EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136068 (Gene tree)
Gene ID: 2317
Gene Symbol: FLNB
Alias: TAP|TABP|ABP-278|FH1|FLN1L|LRS1
Full Name: filamin B
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 163,856 bases
Position: chr3:58,008,400-58,172,255
Accession: 3755
RBP type: non-canonical RBP
Summary: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18809679	Filamin B mediates ICAM-1-driven leukocyte transendothelial migration.	J Biol Chem	2008 Nov 14	Kanters E	doi: 10.1074/jbc.M804888200

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000477629	FLNB-209	2058	-	-	- (aa)	-	-
ENST00000481470	FLNB-210	6497	-	-	- (aa)	-	-
ENST00000470231	FLNB-207	315	-	ENSP00000419954	72 (aa)	-	A0A0C4DGA1
ENST00000484981	FLNB-211	932	-	-	- (aa)	-	-
ENST00000475487	FLNB-208	541	-	-	- (aa)	-	-
ENST00000419752	FLNB-203	2002	-	ENSP00000414532	195 (aa)	-	A0A0A0MT44
ENST00000491408	FLNB-213	475	-	-	- (aa)	-	-
ENST00000358537	FLNB-202	9391	-	ENSP00000351339	2578 (aa)	-	O75369
ENST00000295956	FLNB-201	9463	-	ENSP00000295956	2602 (aa)	-	O75369
ENST00000490882	FLNB-212	8079	XM_005264978	ENSP00000420213	2633 (aa)	XP_005265035	O75369
ENST00000468939	FLNB-206	573	-	-	- (aa)	-	-
ENST00000429972	FLNB-204	9430	-	ENSP00000415599	2591 (aa)	-	O75369
ENST00000466455	FLNB-205	404	-	ENSP00000420199	135 (aa)	-	H7C5L4
ENST00000493452	FLNB-214	7402	-	ENSP00000418510	2409 (aa)	-	E7EN95

Gene Model

Click here to download ENSG00000136068's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa05132	Salmonella infection	KEGG
hsa05205	Proteoglycans in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136068	Myocardial Infarction	8.4324768E-004	-
ENSG00000136068	Myocardial Infarction	1.6321313E-004	-
ENSG00000136068	Alcoholism	1.7E-05	-
ENSG00000136068	Optic Disk	2E-8	28073927
ENSG00000136068	Optic Disk	6E-11	28073927
ENSG00000136068	Binge-Eating Disorder	1E-6	23568457
ENSG00000136068	Optic Disk	5E-6	28073927
ENSG00000136068	Antineoplastic Agents	4E-6	23648065
ENSG00000136068	Carboplatin	4E-6	23648065
ENSG00000136068	Optic Disk	1E-8	25631615
ENSG00000136068	Optic Disk	5E-6	28073927
ENSG00000136068	Gastrointestinal Microbiome	3E-8	27723756
ENSG00000136068	Microbiota	3E-8	27723756
ENSG00000136068	Optic Disk	7E-6	25631615

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136068	rs732527	3	58051208	C	High light scatter reticulocyte percentage of red cells	27863252	[0.026-0.041] unit decrease	0.0333776	EFO_0007986
ENSG00000136068	rs732526	3	58051235	T	Reticulocyte count	27863252	[0.019-0.034] unit decrease	0.02611795	EFO_0007986
ENSG00000136068	rs13096731	3	58063912	A	Gut microbiota (bacterial taxa)	27723756	unit decrease	0.43	EFO_0007874\|EFO_0007883
ENSG00000136068	rs6764184	3	58020539	T	Optic cup area	25631615	[0.0091-0.0209] unit increase	0.015	EFO_0006940
ENSG00000136068	rs6764184	3	58020539	T	Optic cup area	25631615	[0.011-0.031] unit increase	0.021	EFO_0006940
ENSG00000136068	rs13077017	3	58120049	C	Eating disorders (purging via substances)	23568457	[0.044-0.102] unit decrease	0.073	EFO_0005203
ENSG00000136068	rs1623879	3	58041470	G	Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin)	23648065	[1.297-2.148]	1.669	GO_0097328\|GO_0097327
ENSG00000136068	rs732526	3	58051235	T	Reticulocyte fraction of red cells	27863252	[0.02-0.035] unit decrease	0.02786042	EFO_0007986
ENSG00000136068	rs732527	3	58051208	C	Immature fraction of reticulocytes	27863252	[0.024-0.038] unit decrease	0.03087325	EFO_0007986
ENSG00000136068	rs6764184	3	58020539	T	Vertical cup-disc ratio	28073927	[0.0031-0.0109] unit increase	0.007	EFO_0006939
ENSG00000136068	rs6764184	3	58020539	T	Vertical cup-disc ratio	28073927	[0.005-0.009] unit increase	0.007	EFO_0006939
ENSG00000136068	rs12494328	3	58049770	A	Optic cup area	28073927	[0.0081-0.0199] unit increase	0.014	EFO_0006940
ENSG00000136068	rs12494328	3	58049770	A	Optic cup area	28073927	[0.012-0.02] unit increase	0.016	EFO_0006940
ENSG00000136068	rs858215	3	58051084	?	White blood cell count	30595370			EFO_0004308
ENSG00000136068	rs11707429	3	58048107	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136068's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136068	FLNB	100	95.849	ENSMUSG00000025278	Flnb	100	95.849	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	-	IEA	Component
GO:0003334	keratinocyte development	-	IEA	Process
GO:0003382	epithelial cell morphogenesis	-	IEA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0003779	actin binding	8327473.	NAS	Function
GO:0005515	protein binding	10644691.10676904.12393796.12577067.16076904.17474147.19270716.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	16791210.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005903	brush border	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005938	cell cortex	-	IEA	Component
GO:0007016	cytoskeletal anchoring at plasma membrane	9694715.	TAS	Process
GO:0007165	signal transduction	8327473.	TAS	Process
GO:0007519	skeletal muscle tissue development	-	IEA	Process
