EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000136108 (Gene tree)
Gene ID: 26586
Gene Symbol: CKAP2
Alias: LB1|FLJ10749|se20-10|TMAP
Full Name: cytoskeleton associated protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 21,272 bases
Position: chr13:52,455,360-52,476,631
Accession: 1990
RBP type: non-canonical RBP
Summary: This gene encodes a cytoskeleton-associated protein that stabalizes microtubules and plays a role in the regulation of cell division. The encoded protein is itself regulated through phosphorylation at multiple serine and threonine residues. There is a pseudogene of this gene on chromosome 14. Alternative splicing results in multiple transcript variations. [provided by RefSeq, Nov 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000480747	CKAP2-206	537	-	ENSP00000418224	97 (aa)	-	C9J7Y4
ENST00000490903	CKAP2-207	3395	XM_005266344	ENSP00000417830	634 (aa)	XP_005266401	Q8WWK9
ENST00000459902	CKAP2-204	798	-	-	- (aa)	-	-
ENST00000258607	CKAP2-201	3375	-	ENSP00000258607	682 (aa)	-	Q8WWK9
ENST00000468284	CKAP2-205	579	-	ENSP00000418431	93 (aa)	-	C9J649
ENST00000378034	CKAP2-202	1972	-	ENSP00000367273	494 (aa)	-	Q8WWK9
ENST00000378037	CKAP2-203	3629	-	ENSP00000367276	683 (aa)	-	Q8WWK9

Gene Model

Click here to download ENSG00000136108's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136108's network

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	16061649.	IGI	Process
GO:0000922	spindle pole	-	IEA	Component
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005881	cytoplasmic microtubule	16061649.	IDA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0007026	negative regulation of microtubule depolymerization	-	IEA	Process
GO:0015630	microtubule cytoskeleton	-	IDA	Component
GO:0045944	positive regulation of transcription by RNA polymerase II	16061649.	IGI	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24887265	Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer.	PLoS One	2014 Jun 2	Kim HS	doi: 10.1371/journal.pone.0098160
28933561	CKAP2 Promotes Ovarian Cancer Proliferation and Tumorigenesis Through the FAK-ERK Pathway.	DNA Cell Biol	2017 Nov	Zhang M	doi: 10.1089/dna.2017.3876

