EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136169 (Gene tree)
Gene ID: 83852
Gene Symbol: SETDB2
Alias: CLLD8|CLLL8|KMT1F|C13orf4
Full Name: SET domain bifurcated histone lysine methyltransferase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 50,948 bases
Position: chr13:49,444,056-49,495,003
Accession: 20263
RBP type: canonical RBP
Summary: This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000258672	MBD	PF01429.19	2.3e-07	1	1
ENSP00000326477	MBD	PF01429.19	3.4e-07	1	1
ENSP00000346175	MBD	PF01429.19	3.5e-07	1	1
ENSP00000482240	MBD	PF01429.19	3.5e-07	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000354234	SETDB2-203	6139	-	ENSP00000346175	719 (aa)	-	Q96T68
ENST00000258672	SETDB2-201	2138	-	ENSP00000258672	548 (aa)	-	X6R383
ENST00000481439	SETDB2-204	574	-	-	- (aa)	-	-
ENST00000611815	SETDB2-205	5313	-	ENSP00000482240	719 (aa)	-	A0A087WYZ9
ENST00000317257	SETDB2-202	5619	-	ENSP00000326477	707 (aa)	-	Q96T68

Gene Model

Click here to download ENSG00000136169's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136169	Platelet Function Tests	4.5219696E-008	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136169's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136169	SETDB2	53	56.322	ENSAPOG00000020220	-	86	56.322	Acanthochromis_polyacanthus
ENSG00000136169	SETDB2	98	82.514	ENSAMEG00000003443	SETDB2	69	82.514	Ailuropoda_melanoleuca
ENSG00000136169	SETDB2	71	40.625	ENSACIG00000009349	-	83	40.625	Amphilophus_citrinellus
ENSG00000136169	SETDB2	67	52.874	ENSAOCG00000006560	-	76	52.874	Amphiprion_ocellaris
ENSG00000136169	SETDB2	50	52.874	ENSAPEG00000009529	-	66	52.874	Amphiprion_percula
ENSG00000136169	SETDB2	50	54.023	ENSATEG00000008915	-	60	54.023	Anabas_testudineus
ENSG00000136169	SETDB2	99	47.010	ENSAPLG00000009061	SETDB2	100	47.010	Anas_platyrhynchos
ENSG00000136169	SETDB2	100	45.788	ENSACAG00000014036	SETDB2	100	46.112	Anolis_carolinensis
ENSG00000136169	SETDB2	90	93.396	ENSANAG00000028107	SETDB2	99	93.396	Aotus_nancymaae
ENSG00000136169	SETDB2	75	37.241	ENSACLG00000004046	-	84	37.241	Astatotilapia_calliptera
ENSG00000136169	SETDB2	81	61.628	ENSAMXG00000016092	setdb2	88	61.628	Astyanax_mexicanus
ENSG00000136169	SETDB2	100	78.642	ENSBTAG00000007329	SETDB2	100	78.642	Bos_taurus
ENSG00000136169	SETDB2	100	92.786	ENSCJAG00000008864	SETDB2	100	92.786	Callithrix_jacchus
ENSG00000136169	SETDB2	99	80.140	ENSCAFG00000004341	SETDB2	100	80.140	Canis_familiaris
ENSG00000136169	SETDB2	100	80.932	ENSCAFG00020020283	SETDB2	100	80.932	Canis_lupus_dingo
ENSG00000136169	SETDB2	100	78.642	ENSCHIG00000014895	SETDB2	100	78.642	Capra_hircus