GO:0015629	actin cytoskeleton	9651345.	TAS	Component
GO:0016021	integral component of membrane	8327473.	NAS	Component
GO:0030018	Z disc	-	IEA	Component
GO:0030036	actin cytoskeleton organization	-	IEA	Process
GO:0042802	identical protein binding	12393796.	IPI	Function
GO:0043005	neuron projection	-	IEA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045335	phagocytic vesicle	-	IEA	Component
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0071346	cellular response to interferon-gamma	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27779699	Differential expression of filamin B splice variants in giant cell tumor cells.	Oncol Rep	2016 Dec	Tsui JC	doi: 10.3892/or.2016.5197
25925610	Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.	Cell Struct Funct	2015	Iguchi Y	doi: 10.1247/csf.15001
30059005	An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.	Elife	2018 Jul 30	Li J	doi: 10.7554/eLife.37184.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr3	58159645	Missense_Mutation	novel	S2327Y	0.21
ACC	chr3	58142664	Silent	novel	A1732A	0.21
BLCA	chr3	58134728	Missense_Mutation	novel	D1543N	0.19
BLCA	chr3	58168610	Missense_Mutation	rs142229998	G2457S	0.21
BLCA	chr3	58170774	3'UTR	novel		0.1
BLCA	chr3	58008766	Missense_Mutation	NA	Q68E	0.04
BLCA	chr3	58163341	Intron	novel		0.22
BLCA	chr3	58156000	Silent	novel	I2271I	0.19
BLCA	chr3	58169738	Silent	novel	L2522L	0.41
BLCA	chr3	58126758	Frame_Shift_Del	novel	*G1408Afs8**	0.18
BLCA	chr3	58134764	Nonsense_Mutation	novel	Q1555*	0.24
BLCA	chr3	58148314	Missense_Mutation	novel	S1946F	0.33
BLCA	chr3	58148735	Missense_Mutation	rs764333955	I1992V	0.15
BLCA	chr3	58109575	Splice_Site	NA	X734_splice	0.46
BLCA	chr3	58110054	Missense_Mutation	novel	E790K	0.13
BLCA	chr3	58168481	Missense_Mutation	novel	P2414S	0.27
BLCA	chr3	58125669	Silent	NA	S1329S	0.54
BLCA	chr3	58148646	Splice_Region	rs538716668		0.38
BLCA	chr3	58148815	Silent	rs199857882	F2018F	0.4
BLCA	chr3	58008673	Missense_Mutation	novel	I37V	0.3
BLCA	chr3	58138335	Missense_Mutation	novel	D1639N	0.88
BLCA	chr3	58163341	Intron	novel		0.5
BLCA	chr3	58008855	Splice_Region	novel	I97I	0.36
BLCA	chr3	58121312	Missense_Mutation	rs376511120	V979M	0.26
BLCA	chr3	58156062	Missense_Mutation	novel	V2292G	0.16
BLCA	chr3	58077122	Silent	NA	I123I	0.39
BLCA	chr3	58168597	Silent	novel	I2452I	0.4
BLCA	chr3	58123395	Silent	NA	L1143L	0.33
BLCA	chr3	58138359	Missense_Mutation	novel	K1647E	0.11
BLCA	chr3	58153484	Silent	novel	P2159P	0.27
BLCA	chr3	58111860	Missense_Mutation	novel	G852S	0.27
BLCA	chr3	58153560	Missense_Mutation	novel	V2185L	0.21
BLCA	chr3	58110078	Frame_Shift_Ins	novel	*D798Gfs9**	0.06
BLCA	chr3	58163344	Intron	novel		0.41
BLCA	chr3	58008717	Silent	novel	I51I	0.15
BLCA	chr3	58163350	Intron	rs201580886		0.35
BLCA	chr3	58121269	Silent	NA	F964F	0.24
BLCA	chr3	58123371	Missense_Mutation	NA	K1135N	0.55
BLCA	chr3	58098785	Missense_Mutation	novel	D408Y	0.31
BLCA	chr3	58102330	Missense_Mutation	NA	M491I	0.42
BRCA	chr3	58081694	Silent	novel	S235S	0.1
BRCA	chr3	58094856	Missense_Mutation	rs145036794	M270V	0.11
BRCA	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.29
BRCA	chr3	58106723	Silent	rs374969468	N597N	0.21
BRCA	chr3	58111804	Missense_Mutation	NA	S833N	0.07
BRCA	chr3	58168475	Missense_Mutation	NA	A2412S	0.33
BRCA	chr3	58150176	In_Frame_Ins	NA	S2107dup	0.75
BRCA	chr3	58109289	Missense_Mutation	novel	W722C	0.07
BRCA	chr3	58149873	Missense_Mutation	novel	V2039L	0.09
BRCA	chr3	58148808	Missense_Mutation	rs137885421	R2016Q	0.2
BRCA	chr3	58102235	Missense_Mutation	NA	R460G	0.25
BRCA	chr3	58008573	Frame_Shift_Del	novel	*T4Rfs3**	0.15
BRCA	chr3	58154848	Frame_Shift_Ins	NA	*S2234Qfs2**	0.38
BRCA	chr3	58121433	Missense_Mutation	NA	T1019I	0.11
BRCA	chr3	58102224	Missense_Mutation	rs377737248	R456Q	0.14
BRCA	chr3	58109645	Silent	novel	L757L	0.04
BRCA	chr3	58112267	Silent	novel	I898I	0.06
BRCA	chr3	58097962	Missense_Mutation	novel	D378N	0.19
BRCA	chr3	58098765	Missense_Mutation	NA	T401N	0.1
BRCA	chr3	58170655	Frame_Shift_Del	NA	*Q2568Nfs18**	0.55
BRCA	chr3	58168610	Missense_Mutation	rs142229998	G2457S	0.27
BRCA	chr3	58106729	Missense_Mutation	novel	Q599H	0.07
BRCA	chr3	58008727	Missense_Mutation	rs768998920	E55Q	0.09
BRCA	chr3	58154792	Splice_Region	NA	A2212A	0.34
BRCA	chr3	58108551	Missense_Mutation	rs144158201	P679S	0.14
BRCA	chr3	58111853	In_Frame_Del	rs758692518	A850del	0.24
BRCA	chr3	58138352	Silent	NA	G1644G	0.25
BRCA	chr3	58008543	5'UTR	novel		0.4
CESC	chr3	58124368	Missense_Mutation	NA	D1254G	0.2
CESC	chr3	58148678	Missense_Mutation	rs368965386	E1973K	0.28
CESC	chr3	58123614	Silent	NA	F1216F	0.41
CESC	chr3	58110078	In_Frame_Ins	novel	D798delinsGN	0.03
CESC	chr3	58150141	Missense_Mutation	NA	R2094K	0.28
CESC	chr3	58110043	Missense_Mutation	rs142314034	R786Q	0.74
CESC	chr3	58112289	Missense_Mutation	NA	H906Y	0.26
CESC	chr3	58094901	Missense_Mutation	novel	G285R	0.49
CESC	chr3	58123327	Missense_Mutation	novel	S1121P	0.47
