EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135829 (Gene tree)
Gene ID: 1660
Gene Symbol: DHX9
Alias: RHA|LKP|DDX9
Full Name: DExH-box helicase 9
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 48,679 bases
Position: chr1:182,839,304-182,887,982
Accession: 2750
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.[provided by RefSeq, Feb 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000356520	dsrm	PF00035.26	5.4e-26	1	2
ENSP00000356520	dsrm	PF00035.26	5.4e-26	2	2
ENSP00000356520	DEAD	PF00270.29	5.9e-06	1	1
ENSP00000356520	HA2	PF04408.23	3.5e-15	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24726449	Different activities of the conserved lysine residues in the double-stranded RNA binding domains of RNA helicase A in vitro and in the cell.	Biochim Biophys Acta	2014 Jul	Xing L	doi: 10.1016/j.bbagen.2014.04.003
25564528	RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.	Nucleic Acids Res	2015 Jan	Erkizan HV	doi: 10.1093/nar/gku1328
22446849	(1)H, (13)C, and (15)N resonance assignments of the dsRBDs of mouse RNA helicase A.	Biomol NMR Assign	2013 Apr	Nagata T	doi: 10.1007/s12104-012-9380-3
24914047	Repetitive RNA unwinding by RNA helicase A facilitates RNA annealing.	Nucleic Acids Res	2014 Jul	Koh HR	doi: 10.1093/nar/gku523
9671709	Activities of adenovirus virus-associated RNAs: purification and characterization of RNA binding proteins.	Proc Natl Acad Sci U S A	1998 Jul 21	Liao HJ	-
7685763	RNA annealing activity is intrinsically associated with U2AF.	J Biol Chem	1993 Jun 25	Lee CG	-
12946349	Selective regulation of gene expression by nuclear factor 110, a member of the NF90 family of double-stranded RNA-binding proteins.	J Mol Biol	2003 Sep 5	Reichman TW	-
11096080	A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1.	J Biol Chem	2001 Feb 23	Fujii R	-
22454253	Solution structures of the double-stranded RNA-binding domains from RNA helicase A.	Proteins	2012 Jun	Nagata T	doi: 10.1002/prot.24059
21386893	NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication.	PLoS One	2011 Feb 28	Gomila RC	doi: 10.1371/journal.pone.0016687.
21123178	Features of double-stranded RNA-binding domains of RNA helicase A are necessary for selective recognition and translation of complex mRNAs.	J Biol Chem	2011 Feb 18	Ranji A	doi: 10.1074/jbc.M110.176339
12209530	Effect of an exogenous trigger on the pathogenesis of lupus in (NZB x NZW)F1 mice.	Arthritis Rheum	2002 Aug	Yoshida H	-
23015696	In vitro and in vivo analysis of the interaction between RNA helicase A and HIV-1 RNA.	J Virol	2012 Dec	Xing L	doi: 10.1128/JVI.01993-12
24223160	Roles of the linker region of RNA helicase A in HIV-1 RNA metabolism.	PLoS One	2013 Nov 6	Xing L	doi: 10.1371/journal.pone.0078596
28934014	Nucleoplasmic Nup98 controls gene expression by regulating a DExH/D-box protein.	Nucleus	2018 Jan 1	Capitanio JS	doi: 10.1080/19491034.2017.1364826
29765512	DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels.	Oncotarget	2018 Apr 20	Sekiba K	doi: 10.18632/oncotarget.25104
15995249	Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.	J Biol Chem	2005 Sep 2	Friedemann J	-
21957149	DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells.	J Immunol	2011 Nov 1	Zhang Z	doi: 10.4049/jimmunol.1101307
21247876	Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes.	Nucleic Acids Res	2011 May	Jin J	doi: 10.1093/nar/gkq1350
20569003	Monoclonal antibody specific for Dhx9/NDHII/RHA.	Hybridoma (Larchmt)	2010 Jun	Kotani M	doi: 10.1089/hyb.2009.0107.
25964201	An Oral Formulation of YK-4-279: Preclinical Efficacy and Acquired Resistance Patterns in Ewing Sarcoma.	Mol Cancer Ther	2015 Jul	Lamhamedi-Cherradi SE	doi: 10.1158/1535-7163.MCT-14-0334
30805612	Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless.	Nucleic Acids Res	2019 May 7	Ankush Jagtap PK	doi: 10.1093/nar/gkz125.
24965446	Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.	J Virol	2014 Sep	Jefferson M	doi: 10.1128/JVI.00984-14
9184214	The NTPase/helicase activities of Drosophila maleless, an essential factor in dosage compensation.	EMBO J	1997 May 15	Lee CG	-
16935882	DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.	Nucleic Acids Res	2006	Fuller-Pace FV	-
14729462	Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus.	Exp Cell Res	2004 Feb 15	Zhang S	-
8041617	Detection of dsRNA-binding domains in RNA helicase A and Drosophila maleless: implications for monomeric RNA helicases.	Nucleic Acids Res	1994 Jul 11	Gibson TJ	-
10951562	Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA.	Oncogene	2000 Jul 27	Reddy TR	-
10648781	Multiple copies of the Mason-Pfizer monkey virus constitutive RNA transport element lead to enhanced HIV-1 Gag expression in a context-dependent manner.	Nucleic Acids Res	2000 Feb 15	Wodrich H	-
18519039	The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.	FEBS Lett	2008 Jun 25	Prahl M	doi: 10.1016/j.febslet.2008.04.065
10198287	Pre-mRNA and mRNA binding of human nuclear DNA helicase II (RNA helicase A).	J Cell Sci	1999 Apr	Zhang S	-
11038348	Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter.	J Biol Chem	2001 Jan 12	Myohanen S	-
10924507	Specific interaction between RNA helicase A and Tap, two cellular proteins that bind to the constitutive transport element of type D retrovirus.	J Biol Chem	2000 Oct 20	Tang H	-
10748171	A novel shuttle protein binds to RNA helicase A and activates the retroviral constitutive transport element.	J Biol Chem	2000 Jul 14	Westberg C	-
14500838	dsRBM1 and a proline-rich domain of RNA helicase A can form a composite binder to recognize a specific dsDNA.	Nucleic Acids Res	2003 Oct 1	Hung ML	-
19584866	A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma.	Nat Med	2009 Jul	Erkizan HV	doi: 10.1038/nm.1983
23361462	Structural insights into RISC assembly facilitated by dsRNA-binding domains of human RNA helicase A (DHX9).	Nucleic Acids Res	2013 Mar 1	Fu Q	doi: 10.1093/nar/gkt042
20802156	RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.	Proc Natl Acad Sci U S A	2010 Sep 14	Huo L	doi: 10.1073/pnas.1000743107
25149208	Role of the OB-fold of RNA helicase A in the synthesis of HIV-1 RNA.	Biochim Biophys Acta	2014 Nov	Xing L	doi: 10.1016/j.bbagrm.2014.08.008
24667787	Characterization of the transcriptional machinery bound across the widely presumed type 2 diabetes causal variant, rs7903146, within TCF7L2.	Eur J Hum Genet	2015 Jan	Xia Q	doi: 10.1038/ejhg.2014.48
25062910	Helicase associated 2 domain is essential for helicase activity of RNA helicase A.	Biochim Biophys Acta	2014 Oct	Xing L	doi: 10.1016/j.bbapap.2014.07.001
12163469	Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.	J Cell Biol	2002 Aug 5	Fuchsova B	-
15355351	RNA helicase A interacts with nuclear factor kappaB p65 and functions as a transcriptional coactivator.	Eur J Biochem	2004 Sep	Tetsuka T	-
10413677	Nucleolar localization of murine nuclear DNA helicase II (RNA helicase A).	J Cell Sci	1999 Aug	Zhang S	-
12851713	Aromatic residues are required for RNA helicase A mediated transactivation.	Int J Mol Med	2003 Aug	Aratani S	-
12665568	Antithetic effects of MBD2a on gene regulation.	Mol Cell Biol	2003 Apr	Fujita H	-
11416126	Dual roles of RNA helicase A in CREB-dependent transcription.	Mol Cell Biol	2001 Jul	Aratani S	-
16187064	Re-localization of nuclear DNA helicase II during the growth period of bovine oocytes.	Histochem Cell Biol	2006 Jan	Baran V	-
18068128	Functional role of Zic2 phosphorylation in transcriptional regulation.	FEBS Lett	2008 Jan 23	Ishiguro A	-
17015016	A new model for translational regulation of specific mRNAs.	Trends Biochem Sci	2006 Nov	Tettweiler G	-
23220337	RNA helicase is involved in the expression and replication of classical swine fever virus and interacts with untranslated region.	Virus Res	2013 Jan	Sheng C	doi: 10.1016/j.virusres.2012.11.014
20510246	Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein.	J Mol Biol	2010 Jul 23	Schutz P	doi: 10.1016/j.jmb.2010.05.046
20512115	Prp43p contains a processive helicase structural architecture with a specific regulatory domain.	EMBO J	2010 Jul 7	Walbott H	doi: 10.1038/emboj.2010.102
24719423	hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.	J Virol	2014 Jul	Li Y	doi: 10.1128/JVI.00225-14
23853588	Myxoma virus protein M029 is a dual function immunomodulator that inhibits PKR and also conscripts RHA/DHX9 to promote expanded host tropism and viral replication.	PLoS Pathog	2013	Rahman MM	doi: 10.1371/journal.ppat.1003465
27011170	LARP6 Meets Collagen mRNA: Specific Regulation of Type I Collagen Expression.	Int J Mol Sci	2016 Mar 22	Zhang Y	doi: 10.3390/ijms17030419.
