EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135763 (Gene tree)
Gene ID: 9816
Gene Symbol: URB2
Alias: NPA2|NET10|KIAA0133
Full Name: URB2 ribosome biogenesis homolog
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 34,683 bases
Position: chr1:229,626,205-229,660,887
Accession: 28967
RBP type: canonical RBP
Summary: (URB2 Ribosome Biogenesis Homolog) is a Protein Coding gene. Diseases associated with URB2 include Hepatocellular Carcinoma and Buruli Ulcer.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000258243	Urb2	PF10441.9	1.7e-23	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000434387	URB2-202	643	-	ENSP00000395107	84 (aa)	-	Q5VYD0
ENST00000258243	URB2-201	5613	XM_005273360	ENSP00000258243	1524 (aa)	XP_005273417	Q14146

Gene Model

Click here to download ENSG00000135763's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135763	Attention Deficit Disorder with Hyperactivity	1.8740000E-004	18937294
ENSG00000135763	Attention Deficit Disorder with Hyperactivity	1.7980000E-004	18937294
ENSG00000135763	Cytarabine	4E-7	24483146

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135763	rs10799544	1	229648978	?	Red blood cell count	30595370			EFO_0004305
ENSG00000135763	rs59428852	1	229634617	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135763's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135763	URB2	99	61.628	ENSAPOG00000000608	urb2	94	35.161	Acanthochromis_polyacanthus
ENSG00000135763	URB2	99	89.157	ENSAMEG00000009206	URB2	99	83.125	Ailuropoda_melanoleuca
ENSG00000135763	URB2	99	61.446	ENSACIG00000008078	-	99	58.261	Amphilophus_citrinellus
ENSG00000135763	URB2	99	61.905	ENSAOCG00000019961	urb2	99	35.312	Amphiprion_ocellaris
ENSG00000135763	URB2	99	61.905	ENSAPEG00000005263	urb2	99	35.312	Amphiprion_percula
ENSG00000135763	URB2	99	63.095	ENSATEG00000020930	urb2	99	34.444	Anabas_testudineus
ENSG00000135763	URB2	99	72.619	ENSAPLG00000002998	URB2	100	51.000	Anas_platyrhynchos
ENSG00000135763	URB2	99	69.048	ENSACAG00000001285	URB2	100	48.683	Anolis_carolinensis
ENSG00000135763	URB2	100	94.048	ENSANAG00000033963	URB2	100	92.782	Aotus_nancymaae
ENSG00000135763	URB2	99	60.714	ENSACLG00000009254	urb2	95	35.101	Astatotilapia_calliptera
ENSG00000135763	URB2	100	57.647	ENSAMXG00000003474	urb2	100	36.486	Astyanax_mexicanus
ENSG00000135763	URB2	98	81.707	ENSBTAG00000010180	URB2	99	73.539	Bos_taurus
ENSG00000135763	URB2	100	95.238	ENSCJAG00000010968	URB2	100	92.388	Callithrix_jacchus
ENSG00000135763	URB2	99	84.337	ENSCAFG00000012118	URB2	100	82.152	Canis_familiaris
ENSG00000135763	URB2	100	83.333	ENSCAFG00020027217	URB2	99	81.250	Canis_lupus_dingo
ENSG00000135763	URB2	99	79.518	ENSCHIG00000014513	URB2	99	73.276	Capra_hircus
ENSG00000135763	URB2	100	90.476	ENSTSYG00000006924	URB2	99	83.388	Carlito_syrichta
ENSG00000135763	URB2	99	85.542	ENSCPOG00000020777	-	100	81.322	Cavia_porcellus
ENSG00000135763	URB2	100	94.048	ENSCCAG00000023932	URB2	100	92.979	Cebus_capucinus
ENSG00000135763	URB2	100	96.429	ENSCATG00000043366	URB2	100	94.751	Cercocebus_atys
ENSG00000135763	URB2	99	87.952	ENSCLAG00000006268	URB2	100	77.493	Chinchilla_lanigera
ENSG00000135763	URB2	100	96.429	ENSCSAG00000010599	URB2	100	94.488	Chlorocebus_sabaeus
ENSG00000135763	URB2	99	86.747	ENSCHOG00000010163	URB2	71	81.497	Choloepus_hoffmanni
ENSG00000135763	URB2	99	77.381	ENSCPBG00000006191	URB2	100	55.527	Chrysemys_picta_bellii
ENSG00000135763	URB2	100	96.429	ENSCANG00000023711	URB2	100	94.685	Colobus_angolensis_palliatus
ENSG00000135763	URB2	100	82.143	ENSCGRG00001009591	Urb2	100	73.722	Cricetulus_griseus_chok1gshd
ENSG00000135763	URB2	100	82.143	ENSCGRG00000011259	Urb2	100	73.722	Cricetulus_griseus_crigri
ENSG00000135763	URB2	99	55.814	ENSCSEG00000000299	urb2	99	32.914	Cynoglossus_semilaevis
ENSG00000135763	URB2	96	59.756	ENSCVAG00000011011	urb2	99	34.211	Cyprinodon_variegatus