CESC	chr3	58131954	Intron	NA		0.54
CESC	chr3	58146022	Missense_Mutation	novel	T1843A	0.29
CESC	chr3	58149984	Missense_Mutation	rs141559684	A2076T	0.14
CESC	chr3	58169720	Silent	novel	T2516T	0.35
CESC	chr3	58172056	3'UTR	novel		0.8
CESC	chr3	58077148	Missense_Mutation	NA	G132V	0.11
CESC	chr3	58154847	Missense_Mutation	novel	E2231K	0.24
CESC	chr3	58123471	Missense_Mutation	NA	E1169K	0.2
COAD	chr3	58081644	Nonsense_Mutation	NA	E219*	0.41
COAD	chr3	58159559	Silent	rs141740204	S2298S	0.36
COAD	chr3	58148245	Missense_Mutation	novel	A1923V	0.11
COAD	chr3	58148752	Silent	rs199621482	S1997S	0.1
COAD	chr3	58008783	Silent	NA	R73R	0.08
COAD	chr3	58125603	Frame_Shift_Del	NA	Y1308*	0.32
COAD	chr3	58153404	Missense_Mutation	rs752834312	V2133I	0.43
COAD	chr3	58102282	Missense_Mutation	NA	F475L	0.15
COAD	chr3	58134704	Missense_Mutation	novel	S1535G	0.28
COAD	chr3	58170712	Frame_Shift_Ins	NA	*E2589Gfs35**	0.27
COAD	chr3	58149995	Silent	NA	H2079H	0.15
COAD	chr3	58106774	Silent	rs752702695	G614G	0.22
COAD	chr3	58126690	Missense_Mutation	novel	S1384G	0.26
COAD	chr3	58149942	Missense_Mutation	novel	F2062L	0.08
COAD	chr3	58148262	Missense_Mutation	NA	D1929Y	0.2
COAD	chr3	58170713	Frame_Shift_Del	NA	*E2589Rfs48**	0.45
COAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.4
COAD	chr3	58111795	Frame_Shift_Ins	NA	*A832Rfs9**	0.26
COAD	chr3	58141929	Missense_Mutation	novel	W1727C	0.05
COAD	chr3	58102266	Missense_Mutation	rs750354519	R470Q	0.36
COAD	chr3	58121373	Missense_Mutation	rs755928543	R999Q	0.36
COAD	chr3	58150170	Missense_Mutation	rs751795794	R2104W	0.37
COAD	chr3	58102212	Frame_Shift_Ins	novel	*N453Kfs26**	0.31
COAD	chr3	58124341	Missense_Mutation	rs776611311	R1245Q	0.36
COAD	chr3	58124435	Silent	novel	A1276A	0.51
COAD	chr3	58169733	Missense_Mutation	novel	G2521R	0.15
COAD	chr3	58123454	Missense_Mutation	novel	P1163L	0.24
COAD	chr3	58146991	Missense_Mutation	NA	T1909I	0.38
COAD	chr3	58081667	Silent	NA	D226D	0.18
COAD	chr3	58153474	Missense_Mutation	rs771524639	R2156Q	0.21
COAD	chr3	58170713	Frame_Shift_Del	NA	*E2589Rfs48**	0.35
COAD	chr3	58106677	Splice_Region	novel		0.41
COAD	chr3	58124408	Missense_Mutation	NA	K1267N	0.24
COAD	chr3	58169731	Missense_Mutation	novel	A2520V	0.23
COAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.47
COAD	chr3	58077059	Silent	novel	I102I	0.1
COAD	chr3	58130850	Silent	rs375606046	T1444T	0.32
COAD	chr3	58136090	Frame_Shift_Del	NA	*G1596Vfs33**	0.36
COAD	chr3	58148324	Silent	rs149017493	D1949D	0.33
COAD	chr3	58102284	Missense_Mutation	novel	K476T	0.11
COAD	chr3	58106801	Silent	rs2140104	D623D	0.27
COAD	chr3	58153544	Silent	NA	S2179S	0.15
COAD	chr3	58106868	Missense_Mutation	NA	D646H	0.22
COAD	chr3	58148834	Missense_Mutation	NA	V2025M	0.18
COAD	chr3	58159607	Silent	rs766368051	G2314G	0.26
COAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.15
COAD	chr3	58123394	Missense_Mutation	NA	L1143R	0.39
COAD	chr3	58132928	Missense_Mutation	rs111498181	R1504H	0.16
COAD	chr3	58148217	Missense_Mutation	rs769582613	R1914W	0.2
COAD	chr3	58169624	Silent	novel	E2484E	0.09
COAD	chr3	58170713	Frame_Shift_Del	NA	*E2589Rfs48**	0.12
COAD	chr3	58104060	Frame_Shift_Ins	rs746105983	*H532Tfs9**	0.31
COAD	chr3	58153469	Silent	rs368087129	C2154C	0.2
COAD	chr3	58106847	Missense_Mutation	rs763927755	A639T	0.23
COAD	chr3	58008519	5'UTR	novel		0.05
COAD	chr3	58170589	Silent	novel	L2546L	0.06
COAD	chr3	58148788	Silent	NA	G2009G	0.32
ESCA	chr3	58123559	Missense_Mutation	NA	T1198M	0.16
ESCA	chr3	58131954	Intron	NA		0.15
ESCA	chr3	58123187	Missense_Mutation	novel	G1074V	0.51
ESCA	chr3	58104014	Missense_Mutation	novel	F513L	0.54
GBM	chr3	58148851	Splice_Region	novel	A2030A	0.33
GBM	chr3	58163239	Missense_Mutation	novel	S2369R	0.06
GBM	chr3	58109296	Missense_Mutation	rs201814013	V725M	0.5
GBM	chr3	58148669	Missense_Mutation	novel	E1970Q	0.07
GBM	chr3	58156039	Silent	rs113304692	S2284S	0.2
GBM	chr3	58108458	Missense_Mutation	novel	V648I	0.13
GBM	chr3	58081751	Silent	rs371715057	P254P	0.3
GBM	chr3	58130790	Silent	novel	V1424V	0.25
GBM	chr3	58168505	Missense_Mutation	NA	E2422K	0.06
GBM	chr3	58149908	Silent	novel	E2050E	0.24
GBM	chr3	58159675	Missense_Mutation	NA	E2337A	0.45
GBM	chr3	58148753	Missense_Mutation	novel	E1998Q	0.04
GBM	chr3	58097883	Missense_Mutation	novel	Q351H	0.08
GBM	chr3	58124431	Missense_Mutation	novel	G1275E	0.36
GBM	chr3	58105121	Frame_Shift_Ins	novel	*K551Nfs28**	0.09
GBM	chr3	58138315	Missense_Mutation	novel	E1632A	0.15
GBM	chr3	58150138	Missense_Mutation	novel	G2093E	0.06
GBM	chr3	58111851	Missense_Mutation	novel	K849Q	0.08
GBM	chr3	58110068	Silent	rs146159035	D794D	0.42
GBM	chr3	58125601	Missense_Mutation	novel	T1307A	0.25
GBM	chr3	58149969	Missense_Mutation	rs201831615	V2071I	0.12
GBM	chr3	58094847	Missense_Mutation	novel	T267P	0.09
GBM	chr3	58108562	Silent	novel	I682I	0.04
GBM	chr3	58123610	Missense_Mutation	novel	H1215R	0.15
GBM	chr3	58123362	Missense_Mutation	novel	D1132E	0.06
GBM	chr3	58110043	Missense_Mutation	rs142314034	R786Q	0.13