27107641	DHX9/RHA Binding to the PBS-Segment of the Genomic RNA during HIV-1 Assembly Bolsters Virion Infectivity.	J Mol Biol	2016 Jun 5	Boeras I	doi: 10.1016/j.jmb.2016.04.011
28588071	The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation.	EMBO Rep	2017 Jul	Leone S	doi: 10.15252/embr.201744330
30137501	A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kB-mediated innate immunity against DNA virus infection.	Nucleic Acids Res	2018 Sep 28	Ng YC	doi: 10.1093/nar/gky742.
30463980	The Host DHX9 DExH-Box Helicase Is Recruited to Chikungunya Virus Replication Complexes for Optimal Genomic RNA Translation.	J Virol	2019 Feb 5	Matkovic R	doi: 10.1128/JVI.01764-18

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490519	DHX9-208	438	-	-	- (aa)	-	-
ENST00000483416	DHX9-206	814	-	-	- (aa)	-	-
ENST00000479271	DHX9-205	316	-	-	- (aa)	-	-
ENST00000477802	DHX9-204	456	-	-	- (aa)	-	-
ENST00000485081	DHX9-207	2531	-	-	- (aa)	-	-
ENST00000474446	DHX9-203	848	-	-	- (aa)	-	-
ENST00000473076	DHX9-202	1378	-	-	- (aa)	-	-
ENST00000367549	DHX9-201	4240	-	ENSP00000356520	1270 (aa)	-	Q08211

Gene Model

Click here to download ENSG00000135829's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135829's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000135829	DHX9	60	35.930	ENSG00000163214	DHX57	99	32.230
ENSG00000135829	DHX9	63	33.839	ENSG00000067248	DHX29	65	33.148
ENSG00000135829	DHX9	58	33.858	ENSG00000132153	DHX30	63	33.858
ENSG00000135829	DHX9	59	38.501	ENSG00000174953	DHX36	95	43.602
ENSG00000135829	DHX9	60	48.529	ENSG00000047188	YTHDC2	55	48.529

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135829	DHX9	92	96.410	ENSAMEG00000002233	DHX9	98	94.056	Ailuropoda_melanoleuca
ENSG00000135829	DHX9	92	77.013	ENSACIG00000016431	dhx9	98	74.941	Amphilophus_citrinellus
ENSG00000135829	DHX9	85	76.923	ENSAOCG00000010719	dhx9	98	77.344	Amphiprion_ocellaris
ENSG00000135829	DHX9	92	77.740	ENSAPEG00000006339	dhx9	96	75.339	Amphiprion_percula
ENSG00000135829	DHX9	92	78.003	ENSATEG00000007101	dhx9	100	78.205	Anabas_testudineus
ENSG00000135829	DHX9	92	84.681	ENSACAG00000005023	DHX9	93	84.681	Anolis_carolinensis
ENSG00000135829	DHX9	100	98.425	ENSANAG00000030279	DHX9	100	98.425	Aotus_nancymaae
ENSG00000135829	DHX9	96	76.094	ENSACLG00000022296	dhx9	99	78.128	Astatotilapia_calliptera
ENSG00000135829	DHX9	92	95.214	ENSBTAG00000019821	DHX9	91	95.214	Bos_taurus
ENSG00000135829	DHX9	98	41.602	WBGene00004355	rha-1	91	42.739	Caenorhabditis_elegans
ENSG00000135829	DHX9	100	98.189	ENSCJAG00000004821	DHX9	100	98.295	Callithrix_jacchus
ENSG00000135829	DHX9	92	95.812	ENSCAFG00000013205	DHX9	98	93.976	Canis_familiaris
ENSG00000135829	DHX9	92	95.812	ENSCAFG00020014886	DHX9	98	93.976	Canis_lupus_dingo
ENSG00000135829	DHX9	92	92.130	ENSCHIG00000018643	DHX9	98	90.499	Capra_hircus
ENSG00000135829	DHX9	92	96.410	ENSTSYG00000007970	DHX9	100	95.758	Carlito_syrichta
ENSG00000135829	DHX9	85	74.539	ENSCAPG00000015604	DHX9	89	76.842	Cavia_aperea
ENSG00000135829	DHX9	98	88.672	ENSCPOG00000040669	DHX9	92	89.754	Cavia_porcellus
ENSG00000135829	DHX9	90	98.568	ENSCCAG00000022597	DHX9	100	98.568	Cebus_capucinus
ENSG00000135829	DHX9	100	99.216	ENSCATG00000027871	DHX9	100	99.216	Cercocebus_atys
ENSG00000135829	DHX9	92	93.606	ENSCLAG00000010684	DHX9	91	91.554	Chinchilla_lanigera
ENSG00000135829	DHX9	87	99.104	ENSCSAG00000012549	DHX9	99	99.104	Chlorocebus_sabaeus
ENSG00000135829	DHX9	91	85.243	ENSCHOG00000012736	DHX9	99	85.417	Choloepus_hoffmanni
ENSG00000135829	DHX9	93	87.648	ENSCPBG00000015757	DHX9	98	84.652	Chrysemys_picta_bellii
ENSG00000135829	DHX9	94	59.655	ENSCSAVG00000001493	-	100	61.005	Ciona_savignyi
ENSG00000135829	DHX9	100	99.449	ENSCANG00000032888	DHX9	100	99.550	Colobus_angolensis_palliatus
ENSG00000135829	DHX9	92	93.089	ENSCGRG00001015796	Dhx9	95	93.089	Cricetulus_griseus_chok1gshd
ENSG00000135829	DHX9	92	93.089	ENSCGRG00000011336	Dhx9	87	93.089	Cricetulus_griseus_crigri
ENSG00000135829	DHX9	90	74.805	ENSCSEG00000017621	dhx9	99	74.805	Cynoglossus_semilaevis
ENSG00000135829	DHX9	88	78.660	ENSCVAG00000009479	dhx9	98	75.934	Cyprinodon_variegatus
ENSG00000135829	DHX9	92	78.867	ENSDARG00000079725	dhx9	97	76.061	Danio_rerio
ENSG00000135829	DHX9	93	95.678	ENSDNOG00000004038	DHX9	98	92.995	Dasypus_novemcinctus
ENSG00000135829	DHX9	92	94.535	ENSDORG00000012610	Dhx9	91	91.374	Dipodomys_ordii
ENSG00000135829	DHX9	93	50.617	FBgn0002774	mle	88	54.227	Drosophila_melanogaster
ENSG00000135829	DHX9	94	81.319	ENSETEG00000009729	DHX9	90	74.166	Echinops_telfairi
ENSG00000135829	DHX9	83	65.695	ENSEBUG00000015945	-	88	69.102	Eptatretus_burgeri
ENSG00000135829	DHX9	92	96.496	ENSEASG00005006589	DHX9	98	93.780	Equus_asinus_asinus
ENSG00000135829	DHX9	92	96.496	ENSECAG00000011933	DHX9	98	93.780	Equus_caballus
ENSG00000135829	DHX9	81	92.817	ENSEEUG00000004824	DHX9	81	92.817	Erinaceus_europaeus
ENSG00000135829	DHX9	92	77.554	ENSELUG00000010512	dhx9	93	77.722	Esox_lucius
ENSG00000135829	DHX9	93	96.177	ENSFCAG00000019306	DHX9	98	94.476	Felis_catus
ENSG00000135829	DHX9	91	80.289	ENSFALG00000002992	DHX9	94	81.683	Ficedula_albicollis
ENSG00000135829	DHX9	97	90.184	ENSFDAG00000011454	DHX9	100	91.180	Fukomys_damarensis
ENSG00000135829	DHX9	93	88.190	ENSGAGG00000024443	DHX9	96	87.695	Gopherus_agassizii
ENSG00000135829	DHX9	93	86.311	ENSGGOG00000040887	-	99	86.003	Gorilla_gorilla