ENSG00000135763	URB2	100	60.920	ENSDARG00000003217	urb2	99	61.165	Danio_rerio
ENSG00000135763	URB2	99	74.699	ENSDNOG00000043064	URB2	99	60.661	Dasypus_novemcinctus
ENSG00000135763	URB2	99	80.723	ENSDORG00000014975	Urb2	100	75.934	Dipodomys_ordii
ENSG00000135763	URB2	95	75.841	ENSETEG00000002869	URB2	95	75.841	Echinops_telfairi
ENSG00000135763	URB2	100	85.714	ENSEASG00005012060	URB2	99	81.747	Equus_asinus_asinus
ENSG00000135763	URB2	100	85.714	ENSECAG00000012338	URB2	99	87.234	Equus_caballus
ENSG00000135763	URB2	89	86.667	ENSEEUG00000002669	URB2	92	80.851	Erinaceus_europaeus
ENSG00000135763	URB2	100	67.816	ENSELUG00000014647	urb2	99	40.013	Esox_lucius
ENSG00000135763	URB2	99	86.747	ENSFCAG00000007662	URB2	100	80.184	Felis_catus
ENSG00000135763	URB2	100	69.412	ENSFALG00000003385	URB2	100	50.129	Ficedula_albicollis
ENSG00000135763	URB2	99	89.157	ENSFDAG00000021079	URB2	100	76.640	Fukomys_damarensis
ENSG00000135763	URB2	96	62.195	ENSFHEG00000010357	urb2	99	33.960	Fundulus_heteroclitus
ENSG00000135763	URB2	99	54.762	ENSGMOG00000012459	urb2	100	36.184	Gadus_morhua
ENSG00000135763	URB2	99	71.429	ENSGALG00000011101	URB2	100	51.544	Gallus_gallus
ENSG00000135763	URB2	99	63.095	ENSGACG00000016179	urb2	99	38.160	Gasterosteus_aculeatus
ENSG00000135763	URB2	99	75.000	ENSGAGG00000021879	URB2	100	55.491	Gopherus_agassizii
ENSG00000135763	URB2	100	100.000	ENSGGOG00000025643	URB2	100	98.228	Gorilla_gorilla
ENSG00000135763	URB2	99	60.714	ENSHBUG00000018469	urb2	99	35.419	Haplochromis_burtoni
ENSG00000135763	URB2	99	87.952	ENSHGLG00000016561	URB2	99	77.748	Heterocephalus_glaber_female
ENSG00000135763	URB2	99	87.952	ENSHGLG00100001838	URB2	100	75.853	Heterocephalus_glaber_male
ENSG00000135763	URB2	99	59.302	ENSHCOG00000013583	-	99	55.340	Hippocampus_comes
ENSG00000135763	URB2	100	60.920	ENSIPUG00000020315	urb2	99	36.410	Ictalurus_punctatus
ENSG00000135763	URB2	99	83.133	ENSSTOG00000025323	URB2	100	76.115	Ictidomys_tridecemlineatus
ENSG00000135763	URB2	99	84.337	ENSJJAG00000011998	Urb2	100	74.525	Jaculus_jaculus
ENSG00000135763	URB2	96	58.333	ENSKMAG00000020129	urb2	99	33.333	Kryptolebias_marmoratus
ENSG00000135763	URB2	99	60.714	ENSLBEG00000003249	-	99	53.881	Labrus_bergylta
ENSG00000135763	URB2	99	63.953	ENSLACG00000002038	URB2	100	46.164	Latimeria_chalumnae
ENSG00000135763	URB2	100	58.621	ENSLOCG00000015462	urb2	100	41.844	Lepisosteus_oculatus
ENSG00000135763	URB2	99	87.952	ENSLAFG00000012484	URB2	100	78.135	Loxodonta_africana
ENSG00000135763	URB2	99	96.386	ENSMFAG00000039905	URB2	100	94.226	Macaca_fascicularis
ENSG00000135763	URB2	99	96.386	ENSMMUG00000009509	URB2	100	94.357	Macaca_mulatta
ENSG00000135763	URB2	99	96.386	ENSMNEG00000038762	URB2	100	94.029	Macaca_nemestrina
ENSG00000135763	URB2	100	96.429	ENSMLEG00000043252	URB2	100	94.685	Mandrillus_leucophaeus
ENSG00000135763	URB2	98	62.651	ENSMAMG00000020365	urb2	99	34.642	Mastacembelus_armatus
ENSG00000135763	URB2	99	59.524	ENSMZEG00005011027	urb2	99	35.246	Maylandia_zebra
ENSG00000135763	URB2	99	71.429	ENSMGAG00000012073	URB2	100	48.832	Meleagris_gallopavo
ENSG00000135763	URB2	100	80.952	ENSMAUG00000017980	Urb2	100	83.688	Mesocricetus_auratus
ENSG00000135763	URB2	100	90.476	ENSMICG00000033302	URB2	99	84.964	Microcebus_murinus
ENSG00000135763	URB2	100	83.333	ENSMOCG00000020369	Urb2	100	72.692	Microtus_ochrogaster
ENSG00000135763	URB2	99	62.791	ENSMMOG00000001301	-	99	59.223	Mola_mola
ENSG00000135763	URB2	100	76.190	ENSMODG00000009076	-	97	81.651	Monodelphis_domestica
ENSG00000135763	URB2	99	61.628	ENSMALG00000006529	urb2	99	35.702	Monopterus_albus
ENSG00000135763	URB2	100	79.762	ENSMUSG00000031976	Urb2	100	71.531	Mus_musculus
ENSG00000135763	URB2	100	89.286	ENSMPUG00000012438	URB2	100	80.774	Mustela_putorius_furo
ENSG00000135763	URB2	100	83.333	ENSMLUG00000006236	-	99	86.239	Myotis_lucifugus
ENSG00000135763	URB2	100	80.952	ENSNGAG00000016524	Urb2	100	72.823	Nannospalax_galili