GBM	chr3	58123614	Silent	NA	F1216F	0.16
HNSC	chr3	58153633	Missense_Mutation	novel	G2209E	0.23
HNSC	chr3	58105179	Missense_Mutation	novel	F570L	0.23
HNSC	chr3	58159659	Missense_Mutation	rs139262140	E2332K	0.11
HNSC	chr3	58118949	Silent	novel	P941P	0.11
HNSC	chr3	58125692	Missense_Mutation	novel	G1337V	0.52
HNSC	chr3	58077144	Nonsense_Mutation	novel	E131*	0.71
HNSC	chr3	58125613	Missense_Mutation	rs548108800	V1311M	0.12
HNSC	chr3	58105213	Silent	novel	L582L	0.36
HNSC	chr3	58078748	Silent	NA	P191P	0.22
HNSC	chr3	58123630	Missense_Mutation	novel	V1222M	0.37
HNSC	chr3	58148271	Missense_Mutation	novel	E1932K	0.38
HNSC	chr3	58104002	Silent	novel	G509G	0.06
KIRC	chr3	58142724	Silent	rs773899543	P1752P	0.13
KIRC	chr3	58163275	Silent	novel	A2381A	0.08
KIRC	chr3	58163277	Missense_Mutation	novel	G2382E	0.08
KIRC	chr3	58145924	Frame_Shift_Del	novel	*S1810Tfs49**	0.14
KIRC	chr3	58008834	Missense_Mutation	NA	E90D	0.25
KIRP	chr3	58121481	Missense_Mutation	rs752525780	S1035L	0.19
KIRP	chr3	58150171	Missense_Mutation	rs757456736	R2104Q	0.06
KIRP	chr3	58168554	Missense_Mutation	NA	Y2438C	0.04
LGG	chr3	58153560	Missense_Mutation	rs777140253	V2185M	0.15
LGG	chr3	58109323	Splice_Site	NA	X733_splice	0.38
LGG	chr3	58123104	Silent	rs371901421	H1046H	0.19
LGG	chr3	58134626	Missense_Mutation	NA	V1509I	0.11
LGG	chr3	58094835	Splice_Site	novel	X263_splice	0.08
LGG	chr3	58112270	Silent	rs755784561	I899I	0.36
LGG	chr3	58146968	Silent	novel	G1901G	0.13
LGG	chr3	58148751	Missense_Mutation	NA	S1997L	0.39
LGG	chr3	58153630	Missense_Mutation	rs368617386	A2208V	0.33
LGG	chr3	58112148	Splice_Site	NA	X859_splice	0.38
LGG	chr3	58108483	Missense_Mutation	NA	E656G	0.37
LGG	chr3	58094897	Silent	rs770546915	S283S	0.27
LGG	chr3	58125681	Silent	NA	A1333A	0.05
LIHC	chr3	58155967	Nonsense_Mutation	NA	Y2260*	0.29
LIHC	chr3	58008829	Missense_Mutation	rs755518501	R89G	0.49
LIHC	chr3	58121367	Missense_Mutation	NA	T997R	0.52
LIHC	chr3	58098786	Missense_Mutation	novel	D408G	0.04
LIHC	chr3	58081664	Silent	novel	V225V	0.43
LIHC	chr3	58135997	Missense_Mutation	novel	K1564Q	0.29
LIHC	chr3	58109633	Missense_Mutation	novel	E753Q	0.23
LIHC	chr3	58130810	Missense_Mutation	NA	L1431Q	0.2
LIHC	chr3	58126625	Missense_Mutation	novel	G1362V	0.52
LIHC	chr3	58008644	Missense_Mutation	rs760976111	N27S	0.22
LIHC	chr3	58103964	Silent	NA	L497L	0.19
LUAD	chr3	58154901	Missense_Mutation	NA	G2249C	0.41
LUAD	chr3	58138293	Missense_Mutation	rs200727113	A1625T	0.17
LUAD	chr3	58094861	Silent	novel	V271V	0.12
LUAD	chr3	58154841	Missense_Mutation	NA	A2229S	0.88
LUAD	chr3	58168657	Splice_Region	NA	T2472T	0.24
LUAD	chr3	58152718	Intron	novel		0.46
LUAD	chr3	58163107	Intron	rs760455872		0.1
LUAD	chr3	58153387	Missense_Mutation	novel	S2127I	0.29
LUAD	chr3	58110136	Missense_Mutation	novel	G817A	0.3
LUAD	chr3	58134752	Missense_Mutation	NA	L1551M	0.08
LUAD	chr3	58008855	Splice_Region	NA	I97I	0.09
LUAD	chr3	58008810	Silent	novel	V82V	0.39
LUAD	chr3	58125580	Splice_Site	novel	X1300_splice	0.3
LUAD	chr3	58156023	Missense_Mutation	novel	P2279L	0.08
LUAD	chr3	58130906	Missense_Mutation	NA	R1463P	0.33
LUAD	chr3	58150145	Silent	NA	V2095V	0.3
LUAD	chr3	58124395	Missense_Mutation	NA	G1263V	0.16
LUAD	chr3	58138340	Silent	novel	A1640A	0.77
LUAD	chr3	58108470	Missense_Mutation	novel	G652W	0.47
LUSC	chr3	58145962	Missense_Mutation	NA	S1823C	0.55
LUSC	chr3	58098866	Missense_Mutation	rs781162510	D435N	0.56
LUSC	chr3	58148304	Missense_Mutation	novel	K1943E	0.74
LUSC	chr3	58106865	Missense_Mutation	novel	P645S	0.37
LUSC	chr3	58105191	Silent	NA	S574S	0.06
LUSC	chr3	58109308	Missense_Mutation	novel	H729Y	0.14
LUSC	chr3	58141872	Missense_Mutation	NA	E1708D	0.38
LUSC	chr3	58148659	Silent	NA	F1966F	0.35
LUSC	chr3	58170732	Silent	NA	P2593P	0.43
LUSC	chr3	58126710	Silent	rs374070003	F1390F	0.16
LUSC	chr3	58008770	Missense_Mutation	novel	R69L	0.24
LUSC	chr3	58077270	Missense_Mutation	rs587777259	A173T	0.29
OV	chr3	58123380	Nonsense_Mutation	novel	*S1139Gfs11**	0.05
OV	chr3	58130847	Silent	NA	F1443F	0.5
OV	chr3	58130767	Missense_Mutation	novel	D1417H	0.11
OV	chr3	58123183	Silent	novel	L1073L	0.1
OV	chr3	58149934	Missense_Mutation	novel	V2059G	0.07
OV	chr3	58163193	Frame_Shift_Ins	novel	*H2355Tfs98**	0.04
OV	chr3	58163194	In_Frame_Ins	novel	V2354_H2355insRISNSI	0.03
OV	chr3	58123263	Frame_Shift_Del	novel	*L1100Ffs93**	0.04
OV	chr3	58168492	Missense_Mutation	novel	L2417F	0.26
OV	chr3	58097948	Missense_Mutation	novel	K373T	0.33
OV	chr3	58098726	Missense_Mutation	novel	D388A	0.04
OV	chr3	58138406	Silent	novel	A1662A	0.06
OV	chr3	58154811	Missense_Mutation	novel	R2219W	0.06
OV	chr3	58125597	Missense_Mutation	NA	E1305D	0.35
OV	chr3	58123123	Nonsense_Mutation	novel	*G1053delinsVSMVILRC*	0.18
OV	chr3	58169710	Frame_Shift_Ins	novel	*S2513Rfs5**	0.04
OV	chr3	58138462	Missense_Mutation	rs780823510	P1681L	0.03
OV	chr3	58123456	Missense_Mutation	novel	G1164W	0.07
OV	chr3	58136084	Frame_Shift_Ins	novel	*T1593Ifs40**	0.08
OV	chr3	58008782	Missense_Mutation	NA	R73L	0.29
OV	chr3	58109573	Splice_Region	novel		0.33
