EuRBPDB

Description

Ensembl ID: ENSG00000135900 (Gene tree)
Gene ID: 65080
Gene Symbol: MRPL44
Alias: FLJ12701|FLJ13990
Full Name: mitochondrial ribosomal protein L44
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 16,825 bases
Position: chr2:223,950,890-223,967,714
Accession: 16650
RBP type: non-canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000258383	MRPL44-201	1748	-	ENSP00000258383	332 (aa)	-	Q9H9J2

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135900	MRPL44	80	36.364	FBgn0037330	mRpL44	82	36.364	Drosophila_melanogaster
ENSG00000135900	MRPL44	100	85.586	ENSMUSG00000026248	Mrpl44	100	85.586	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003725	double-stranded RNA binding	21873635.	IBA	Function
GO:0004525	ribonuclease III activity	21873635.	IBA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006396	RNA processing	21873635.	IBA	Process
GO:0030422	production of siRNA involved in RNA interference	21873635.	IBA	Process
GO:0031053	primary miRNA processing	21873635.	IBA	Process
GO:0031054	pre-miRNA processing	21873635.	IBA	Process
GO:0070125	mitochondrial translational elongation	23315540.	IMP	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process