ENSG00000135829	DHX9	100	99.921	ENSGGOG00000013533	DHX9	100	99.921	Gorilla_gorilla
ENSG00000135829	DHX9	96	75.851	ENSHBUG00000004129	dhx9	93	77.815	Haplochromis_burtoni
ENSG00000135829	DHX9	92	93.265	ENSHGLG00000005769	DHX9	91	90.625	Heterocephalus_glaber_female
ENSG00000135829	DHX9	92	93.265	ENSHGLG00100015628	DHX9	88	90.625	Heterocephalus_glaber_male
ENSG00000135829	DHX9	92	78.741	ENSIPUG00000016675	dhx9	91	78.693	Ictalurus_punctatus
ENSG00000135829	DHX9	92	92.143	ENSJJAG00000003249	Dhx9	86	92.485	Jaculus_jaculus
ENSG00000135829	DHX9	93	95.270	ENSLAFG00000022058	DHX9	98	92.103	Loxodonta_africana
ENSG00000135829	DHX9	100	99.685	ENSMFAG00000041152	DHX9	100	99.685	Macaca_fascicularis
ENSG00000135829	DHX9	100	99.685	ENSMMUG00000005635	DHX9	100	99.685	Macaca_mulatta
ENSG00000135829	DHX9	100	99.685	ENSMNEG00000041195	DHX9	100	99.685	Macaca_nemestrina
ENSG00000135829	DHX9	100	99.606	ENSMLEG00000039925	DHX9	100	99.606	Mandrillus_leucophaeus
ENSG00000135829	DHX9	92	78.438	ENSMAMG00000018644	dhx9	99	78.523	Mastacembelus_armatus
ENSG00000135829	DHX9	96	76.094	ENSMZEG00005014167	dhx9	93	78.067	Maylandia_zebra
ENSG00000135829	DHX9	92	93.089	ENSMAUG00000020414	Dhx9	85	93.089	Mesocricetus_auratus
ENSG00000135829	DHX9	92	96.410	ENSMICG00000008285	DHX9	98	93.881	Microcebus_murinus
ENSG00000135829	DHX9	92	93.345	ENSMOCG00000019404	Dhx9	85	93.345	Microtus_ochrogaster
ENSG00000135829	DHX9	89	74.803	ENSMMOG00000001268	dhx9	98	74.716	Mola_mola
ENSG00000135829	DHX9	92	90.794	ENSMODG00000006955	DHX9	98	88.523	Monodelphis_domestica
ENSG00000135829	DHX9	91	77.277	ENSMALG00000000318	dhx9	100	77.400	Monopterus_albus
ENSG00000135829	DHX9	92	93.339	MGP_CAROLIEiJ_G0014709	Dhx9	100	91.293	Mus_caroli
ENSG00000135829	DHX9	92	93.424	ENSMUSG00000042699	Dhx9	100	91.429	Mus_musculus
ENSG00000135829	DHX9	92	93.339	MGP_SPRETEiJ_G0015516	Dhx9	97	96.250	Mus_spretus
ENSG00000135829	DHX9	93	96.347	ENSMPUG00000011544	DHX9	98	96.347	Mustela_putorius_furo
ENSG00000135829	DHX9	92	93.846	ENSMLUG00000011163	DHX9	98	91.888	Myotis_lucifugus
ENSG00000135829	DHX9	100	99.373	ENSNLEG00000018013	DHX9	100	99.373	Nomascus_leucogenys
ENSG00000135829	DHX9	70	93.750	ENSMEUG00000001470	-	76	93.750	Notamacropus_eugenii
ENSG00000135829	DHX9	84	92.308	ENSOPRG00000016111	DHX9	93	92.308	Ochotona_princeps
ENSG00000135829	DHX9	92	92.424	ENSODEG00000012659	DHX9	92	89.486	Octodon_degus
ENSG00000135829	DHX9	92	78.002	ENSONIG00000000293	dhx9	97	75.594	Oreochromis_niloticus
ENSG00000135829	DHX9	92	90.248	ENSOANG00000000989	DHX9	92	90.334	Ornithorhynchus_anatinus
ENSG00000135829	DHX9	92	95.396	ENSOCUG00000014651	DHX9	98	92.754	Oryctolagus_cuniculus
ENSG00000135829	DHX9	92	77.280	ENSORLG00000007454	dhx9	96	75.000	Oryzias_latipes
ENSG00000135829	DHX9	92	77.020	ENSORLG00020015369	dhx9	96	76.897	Oryzias_latipes_hni
ENSG00000135829	DHX9	93	76.775	ENSORLG00015000892	dhx9	99	74.284	Oryzias_latipes_hsok
ENSG00000135829	DHX9	92	77.937	ENSOMEG00000002437	dhx9	99	77.937	Oryzias_melastigma
ENSG00000135829	DHX9	92	94.710	ENSOGAG00000002620	DHX9	98	93.650	Otolemur_garnettii
ENSG00000135829	DHX9	92	94.620	ENSOARG00000019089	DHX9	91	94.881	Ovis_aries
ENSG00000135829	DHX9	100	100.000	ENSPPAG00000030190	DHX9	100	100.000	Pan_paniscus
ENSG00000135829	DHX9	92	96.170	ENSPPRG00000005890	DHX9	98	94.767	Panthera_pardus
ENSG00000135829	DHX9	92	96.170	ENSPTIG00000021059	DHX9	98	94.767	Panthera_tigris_altaica
ENSG00000135829	DHX9	100	100.000	ENSPTRG00000001759	DHX9	100	100.000	Pan_troglodytes
ENSG00000135829	DHX9	100	99.216	ENSPANG00000012826	DHX9	100	99.216	Papio_anubis
ENSG00000135829	DHX9	98	75.179	ENSPKIG00000006698	dhx9	93	78.553	Paramormyrops_kingsleyae
ENSG00000135829	DHX9	93	87.279	ENSPSIG00000006241	DHX9	98	84.370	Pelodiscus_sinensis
ENSG00000135829	DHX9	92	78.565	ENSPMGG00000009280	dhx9	96	75.381	Periophthalmus_magnuspinnatus
ENSG00000135829	DHX9	92	93.174	ENSPEMG00000001238	Dhx9	85	93.174	Peromyscus_maniculatus_bairdii
ENSG00000135829	DHX9	92	91.126	ENSPCIG00000003716	DHX9	98	91.468	Phascolarctos_cinereus
ENSG00000135829	DHX9	91	78.024	ENSPFOG00000019152	-	100	78.024	Poecilia_formosa
ENSG00000135829	DHX9	92	78.257	ENSPLAG00000001496	dhx9	96	78.154	Poecilia_latipinna
ENSG00000135829	DHX9	91	77.939	ENSPMEG00000019991	dhx9	99	77.939	Poecilia_mexicana
ENSG00000135829	DHX9	92	77.273	ENSPREG00000019307	dhx9	97	77.395	Poecilia_reticulata
ENSG00000135829	DHX9	100	99.843	ENSPPYG00000000431	DHX9	100	99.843	Pongo_abelii
ENSG00000135829	DHX9	86	96.104	ENSPCAG00000011042	DHX9	91	93.202	Procavia_capensis
ENSG00000135829	DHX9	93	96.599	ENSPCOG00000018029	DHX9	98	93.961	Propithecus_coquereli
ENSG00000135829	DHX9	92	95.047	ENSPVAG00000000836	DHX9	98	93.403	Pteropus_vampyrus
ENSG00000135829	DHX9	92	77.496	ENSPNYG00000008480	dhx9	99	75.859	Pundamilia_nyererei
ENSG00000135829	DHX9	92	79.269	ENSPNAG00000021343	dhx9	98	73.913	Pygocentrus_nattereri
ENSG00000135829	DHX9	92	93.350	ENSRNOG00000002735	Dhx9	99	93.345	Rattus_norvegicus
ENSG00000135829	DHX9	100	99.528	ENSRBIG00000041202	DHX9	100	99.528	Rhinopithecus_bieti
ENSG00000135829	DHX9	100	99.528	ENSRROG00000044740	DHX9	100	99.528	Rhinopithecus_roxellana
ENSG00000135829	DHX9	100	93.412	ENSSBOG00000026174	DHX9	100	93.412	Saimiri_boliviensis_boliviensis
ENSG00000135829	DHX9	92	91.567	ENSSHAG00000008540	DHX9	97	91.993	Sarcophilus_harrisii
ENSG00000135829	DHX9	92	78.154	ENSSFOG00015017378	dhx9	92	79.518	Scleropages_formosus