OV	chr3	58106821	Missense_Mutation	novel	S630N	0.08
OV	chr3	58098740	Missense_Mutation	novel	V393L	0.31
OV	chr3	58112196	Missense_Mutation	NA	A875P	0.25
OV	chr3	58077141	Missense_Mutation	NA	D130H	0.23
OV	chr3	58109615	Missense_Mutation	novel	V747M	0.06
OV	chr3	58150138	Missense_Mutation	novel	G2093E	0.16
OV	chr3	58123531	Missense_Mutation	novel	T1189S	0.09
OV	chr3	58123398	Silent	NA	E1144E	0.27
OV	chr3	58146847	Missense_Mutation	novel	P1861L	0.14
OV	chr3	58146887	Silent	novel	G1874G	0.13
PAAD	chr3	58098794	Missense_Mutation	novel	N411D	0.03
PAAD	chr3	58121474	Missense_Mutation	novel	E1033K	0.18
PAAD	chr3	58148333	Nonsense_Mutation	novel	C1952*	0.09
PCPG	chr3	58118898	Frame_Shift_Del	novel	Y924*	0.35
PRAD	chr3	58111882	Splice_Site	novel	X859_splice	0.29
PRAD	chr3	58130725	Splice_Site	novel	X1408_splice	0.27
PRAD	chr3	58163168	Missense_Mutation	novel	R2346G	0.15
PRAD	chr3	58123155	Silent	rs769902031	I1063I	0.27
PRAD	chr3	58170690	Silent	rs543564224	G2579G	0.08
PRAD	chr3	58078716	Splice_Site	novel	X181_splice	0.47
PRAD	chr3	58094940	Missense_Mutation	novel	G298R	0.32
PRAD	chr3	58096157	Missense_Mutation	NA	D308G	0.52
PRAD	chr3	58121482	Silent	rs541935783	S1035S	0.36
PRAD	chr3	58123431	Silent	rs542106385	S1155S	0.36
PRAD	chr3	58136067	Missense_Mutation	rs756266678	R1587H	0.64
READ	chr3	58136166	Missense_Mutation	rs753946814	T1620M	0.32
READ	chr3	58081644	Nonsense_Mutation	NA	E219*	0.4
READ	chr3	58108557	Missense_Mutation	novel	K681Q	0.63
READ	chr3	58141901	Missense_Mutation	NA	N1718T	0.21
READ	chr3	58142656	Missense_Mutation	rs773991765	E1730K	0.26
READ	chr3	58168456	Missense_Mutation	NA	F2405L	0.27
READ	chr3	58170512	Intron	novel		0.2
SARC	chr3	58172247	3'UTR	novel		0.11
SARC	chr3	58163282	Missense_Mutation	novel	P2384S	0.14
SARC	chr3	58148833	Silent	rs144036986	I2024I	0.29
SKCM	chr3	58156011	Missense_Mutation	NA	P2275L	0.34
SKCM	chr3	58121285	Missense_Mutation	NA	G970R	0.22
SKCM	chr3	58112166	Missense_Mutation	NA	P865A	0.34
SKCM	chr3	58098765	Missense_Mutation	NA	T401I	0.44
SKCM	chr3	58125612	Silent	rs150901141	D1310D	0.37
SKCM	chr3	58118914	Missense_Mutation	NA	P930S	0.31
SKCM	chr3	58098754	Silent	novel	Q397Q	0.38
SKCM	chr3	58134728	Missense_Mutation	novel	D1543N	0.47
SKCM	chr3	58106724	Missense_Mutation	rs776030392	D598N	0.48
SKCM	chr3	58150138	Missense_Mutation	novel	G2093E	0.08
SKCM	chr3	58154814	Missense_Mutation	novel	E2220K	0.15
SKCM	chr3	58135989	Missense_Mutation	NA	G1561E	0.22
SKCM	chr3	58168505	Missense_Mutation	NA	E2422K	0.25
SKCM	chr3	58121447	Missense_Mutation	rs747814541	P1024S	0.49
SKCM	chr3	58156006	Missense_Mutation	novel	E2273D	0.33
SKCM	chr3	58121238	Splice_Region	rs547470359		0.43
SKCM	chr3	58078756	Missense_Mutation	NA	P194L	0.17
SKCM	chr3	58108531	Missense_Mutation	NA	P672L	0.15
SKCM	chr3	58123617	Silent	rs771276246	P1217P	0.34
SKCM	chr3	58123623	Silent	novel	R1219R	0.25
SKCM	chr3	58081757	Silent	NA	K256K	0.87
SKCM	chr3	58078734	Missense_Mutation	novel	E187K	0.63
SKCM	chr3	58121495	Missense_Mutation	novel	P1040S	0.34
SKCM	chr3	58148727	Missense_Mutation	novel	P1989L	0.44
SKCM	chr3	58159560	Missense_Mutation	novel	G2299R	0.27
SKCM	chr3	58081689	Silent	NA	L234L	0.09
SKCM	chr3	58098875	Missense_Mutation	NA	P438S	0.23
SKCM	chr3	58121302	Silent	NA	G975G	0.3
SKCM	chr3	58148816	Missense_Mutation	rs762780598	E2019K	0.28
SKCM	chr3	58163330	Missense_Mutation	NA	G2400S	0.35
SKCM	chr3	58123644	Silent	novel	V1226V	0.45
SKCM	chr3	58130758	Missense_Mutation	novel	P1414S	0.15
SKCM	chr3	58123221	Silent	rs779160545	I1085I	0.31
SKCM	chr3	58104060	Frame_Shift_Ins	rs746105983	*H532Tfs9**	0.29
SKCM	chr3	58126720	Missense_Mutation	rs767271335	D1394N	0.39
SKCM	chr3	58123451	Missense_Mutation	NA	G1162E	0.4
SKCM	chr3	58149959	Silent	NA	G2067G	0.48
SKCM	chr3	58123364	Missense_Mutation	NA	P1133L	0.25
SKCM	chr3	58168539	Missense_Mutation	NA	E2433G	0.31
SKCM	chr3	58123471	Missense_Mutation	NA	E1169K	0.41
SKCM	chr3	58123335	Silent	novel	F1123F	0.33
SKCM	chr3	58130751	Silent	novel	F1411F	0.3
SKCM	chr3	58121301	Missense_Mutation	NA	G975E	0.57
SKCM	chr3	58109243	Missense_Mutation	rs780137252	S707L	0.35
SKCM	chr3	58108535	Silent	NA	K673K	0.48
SKCM	chr3	58168551	Missense_Mutation	NA	G2437E	0.16
SKCM	chr3	58124446	Missense_Mutation	NA	C1280Y	0.2
SKCM	chr3	58123639	Missense_Mutation	NA	A1225P	0.2
SKCM	chr3	58098765	Missense_Mutation	NA	T401I	0.3
SKCM	chr3	58145969	Missense_Mutation	NA	S1825F	0.34
SKCM	chr3	58109286	Silent	NA	V721V	0.23
SKCM	chr3	58110072	Missense_Mutation	NA	D796N	0.38
SKCM	chr3	58150151	Missense_Mutation	NA	E2097D	0.34
SKCM	chr3	58156073	Nonsense_Mutation	NA	Q2296*	0.28
SKCM	chr3	58153379	Silent	NA	I2124I	0.4
SKCM	chr3	58134735	Missense_Mutation	rs760317090	R1545Q	0.46
SKCM	chr3	58153547	Silent	NA	P2180P	0.33
SKCM	chr3	58123615	Missense_Mutation	NA	P1217S	0.42
SKCM	chr3	58109292	Silent	NA	G723G	0.21
SKCM	chr3	58145988	Silent	NA	L1831L	0.65
SKCM	chr3	58121402	Missense_Mutation	rs760728571	R1009W	0.19
SKCM	chr3	58153562	Silent	NA	V2185V	0.5