ENSG00000135763	URB2	100	97.619	ENSNLEG00000014450	URB2	100	96.785	Nomascus_leucogenys
ENSG00000135763	URB2	91	63.706	ENSMEUG00000016434	URB2	94	63.706	Notamacropus_eugenii
ENSG00000135763	URB2	100	83.333	ENSOPRG00000009906	URB2	92	76.481	Ochotona_princeps
ENSG00000135763	URB2	99	87.952	ENSODEG00000005593	URB2	100	76.247	Octodon_degus
ENSG00000135763	URB2	99	60.714	ENSONIG00000017078	urb2	99	38.014	Oreochromis_niloticus
ENSG00000135763	URB2	99	75.000	ENSOANG00000013732	URB2	100	50.359	Ornithorhynchus_anatinus
ENSG00000135763	URB2	100	89.286	ENSOCUG00000010700	URB2	99	81.353	Oryctolagus_cuniculus
ENSG00000135763	URB2	100	56.322	ENSORLG00000010915	urb2	99	34.445	Oryzias_latipes
ENSG00000135763	URB2	100	56.322	ENSORLG00020003361	urb2	99	34.608	Oryzias_latipes_hni
ENSG00000135763	URB2	100	56.322	ENSORLG00015001534	urb2	99	34.685	Oryzias_latipes_hsok
ENSG00000135763	URB2	99	59.302	ENSOMEG00000010076	urb2	99	34.409	Oryzias_melastigma
ENSG00000135763	URB2	100	89.286	ENSOGAG00000003021	URB2	99	80.446	Otolemur_garnettii
ENSG00000135763	URB2	99	80.723	ENSOARG00000003102	URB2	99	73.211	Ovis_aries
ENSG00000135763	URB2	100	100.000	ENSPPAG00000040629	URB2	100	98.753	Pan_paniscus
ENSG00000135763	URB2	99	86.747	ENSPPRG00000012767	URB2	100	79.803	Panthera_pardus
ENSG00000135763	URB2	99	86.747	ENSPTIG00000012577	URB2	100	89.394	Panthera_tigris_altaica
ENSG00000135763	URB2	100	100.000	ENSPTRG00000002092	URB2	100	98.688	Pan_troglodytes
ENSG00000135763	URB2	100	96.429	ENSPANG00000002245	URB2	100	92.126	Papio_anubis
ENSG00000135763	URB2	100	66.667	ENSPKIG00000005787	urb2	100	39.859	Paramormyrops_kingsleyae
ENSG00000135763	URB2	99	73.810	ENSPSIG00000002690	URB2	100	54.756	Pelodiscus_sinensis
ENSG00000135763	URB2	99	59.524	ENSPMGG00000002006	-	99	53.153	Periophthalmus_magnuspinnatus
ENSG00000135763	URB2	89	84.000	ENSPEMG00000019551	Urb2	100	73.598	Peromyscus_maniculatus_bairdii
ENSG00000135763	URB2	100	78.571	ENSPCIG00000030071	URB2	100	63.874	Phascolarctos_cinereus
ENSG00000135763	URB2	96	58.537	ENSPFOG00000014330	urb2	99	34.459	Poecilia_formosa
ENSG00000135763	URB2	96	58.537	ENSPLAG00000014654	urb2	99	33.869	Poecilia_latipinna
ENSG00000135763	URB2	96	57.317	ENSPMEG00000012356	urb2	99	33.890	Poecilia_mexicana
ENSG00000135763	URB2	96	58.333	ENSPREG00000010268	urb2	99	33.828	Poecilia_reticulata
ENSG00000135763	URB2	100	96.429	ENSPPYG00000000123	URB2	99	96.783	Pongo_abelii
ENSG00000135763	URB2	100	89.286	ENSPCOG00000023537	URB2	99	86.211	Propithecus_coquereli
ENSG00000135763	URB2	100	65.334	ENSPVAG00000002108	URB2	100	65.334	Pteropus_vampyrus
ENSG00000135763	URB2	99	60.714	ENSPNYG00000016840	urb2	95	35.101	Pundamilia_nyererei
ENSG00000135763	URB2	100	60.000	ENSPNAG00000013684	urb2	100	36.930	Pygocentrus_nattereri
ENSG00000135763	URB2	100	82.143	ENSRNOG00000026853	Urb2	97	72.858	Rattus_norvegicus
ENSG00000135763	URB2	100	97.619	ENSRBIG00000037937	URB2	100	94.357	Rhinopithecus_bieti
ENSG00000135763	URB2	100	97.619	ENSRROG00000039854	URB2	100	94.094	Rhinopithecus_roxellana
ENSG00000135763	URB2	100	91.929	ENSSBOG00000023055	URB2	100	91.929	Saimiri_boliviensis_boliviensis
ENSG00000135763	URB2	100	77.381	ENSSHAG00000014735	URB2	100	64.594	Sarcophilus_harrisii
ENSG00000135763	URB2	99	63.953	ENSSFOG00015015432	urb2	98	39.723	Scleropages_formosus
ENSG00000135763	URB2	99	61.628	ENSSMAG00000004984	urb2	95	34.089	Scophthalmus_maximus
ENSG00000135763	URB2	99	61.628	ENSSDUG00000000902	urb2	99	34.593	Seriola_dumerili
ENSG00000135763	URB2	99	76.190	ENSSPUG00000018549	URB2	100	53.610	Sphenodon_punctatus
ENSG00000135763	URB2	99	63.095	ENSSPAG00000013632	urb2	96	54.321	Stegastes_partitus
ENSG00000135763	URB2	99	85.542	ENSSSCG00000010186	URB2	99	75.246	Sus_scrofa
ENSG00000135763	URB2	100	65.882	ENSTGUG00000009990	URB2	100	49.935	Taeniopygia_guttata
ENSG00000135763	URB2	99	61.905	ENSTRUG00000008173	urb2	99	34.618	Takifugu_rubripes