ENSG00000135829	DHX9	91	76.669	ENSSDUG00000017407	dhx9	100	76.669	Seriola_dumerili
ENSG00000135829	DHX9	90	78.068	ENSSLDG00000003926	dhx9	99	78.068	Seriola_lalandi_dorsalis
ENSG00000135829	DHX9	83	96.413	ENSSARG00000003931	DHX9	92	96.413	Sorex_araneus
ENSG00000135829	DHX9	92	87.149	ENSSPUG00000003934	DHX9	92	87.149	Sphenodon_punctatus
ENSG00000135829	DHX9	92	95.389	ENSSSCG00000026806	DHX9	84	95.400	Sus_scrofa
ENSG00000135829	DHX9	68	78.382	ENSTGUG00000004038	-	100	78.382	Taeniopygia_guttata
ENSG00000135829	DHX9	80	79.624	ENSTBEG00000014052	DHX9	80	79.624	Tupaia_belangeri
ENSG00000135829	DHX9	91	93.588	ENSTTRG00000007665	DHX9	100	93.588	Tursiops_truncatus
ENSG00000135829	DHX9	92	96.410	ENSUAMG00000012201	DHX9	100	95.321	Ursus_americanus
ENSG00000135829	DHX9	92	96.496	ENSUMAG00000016482	DHX9	98	94.137	Ursus_maritimus
ENSG00000135829	DHX9	86	91.529	ENSVPAG00000008097	DHX9	86	91.529	Vicugna_pacos
ENSG00000135829	DHX9	92	95.812	ENSVVUG00000008915	DHX9	98	93.896	Vulpes_vulpes
ENSG00000135829	DHX9	93	81.435	ENSXETG00000012515	dhx9	93	81.664	Xenopus_tropicalis
ENSG00000135829	DHX9	92	78.003	ENSXMAG00000011305	dhx9	94	77.937	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000380	alternative mRNA splicing, via spliceosome	28221134.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	11038348.	IDA	Function
GO:0000993	RNA polymerase II complex binding	11416126.	IDA	Function
GO:0001069	regulatory region RNA binding	28355180.	IDA	Function
GO:0001085	RNA polymerase II transcription factor binding	17303075.	IPI	Function
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0003677	DNA binding	-	ISS	Function
GO:0003688	DNA replication origin binding	24990949.	IDA	Function
GO:0003690	double-stranded DNA binding	9111062.12711669.	IDA	Function
GO:0003697	single-stranded DNA binding	9111062.10198287.20696886.21957149.	IDA	Function
GO:0003712	transcription coregulator activity	11416126.	IMP	Function
GO:0003713	transcription coactivator activity	9323138.	IMP	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	1537828.	IDA	Function
GO:0003724	RNA helicase activity	8690889.	TAS	Function
GO:0003725	double-stranded RNA binding	9111062.10198287.12711669.21957149.27107641.28636595.	IDA	Function
GO:0003727	single-stranded RNA binding	9111062.10198287.	IDA	Function
GO:0003729	mRNA binding	10198287.	IDA	Function
GO:0003729	mRNA binding	28221134.	IMP	Function
GO:0004003	ATP-dependent DNA helicase activity	21873635.	IBA	Function
GO:0004003	ATP-dependent DNA helicase activity	12711669.	IMP	Function
GO:0004004	ATP-dependent RNA helicase activity	28221134.	IDA	Function
GO:0004004	ATP-dependent RNA helicase activity	-	ISS	Function
GO:0005515	protein binding	9323138.9662397.10924507.11402034.11687588.12711669.14704337.15084609.15355351.17289661.17498979.17531811.18519039.18596238.19955415.20123736.20696886.21247876.21849455.21903422.22190748.23361462.23652018.23986595.24965446.28221134.28355180.28636595.29395061.	IPI	Function
GO:0005524	ATP binding	11416126.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9162007.10198287.10207077.11687588.15121898.16375861.16680162.17498979.24965446.	IDA	Component
GO:0005654	nucleoplasm	28221134.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005726	perichromatin fibrils	10198287.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005737	cytoplasm	9162007.10198287.10207077.16375861.16680162.20696886.	IDA	Component
GO:0005813	centrosome	17498979.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005844	polysome	21247876.22190748.	IDA	Component
GO:0006260	DNA replication	-	IEA	Process
GO:0006353	DNA-templated transcription, termination	-	IEA	Process
GO:0006357	regulation of transcription by RNA polymerase II	9662397.	IMP	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0010501	RNA secondary structure unwinding	1537828.9111062.	IDA	Process
GO:0015629	actin cytoskeleton	11687588.	IDA	Component
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0016604	nuclear body	28221134.	IDA	Component
GO:0016887	ATPase activity	11416126.	IMP	Function
GO:0016887	ATPase activity	-	ISS	Function
GO:0017111	nucleoside-triphosphatase activity	-	ISS	Function
GO:0030423	targeting of mRNA for destruction involved in RNA interference	17531811.	IMP	Process
GO:0031490	chromatin DNA binding	24049074.	IDA	Function
GO:0032481	positive regulation of type I interferon production	-	TAS	Process
GO:0032508	DNA duplex unwinding	9111062.21561811.	IDA	Process
GO:0032508	DNA duplex unwinding	12711669.	IMP	Process
GO:0032508	DNA duplex unwinding	-	ISS	Process
GO:0032741	positive regulation of interleukin-18 production	-	ISS	Process
GO:0032991	protein-containing complex	11687588.	IDA	Component
GO:0033681	ATP-dependent 3'-5' DNA/RNA helicase activity	1537828.21561811.	IDA	Function
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	21873635.	IBA	Function
GO:0034459	ATP-dependent 3'-5' RNA helicase activity	1537828.21561811.	IDA	Function
GO:0035068	micro-ribonucleoprotein complex	17531811.23361462.	IDA	Component
GO:0035197	siRNA binding	23361462.	IDA	Function
GO:0035549	positive regulation of interferon-beta secretion	21957149.	IMP	Process
GO:0035613	RNA stem-loop binding	11096080.16680162.	IDA	Function
GO:0036464	cytoplasmic ribonucleoprotein granule	10198287.15121898.	IDA	Component
GO:0039695	DNA-templated viral transcription	11096080.	IDA	Process
