EuRBPDB

Description

Ensembl ID: ENSG00000135778 (Gene tree)
Gene ID: 84284
Gene Symbol: NTPCR
Alias: MGC13186|HCR-NTPase|THEP1|C1orf57
Full Name: nucleoside-triphosphatase, cancer-related
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 33,347 bases
Position: chr1:232,950,536-232,983,882
Accession: 28204
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10329567	Mammalian reovirus L3 gene sequences and evidence for a distinct amino-terminal region of the lambda1 protein.	Virology	1999 May 25	Harrison SJ	-
12788635	Effect of selected mutations in the C-terminal region of the vaccinia virus nucleoside triphosphate phosphohydrolase I on binding to the H4L subunit of the viral RNA polymerase and early gene transcription termination in vitro.	Virology	2003 May 25	Piacente SC	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000366627	NTPCR-201	1762	-	ENSP00000355586	228 (aa)	-	Q5TDF0
ENST00000496662	NTPCR-208	882	NR_138025	-	- (aa)	-	-
ENST00000479125	NTPCR-203	761	NR_138027	-	- (aa)	-	-
ENST00000366628	NTPCR-202	6311	-	ENSP00000355587	190 (aa)	-	Q9BSD7
ENST00000487953	NTPCR-204	527	-	-	- (aa)	-	-
ENST00000490098	NTPCR-205	8705	-	-	- (aa)	-	-
ENST00000490807	NTPCR-206	980	-	-	- (aa)	-	-
ENST00000494689	NTPCR-207	767	NR_138026	-	- (aa)	-	-

Gene Model

Pathways

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135778	Platelet Function Tests	2.9953622E-006	-
ENSG00000135778	Platelet Function Tests	1.5140400E-005	-
ENSG00000135778	Platelet Function Tests	8.3766608E-006	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135778	NTPCR	99	82.011	ENSMUSG00000031851	Ntpcr	99	82.011	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0016311	dephosphorylation	-	IEA	Process
GO:0017111	nucleoside-triphosphatase activity	-	IEA	Function
GO:0098519	nucleotide phosphatase activity, acting on free nucleotides	-	IEA	Function