ENSG00000136169	SETDB2	99	84.801	ENSTSYG00000014051	SETDB2	99	84.801	Carlito_syrichta
ENSG00000136169	SETDB2	90	72.912	ENSCAPG00000014168	-	98	72.912	Cavia_aperea
ENSG00000136169	SETDB2	93	78.824	ENSCPOG00000002194	SETDB2	97	75.153	Cavia_porcellus
ENSG00000136169	SETDB2	100	92.221	ENSCCAG00000031604	SETDB2	100	92.221	Cebus_capucinus
ENSG00000136169	SETDB2	100	96.747	ENSCATG00000002055	SETDB2	100	96.747	Cercocebus_atys
ENSG00000136169	SETDB2	100	76.238	ENSCLAG00000007348	SETDB2	100	76.238	Chinchilla_lanigera
ENSG00000136169	SETDB2	100	96.605	ENSCSAG00000017713	SETDB2	100	96.605	Chlorocebus_sabaeus
ENSG00000136169	SETDB2	89	52.419	ENSCPBG00000008524	SETDB2	92	43.662	Chrysemys_picta_bellii
ENSG00000136169	SETDB2	99	92.737	ENSCANG00000033506	SETDB2	100	92.737	Colobus_angolensis_palliatus
ENSG00000136169	SETDB2	100	73.061	ENSCGRG00001011194	Setdb2	100	73.061	Cricetulus_griseus_chok1gshd
ENSG00000136169	SETDB2	100	73.061	ENSCGRG00000000801	Setdb2	100	73.061	Cricetulus_griseus_crigri
ENSG00000136169	SETDB2	69	54.545	ENSCVAG00000004116	-	89	43.885	Cyprinodon_variegatus
ENSG00000136169	SETDB2	60	54.167	ENSDARG00000101462	setdb2	72	54.167	Danio_rerio
ENSG00000136169	SETDB2	100	78.164	ENSDNOG00000033679	SETDB2	100	78.164	Dasypus_novemcinctus
ENSG00000136169	SETDB2	99	71.049	ENSDORG00000026163	Setdb2	100	71.049	Dipodomys_ordii
ENSG00000136169	SETDB2	80	78.704	ENSETEG00000004821	SETDB2	81	78.704	Echinops_telfairi
ENSG00000136169	SETDB2	100	83.593	ENSEASG00005017285	SETDB2	100	83.593	Equus_asinus_asinus
ENSG00000136169	SETDB2	100	83.734	ENSECAG00000020357	SETDB2	100	83.734	Equus_caballus
ENSG00000136169	SETDB2	99	72.370	ENSEEUG00000011247	SETDB2	100	72.370	Erinaceus_europaeus
ENSG00000136169	SETDB2	73	58.140	ENSELUG00000024242	-	79	58.140	Esox_lucius
ENSG00000136169	SETDB2	100	83.027	ENSFCAG00000012034	SETDB2	100	83.027	Felis_catus
ENSG00000136169	SETDB2	99	46.685	ENSFALG00000008379	SETDB2	97	46.685	Ficedula_albicollis
ENSG00000136169	SETDB2	99	76.528	ENSFDAG00000017408	SETDB2	100	76.528	Fukomys_damarensis
ENSG00000136169	SETDB2	99	45.753	ENSGALG00000017006	SETDB2	97	45.753	Gallus_gallus
ENSG00000136169	SETDB2	67	55.172	ENSGAFG00000000077	-	77	55.172	Gambusia_affinis
ENSG00000136169	SETDB2	67	53.659	ENSGACG00000015463	-	77	53.659	Gasterosteus_aculeatus
ENSG00000136169	SETDB2	99	50.275	ENSGAGG00000014099	SETDB2	96	50.275	Gopherus_agassizii
ENSG00000136169	SETDB2	100	99.444	ENSGGOG00000016016	SETDB2	100	99.444	Gorilla_gorilla
ENSG00000136169	SETDB2	75	37.241	ENSHBUG00000001477	-	84	37.241	Haplochromis_burtoni
ENSG00000136169	SETDB2	100	77.652	ENSHGLG00000003820	SETDB2	99	77.652	Heterocephalus_glaber_female