GO:0042788	polysomal ribosome	16680162.	IDA	Component
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21561811.	IDA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	-	ISS	Function
GO:0044806	G-quadruplex DNA unwinding	21561811.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045089	positive regulation of innate immune response	-	ISS	Process
GO:0045142	triplex DNA binding	24049074.	IDA	Function
GO:0045739	positive regulation of DNA repair	24049074.	IMP	Process
GO:0045740	positive regulation of DNA replication	24990949.	IMP	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0045944	positive regulation of transcription by RNA polymerase II	9323138.11038348.11416126.21957149.	IMP	Process
GO:0046833	positive regulation of RNA export from nucleus	11402034.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0047429	nucleoside-triphosphate diphosphatase activity	1537828.	IDA	Function
GO:0048146	positive regulation of fibroblast proliferation	24990949.	IMP	Process
GO:0048511	rhythmic process	-	IEA	Process
GO:0050434	positive regulation of viral transcription	11096080.	IDA	Process
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process
GO:0050684	regulation of mRNA processing	28355180.	IDA	Process
GO:0050691	regulation of defense response to virus by host	-	ISS	Process
GO:0050729	positive regulation of inflammatory response	-	ISS	Process
GO:0051028	mRNA transport	-	IEA	Process
GO:0051092	positive regulation of NF-kappaB transcription factor activity	15355351.	IMP	Process
GO:0060760	positive regulation of response to cytokine stimulus	21957149.	IMP	Process
GO:0061676	importin-alpha family protein binding	16375861.	IDA	Function
GO:0070063	RNA polymerase binding	9323138.	IDA	Function
GO:0070269	pyroptosis	-	ISS	Process
GO:0070578	RISC-loading complex	17531811.	IMP	Component
GO:0070922	small RNA loading onto RISC	17531811.	IMP	Process
GO:0070934	CRD-mediated mRNA stabilization	19029303.	IMP	Process
GO:0070937	CRD-mediated mRNA stability complex	19029303.	IDA	Component
GO:0071356	cellular response to tumor necrosis factor	15355351.	IMP	Process
GO:0071360	cellular response to exogenous dsRNA	21957149.	IMP	Process
GO:0097165	nuclear stress granule	10198287.	IDA	Component
GO:0097165	nuclear stress granule	24965446.	IMP	Component
GO:1902741	positive regulation of interferon-alpha secretion	21957149.	IMP	Process
GO:1903608	protein localization to cytoplasmic stress granule	24965446.	IMP	Process
GO:1904469	positive regulation of tumor necrosis factor secretion	20696886.21957149.	IMP	Process
GO:1904973	positive regulation of viral translation	16680162.	IMP	Process
GO:1905172	RISC complex binding	17531811.	IDA	Function
GO:1905538	polysome binding	16680162.21247876.	IDA	Function
GO:1905698	positive regulation of polysome binding	22190748.	IMP	Process
GO:1990518	single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity	20669935.24049074.	IDA	Function
GO:1990825	sequence-specific mRNA binding	9162007.11402034.	IDA	Function
GO:1990841	promoter-specific chromatin binding	28221134.	IMP	Function
GO:1990904	ribonucleoprotein complex	21873635.	IBA	Component
GO:1990904	ribonucleoprotein complex	11402034.12711669.14704337.16680162.17289661.18809582.22190748.	IDA	Component
GO:1990904	ribonucleoprotein complex	28221134.	IMP	Component
GO:2000373	positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity	12711669.	IMP	Process
GO:2000637	positive regulation of gene silencing by miRNA	17531811.	IMP	Process
GO:2000765	regulation of cytoplasmic translation	28355180.	IDA	Process
GO:2000767	positive regulation of cytoplasmic translation	16680162.21247876.22190748.	IMP	Process
GO:2000778	positive regulation of interleukin-6 secretion	20696886.21957149.	IMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
18519039	The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA.	FEBS Lett	2008 Jun 25	Prahl M	doi: 10.1016/j.febslet.2008.04.065
26885691	The RNA helicase A in malignant transformation.	Oncotarget	2016 May 10	Fidaleo M	doi: 10.18632/oncotarget.7377.
14769796	RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells.	J Biol Chem	2004 Apr 23	Zhong X	-
19197335	Genetic sequence variations of BRCA1-interacting genes AURKA, BAP1, BARD1 and DHX9 in French Canadian families with high risk of breast cancer.	J Hum Genet	2009 Mar	Gu??nard F	doi: 10.1038/jhg.2009.6
20802156	RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus.	Proc Natl Acad Sci U S A	2010 Sep 14	Huo L	doi: 10.1073/pnas.1000743107
27034008	The biology of DHX9 and its potential as a therapeutic target.	Oncotarget	2016 Jul 5	Lee T	doi: 10.18632/oncotarget.8446.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr1	182854069	Missense_Mutation	novel	H173Y	0.2
BLCA	chr1	182880594	Frame_Shift_Del	novel	*C872Vfs45**	0.37	dsrm
BLCA	chr1	182843394	Missense_Mutation	novel	R71Q	0.15
BLCA	chr1	182858578	Missense_Mutation	novel	Q280E	0.19
BLCA	chr1	182881279	Missense_Mutation	novel	I880M	0.15	dsrm
BLCA	chr1	182853404	Missense_Mutation	novel	Q155E	0.16
BLCA	chr1	182887134	Silent	novel	S1171S	0.36
BLCA	chr1	182884754	Missense_Mutation	novel	M1134I	0.44
BLCA	chr1	182872490	Nonsense_Mutation	NA	Q571*	0.06
BLCA	chr1	182858737	Missense_Mutation	novel	E302G	0.08
BLCA	chr1	182876108	Missense_Mutation	novel	S625C	0.38
BLCA	chr1	182858578	Missense_Mutation	novel	Q280E	0.16
BLCA	chr1	182854156	Missense_Mutation	novel	Q202E	0.49
