer risk among Asians. | Tumour Biol | 2014 Jun | Zhuo X | doi: 10.1007/s13277-014-1695-5 |
19029954 | Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells. | Oncogene | 2009 Feb 5 | Sui X | doi: 10.1038/onc.2008.423 |
15492852 | Alteration of the MDM2-p73-P14ARF pathway related to tumour progression during urinary bladder carcinogenesis. | Int J Mol Med | 2004 Nov | Schlott T | - |
22467100 | Murine double minute clone 2,309T/G and 285G/C promoter single nucleotide polymorphism as a risk factor for breast cancer: a Polish experience. | Int J Biol Markers | 2012 Jul 19 | Piotrowski P | doi: 10.5301/JBM.2012.9140. |
23383041 | The MDM2 309T>G polymorphism and ovarian cancer risk: a meta-analysis of 1534 cases and 2211 controls. | PLoS One | 2013 | Ma YY | doi: 10.1371/journal.pone.0055019 |
23881403 | Cooperation among Numb, MDM2 and p53 in the development and progression of pancreatic cancer. | Cell Tissue Res | 2013 Nov | Sheng W | doi: 10.1007/s00441-013-1679-6 |
20855462 | Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population. | Clin Cancer Res | 2010 Nov 1 | Sun T | doi: 10.1158/1078-0432.CCR-10-1261 |
11956627 | Distinct promoter usage of mdm2 gene in human breast cancer. | Oncol Rep | 2002 May-Jun | Okumura N | - |
19523862 | No evidence for association of the MDM2-309 T/G promoter polymorphism with prostate cancer outcomes. | Urol Oncol | 2011 May-Jun | Jaboin JJ | doi: 10.1016/j.urolonc.2009.03.031 |
19945467 | Downregulation of p53 by phosphatase of regenerating liver 3 is mediated by MDM2 and PIRH2. | Life Sci | 2010 Jan 2 | Min SH | doi: 10.1016/j.lfs.2009.11.010 |
24098760 | An updated meta-analysis on the association of MDM2 SNP309 polymorphism with colorectal cancer risk. | PLoS One | 2013 Sep 30 | Qin X | doi: 10.1371/journal.pone.0076031 |
19639206 | The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. | Oncol Rep | 2009 Sep | Lang A | - |
24292333 | Subcellular localization of Mdm2 expression and prognosis of breast cancer. | Int J Clin Oncol | 2014 Oct | Park HS | doi: 10.1007/s10147-013-0639-1 |
15714438 | Alternative splicing of MDM2 mRNA in lung carcinomas and lung cell lines. | Environ Mol Mutagen | 2005 Jul | Weng MW | - |
26317544 | KMT Set7/9 affects genotoxic stress response via the Mdm2 axis. | Oncotarget | 2015 Sep 22 | Lezina L | doi: 10.18632/oncotarget.4584. |
27890964 | Association of the MDM2 SNP285 Polymorphism with Cancer Susceptibility: A Meta-Analysis. | Dis Markers | 2016 | Wang P | - |
22330136 | Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop. | Oncogene | 2013 Jan 3 | Zhang J | doi: 10.1038/onc.2012.28 |
21504894 | MDM2 interacts with NME2 (non-metastatic cells 2, protein) and suppresses the ability of NME2 to negatively regulate cell motility. | Carcinogenesis | 2011 Aug | Polanski R | doi: 10.1093/carcin/bgr070 |
21602883 | Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression. | Oncogene | 2011 Nov 17 | Lushnikova T | doi: 10.1038/onc.2011.172 |
25040988 | The MDM2 SNP309T>G polymorphism increases bladder cancer risk among Caucasians: a meta-analysis. | Asian Pac J Cancer Prev | 2014 | Wang HG | - |
20200430 | TP53, MDM2, NQO1, and susceptibility to cervical cancer. | Cancer Epidemiol Biomarkers Prev | 2010 Mar | Hu X | doi: 10.1158/1055-9965.EPI-09-0886 |
20021639 | Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patients. | Breast Cancer Res | 2009 | Schmidt MK | doi: 10.1186/bcr2460 |
23039163 | Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers. | BMC Cancer | 2012 Oct 5 | Bjornslett M | doi: 10.1186/1471-2407-12-454. |
19941079 | Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors. | Ann Surg Oncol | 2010 Apr | Chien WP | doi: 10.1245/s10434-009-0853-2 |
23167337 | Meta-analysis of associations between the MDM2-T309G polymorphism and prostate cancer risk. | Asian Pac J Cancer Prev | 2012 | Chen T | - |
25001177 | Netrin-1 promoted pancreatic cancer cell proliferation by upregulation of Mdm2. | Tumour Biol | 2014 Oct | Huang Q | doi: 10.1007/s13277-014-2195-3 |
25201204 | Lung cancer stem cells, p53 mutations and MDM2. | Subcell Biochem | 2014 | Gadepalli VS | doi: 10.1007/978-94-017-9211-0_19. |
24147044 | Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator. | PLoS One | 2013 Oct 11 | Okoro DR | doi: 10.1371/journal.pone.0077643 |
22349818 | Coordinate regulation of estrogen receptor β degradation by Mdm2 and CREB-binding protein in response to growth signals. | Oncogene | 2013 Jan 3 | Sanchez M | doi: 10.1038/onc.2012.19 |
27798881 | Expression of the p53 Inhibitors MDM2 and MDM4 as Outcome Predictor in Muscle-invasive Bladder Cancer. | Anticancer Res | 2016 Oct | Kriegmair MC | - |