ENSG00000135763	URB2	99	60.714	ENSTNIG00000017689	urb2	99	36.446	Tetraodon_nigroviridis
ENSG00000135763	URB2	99	83.133	ENSTTRG00000014864	URB2	99	67.367	Tursiops_truncatus
ENSG00000135763	URB2	99	89.157	ENSUAMG00000015022	URB2	99	82.863	Ursus_americanus
ENSG00000135763	URB2	99	89.157	ENSUMAG00000004728	URB2	99	82.928	Ursus_maritimus
ENSG00000135763	URB2	96	87.654	ENSVPAG00000001750	-	63	87.143	Vicugna_pacos
ENSG00000135763	URB2	99	84.337	ENSVVUG00000006747	URB2	100	82.021	Vulpes_vulpes
ENSG00000135763	URB2	99	65.517	ENSXETG00000023331	urb2	100	42.071	Xenopus_tropicalis
ENSG00000135763	URB2	96	58.333	ENSXCOG00000012170	-	98	56.863	Xiphophorus_couchianus
ENSG00000135763	URB2	96	58.333	ENSXMAG00000015059	urb2	99	33.824	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0016235	aggresome	-	IDA	Component
GO:0030496	midbody	19799413.	IDA	Component
GO:0042254	ribosome biogenesis	21873635.	IBA	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr1	229632275	Missense_Mutation	novel	L45I	0.05
BLCA	chr1	229638163	Missense_Mutation	novel	L1184V	0.23
BLCA	chr1	229637776	Missense_Mutation	novel	L1055F	0.71
BLCA	chr1	229637700	Missense_Mutation	novel	F1029L	0.28
BLCA	chr1	229635097	Missense_Mutation	rs780581627	E162K	0.35
BLCA	chr1	229643550	Nonsense_Mutation	NA	Q1218*	0.17
BLCA	chr1	229636107	Silent	NA	L498L	0.34
BLCA	chr1	229637197	Missense_Mutation	rs759945900	E862K	0.13
BLCA	chr1	229637921	Missense_Mutation	NA	S1103L	0.19
BLCA	chr1	229637916	Silent	novel	L1101L	0.51
BRCA	chr1	229637156	Missense_Mutation	novel	V848D	0.08
BRCA	chr1	229647662	Silent	NA	V1353V	0.14
BRCA	chr1	229637263	Missense_Mutation	NA	I884L	0.25
BRCA	chr1	229637852	Missense_Mutation	NA	A1080D	0.37
BRCA	chr1	229635024	Silent	NA	V137V	0.54
BRCA	chr1	229635126	Silent	novel	E171E	0.14
BRCA	chr1	229654254	Missense_Mutation	NA	I1415V	0.15	Urb2
BRCA	chr1	229635521	Missense_Mutation	novel	S303L	0.19
BRCA	chr1	229659326	3'UTR	novel		0.15
BRCA	chr1	229638118	Missense_Mutation	rs766954381	A1169T	0.2
BRCA	chr1	229637011	Missense_Mutation	NA	L800V	0.23
BRCA	chr1	229635521	Missense_Mutation	novel	S303L	0.11
BRCA	chr1	229636125	Silent	novel	E504E	0.23
BRCA	chr1	229635281	Missense_Mutation	NA	G223D	0.53
CESC	chr1	229638244	Missense_Mutation	novel	A1211P	0.39
COAD	chr1	229636700	Missense_Mutation	NA	A696V	0.15
COAD	chr1	229635760	Missense_Mutation	rs763894401	E383K	0.19
COAD	chr1	229636377	Silent	NA	P588P	0.6
COAD	chr1	229636389	Silent	novel	G592G	0.09
COAD	chr1	229637040	Silent	novel	S809S	0.27
COAD	chr1	229635028	Missense_Mutation	novel	Y139H	0.23
COAD	chr1	229659318	3'UTR	rs776534161		0.31
COAD	chr1	229637158	Missense_Mutation	novel	V849M	0.17
COAD	chr1	229636048	Missense_Mutation	rs767496560	R479C	0.27
COAD	chr1	229659222	Silent	NA	I1500I	0.3
COAD	chr1	229636995	Silent	novel	A794A	0.35
COAD	chr1	229647588	Missense_Mutation	novel	L1329V	0.31	Urb2
COAD	chr1	229637898	In_Frame_Del	NA	G1096del	0.45
COAD	chr1	229637376	Silent	novel	L921L	0.07
COAD	chr1	229636313	Missense_Mutation	novel	R567Q	0.16
COAD	chr1	229636513	Missense_Mutation	NA	L634I	0.37
COAD	chr1	229637885	Missense_Mutation	NA	V1091G	0.25
COAD	chr1	229638023	Missense_Mutation	NA	A1137V	0.58
COAD	chr1	229635974	Missense_Mutation	rs781217311	R454H	0.22
COAD	chr1	229636293	Silent	NA	T560T	0.45
COAD	chr1	229627745	Missense_Mutation	NA	P38T	0.18
COAD	chr1	229643586	Missense_Mutation	novel	L1230V	0.34
COAD	chr1	229627674	Missense_Mutation	NA	S14N	0.2
COAD	chr1	229635536	Missense_Mutation	novel	Y308C	0.08
COAD	chr1	229636962	Silent	novel	E783E	0.07
COAD	chr1	229636295	Missense_Mutation	novel	P561H	0.27
ESCA	chr1	229638061	Missense_Mutation	novel	H1150Y	0.16
ESCA	chr1	229637441	Missense_Mutation	rs749450816	T943M	0.29
ESCA	chr1	229635831	Silent	novel	P406P	0.25
ESCA	chr1	229635417	Silent	novel	T268T	0.14
ESCA	chr1	229635719	Missense_Mutation	novel	N369S	0.44
ESCA	chr1	229645941	Missense_Mutation	rs772780409	A1293V	0.46