ENSG00000136169	SETDB2	100	77.793	ENSHGLG00100008642	SETDB2	99	77.793	Heterocephalus_glaber_male
ENSG00000136169	SETDB2	74	58.824	ENSIPUG00000011157	setdb2	86	58.824	Ictalurus_punctatus
ENSG00000136169	SETDB2	100	80.481	ENSSTOG00000002985	SETDB2	100	80.481	Ictidomys_tridecemlineatus
ENSG00000136169	SETDB2	99	71.773	ENSJJAG00000011079	Setdb2	99	71.773	Jaculus_jaculus
ENSG00000136169	SETDB2	62	62.500	ENSKMAG00000012100	-	82	62.500	Kryptolebias_marmoratus
ENSG00000136169	SETDB2	99	39.414	ENSLACG00000009640	SETDB2	99	38.089	Latimeria_chalumnae
ENSG00000136169	SETDB2	69	65.333	ENSLOCG00000009739	-	97	34.450	Lepisosteus_oculatus
ENSG00000136169	SETDB2	99	78.333	ENSLAFG00000012612	SETDB2	100	78.333	Loxodonta_africana
ENSG00000136169	SETDB2	100	96.605	ENSMFAG00000032631	SETDB2	100	96.605	Macaca_fascicularis
ENSG00000136169	SETDB2	100	96.605	ENSMMUG00000013473	SETDB2	100	96.605	Macaca_mulatta
ENSG00000136169	SETDB2	100	96.605	ENSMNEG00000037148	SETDB2	100	96.605	Macaca_nemestrina
ENSG00000136169	SETDB2	100	96.747	ENSMLEG00000043613	SETDB2	100	96.747	Mandrillus_leucophaeus
ENSG00000136169	SETDB2	72	46.825	ENSMAMG00000022781	-	80	46.825	Mastacembelus_armatus
ENSG00000136169	SETDB2	75	37.241	ENSMZEG00005012098	-	84	37.241	Maylandia_zebra
ENSG00000136169	SETDB2	99	45.170	ENSMGAG00000015017	SETDB2	100	45.170	Meleagris_gallopavo
ENSG00000136169	SETDB2	100	71.610	ENSMAUG00000012871	Setdb2	100	71.610	Mesocricetus_auratus
ENSG00000136169	SETDB2	100	85.149	ENSMICG00000012641	SETDB2	100	85.149	Microcebus_murinus
ENSG00000136169	SETDB2	100	68.785	ENSMOCG00000021987	Setdb2	100	68.785	Microtus_ochrogaster
ENSG00000136169	SETDB2	100	54.039	ENSMODG00000010929	SETDB2	100	53.900	Monodelphis_domestica
ENSG00000136169	SETDB2	67	54.118	ENSMALG00000001256	-	73	54.118	Monopterus_albus
ENSG00000136169	SETDB2	100	67.232	MGP_CAROLIEiJ_G0019367	Setdb2	100	67.232	Mus_caroli
ENSG00000136169	SETDB2	100	67.514	ENSMUSG00000071350	Setdb2	100	67.514	Mus_musculus
ENSG00000136169	SETDB2	100	68.644	MGP_PahariEiJ_G0030385	Setdb2	100	68.644	Mus_pahari
ENSG00000136169	SETDB2	100	67.655	MGP_SPRETEiJ_G0020259	Setdb2	100	67.655	Mus_spretus
ENSG00000136169	SETDB2	99	80.484	ENSMPUG00000018019	SETDB2	99	80.484	Mustela_putorius_furo
ENSG00000136169	SETDB2	99	78.348	ENSMLUG00000004378	SETDB2	99	78.348	Myotis_lucifugus
ENSG00000136169	SETDB2	100	75.813	ENSNGAG00000013911	Setdb2	100	75.813	Nannospalax_galili
ENSG00000136169	SETDB2	100	98.331	ENSNLEG00000003613	SETDB2	100	98.331	Nomascus_leucogenys
ENSG00000136169	SETDB2	93	47.717	ENSMEUG00000005220	-	100	48.159	Notamacropus_eugenii