BLCA	chr1	182853366	Missense_Mutation	NA	G142E	0.23
BLCA	chr1	182881422	Missense_Mutation	novel	A928G	0.2
BLCA	chr1	182880494	Splice_Region	novel		0.17
BLCA	chr1	182876227	Missense_Mutation	NA	T665A	0.24
BLCA	chr1	182883594	Missense_Mutation	novel	K1073N	0.23
BLCA	chr1	182876518	Missense_Mutation	NA	P701S	0.44
BLCA	chr1	182881292	Missense_Mutation	novel	A885P	0.24	dsrm
BRCA	chr1	182867017	Missense_Mutation	NA	D511Y	0.24
BRCA	chr1	182884712	Silent	NA	I1120I	0.23
BRCA	chr1	182872361	Missense_Mutation	rs754675901	R528C	0.19
BRCA	chr1	182858580	Silent	novel	Q280Q	0.06
BRCA	chr1	182858761	Missense_Mutation	novel	L310R	0.22
BRCA	chr1	182887372	Missense_Mutation	novel	G1251S	0.21
BRCA	chr1	182878024	Missense_Mutation	NA	Q734H	0.15
BRCA	chr1	182884632	Missense_Mutation	NA	H1094Y	0.18
BRCA	chr1	182881353	Missense_Mutation	NA	R905Q	0.08
BRCA	chr1	182880572	Missense_Mutation	NA	R863H	0.12	dsrm
BRCA	chr1	182874945	Missense_Mutation	novel	E602D	0.12
BRCA	chr1	182876878	Missense_Mutation	NA	V725F	0.34
BRCA	chr1	182843358	Missense_Mutation	novel	S59N	0.04
BRCA	chr1	182842633	Missense_Mutation	NA	I23V	0.63
CESC	chr1	182858804	Missense_Mutation	NA	Q324H	0.58
CESC	chr1	182858184	Missense_Mutation	NA	H252Y	0.33
CESC	chr1	182866478	Missense_Mutation	novel	R456Q	0.31
CESC	chr1	182874877	Missense_Mutation	NA	Q580E	0.11
CESC	chr1	182881539	Missense_Mutation	NA	E936K	0.09
CESC	chr1	182876854	Missense_Mutation	NA	E717K	0.38
CESC	chr1	182843334	Missense_Mutation	NA	S51Y	0.48
CHOL	chr1	182876890	Missense_Mutation	novel	I729V	0.4
CHOL	chr1	182881334	Missense_Mutation	NA	R899W	0.2
COAD	chr1	182866478	Missense_Mutation	novel	R456Q	0.17
COAD	chr1	182881334	Missense_Mutation	NA	R899W	0.43
COAD	chr1	182887424	Missense_Mutation	novel	G1268D	0.03
COAD	chr1	182887451	3'UTR	novel		0.1
COAD	chr1	182858786	Silent	novel	F318F	0.11
COAD	chr1	182866531	Nonsense_Mutation	novel	R474*	0.17
COAD	chr1	182876145	Silent	rs771546846	I637I	0.19
COAD	chr1	182876081	Missense_Mutation	novel	Y616C	0.25
COAD	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.41
COAD	chr1	182872380	Missense_Mutation	NA	Y534C	0.17
COAD	chr1	182876118	Silent	rs191883464	N628N	0.39
COAD	chr1	182884758	Missense_Mutation	NA	R1136C	0.25
COAD	chr1	182887209	Silent	rs781296469	S1196S	0.31
COAD	chr1	182858799	Nonsense_Mutation	novel	R323*	0.4
COAD	chr1	182878122	Missense_Mutation	novel	R767Q	0.18
COAD	chr1	182887179	Silent	novel	G1186G	0.08
COAD	chr1	182887360	Missense_Mutation	NA	F1247V	0.16
COAD	chr1	182858642	Splice_Site	novel	X300_splice	0.08
COAD	chr1	182881579	Missense_Mutation	NA	T949I	0.1
COAD	chr1	182867005	Missense_Mutation	novel	H507Y	0.07
COAD	chr1	182842585	Missense_Mutation	NA	F7V	0.28
COAD	chr1	182878065	Missense_Mutation	novel	Y748C	0.38
COAD	chr1	182876197	Frame_Shift_Ins	novel	*L657Ffs44**	0.34
COAD	chr1	182853404	Frame_Shift_Ins	novel	*Q155Lfs8**	0.08
COAD	chr1	182853405	Missense_Mutation	novel	Q155L	0.08
COAD	chr1	182866478	Missense_Mutation	novel	R456Q	0.18
COAD	chr1	182878128	Missense_Mutation	NA	R769Q	0.28
COAD	chr1	182887219	Missense_Mutation	novel	G1200S	0.06
ESCA	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.29
ESCA	chr1	182860032	Missense_Mutation	novel	E394K	0.29
ESCA	chr1	182887430	Missense_Mutation	novel	Y1270F	0.6
ESCA	chr1	182881396	Silent	novel	L919L	0.3
ESCA	chr1	182874953	Missense_Mutation	novel	D605V	0.72
GBM	chr1	182876089	Nonsense_Mutation	novel	E619*	0.17
GBM	chr1	182878164	Missense_Mutation	NA	R781H	0.22
HNSC	chr1	182887154	Missense_Mutation	novel	S1178C	0.05
HNSC	chr1	182884777	Missense_Mutation	novel	S1142L	0.32
HNSC	chr1	182876461	Missense_Mutation	novel	Q682E	0.1
HNSC	chr1	182883320	Silent	novel	S1032S	0.3
HNSC	chr1	182866537	Missense_Mutation	novel	E476K	0.27
HNSC	chr1	182843396	Missense_Mutation	novel	I72V	0.09
HNSC	chr1	182860092	Frame_Shift_Ins	novel	*G414Vfs16**	0.12
HNSC	chr1	182860093	In_Frame_Ins	novel	G414_C415insSFKKLPSL	0.1
HNSC	chr1	182887236	Silent	novel	S1205S	0.19
HNSC	chr1	182858814	Missense_Mutation	novel	G328S	0.27
KIRC	chr1	182874910	Frame_Shift_Del	novel	*K592Rfs19**	0.3
KIRC	chr1	182880505	Missense_Mutation	NA	A841T	0.22	dsrm
KIRC	chr1	182877927	Intron	novel		0.2
KIRC	chr1	182872362	Missense_Mutation	rs778625494	R528H	0.2
KIRC	chr1	182880549	Silent	novel	L855L	0.19
KIRP	chr1	182853324	Missense_Mutation	novel	G128E	0.54
KIRP	chr1	182881572	Missense_Mutation	NA	M947V	0.73
KIRP	chr1	182887291	Missense_Mutation	NA	G1224R	0.43
KIRP	chr1	182859094	Missense_Mutation	novel	E373K	0.36
LGG	chr1	182858160	Missense_Mutation	novel	L244M	0.29
LGG	chr1	182884740	Missense_Mutation	rs370793590	R1130C	0.47
LIHC	chr1	182883631	Missense_Mutation	NA	D1086N	0.28
LIHC	chr1	182843428	Frame_Shift_Del	novel	*F83Lfs3**	0.43
LIHC	chr1	182879338	Missense_Mutation	novel	G814S	0.2
LIHC	chr1	182883247	Missense_Mutation	NA	E1008V	0.54
LIHC	chr1	182842636	Missense_Mutation	novel	R24G	0.1
LIHC	chr1	182858809	Missense_Mutation	novel	Q326R	0.08
LIHC	chr1	182859097	Nonsense_Mutation	novel	Q374*	0.09
LIHC	chr1	182878130	Missense_Mutation	NA	P770A	0.1
LIHC	chr1	182866998	Silent	NA	G504G	0.21
LIHC	chr1	182867027	Missense_Mutation	novel	H514L	0.14
LIHC	chr1	182854169	Missense_Mutation	NA	D206G	0.05
LIHC	chr1	182883247	Missense_Mutation	NA	E1008V	0.05
LIHC	chr1	182854169	Missense_Mutation	NA	D206G	0.62
LIHC	chr1	182881287	Missense_Mutation	novel	I883T	0.09	dsrm