GBM	chr1	229637586	Missense_Mutation	novel	D991E	0.95
GBM	chr1	229636336	Missense_Mutation	novel	M575L	0.08
GBM	chr1	229636630	Missense_Mutation	novel	C673S	0.1
GBM	chr1	229637447	Missense_Mutation	novel	C945F	0.03
GBM	chr1	229636899	Silent	novel	L762L	0.23
GBM	chr1	229638032	Missense_Mutation	novel	S1140C	0.04
GBM	chr1	229637008	Missense_Mutation	novel	P799S	0.39
GBM	chr1	229636923	Silent	novel	L770L	0.09
GBM	chr1	229637007	Silent	novel	S798S	0.11
GBM	chr1	229636397	In_Frame_Ins	novel	P595_E596insK	0.38
GBM	chr1	229636266	Missense_Mutation	NA	F551L	0.2
GBM	chr1	229635890	Missense_Mutation	novel	D426A	0.48
GBM	chr1	229635501	Frame_Shift_Ins	novel	*T297Sfs17**	0.14
GBM	chr1	229636702	Frame_Shift_Del	novel	*I697Sfs4**	0.05
GBM	chr1	229637422	Missense_Mutation	novel	L937M	0.43
HNSC	chr1	229635219	Silent	novel	L202L	0.13
HNSC	chr1	229654362	Missense_Mutation	novel	A1451T	0.06	Urb2
HNSC	chr1	229647576	Missense_Mutation	novel	V1325F	0.23	Urb2
HNSC	chr1	229637649	Silent	novel	L1012L	0.34
HNSC	chr1	229636686	Silent	rs781516976	F691F	0.74
HNSC	chr1	229635089	Frame_Shift_Del	novel	*R159Sfs8**	0.19
HNSC	chr1	229635391	Missense_Mutation	novel	D260Y	0.06
HNSC	chr1	229635973	Missense_Mutation	rs115399585	R454C	0.31
HNSC	chr1	229637129	Missense_Mutation	novel	P839L	0.05
HNSC	chr1	229659214	Missense_Mutation	novel	R1498G	0.23	Urb2
HNSC	chr1	229659148	Missense_Mutation	novel	L1476F	0.32	Urb2
HNSC	chr1	229637295	Silent	rs749447215	I894I	0.39
KIRC	chr1	229638143	Missense_Mutation	NA	A1177V	0.23
KIRC	chr1	229636981	Frame_Shift_Ins	novel	*K790Rfs14**	0.09
KIRC	chr1	229635138	Frame_Shift_Del	novel	*A176Pfs7**	0.16
KIRC	chr1	229638050	Missense_Mutation	rs141779194	T1146M	0.27
KIRP	chr1	229636074	Silent	NA	Q487Q	0.47
KIRP	chr1	229636109	Missense_Mutation	NA	S499F	0.34
LAML	chr1	229635131	Missense_Mutation	novel	I173T	0.18
LGG	chr1	229637203	Missense_Mutation	rs768077441	I864V	0.34
LGG	chr1	229637667	Missense_Mutation	novel	S1018R	0.29
LGG	chr1	229643585	Silent	novel	A1229A	0.12
LGG	chr1	229635071	Missense_Mutation	novel	L153H	0.16
LGG	chr1	229638145	Missense_Mutation	novel	A1178T	0.24
LGG	chr1	229637636	Frame_Shift_Del	novel	*L1008Qfs8**	0.07
LIHC	chr1	229643612	Silent	NA	G1238G	0.5
LIHC	chr1	229637335	Missense_Mutation	NA	S908C	0.93
LIHC	chr1	229659123	Missense_Mutation	NA	K1467N	0.07	Urb2
LIHC	chr1	229635120	Missense_Mutation	NA	L169F	0.34
LUAD	chr1	229636618	Missense_Mutation	novel	L669I	0.13
LUAD	chr1	229643563	Missense_Mutation	rs753287753	D1222V	0.05
LUAD	chr1	229638044	Missense_Mutation	NA	D1144V	0.2
LUAD	chr1	229638046	Missense_Mutation	NA	R1145W	0.19
LUAD	chr1	229643637	Missense_Mutation	NA	M1247L	0.32
LUAD	chr1	229659413	3'UTR	novel		0.53
LUAD	chr1	229636030	Frame_Shift_Ins	rs763473884	*L474Ffs10**	0.14
LUAD	chr1	229636266	Missense_Mutation	NA	F551L	0.18
LUAD	chr1	229643530	Splice_Region	novel		0.17
LUAD	chr1	229636638	Silent	NA	E675E	0.21
LUAD	chr1	229637649	Silent	NA	L1012L	0.15
LUAD	chr1	229634919	Splice_Region	novel	I102I	0.18
LUAD	chr1	229645859	Missense_Mutation	NA	A1266S	0.42
LUAD	chr1	229637113	Missense_Mutation	NA	V834L	0.25
LUAD	chr1	229638111	Silent	NA	P1166P	0.33
LUAD	chr1	229654348	Missense_Mutation	NA	S1446F	0.37	Urb2
LUAD	chr1	229636223	Missense_Mutation	novel	L537Q	0.18
LUAD	chr1	229637826	Silent	novel	L1071L	0.25
LUAD	chr1	229659127	Missense_Mutation	novel	L1469V	0.05	Urb2
LUAD	chr1	229636089	Silent	NA	S492S	0.08
LUAD	chr1	229647701	Silent	novel	V1366V	0.2
LUAD	chr1	229651298	Missense_Mutation	rs746722891	R1405W	0.12	Urb2
LUAD	chr1	229636796	Missense_Mutation	novel	G728V	0.13
LUAD	chr1	229643531	Splice_Site	NA	X1212_splice	0.18
LUAD	chr1	229659191	Missense_Mutation	novel	R1490L	0.38	Urb2
LUAD	chr1	229637336	Missense_Mutation	NA	S908I	0.09
LUAD	chr1	229636085	Missense_Mutation	novel	A491V	0.1
LUAD	chr1	229636885	Missense_Mutation	novel	D758H	0.19
LUAD	chr1	229635928	Missense_Mutation	rs764093845	E439K	0.28