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr13	52473996	Missense_Mutation	novel	P573A	0.2
BLCA	chr13	52461561	Silent	NA	T246T	0.27
BLCA	chr13	52462558	Missense_Mutation	NA	L433F	0.07
BLCA	chr13	52462406	Missense_Mutation	novel	K383E	0.21
BLCA	chr13	52475168	3'UTR	novel		0.84
BLCA	chr13	52456542	Silent	novel	L30L	0.48
BLCA	chr13	52461887	In_Frame_Ins	novel	S355delinsRVLFLIIP	0.1
BLCA	chr13	52455499	5'UTR	novel		0.56
BLCA	chr13	52465551	Intron	novel		0.17
BRCA	chr13	52473937	Missense_Mutation	NA	L553R	0.44
BRCA	chr13	52461461	Missense_Mutation	NA	P213H	0.14
BRCA	chr13	52461725	Missense_Mutation	novel	K301R	0.28
BRCA	chr13	52468314	Missense_Mutation	NA	L506V	0.56
BRCA	chr13	52461055	Splice_Region	novel		0.29
BRCA	chr13	52475003	Missense_Mutation	NA	L638F	0.6
BRCA	chr13	52465376	Missense_Mutation	novel	W464R	0.04
CESC	chr13	52474026	Missense_Mutation	novel	E583K	0.09
CESC	chr13	52475259	3'UTR	novel		0.2
CESC	chr13	52456552	Missense_Mutation	NA	L34V	0.16
CESC	chr13	52473894	Missense_Mutation	novel	G539C	0.12
CESC	chr13	52461759	Missense_Mutation	NA	K312N	0.38
CHOL	chr13	52461305	Missense_Mutation	novel	T161I	0.09
COAD	chr13	52461623	In_Frame_Del	NA	T267_Q270delinsK	0.12
COAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.44
COAD	chr13	52462448	Missense_Mutation	NA	G397R	0.1
COAD	chr13	52465472	Splice_Region	NA		0.3
COAD	chr13	52462405	Frame_Shift_Del	NA	*R384Gfs6**	0.18
COAD	chr13	52461702	Frame_Shift_Del	NA	*T295Qfs14**	0.12
COAD	chr13	52461734	Missense_Mutation	NA	S304Y	0.14
COAD	chr13	52473915	Missense_Mutation	NA	K546Q	0.23
COAD	chr13	52455538	5'UTR	novel		0.26
COAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.28
COAD	chr13	52474011	Frame_Shift_Del	novel	*T579Pfs11**	0.07
COAD	chr13	52455538	5'UTR	novel		0.12
COAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.38
COAD	chr13	52475122	Missense_Mutation	NA	Y678C	0.28
COAD	chr13	52474907	Silent	NA	K606K	0.27
COAD	chr13	52474976	Silent	NA	R629R	0.14
COAD	chr13	52461197	Missense_Mutation	NA	N125I	0.11
COAD	chr13	52474030	Missense_Mutation	rs745449940	T584M	0.1
COAD	chr13	52456589	Missense_Mutation	NA	E46G	0.31
COAD	chr13	52468301	Silent	rs766203069	T501T	0.26
COAD	chr13	52473848	Silent	NA	S523S	0.22
GBM	chr13	52461703	Missense_Mutation	novel	K294Q	0.33
GBM	chr13	52474975	Missense_Mutation	rs370416292	R629Q	0.26
GBM	chr13	52461339	Missense_Mutation	novel	K172N	0.41
GBM	chr13	52461759	Missense_Mutation	novel	K312N	0.12
GBM	chr13	52455533	5'UTR	rs767416626		0.74
GBM	chr13	52460965	Splice_Site	novel	X75_splice	0.15
HNSC	chr13	52475348	3'UTR	novel		0.38
HNSC	chr13	52461919	Nonsense_Mutation	novel	E366*	0.36
HNSC	chr13	52461616	Missense_Mutation	rs545281527	R265W	0.44
HNSC	chr13	52474029	Missense_Mutation	novel	T584A	0.22
HNSC	chr13	52468298	Silent	novel	H500H	0.24
HNSC	chr13	52461775	Missense_Mutation	rs752317658	I318V	0.13
KIRC	chr13	52461663	Silent	NA	T280T	0.53
KIRP	chr13	52468291	Missense_Mutation	NA	M498K	0.09
LAML	chr13	52461773	Missense_Mutation	novel	S317F	0.07
LGG	chr13	52461151	Missense_Mutation	novel	T110A	0.04
LGG	chr13	52465511	Intron	novel		0.14
LGG	chr13	52475347	3'UTR	novel		0.18
LIHC	chr13	52465446	Missense_Mutation	novel	A487G	0.28
LIHC	chr13	52474978	Missense_Mutation	rs73186408	R630H	0.54
LUAD	chr13	52465445	Missense_Mutation	NA	A487T	0.18
LUAD	chr13	52456599	Missense_Mutation	novel	M49I	0.27
LUAD	chr13	52462457	Missense_Mutation	NA	E400K	0.28
LUAD	chr13	52461923	Missense_Mutation	NA	R367T	0.21
LUAD	chr13	52455466	5'Flank	novel		0.17
LUAD	chr13	52455587	Missense_Mutation	NA	Q11K	0.15
LUAD	chr13	52462523	Nonsense_Mutation	novel	K422*	0.09
LUAD	chr13	52465310	Missense_Mutation	NA	D442N	0.26
LUAD	chr13	52475055	Missense_Mutation	novel	T656S	0.21
LUAD	chr13	52461798	Missense_Mutation	novel	R325S	0.25
LUSC	chr13	52475155	3'UTR	rs773049041		0.14
LUSC	chr13	52475155	3'UTR	novel		0.18
LUSC	chr13	52475114	Silent	novel	R675R	0.25
LUSC	chr13	52461326	Missense_Mutation	novel	A168G	0.09
OV	chr13	52474021	Missense_Mutation	NA	N581S	0.21
PAAD	chr13	52455489	5'UTR	novel		0.19
READ	chr13	52465600	Intron	novel		0.19
READ	chr13	52462555	Missense_Mutation	NA	N432K	0.33
SARC	chr13	52473904	Missense_Mutation	novel	V542A	0.25
SKCM	chr13	52460952	Missense_Mutation	NA	V71A	0.29
SKCM	chr13	52474892	Splice_Region	novel		0.29
SKCM	chr13	52474996	Missense_Mutation	NA	S636F	0.39