LIHC	chr1	182854120	Missense_Mutation	novel	Q190E	0.15
LUAD	chr1	182866507	Missense_Mutation	NA	G466R	0.07
LUAD	chr1	182854159	Missense_Mutation	novel	V203L	0.27
LUAD	chr1	182860134	Missense_Mutation	NA	D428N	0.09
LUAD	chr1	182881350	Missense_Mutation	NA	H904L	0.05
LUAD	chr1	182858184	Missense_Mutation	NA	H252Y	0.17
LUAD	chr1	182881292	Missense_Mutation	novel	A885S	0.37	dsrm
LUAD	chr1	182876112	Silent	rs755270102	Q626Q	0.25
LUAD	chr1	182876149	Missense_Mutation	NA	A639S	0.26
LUAD	chr1	182854112	Frame_Shift_Ins	novel	*Y188Ifs12**	0.05
LUAD	chr1	182854113	In_Frame_Ins	novel	Q187_Y188insITF	0.05
LUAD	chr1	182866981	Nonsense_Mutation	novel	E499*	0.11
LUAD	chr1	182881379	Missense_Mutation	novel	D914H	0.03
LUAD	chr1	182853397	Silent	rs778356288	K152K	0.31
LUAD	chr1	182858607	Missense_Mutation	NA	I289M	0.12
LUAD	chr1	182883170	In_Frame_Del	novel	G983_D989del	0.18
LUAD	chr1	182876071	Missense_Mutation	novel	G613C	0.32
LUAD	chr1	182878169	Missense_Mutation	NA	E783Q	0.34
LUAD	chr1	182854033	Silent	NA	L161L	0.12
LUAD	chr1	182878173	Missense_Mutation	novel	R784K	0.4
LUAD	chr1	182887426	Frame_Shift_Ins	novel	*G1269Afs53**	0.12
LUAD	chr1	182877998	Intron	novel		0.24
LUAD	chr1	182878129	Silent	rs756240932	R769R	0.67
LUAD	chr1	182887265	Missense_Mutation	NA	G1215V	0.45
LUAD	chr1	182874874	Missense_Mutation	novel	I579V	0.41
LUSC	chr1	182883625	Missense_Mutation	novel	V1084I	0.09
LUSC	chr1	182876903	Missense_Mutation	NA	K733R	0.36
LUSC	chr1	182858180	Silent	novel	L250L	0.35
LUSC	chr1	182883570	Silent	novel	L1065L	0.16
LUSC	chr1	182859994	Missense_Mutation	novel	I381N	0.22
LUSC	chr1	182878030	Silent	NA	V736V	0.15
LUSC	chr1	182884779	Missense_Mutation	novel	A1143T	0.07
LUSC	chr1	182858614	Missense_Mutation	novel	E292Q	0.38
LUSC	chr1	182854145	Missense_Mutation	NA	Y198C	0.42
LUSC	chr1	182883347	Silent	novel	P1041P	0.22
LUSC	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.26
LUSC	chr1	182858212	Missense_Mutation	novel	G261V	0.08
LUSC	chr1	182842563	5'UTR	novel		0.14
OV	chr1	182853417	Splice_Site	NA	X159_splice	0.47
OV	chr1	182860091	Silent	novel	T413T	0.06
OV	chr1	182860093	Missense_Mutation	novel	G414E	0.07
OV	chr1	182883165	Missense_Mutation	NA	N981D	0.19
OV	chr1	182876469	Silent	NA	L684L	0.17
OV	chr1	182843348	Missense_Mutation	NA	D56H	0.52
PAAD	chr1	182874877	Nonsense_Mutation	novel	Q580*	0.25
PAAD	chr1	182876883	Silent	novel	V726V	0.18
PAAD	chr1	182878112	Nonsense_Mutation	NA	R764*	0.17
PAAD	chr1	182881411	Silent	novel	A924A	0.08
PAAD	chr1	182883276	Missense_Mutation	novel	R1018C	0.18
READ	chr1	182859051	Silent	NA	E358E	0.15
READ	chr1	182860155	Missense_Mutation	NA	A435S	0.19
READ	chr1	182883293	Silent	novel	H1023H	0.12
READ	chr1	182877856	Intron	novel		0.18
READ	chr1	182872444	Missense_Mutation	NA	F555L	0.46
READ	chr1	182887658	3'UTR	novel		0.43
READ	chr1	182842585	Missense_Mutation	NA	F7V	0.37
READ	chr1	182876200	Missense_Mutation	novel	F656V	0.06
SKCM	chr1	182858833	Missense_Mutation	NA	P334H	0.39
SKCM	chr1	182884757	Silent	NA	I1135I	0.35
SKCM	chr1	182876127	Silent	NA	E631E	0.55
SKCM	chr1	182883203	Silent	NA	S993S	0.24
SKCM	chr1	182876131	Missense_Mutation	NA	P633S	0.34
SKCM	chr1	182858742	Missense_Mutation	NA	P304S	0.4
SKCM	chr1	182876503	Missense_Mutation	novel	R696C	0.5
SKCM	chr1	182887287	Silent	NA	S1222S	0.33
SKCM	chr1	182883590	Missense_Mutation	NA	S1072F	0.09
SKCM	chr1	182884757	Silent	NA	I1135I	0.3
SKCM	chr1	182866534	Missense_Mutation	NA	F475L	0.28
SKCM	chr1	182854102	Missense_Mutation	NA	R184C	0.23
SKCM	chr1	182876087	Missense_Mutation	NA	P618L	0.2
SKCM	chr1	182880559	Missense_Mutation	novel	P859S	0.14	dsrm
SKCM	chr1	182887235	Missense_Mutation	NA	S1205F	0.39
SKCM	chr1	182876472	Silent	NA	P685P	0.3
SKCM	chr1	182866993	Nonsense_Mutation	NA	R503*	0.38
SKCM	chr1	182878072	Silent	rs180944343	T750T	0.52
SKCM	chr1	182883345	Missense_Mutation	NA	P1041S	0.62
SKCM	chr1	182852263	Missense_Mutation	novel	P95S	0.14
STAD	chr1	182852264	Missense_Mutation	NA	P95H	0.24
STAD	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.1
STAD	chr1	182880515	Missense_Mutation	novel	A844V	0.1	dsrm
STAD	chr1	182887425	Silent	NA	G1268G	0.37
STAD	chr1	182874935	Missense_Mutation	rs757918330	D599G	0.44
STAD	chr1	182879248	Splice_Site	NA	X784_splice	0.36
STAD	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.33
STAD	chr1	182887224	Silent	NA	G1201G	0.07
STAD	chr1	182859072	Missense_Mutation	novel	K365N	0.06
STAD	chr1	182878104	Missense_Mutation	NA	R761Q	0.15
STAD	chr1	182860027	Missense_Mutation	NA	K392T	0.15
STAD	chr1	182887378	Frame_Shift_Ins	novel	*A1255Gfs27**	0.18
STAD	chr1	182884796	Frame_Shift_Del	novel	*M1149Dfs25**	0.3
STAD	chr1	182858815	Missense_Mutation	novel	G328D	0.23
STAD	chr1	182874917	Missense_Mutation	novel	K593R	0.38
STAD	chr1	182884664	Silent	NA	R1104R	0.23
STAD	chr1	182878163	Missense_Mutation	novel	R781C	0.25
STAD	chr1	182887123	Missense_Mutation	novel	D1168N	0.21
STAD	chr1	182866509	Frame_Shift_Del	novel	*S468Afs19**	0.06
STAD	chr1	182866980	Silent	NA	L498L	0.2
STAD	chr1	182887379	Frame_Shift_Del	novel	*A1255Pfs63**	0.36
UCEC	chr1	182858139	Missense_Mutation	NA	L237M	0.46
UCEC	chr1	182881335	Missense_Mutation	rs1049265	R899Q	0.05
UCEC	chr1	182887372	Missense_Mutation	novel	G1251C	0.23
UCEC	chr1	182872391	Missense_Mutation	rs776849743	R538C	0.35
UCEC	chr1	182876222	Missense_Mutation	NA	I663S	0.37
UCEC	chr1	182883523	Nonsense_Mutation	NA	R1050*	0.18