LUSC	chr1	229635124	Nonsense_Mutation	NA	E171*	0.4
LUSC	chr1	229637030	Missense_Mutation	novel	S806F	0.36
LUSC	chr1	229637031	Silent	rs758933137	S806S	0.35
LUSC	chr1	229635858	Silent	rs374430308	L415L	0.08
LUSC	chr1	229637468	Nonsense_Mutation	novel	L952*	0.79
LUSC	chr1	229638199	Missense_Mutation	NA	D1196H	0.2
LUSC	chr1	229638117	Silent	rs114023508	L1168L	0.19
LUSC	chr1	229634940	Silent	NA	E109E	0.06
LUSC	chr1	229636984	Missense_Mutation	novel	I791V	0.33
LUSC	chr1	229635541	Missense_Mutation	rs747838556	L310F	0.17
LUSC	chr1	229636467	Silent	NA	A618A	0.47
LUSC	chr1	229635159	Missense_Mutation	NA	L182F	0.28
LUSC	chr1	229635859	Missense_Mutation	novel	I416L	0.25
LUSC	chr1	229636728	Silent	novel	A705A	0.33
LUSC	chr1	229654363	Frame_Shift_Del	novel	*Q1452Sfs9**	0.12	Urb2
LUSC	chr1	229637887	Missense_Mutation	novel	V1092L	0.4
LUSC	chr1	229635146	Missense_Mutation	NA	G178D	0.26
LUSC	chr1	229647730	Nonsense_Mutation	NA	S1376*	0.04	Urb2
LUSC	chr1	229659294	Silent	NA	A1524A	0.39
LUSC	chr1	229635431	Missense_Mutation	NA	N273I	0.4
OV	chr1	229637476	Missense_Mutation	NA	G955R	0.11
OV	chr1	229636437	Silent	novel	L608L	0.08
OV	chr1	229636776	Silent	novel	A721A	0.09
OV	chr1	229636810	Missense_Mutation	NA	L733F	0.18
OV	chr1	229636434	In_Frame_Ins	novel	L607_L608insASGPSTV	0.19
OV	chr1	229635633	Silent	novel	L340L	0.12
OV	chr1	229635569	Missense_Mutation	novel	G319V	0.08
OV	chr1	229635430	Missense_Mutation	novel	N273H	0.08
OV	chr1	229636872	Frame_Shift_Ins	novel	*L754Gfs23**	0.14
OV	chr1	229654345	Missense_Mutation	novel	F1445C	0.07	Urb2
OV	chr1	229636437	Silent	novel	L608L	0.1
OV	chr1	229636179	Silent	novel	Q522Q	0.09
OV	chr1	229636645	Missense_Mutation	novel	Y678D	0.09
OV	chr1	229636647	Nonsense_Mutation	novel	Y678*	0.06
OV	chr1	229635151	Nonsense_Mutation	novel	*Y180Sfs2**	0.07
OV	chr1	229638163	Silent	novel	L1184L	0.13
OV	chr1	229636089	Frame_Shift_Del	novel	*G493Afs32**	0.2
OV	chr1	229637146	Missense_Mutation	novel	D845Y	0.05
OV	chr1	229638142	Missense_Mutation	novel	A1177S	0.07
OV	chr1	229636666	Missense_Mutation	novel	T685S	0.06
OV	chr1	229636156	Missense_Mutation	novel	S515A	0.13
PAAD	chr1	229659275	Missense_Mutation	novel	G1518E	0.26
PRAD	chr1	229637571	Silent	novel	L986L	0.1
PRAD	chr1	229636109	Missense_Mutation	NA	S499F	0.26
PRAD	chr1	229635454	Missense_Mutation	rs116505905	V281M	0.31
PRAD	chr1	229636016	Missense_Mutation	rs747719182	R468Q	0.06
READ	chr1	229632274	Silent	NA	L44L	0.31
READ	chr1	229637639	Missense_Mutation	NA	M1009T	0.2
READ	chr1	229635185	Missense_Mutation	NA	R191I	0.46
READ	chr1	229635745	Missense_Mutation	rs765588103	D378N	0.52
READ	chr1	229635987	Missense_Mutation	NA	Q458H	0.41
READ	chr1	229643590	Missense_Mutation	novel	F1231S	0.38
READ	chr1	229635760	Missense_Mutation	rs763894401	E383K	0.68
READ	chr1	229638051	Silent	rs531090167	T1146T	0.12
SARC	chr1	229638064	Missense_Mutation	novel	V1151F	0.13
SARC	chr1	229643656	Missense_Mutation	novel	G1253A	0.15
SARC	chr1	229651264	Missense_Mutation	novel	L1393F	0.08	Urb2
SARC	chr1	229636090	Missense_Mutation	novel	G493S	0.26
SKCM	chr1	229636550	Missense_Mutation	rs535197034	S646L	0.22
SKCM	chr1	229659138	Missense_Mutation	NA	E1472D	0.35	Urb2
SKCM	chr1	229659186	Silent	NA	F1488F	0.41
SKCM	chr1	229651252	Silent	NA	I1389I	0.46
SKCM	chr1	229638069	Silent	NA	A1152A	0.97
SKCM	chr1	229638190	Missense_Mutation	novel	P1193S	0.47
SKCM	chr1	229635738	Silent	rs747159360	I375I	0.35
SKCM	chr1	229636909	Silent	NA	L766L	0.29
SKCM	chr1	229643678	Nonsense_Mutation	NA	W1260*	0.2
SKCM	chr1	229635958	Nonsense_Mutation	NA	Q449*	0.43
SKCM	chr1	229637265	Silent	novel	I884I	0.41
SKCM	chr1	229637105	Missense_Mutation	rs753402625	S831L	0.37
SKCM	chr1	229637884	Missense_Mutation	NA	V1091L	0.18
SKCM	chr1	229638191	Missense_Mutation	NA	P1193L	0.07
SKCM	chr1	229636435	Silent	novel	L608L	0.17
SKCM	chr1	229636436	Missense_Mutation	novel	L608P	0.17
SKCM	chr1	229637658	Missense_Mutation	rs759247481	M1015I	0.27