SKCM	chr3	58132883	Missense_Mutation	NA	G1489E	0.37
SKCM	chr3	58138314	Missense_Mutation	rs768316224	E1632K	0.12
SKCM	chr3	58098773	Silent	NA	L404L	0.15
SKCM	chr3	58168494	Missense_Mutation	NA	S2418F	0.43
SKCM	chr3	58169633	Silent	NA	S2487S	0.2
SKCM	chr3	58168627	Silent	rs753695923	I2462I	0.11
SKCM	chr3	58108491	Missense_Mutation	NA	G659R	0.28
SKCM	chr3	58109596	Silent	NA	S740S	0.07
SKCM	chr3	58148753	Missense_Mutation	NA	E1998K	0.19
SKCM	chr3	58163034	Intron	novel		0.5
SKCM	chr3	58112289	Missense_Mutation	NA	H906Y	0.11
SKCM	chr3	58123342	Missense_Mutation	NA	D1126N	0.08
SKCM	chr3	58098884	Missense_Mutation	NA	P441S	0.18
SKCM	chr3	58132881	Silent	NA	E1488E	0.48
SKCM	chr3	58156038	Missense_Mutation	NA	S2284F	0.49
SKCM	chr3	58169632	Missense_Mutation	rs771879974	S2487F	0.42
SKCM	chr3	58098889	Silent	rs368128453	F442F	0.3
SKCM	chr3	58109211	Missense_Mutation	NA	M696I	0.33
SKCM	chr3	58105173	Silent	novel	A568A	0.5
SKCM	chr3	58153598	Silent	NA	R2197R	0.24
SKCM	chr3	58126680	Missense_Mutation	novel	D1380E	0.34
SKCM	chr3	58169698	Missense_Mutation	NA	S2509F	0.18
SKCM	chr3	58102258	Silent	NA	V467V	0.37
SKCM	chr3	58169701	Missense_Mutation	rs754275385	S2510L	0.29
SKCM	chr3	58148767	Silent	NA	A2002A	0.33
SKCM	chr3	58169633	Silent	NA	S2487S	0.45
SKCM	chr3	58168494	Missense_Mutation	NA	S2418F	0.97
SKCM	chr3	58149983	Silent	rs572257596	F2075F	0.36
SKCM	chr3	58141910	Missense_Mutation	novel	P1721L	0.28
SKCM	chr3	58155968	Missense_Mutation	novel	E2261K	0.29
SKCM	chr3	58123177	Missense_Mutation	novel	G1071R	0.34
SKCM	chr3	58138314	Missense_Mutation	rs768316224	E1632K	0.44
STAD	chr3	58104060	Frame_Shift_Ins	rs746105983	*H532Tfs9**	0.26
STAD	chr3	58123432	Missense_Mutation	rs771189591	V1156I	0.3
STAD	chr3	58138308	Missense_Mutation	novel	T1630S	0.26
STAD	chr3	58148792	Missense_Mutation	rs781212517	G2011S	0.36
STAD	chr3	58126635	Silent	NA	V1365V	0.2
STAD	chr3	58169621	Silent	rs201257749	N2483N	0.3
STAD	chr3	58104009	Missense_Mutation	rs201544295	A512T	0.22
STAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.3
STAD	chr3	58153496	Silent	rs746887183	G2163G	0.37
STAD	chr3	58156049	Missense_Mutation	rs765247131	R2288C	0.35
STAD	chr3	58153473	Missense_Mutation	novel	R2156W	0.26
STAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.33
STAD	chr3	58170713	Frame_Shift_Del	NA	*E2589Rfs48**	0.21
STAD	chr3	58146046	Nonsense_Mutation	NA	E1851*	0.37
STAD	chr3	58148678	Missense_Mutation	rs368965386	E1973K	0.33
STAD	chr3	58149984	Missense_Mutation	rs141559684	A2076T	0.35
STAD	chr3	58097963	Missense_Mutation	NA	D378G	0.18
STAD	chr3	58136089	Silent	rs779187199	Y1594Y	0.34
STAD	chr3	58118901	Silent	NA	G925G	0.08
STAD	chr3	58125677	Missense_Mutation	novel	Q1332L	0.08
STAD	chr3	58111830	Missense_Mutation	novel	S842P	0.05
STAD	chr3	58156047	Missense_Mutation	NA	A2287V	0.31
STAD	chr3	58121478	Missense_Mutation	NA	A1034D	0.1
STAD	chr3	58078748	Silent	rs777288549	P191P	0.4
STAD	chr3	58138485	Missense_Mutation	rs762205881	R1689C	0.3
STAD	chr3	58159638	Missense_Mutation	novel	S2325G	0.39
STAD	chr3	58125745	Splice_Site	novel	X1354_splice	0.08
STAD	chr3	58136121	Missense_Mutation	rs201630300	R1605H	0.18
STAD	chr3	58163163	Missense_Mutation	NA	A2344D	0.37
STAD	chr3	58104060	Frame_Shift_Ins	rs746105983	*H532Tfs9**	0.25
STAD	chr3	58112233	Missense_Mutation	rs753985242	P887L	0.34
STAD	chr3	58081720	Frame_Shift_Ins	novel	*A246Gfs49**	0.24
STAD	chr3	58170555	Intron	novel		0.24
STAD	chr3	58094867	Silent	NA	Q273Q	0.31
STAD	chr3	58154841	Missense_Mutation	rs754754415	A2229T	0.25
STAD	chr3	58156031	Missense_Mutation	NA	A2282T	0.3
STAD	chr3	58132847	Frame_Shift_Ins	novel	*V1481Qfs2**	0.27
STAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.14
STAD	chr3	58008604	Missense_Mutation	NA	W14R	0.1
STAD	chr3	58108461	Nonsense_Mutation	rs80356517	R649*	0.27
STAD	chr3	58112310	Missense_Mutation	NA	T913A	0.29
STAD	chr3	58123572	Nonsense_Mutation	NA	Y1202*	0.1
STAD	chr3	58008635	Frame_Shift_Del	novel	*W25Tfs5**	0.14
STAD	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.2
STAD	chr3	58124352	Missense_Mutation	NA	T1249A	0.14
STAD	chr3	58146027	Silent	rs202240037	I1844I	0.23
STAD	chr3	58148319	Nonsense_Mutation	NA	R1948*	0.16
STAD	chr3	58136089	Silent	rs779187199	Y1594Y	0.29
STAD	chr3	58132847	Frame_Shift_Ins	novel	*V1481Qfs2**	0.23
STAD	chr3	58143474	Splice_Region	NA	G1762G	0.23
THYM	chr3	58106822	Silent	novel	S630S	0.1
UCEC	chr3	58143548	Missense_Mutation	novel	R1787T	0.31
UCEC	chr3	58172008	3'UTR	novel		0.62
UCEC	chr3	58110127	Missense_Mutation	novel	P814H	0.26
UCEC	chr3	58149887	Missense_Mutation	novel	S2043R	0.13
UCEC	chr3	58103988	Missense_Mutation	NA	D505Y	0.27
UCEC	chr3	58109195	Missense_Mutation	NA	R691H	0.34
UCEC	chr3	58123231	Missense_Mutation	rs369045614	D1089N	0.25
UCEC	chr3	58123597	Missense_Mutation	rs147162135	E1211K	0.35
UCEC	chr3	58170614	Frame_Shift_Del	novel	*C2556Afs6**	0.13
UCEC	chr3	58104009	Missense_Mutation	rs201544295	A512T	0.13
UCEC	chr3	58150178	Silent	rs769818063	P2106P	0.22