UCEC	chr1	182877832	Intron	novel		0.5
UCEC	chr1	182881317	Missense_Mutation	novel	F893S	0.2	dsrm
UCEC	chr1	182887328	Missense_Mutation	novel	G1236E	0.46
UCEC	chr1	182881342	Silent	novel	G901G	0.06
UCEC	chr1	182887122	Silent	rs555438540	Y1167Y	0.3
UCEC	chr1	182884813	Missense_Mutation	NA	R1154Q	0.33
UCEC	chr1	182860173	Missense_Mutation	NA	V441I	0.3
UCEC	chr1	182881383	Missense_Mutation	novel	H915R	0.47
UCEC	chr1	182883523	Nonsense_Mutation	NA	R1050*	0.47
UCEC	chr1	182881545	Missense_Mutation	novel	R938C	0.43
UCEC	chr1	182872431	Missense_Mutation	novel	F551C	0.28
UCEC	chr1	182876146	Missense_Mutation	novel	E638K	0.07
UCEC	chr1	182887497	3'UTR	rs193146921		0.06
UCEC	chr1	182887179	Nonsense_Mutation	novel	*G1193Sfs4**	0.04
UCEC	chr1	182872372	Silent	NA	V531V	0.23
UCEC	chr1	182881314	Missense_Mutation	novel	P892L	0.1	dsrm
UCEC	chr1	182874935	Missense_Mutation	rs757918330	D599G	0.07
UCEC	chr1	182876197	Frame_Shift_Ins	novel	*L657Ffs44**	0.06
UCEC	chr1	182842617	Missense_Mutation	NA	M17I	0.04
UCEC	chr1	182859099	Silent	NA	Q374Q	0.44
UCEC	chr1	182887160	Missense_Mutation	NA	Y1180C	0.41
UCEC	chr1	182876142	Silent	rs747582738	L636L	0.16
UCEC	chr1	182852264	Missense_Mutation	NA	P95H	0.45
UCEC	chr1	182866508	Missense_Mutation	novel	G466E	0.4
UCEC	chr1	182887553	3'UTR	novel		0.43
UCEC	chr1	182887472	3'UTR	novel		0.08
UCEC	chr1	182876197	Missense_Mutation	novel	V655F	0.13
UCEC	chr1	182883524	Missense_Mutation	novel	R1050Q	0.37
UCEC	chr1	182860112	Silent	rs550443659	Q420Q	0.14
UCEC	chr1	182884740	Missense_Mutation	rs370793590	R1130C	0.38
UCEC	chr1	182887473	3'UTR	rs753798673		0.26
UCEC	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.46
UCEC	chr1	182854152	Silent	novel	Y200Y	0.35
UCEC	chr1	182881558	Missense_Mutation	novel	H942R	0.43
UCEC	chr1	182843398	Frame_Shift_Del	novel	*E74Kfs3**	0.52
UCEC	chr1	182876874	Silent	rs768970996	N723N	0.52
UCEC	chr1	182880546	Silent	novel	I854I	0.36
UCEC	chr1	182883301	Missense_Mutation	novel	S1026Y	0.51
UCEC	chr1	182858107	Frame_Shift_Del	novel	*F227Lfs50**	0.31
UCEC	chr1	182867012	Missense_Mutation	NA	I509S	0.43
UCEC	chr1	182887461	3'UTR	novel		0.39
UCEC	chr1	182881385	Missense_Mutation	novel	V916I	0.51
UCEC	chr1	182858620	Missense_Mutation	novel	N294H	0.4
UCEC	chr1	182881358	Missense_Mutation	novel	F907V	0.38
UCEC	chr1	182843393	Nonsense_Mutation	NA	R71*	0.42
UCEC	chr1	182876874	Missense_Mutation	novel	N723K	0.2
UCEC	chr1	182872391	Missense_Mutation	rs776849743	R538C	0.36
UCEC	chr1	182887227	Silent	rs766786769	S1202S	0.39
UCEC	chr1	182887657	3'UTR	novel		0.21
UCEC	chr1	182881385	Missense_Mutation	novel	V916I	0.3
UCEC	chr1	182883580	Missense_Mutation	novel	L1069F	0.49
UCEC	chr1	182866531	Nonsense_Mutation	novel	R474*	0.42
UCEC	chr1	182858786	Silent	novel	F318F	0.1
UCEC	chr1	182883523	Nonsense_Mutation	NA	R1050*	0.19
UCEC	chr1	182866574	Missense_Mutation	novel	F488C	0.27
UCEC	chr1	182887379	Frame_Shift_Del	novel	*A1255Pfs63**	0.21
UCEC	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.19
UCEC	chr1	182880529	Missense_Mutation	novel	T849A	0.45	dsrm
UCEC	chr1	182858556	Silent	NA	E272E	0.14
UCEC	chr1	182866460	Missense_Mutation	NA	A450V	0.2
UCEC	chr1	182887082	Splice_Site	novel	X1154_splice	0.39
UCEC	chr1	182860112	Missense_Mutation	novel	Q420H	0.28
UCEC	chr1	182867002	Missense_Mutation	novel	S506G	0.1
UCEC	chr1	182843393	Nonsense_Mutation	NA	R71*	0.42
UCEC	chr1	182887367	Missense_Mutation	rs780048503	R1249Q	0.28
UCEC	chr1	182854070	Missense_Mutation	NA	H173R	0.16
UCEC	chr1	182881334	Missense_Mutation	NA	R899W	0.36
UCEC	chr1	182883523	Nonsense_Mutation	NA	R1050*	0.41
UCEC	chr1	182887318	Missense_Mutation	NA	D1233Y	0.27
UCEC	chr1	182866461	Silent	NA	A450A	0.05
UCEC	chr1	182858622	Frame_Shift_Del	novel	L295*	0.07
UCEC	chr1	182883523	Nonsense_Mutation	NA	R1050*	0.32
UCEC	chr1	182853362	Nonsense_Mutation	NA	R141*	0.17
UCEC	chr1	182883276	Missense_Mutation	novel	R1018C	0.16
UCEC	chr1	182884740	Missense_Mutation	rs370793590	R1130C	0.14
UCEC	chr1	182887663	3'UTR	novel		0.37
UCEC	chr1	182883563	Frame_Shift_Del	novel	*L1065Cfs20**	0.25
UCEC	chr1	182866458	Silent	NA	S449S	0.18
UCEC	chr1	182876542	Splice_Site	NA	X708_splice	0.17
UCEC	chr1	182883608	Missense_Mutation	novel	D1078A	0.08
UCEC	chr1	182867012	Missense_Mutation	NA	I509S	0.17
UCEC	chr1	182872451	Missense_Mutation	novel	C558R	0.42
UCEC	chr1	182887538	3'UTR	novel		0.32
UCS	chr1	182881318	Silent	novel	F893F	0.52
UCS	chr1	182860173	Missense_Mutation	novel	V441L	0.33
UCS	chr1	182852330	Missense_Mutation	novel	L117R	0.34
UCS	chr1	182879282	Missense_Mutation	novel	R795Q	0.27

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.0417	0.0017831
KIRC	AMP	0.089	0.059566
PAAD	AMP	0.2283	0.085665
TGCT	AMP	0.3467	0.088103
THCA	AMP	0.0501	0.075436

Survival Analysis

Cancer	P-value	Q-value
THYM	0.044	Kaplan-Meier Survival Analysis
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.003	Kaplan-Meier Survival Analysis
ACC	0.00032	Kaplan-Meier Survival Analysis
UCS	0.042	Kaplan-Meier Survival Analysis
SKCM	0.047	Kaplan-Meier Survival Analysis
BRCA	0.046	Kaplan-Meier Survival Analysis
KIRP	0.02	Kaplan-Meier Survival Analysis
PAAD	0.0028	Kaplan-Meier Survival Analysis
PCPG	0.018	Kaplan-Meier Survival Analysis
READ	0.035	Kaplan-Meier Survival Analysis
KICH	0.047	Kaplan-Meier Survival Analysis
LIHC	0.00077	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742