SKCM	chr1	229637259	Silent	rs559764814	F882F	0.16
SKCM	chr1	229635729	Silent	NA	I372I	0.13
SKCM	chr1	229637629	Missense_Mutation	NA	E1006K	0.3
SKCM	chr1	229635825	Silent	rs771513516	P404P	0.33
SKCM	chr1	229638033	Silent	novel	S1140S	0.45
SKCM	chr1	229635177	Silent	novel	V188V	0.16
SKCM	chr1	229636372	Missense_Mutation	NA	L587F	0.53
SKCM	chr1	229659168	Silent	rs775325361	I1482I	0.6
SKCM	chr1	229636350	Silent	rs754675516	L579L	0.34
SKCM	chr1	229637619	Silent	rs768908969	G1002G	0.45
SKCM	chr1	229659186	Silent	NA	F1488F	0.54
SKCM	chr1	229634947	Missense_Mutation	NA	L112F	0.28
SKCM	chr1	229637684	Missense_Mutation	novel	R1024K	0.14
SKCM	chr1	229637990	Missense_Mutation	novel	A1126V	0.3
STAD	chr1	229636979	Frame_Shift_Del	novel	*I791Yfs22**	0.34
STAD	chr1	229636465	Missense_Mutation	rs764447714	A618T	0.22
STAD	chr1	229636720	Missense_Mutation	rs574261258	D703N	0.13
STAD	chr1	229638047	Missense_Mutation	NA	R1145K	0.14
STAD	chr1	229637250	Silent	NA	K879K	0.11
STAD	chr1	229636652	Missense_Mutation	NA	Q680P	0.27
STAD	chr1	229645942	Silent	rs145362478	A1293A	0.44
STAD	chr1	229651309	Silent	NA	R1408R	0.14
STAD	chr1	229643579	Frame_Shift_Del	novel	*G1228Efs8**	0.19
STAD	chr1	229635613	Missense_Mutation	NA	C334R	0.13
STAD	chr1	229637525	Missense_Mutation	NA	F971C	0.17
STAD	chr1	229636511	Missense_Mutation	novel	P633L	0.16
STAD	chr1	229636695	Silent	NA	E694E	0.12
STAD	chr1	229635416	Missense_Mutation	rs114879838	T268M	0.46
STAD	chr1	229635655	Missense_Mutation	NA	L348M	0.25
STAD	chr1	229645938	Missense_Mutation	rs747572919	R1292H	0.25
STAD	chr1	229635081	Silent	rs779255675	S156S	0.27
STAD	chr1	229635955	Missense_Mutation	NA	A448T	0.27
THYM	chr1	229635372	Silent	novel	S253S	0.15
UCEC	chr1	229659177	Silent	rs776626236	D1485D	0.43
UCEC	chr1	229635097	Missense_Mutation	rs780581627	E162K	0.31
UCEC	chr1	229636590	Missense_Mutation	NA	I659M	0.37
UCEC	chr1	229634963	Missense_Mutation	NA	R117I	0.18
UCEC	chr1	229637006	Missense_Mutation	novel	S798I	0.18
UCEC	chr1	229635185	Missense_Mutation	NA	R191I	0.33
UCEC	chr1	229659284	Missense_Mutation	NA	R1521I	0.45
UCEC	chr1	229632345	Missense_Mutation	novel	E68G	0.24
UCEC	chr1	229637988	Silent	novel	E1125E	0.22
UCEC	chr1	229635621	Missense_Mutation	NA	K336N	0.59
UCEC	chr1	229635749	Missense_Mutation	novel	R379K	0.29
UCEC	chr1	229636849	Missense_Mutation	novel	N746D	0.42
UCEC	chr1	229637552	Missense_Mutation	novel	R980I	0.32
UCEC	chr1	229659115	Missense_Mutation	novel	A1465S	0.38	Urb2
UCEC	chr1	229632415	Missense_Mutation	novel	K91N	0.04
UCEC	chr1	229659215	Missense_Mutation	NA	R1498I	0.21	Urb2
UCEC	chr1	229636844	Missense_Mutation	NA	V744A	0.19
UCEC	chr1	229637754	Frame_Shift_Ins	novel	*Q1048Nfs40**	0.07
UCEC	chr1	229637756	In_Frame_Ins	novel	Q1048delinsHM	0.05
UCEC	chr1	229638025	Missense_Mutation	rs747826493	D1138N	0.27
UCEC	chr1	229637133	Nonsense_Mutation	novel	W840*	0.19
UCEC	chr1	229637765	Missense_Mutation	novel	Q1051R	0.18
UCEC	chr1	229659368	3'UTR	novel		0.19
UCEC	chr1	229637555	Missense_Mutation	novel	A981V	0.15
UCEC	chr1	229637134	Missense_Mutation	novel	L841F	0.34
UCEC	chr1	229647520	Missense_Mutation	rs142409402	R1306Q	0.1
UCEC	chr1	229659255	Nonsense_Mutation	NA	Y1511*	0.42	Urb2
UCEC	chr1	229638003	Silent	NA	Q1130Q	0.31
UCEC	chr1	229636748	Missense_Mutation	novel	R712I	0.19
UCEC	chr1	229637150	Missense_Mutation	rs768764374	H846R	0.38
UCEC	chr1	229635327	Silent	novel	E238E	0.32
UCEC	chr1	229637301	Silent	novel	G896G	0.52
UCEC	chr1	229637513	Missense_Mutation	novel	G967D	0.27
UCEC	chr1	229654317	Missense_Mutation	rs147338452	A1436T	0.41	Urb2
UCEC	chr1	229635346	Missense_Mutation	NA	I245V	0.11
UCEC	chr1	229635454	Missense_Mutation	rs116505905	V281M	0.25
UCEC	chr1	229635785	Missense_Mutation	rs747162812	R391H	0.44
UCEC	chr1	229637483	Missense_Mutation	novel	S957I	0.41
UCEC	chr1	229635974	Missense_Mutation	rs781217311	R454H	0.4