UCEC	chr3	58153420	Missense_Mutation	novel	G2138D	0.18
UCEC	chr3	58154925	Missense_Mutation	novel	P2257S	0.15
UCEC	chr3	58163295	Missense_Mutation	novel	S2388F	0.38
UCEC	chr3	58162963	Intron	novel		0.2
UCEC	chr3	58106805	Missense_Mutation	rs372998485	E625K	0.48
UCEC	chr3	58121345	Missense_Mutation	novel	P990T	0.13
UCEC	chr3	58146964	Missense_Mutation	NA	P1900H	0.47
UCEC	chr3	58106687	Silent	novel	A585A	0.1
UCEC	chr3	58123287	Nonsense_Mutation	NA	Y1107*	0.23
UCEC	chr3	58108543	Missense_Mutation	NA	G676V	0.45
UCEC	chr3	58123244	Missense_Mutation	novel	G1093E	0.45
UCEC	chr3	58136028	Missense_Mutation	novel	G1574D	0.6
UCEC	chr3	58121308	Silent	rs574484752	L977L	0.47
UCEC	chr3	58148247	Missense_Mutation	novel	A1924T	0.52
UCEC	chr3	58121497	Silent	novel	P1040P	0.15
UCEC	chr3	58168560	Missense_Mutation	novel	V2440G	0.44
UCEC	chr3	58077132	Missense_Mutation	rs764628343	V127M	0.44
UCEC	chr3	58077283	Missense_Mutation	novel	S177I	0.41
UCEC	chr3	58094913	Missense_Mutation	rs764368324	V289M	0.48
UCEC	chr3	58131964	Intron	novel		0.33
UCEC	chr3	58123287	Nonsense_Mutation	NA	Y1107*	0.28
UCEC	chr3	58123500	Silent	rs202128264	A1178A	0.25
UCEC	chr3	58146821	Splice_Region	NA	G1852G	0.25
UCEC	chr3	58154908	Missense_Mutation	NA	S2251Y	0.22
UCEC	chr3	58163181	Missense_Mutation	NA	H2350R	0.19
UCEC	chr3	58081657	Missense_Mutation	rs574643677	P223L	0.4
UCEC	chr3	58098890	Missense_Mutation	rs200902568	V443I	0.37
UCEC	chr3	58109585	Missense_Mutation	rs745714160	G737R	0.32
UCEC	chr3	58094948	Silent	NA	K300K	0.45
UCEC	chr3	58077173	Silent	rs192491895	T140T	0.25
UCEC	chr3	58123144	Missense_Mutation	rs373579468	E1060K	0.4
UCEC	chr3	58130825	Missense_Mutation	rs140018418	R1436Q	0.38
UCEC	chr3	58146882	Missense_Mutation	novel	D1873Y	0.11
UCEC	chr3	58110146	Silent	novel	T820T	0.11
UCEC	chr3	58104013	Missense_Mutation	NA	F513S	0.3
UCEC	chr3	58159577	Silent	novel	Q2304Q	0.06
UCEC	chr3	58118904	Silent	novel	G926G	0.13
UCEC	chr3	58106841	Missense_Mutation	NA	H637N	0.48
UCEC	chr3	58121437	Silent	rs201490778	Y1020Y	0.5
UCEC	chr3	58148680	Missense_Mutation	NA	E1973D	0.58
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.36
UCEC	chr3	58108478	Frame_Shift_Ins	NA	*L655Ifs19**	0.34
UCEC	chr3	58109307	Silent	rs763117090	P728P	0.36
UCEC	chr3	58168643	Missense_Mutation	novel	K2468E	0.31
UCEC	chr3	58078438	Intron	novel		0.27
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.33
UCEC	chr3	58121326	Silent	rs779917220	S983S	0.35
UCEC	chr3	58123141	Missense_Mutation	novel	A1059T	0.25
UCEC	chr3	58134693	Missense_Mutation	novel	G1531V	0.25
UCEC	chr3	58153404	Missense_Mutation	rs752834312	V2133I	0.23
UCEC	chr3	58163047	Intron	novel		0.41
UCEC	chr3	58124391	Frame_Shift_Del	novel	*G1263Vfs41**	0.21
UCEC	chr3	58078360	Intron	novel		0.21
UCEC	chr3	58094898	Missense_Mutation	rs147844614	A284T	0.42
UCEC	chr3	58105127	Missense_Mutation	rs765729388	R553H	0.4
UCEC	chr3	58126725	Silent	rs373754367	Y1395Y	0.4
UCEC	chr3	58138293	Missense_Mutation	rs200727113	A1625T	0.49
UCEC	chr3	58148788	Silent	NA	G2009G	0.28
UCEC	chr3	58169659	Missense_Mutation	rs149182236	S2496L	0.35
UCEC	chr3	58106775	Missense_Mutation	rs758230977	E615K	0.13
UCEC	chr3	58077167	Silent	novel	K138K	0.44
UCEC	chr3	58098739	Missense_Mutation	novel	E392D	0.49
UCEC	chr3	58131954	Intron	NA		0.67
UCEC	chr3	58156046	Missense_Mutation	novel	A2287T	0.46
UCEC	chr3	58163062	Intron	novel		0.52
UCEC	chr3	58168495	Silent	rs563382903	S2418S	0.33
UCEC	chr3	58168628	Missense_Mutation	rs140098061	V2463M	0.38
UCEC	chr3	58008847	Missense_Mutation	novel	V95L	0.25
UCEC	chr3	58159668	Missense_Mutation	rs147537617	V2335M	0.48
UCEC	chr3	58153630	Missense_Mutation	rs368617386	A2208V	0.26
UCEC	chr3	58008836	Missense_Mutation	rs555125243	S91N	0.51
UCEC	chr3	58078358	Intron	novel		0.5
UCEC	chr3	58104015	Missense_Mutation	rs147001986	E514K	0.41
UCEC	chr3	58124355	Missense_Mutation	rs763174083	D1250N	0.47
UCEC	chr3	58126711	Missense_Mutation	rs769402488	A1391T	0.51
UCEC	chr3	58148656	Silent	novel	S1965S	0.52
UCEC	chr3	58148764	Silent	rs184065600	D2001D	0.56
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.53
UCEC	chr3	58008564	5'UTR	novel		0.3
UCEC	chr3	58008756	Silent	NA	R64R	0.08
UCEC	chr3	58105180	Missense_Mutation	rs760127618	V571M	0.13
UCEC	chr3	58131954	Intron	NA		0.33
UCEC	chr3	58145983	Missense_Mutation	NA	G1830C	0.31
UCEC	chr3	58146995	Splice_Site	NA	X1910_splice	0.13
UCEC	chr3	58148264	Silent	NA	D1929D	0.1
UCEC	chr3	58102314	Missense_Mutation	novel	E486G	0.39
UCEC	chr3	58108461	Nonsense_Mutation	rs80356517	R649*	0.44
UCEC	chr3	58154876	Silent	rs777080172	F2240F	0.45
UCEC	chr3	58156040	Missense_Mutation	novel	D2285N	0.39
UCEC	chr3	58112284	Missense_Mutation	rs748860299	Y904C	0.22
UCEC	chr3	58118904	Silent	novel	G926G	0.33
UCEC	chr3	58143566	Missense_Mutation	novel	V1793A	0.27
UCEC	chr3	58134705	Missense_Mutation	novel	S1535N	0.31
UCEC	chr3	58109637	Missense_Mutation	novel	R754I	0.2
UCEC	chr3	58126726	Missense_Mutation	novel	D1396Y	0.25