SKCM	chr13	52461531	Missense_Mutation	NA	M236I	0.2
SKCM	chr13	52473989	Frame_Shift_Del	novel	*K571Rfs5**	0.26
SKCM	chr13	52473881	Frame_Shift_Del	novel	*S534Rfs9**	0.4
SKCM	chr13	52465413	Missense_Mutation	NA	P476L	0.07
SKCM	chr13	52461359	Missense_Mutation	novel	Y179C	0.29
SKCM	chr13	52474996	Missense_Mutation	NA	S636F	0.17
SKCM	chr13	52475170	3'UTR	novel		0.21
STAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.43
STAD	chr13	52475062	Missense_Mutation	NA	L658S	0.24
STAD	chr13	52468294	Missense_Mutation	rs750005059	R499Q	0.21
STAD	chr13	52461726	Missense_Mutation	NA	K301N	0.34
STAD	chr13	52455495	5'UTR	novel		0.23
STAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.41
STAD	chr13	52460974	Splice_Site	novel	X79_splice	0.12
STAD	chr13	52461925	Frame_Shift_Ins	novel	*S372Kfs4**	0.12
STAD	chr13	52474978	Missense_Mutation	rs73186408	R630H	0.66
STAD	chr13	52475160	3'UTR	novel		0.22
STAD	chr13	52473900	Missense_Mutation	novel	D541H	0.06
STAD	chr13	52461548	Missense_Mutation	NA	F242S	0.18
STAD	chr13	52474899	Frame_Shift_Del	rs752250702	*K606Rfs14**	0.5
THCA	chr13	52475242	3'UTR	novel		0.08
THCA	chr13	52475201	3'UTR	novel		0.06
UCEC	chr13	52461618	Silent	NA	R265R	0.17
UCEC	chr13	52474974	Nonsense_Mutation	rs768288248	R629*	0.32
UCEC	chr13	52475144	3'UTR	novel		0.07
UCEC	chr13	52465516	Intron	rs763976569		0.35
UCEC	chr13	52465515	Intron	rs371952071		0.35
UCEC	chr13	52456537	Missense_Mutation	novel	K29Q	0.59
UCEC	chr13	52461207	Silent	rs763445264	P128P	0.46
UCEC	chr13	52468301	Silent	rs766203069	T501T	0.43
UCEC	chr13	52461195	Missense_Mutation	novel	S124R	0.35
UCEC	chr13	52475057	Silent	rs754490339	T656T	0.48
UCEC	chr13	52461907	Nonsense_Mutation	novel	E362*	0.36
UCEC	chr13	52456538	Missense_Mutation	NA	K29T	0.42
UCEC	chr13	52462368	Missense_Mutation	rs757075646	R370H	0.22
UCEC	chr13	52465360	Silent	novel	K458K	0.1
UCEC	chr13	52475355	3'UTR	novel		0.19
UCEC	chr13	52475356	3'UTR	novel		0.15
UCEC	chr13	52465538	Intron	novel		0.06
UCEC	chr13	52474968	Missense_Mutation	rs748867286	R627C	0.23
UCEC	chr13	52473873	Nonsense_Mutation	novel	E532*	0.44
UCEC	chr13	52474898	Frame_Shift_Ins	rs755784201	*V607Gfs4**	0.5
UCEC	chr13	52465474	Intron	novel		0.41
UCEC	chr13	52475378	3'UTR	novel		0.5
UCEC	chr13	52465715	Intron	novel		0.19
UCEC	chr13	52473962	Missense_Mutation	novel	D561E	0.38
UCEC	chr13	52462394	Missense_Mutation	novel	G379R	0.38
UCEC	chr13	52462487	Missense_Mutation	novel	M410L	0.36
UCEC	chr13	52456569	Silent	novel	T39T	0.33
UCEC	chr13	52473988	Frame_Shift_Ins	novel	*D572Rfs5**	0.46
UCEC	chr13	52455510	5'UTR	novel		0.48
UCEC	chr13	52461446	Missense_Mutation	novel	L208R	0.62
UCEC	chr13	52473989	Frame_Shift_Del	novel	*D572Ifs18**	0.07
UCEC	chr13	52475057	Silent	rs754490339	T656T	0.15
UCEC	chr13	52460949	Missense_Mutation	novel	K70T	0.36
UCEC	chr13	52465551	Intron	novel		0.27
UCEC	chr13	52474974	Nonsense_Mutation	rs768288248	R629*	0.46
UCEC	chr13	52456524	Missense_Mutation	novel	E24D	0.36
UCEC	chr13	52475163	3'UTR	novel		0.41
UCEC	chr13	52461895	Missense_Mutation	rs750786244	A358P	0.81
UCEC	chr13	52474030	Missense_Mutation	rs745449940	T584M	0.08
UCEC	chr13	52460905	Missense_Mutation	NA	D55E	0.41
UCEC	chr13	52475113	Missense_Mutation	novel	R675Q	0.53
UCEC	chr13	52461559	Missense_Mutation	NA	T246A	0.13
UCEC	chr13	52456596	Missense_Mutation	novel	E48D	0.34
UCEC	chr13	52461635	Missense_Mutation	rs761550006	G271D	0.45
UCEC	chr13	52465793	Intron	novel		0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.322	2.1677e-19
COAD	DEL	0.0288	0.24773
GBM	DEL	0.3934	4.92e-12
KIRC	DEL	0.1155	0.031318
LGG	DEL	0.2144	5.4722e-09
MESO	DEL	0.4023	0.0010209
THCA	DEL	0.0341	0.011063

Survival Analysis

Cancer	P-value	Q-value
THYM	0.01	Kaplan-Meier Survival Analysis
STAD	0.022	Kaplan-Meier Survival Analysis
SARC	0.014	Kaplan-Meier Survival Analysis
MESO	0.0013	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
HNSC	0.018	Kaplan-Meier Survival Analysis
PRAD	0.0026	Kaplan-Meier Survival Analysis
KIRP	0.00051	Kaplan-Meier Survival Analysis
CESC	0.008	Kaplan-Meier Survival Analysis
KICH	0.013	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
GBM	0.027	Kaplan-Meier Survival Analysis
LIHC	0.00014	Kaplan-Meier Survival Analysis
LGG	0.00049	Kaplan-Meier Survival Analysis
LUAD	0.016	Kaplan-Meier Survival Analysis
UVM	0.0028	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742