25637791 | Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. | Cancer Lett | 2015 Apr 10 | Wu B | doi: 10.1016/j.canlet.2015.01.034 |
25327560 | Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). | Oncotarget | 2014 Sep 30 | Knappskog S | - |
27604213 | Relationship Between Murine Double Minute 2 (MDM2) T309G Polymorphism and Endometrial Cancer Risk: A Meta-Analysis. | Med Sci Monit | 2016 Sep 8 | Xue Z | - |
28406480 | WDR79 promotes the proliferation of non-small cell lung cancer cells via USP7-mediated regulation of the Mdm2-p53 pathway. | Cell Death Dis | 2017 Apr 13 | Sun Y | doi: 10.1038/cddis.2017.162. |
27693458 | 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway. | Cancer Lett | 2016 Dec 1 | Xu J | doi: 10.1016/j.canlet.2016.09.011 |
27130667 | Long non-coding RNA LOC572558 inhibits bladder cancer cell proliferation and tumor growth by regulating the AKT-MDM2-p53 signaling axis. | Cancer Lett | 2016 Oct 1 | Zhu Y | doi: 10.1016/j.canlet.2016.04.030 |
27617579 | FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. | Oncogene | 2017 Mar 23 | Liu T | doi: 10.1038/onc.2016.331 |
26956143 | Evaluation of TP53 Pro72Arg and MDM2 SNP285-SNP309 polymorphisms in an Italian cohort of LFS suggestive patients lacking identifiable TP53 germline mutations. | Fam Cancer | 2016 Oct | Ponti F | doi: 10.1007/s10689-016-9895-3. |
28817834 | MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. | Br J Cancer | 2017 Oct 10 | Chen Y | doi: 10.1038/bjc.2017.265 |
27957778 | Assessment of TP53 Polymorphisms and MDM2 SNP309 in Premenopausal Breast Cancer Risk. | Hum Mutat | 2017 Mar | Samuel N | doi: 10.1002/humu.23154 |
29175211 | Nutlin sensitizes lung carcinoma cells to interferon-alpha treatment in MDM2-dependent but p53-independent manner. | Biochem Biophys Res Commun | 2018 Jan 1 | Shuvalov O | doi: 10.1016/j.bbrc.2017.11.118 |
26025918 | MDM2 and P53 polymorphisms contribute together to the risk and survival of prostate cancer. | Oncotarget | 2016 May 31 | Xue L | doi: 10.18632/oncotarget.3923. |
27184007 | Mouse double minute 2 (MDM2) upregulates Snail expression and induces epithelial-to-mesenchymal transition in breast cancer cells in vitro and in vivo. | Oncotarget | 2016 Jun 14 | Lu X | doi: 10.18632/oncotarget.9287. |
27259273 | MDM2 knockdown mediated by a triazine-modified dendrimer in the treatment of non-small cell lung cancer. | Oncotarget | 2016 Jul 12 | Huang Q | doi: 10.18632/oncotarget.9768. |
27081698 | Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate. | Oncotarget | 2016 May 10 | Gansmo LB | doi: 10.18632/oncotarget.8705. |
26993775 | PIM1 destabilization activates a p53-dependent response to ribosomal stress in cancer cells. | Oncotarget | 2016 Apr 26 | Sagar V | doi: 10.18632/oncotarget.8070. |
27004407 | Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer. | Oncotarget | 2016 Apr 26 | Xiong J | doi: 10.18632/oncotarget.8207. |
28418896 | NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway. | Oncotarget | 2017 Jun 6 | Jana A | doi: 10.18632/oncotarget.16343. |
28567715 | MDMX is a prognostic factor for non-small cell lung cancer and regulates its sensitivity to cisplatin. | Cell Oncol (Dordr) | 2017 Aug | Zhao H | doi: 10.1007/s13402-017-0325-9 |
29096752 | The association between murine double minute 2 (MDM2) rs2279744 and endometrial cancer risk in a Chinese Han population. | Cell Mol Biol (Noisy-le-grand) | 2017 Oct 31 | Wu JP | doi: 10.14715/cmb/2017.63.10.20. |
29699057 | Significant Association of the MDM2 T309G Polymorphism with Breast Cancer Risk in a Turkish Population | Asian Pac J Cancer Prev | 2018 Apr 27 | Yilmaz M | - |
28800790 | miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer. | Oncol Res | 2018 Jun 11 | Kong Q | doi: 10.3727/096504017X15021536183490 |
29734849 | Antiproliferative and apoptosis-induction studies of 5-hydroxy 3',4',7-trimethoxyflavone in human breast cancer cells MCF-7: an in vitro and in silico approach. | J Recept Signal Transduct Res | 2018 Jun | Sudha A | doi: 10.1080/10799893.2018.1468780 |
29777315 | The MDM2 rs937283 A>G variant significantly increases the risk of lung and gastric cancer in Chinese population. | Int J Clin Oncol | 2018 Oct | Chen B | doi: 10.1007/s10147-018-1295-2 |
30194081 | Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan. | Cancer Genomics Proteomics | 2018 Sep-Oct | Yueh TC | doi: 10.21873/cgp.20099. |
29755129 | Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. | Oncogene | 2018 Aug | McClurg UL | doi: 10.1038/s41388-018-0283-3 |
26719543 | IMPORTANCE OF APOPTOSIS MARKERS (MDM2, BCL-2 AND Bax) IN BENIGN PROSTATIC HYPERPLASIA AND PROSTATE CANCER. | Georgian Med News | 2015 Dec | Saker Z | - |