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.4
UCEC	chr3	58077132	Missense_Mutation	rs764628343	V127M	0.35
UCEC	chr3	58154900	Silent	rs749958082	C2248C	0.35
UCEC	chr3	58155967	Silent	rs541513836	Y2260Y	0.51
UCEC	chr3	58159608	Missense_Mutation	rs754457328	A2315T	0.41
UCEC	chr3	58170663	Silent	rs371474716	N2570N	0.43
UCEC	chr3	58132858	Missense_Mutation	rs563226585	V1481I	0.37
UCEC	chr3	58078438	Intron	novel		0.36
UCEC	chr3	58112148	Splice_Site	NA	X859_splice	0.4
UCEC	chr3	58136046	Missense_Mutation	novel	Y1580C	0.27
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.56
UCEC	chr3	58106802	Missense_Mutation	rs779944490	D624N	0.4
UCEC	chr3	58149995	Silent	NA	H2079H	0.33
UCEC	chr3	58154877	Missense_Mutation	rs759839575	D2241N	0.38
UCEC	chr3	58170664	Missense_Mutation	novel	V2571I	0.38
UCEC	chr3	58170712	Frame_Shift_Ins	NA	*E2589Gfs35**	0.42
UCEC	chr3	58105211	Missense_Mutation	novel	S581Y	0.38
UCEC	chr3	58106724	Missense_Mutation	rs776030392	D598N	0.36
UCEC	chr3	58123382	Missense_Mutation	rs200677231	S1139L	0.49
UCEC	chr3	58143545	Missense_Mutation	novel	V1786A	0.49
UCEC	chr3	58109228	Missense_Mutation	novel	G702D	0.4
UCEC	chr3	58148294	Silent	rs755062959	T1939T	0.33
UCEC	chr3	58126653	Silent	rs199540577	S1371S	0.27
UCEC	chr3	58143588	Silent	novel	I1800I	0.26
UCEC	chr3	58154887	Missense_Mutation	NA	K2244T	0.37
UCEC	chr3	58172201	3'UTR	rs557972630		0.12
UCEC	chr3	58162908	Intron	novel		0.3
UCEC	chr3	58109201	Missense_Mutation	novel	D693G	0.18
UCEC	chr3	58118896	Missense_Mutation	novel	Y924H	0.32
UCEC	chr3	58168537	Missense_Mutation	novel	Q2432H	0.17
UCEC	chr3	58171997	3'UTR	novel		0.44
UCEC	chr3	58163274	Missense_Mutation	rs752183022	A2381V	0.39
UCEC	chr3	58096219	Splice_Site	NA	X328_splice	0.29
UCEC	chr3	58097883	Missense_Mutation	novel	Q351H	0.08
UCEC	chr3	58123105	Missense_Mutation	novel	G1047C	0.04
UCEC	chr3	58153623	Nonsense_Mutation	novel	G2206*	0.3
UCEC	chr3	58118921	Missense_Mutation	novel	S932N	0.27
UCEC	chr3	58098890	Missense_Mutation	rs200902568	V443I	0.41
UCEC	chr3	58121282	Frame_Shift_Ins	novel	*A971Gfs122**	0.27
UCEC	chr3	58109316	Silent	NA	P731P	0.2
UCEC	chr3	58124384	Silent	novel	T1259T	0.55
UCEC	chr3	58081736	Missense_Mutation	novel	K249N	0.15
UCEC	chr3	58138452	Missense_Mutation	novel	A1678T	0.24
UCEC	chr3	58154913	Missense_Mutation	novel	I2253V	0.15
UCEC	chr3	58145939	Missense_Mutation	NA	Y1815C	0.34
UCEC	chr3	58112273	Silent	rs779818713	D900D	0.44
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.42
UCEC	chr3	58123110	Silent	rs376519914	P1048P	0.41
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.12
UCEC	chr3	58145924	Missense_Mutation	NA	S1810N	0.2
UCEC	chr3	58108559	Missense_Mutation	NA	K681N	0.35
UCEC	chr3	58170903	3'UTR	novel		0.33
UCEC	chr3	58078756	Missense_Mutation	novel	P194H	0.26
UCEC	chr3	58136099	Missense_Mutation	rs775231905	D1598N	0.24
UCEC	chr3	58149984	Missense_Mutation	rs141559684	A2076T	0.25
UCEC	chr3	58159670	Silent	novel	V2335V	0.25
UCEC	chr3	58163204	Missense_Mutation	rs147116528	D2358N	0.45
UCEC	chr3	58169681	Silent	rs777882704	S2503S	0.41
UCEC	chr3	58170754	Missense_Mutation	novel	V2601L	0.28
UCEC	chr3	58170858	3'UTR	novel		0.33
UCEC	chr3	58077167	Silent	novel	K138K	0.4
UCEC	chr3	58153496	Silent	rs746887183	G2163G	0.36
UCEC	chr3	58123142	Missense_Mutation	rs570950728	A1059V	0.38
UCEC	chr3	58104061	Frame_Shift_Del	rs758401425	*G531Dfs42**	0.45
UCEC	chr3	58154879	Silent	novel	D2241D	0.3
UCEC	chr3	58008817	Missense_Mutation	NA	E85K	0.24
UCEC	chr3	58081667	Silent	NA	D226D	0.26
UCEC	chr3	58097941	Missense_Mutation	rs201867517	A371T	0.28
UCEC	chr3	58105160	Missense_Mutation	NA	V564A	0.31
UCEC	chr3	58081669	Missense_Mutation	NA	E227G	0.35
UCEC	chr3	58163255	Missense_Mutation	rs767864936	V2375I	0.38
UCEC	chr3	58141909	Frame_Shift_Del	novel	*P1722Lfs7**	0.42
UCEC	chr3	58145940	Silent	rs755702006	Y1815Y	0.42
UCEC	chr3	58121334	Missense_Mutation	rs779247120	R986Q	0.41
UCEC	chr3	58123291	Missense_Mutation	rs200947960	V1109I	0.39
UCEC	chr3	58109632	Silent	novel	V752V	0.41
UCEC	chr3	58110104	Silent	rs778108689	T806T	0.42
UCEC	chr3	58123408	Missense_Mutation	novel	V1148M	0.33
UCEC	chr3	58132827	Silent	novel	N1470N	0.39
UCEC	chr3	58148791	Silent	rs770306813	R2010R	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.75	0.016387
LUAD	DEL	0.3314	0.0021265
PAAD	DEL	0.1848	0.030662
SARC	DEL	0.214	0.0034746
SKCM	DEL	0.1471	0.13887
TGCT	AMP	0.1533	0.23596
THYM	DEL	0.0813	0.037527
UCS	DEL	0.5357	4.5515e-05

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0039	Kaplan-Meier Survival Analysis
MESO	0.00012	Kaplan-Meier Survival Analysis
BRCA	0.015	Kaplan-Meier Survival Analysis
ESCA	0.031	Kaplan-Meier Survival Analysis
KIRP	0.048	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
CESC	0.0083	Kaplan-Meier Survival Analysis
READ	0.0015	Kaplan-Meier Survival Analysis
LAML	0.018	Kaplan-Meier Survival Analysis
LUAD	0.014	Kaplan-Meier Survival Analysis
OV	0.0096	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742