UCEC	chr1	229636751	Missense_Mutation	novel	K713T	0.35
UCEC	chr1	229637754	Frame_Shift_Ins	novel	*Q1048Nfs40**	0.06
UCEC	chr1	229637756	In_Frame_Ins	novel	Q1048delinsHM	0.03
UCEC	chr1	229638083	Missense_Mutation	NA	V1157A	0.36
UCEC	chr1	229636049	Missense_Mutation	rs752766281	R479H	0.42
UCEC	chr1	229659318	3'UTR	rs776534161		0.41
UCEC	chr1	229634963	Missense_Mutation	NA	R117I	0.24
UCEC	chr1	229635593	Missense_Mutation	novel	V327A	0.28
UCEC	chr1	229635795	Silent	novel	A394A	0.34
UCEC	chr1	229636103	Missense_Mutation	novel	V497A	0.18
UCEC	chr1	229637434	Missense_Mutation	novel	F941L	0.35
UCEC	chr1	229659191	Missense_Mutation	rs138399002	R1490Q	0.58	Urb2
UCEC	chr1	229637197	Missense_Mutation	rs759945900	E862K	0.28
UCEC	chr1	229636415	Missense_Mutation	novel	K601T	0.47
UCEC	chr1	229635911	Missense_Mutation	rs567382344	S433L	0.42
UCEC	chr1	229636664	Missense_Mutation	novel	R684M	0.1
UCEC	chr1	229647754	Splice_Site	novel	X1383_splice	0.17
UCEC	chr1	229654320	Missense_Mutation	rs765047341	A1437T	0.16	Urb2
UCEC	chr1	229636773	Silent	rs374249981	T720T	0.41
UCEC	chr1	229659279	Silent	novel	E1519E	0.29
UCEC	chr1	229659168	Silent	rs775325361	I1482I	0.2
UCEC	chr1	229647719	Silent	novel	N1372N	0.58
UCEC	chr1	229635754	Missense_Mutation	rs763537395	R381W	0.29
UCEC	chr1	229654371	Missense_Mutation	rs369349530	V1454M	0.38	Urb2
UCEC	chr1	229635540	Missense_Mutation	novel	K309N	0.3
UCEC	chr1	229636808	Missense_Mutation	novel	G732V	0.2
UCEC	chr1	229637291	Missense_Mutation	novel	S893N	0.18
UCEC	chr1	229632335	Missense_Mutation	NA	D65N	0.27
UCEC	chr1	229636566	Frame_Shift_Del	novel	*T653Hfs7**	0.05
UCEC	chr1	229647629	Silent	rs748000802	H1342H	0.37
UCEC	chr1	229638008	Missense_Mutation	novel	C1132Y	0.32
UCEC	chr1	229637768	Missense_Mutation	NA	G1052D	0.18
UCEC	chr1	229647599	Frame_Shift_Del	NA	*E1334Rfs25**	0.41	Urb2
UCEC	chr1	229636446	Nonsense_Mutation	NA	Y611*	0.4
UCEC	chr1	229637928	Silent	rs762912459	P1105P	0.63
UCEC	chr1	229637109	Silent	NA	G832G	0.13
UCEC	chr1	229636032	Silent	novel	V473V	0.2
UCEC	chr1	229636858	Missense_Mutation	novel	I749L	0.17
UCEC	chr1	229637158	Missense_Mutation	novel	V849M	0.21
UCEC	chr1	229638080	Missense_Mutation	novel	G1156D	0.18
UCEC	chr1	229645933	Silent	novel	L1290L	0.16
UCEC	chr1	229651269	Missense_Mutation	novel	S1395Y	0.44	Urb2
UCEC	chr1	229659290	Missense_Mutation	rs139372652	T1523M	0.53
UCEC	chr1	229659461	3'UTR	novel		0.17
UCEC	chr1	229635964	Missense_Mutation	NA	A451T	0.19
UCEC	chr1	229636655	Missense_Mutation	NA	K681T	0.2
UCEC	chr1	229635745	Missense_Mutation	rs765588103	D378N	0.29
UCEC	chr1	229634961	Missense_Mutation	novel	Q116H	0.21
UCEC	chr1	229635919	Missense_Mutation	novel	I436V	0.28
UCEC	chr1	229643544	Missense_Mutation	novel	P1216S	0.26
UCEC	chr1	229636833	Nonsense_Mutation	novel	W740*	0.43
UCEC	chr1	229637519	Missense_Mutation	rs759298857	D969G	0.33
UCS	chr1	229635454	Missense_Mutation	rs116505905	V281M	0.44
UCS	chr1	229627744	Frame_Shift_Ins	novel	*P38Afs3**	0.17
UCS	chr1	229637749	Missense_Mutation	novel	E1046K	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.0809	0.033566
DLBC	DEL	0.125	0.0017831
KIRC	DEL	0.0663	0.018371
LGG	DEL	0.0312	0.11599
LIHC	AMP	0.6595	4.3428e-09
PCPG	DEL	0.0988	0.12617
PRAD	DEL	0.0752	0.00015401
READ	AMP	0.2545	0.14328
SARC	DEL	0.2957	2.6086e-08
TGCT	DEL	0.0267	0.16985
THYM	AMP	0.187	0.24554
UCEC	AMP	0.3692	2.3921e-06

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0015	Kaplan-Meier Survival Analysis
ACC	0.0057	Kaplan-Meier Survival Analysis
SKCM	0.00014	Kaplan-Meier Survival Analysis
KIRP	0.0032	Kaplan-Meier Survival Analysis
CESC	0.0037	Kaplan-Meier Survival Analysis
LAML	0.044	Kaplan-Meier Survival Analysis
KICH	0.032	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
GBM	0.042	Kaplan-Meier Survival Analysis
LIHC	0.0077	Kaplan-Meier Survival Analysis
LGG	0.004	Kaplan-Meier Survival Analysis
LUAD	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742