ENSG00000136169	SETDB2	83	77.650	ENSOPRG00000012261	SETDB2	83	77.650	Ochotona_princeps
ENSG00000136169	SETDB2	69	43.478	ENSONIG00000009000	-	85	43.478	Oreochromis_niloticus
ENSG00000136169	SETDB2	99	54.944	ENSOANG00000015546	SETDB2	93	55.618	Ornithorhynchus_anatinus
ENSG00000136169	SETDB2	100	79.144	ENSOCUG00000003755	SETDB2	100	79.144	Oryctolagus_cuniculus
ENSG00000136169	SETDB2	67	52.273	ENSORLG00000001147	-	76	52.273	Oryzias_latipes
ENSG00000136169	SETDB2	69	52.273	ENSORLG00020006680	-	81	52.273	Oryzias_latipes_hni
ENSG00000136169	SETDB2	67	52.273	ENSORLG00015009952	-	77	52.500	Oryzias_latipes_hsok
ENSG00000136169	SETDB2	99	79.943	ENSOGAG00000005339	SETDB2	99	79.943	Otolemur_garnettii
ENSG00000136169	SETDB2	100	78.925	ENSOARG00000008487	SETDB2	100	78.925	Ovis_aries
ENSG00000136169	SETDB2	100	99.444	ENSPPAG00000039854	SETDB2	100	99.444	Pan_paniscus
ENSG00000136169	SETDB2	100	82.744	ENSPPRG00000000069	SETDB2	100	82.744	Panthera_pardus
ENSG00000136169	SETDB2	100	82.744	ENSPTIG00000006314	SETDB2	100	82.744	Panthera_tigris_altaica
ENSG00000136169	SETDB2	100	99.583	ENSPTRG00000005873	SETDB2	100	99.583	Pan_troglodytes
ENSG00000136169	SETDB2	100	96.605	ENSPANG00000017051	SETDB2	100	96.605	Papio_anubis
ENSG00000136169	SETDB2	73	61.628	ENSPKIG00000009795	-	83	61.628	Paramormyrops_kingsleyae
ENSG00000136169	SETDB2	99	47.657	ENSPSIG00000002200	SETDB2	95	47.657	Pelodiscus_sinensis
ENSG00000136169	SETDB2	52	70.979	ENSPEMG00000020697	-	100	70.979	Peromyscus_maniculatus_bairdii
ENSG00000136169	SETDB2	100	55.230	ENSPCIG00000002912	SETDB2	100	55.230	Phascolarctos_cinereus
ENSG00000136169	SETDB2	73	44.444	ENSPFOG00000006673	-	85	44.444	Poecilia_formosa
ENSG00000136169	SETDB2	73	45.185	ENSPLAG00000016914	-	85	45.185	Poecilia_latipinna
ENSG00000136169	SETDB2	73	45.185	ENSPMEG00000003842	-	85	45.185	Poecilia_mexicana
ENSG00000136169	SETDB2	73	42.963	ENSPREG00000022531	-	85	42.963	Poecilia_reticulata
ENSG00000136169	SETDB2	100	97.878	ENSPPYG00000005368	SETDB2	100	97.878	Pongo_abelii
ENSG00000136169	SETDB2	58	92.647	ENSPCAG00000010230	-	58	92.647	Procavia_capensis
ENSG00000136169	SETDB2	93	86.061	ENSPCOG00000017644	SETDB2	99	86.061	Propithecus_coquereli
ENSG00000136169	SETDB2	100	77.051	ENSPVAG00000006911	SETDB2	100	77.051	Pteropus_vampyrus
ENSG00000136169	SETDB2	53	42.647	ENSPNYG00000023676	-	74	42.647	Pundamilia_nyererei
ENSG00000136169	SETDB2	73	60.000	ENSPNAG00000011459	setdb2	99	31.877	Pygocentrus_nattereri
ENSG00000136169	SETDB2	100	67.893	ENSRNOG00000021680	Setdb2	100	67.893	Rattus_norvegicus
ENSG00000136169	SETDB2	100	97.313	ENSRBIG00000006562	SETDB2	100	97.313	Rhinopithecus_bieti
ENSG00000136169	SETDB2	100	97.171	ENSRROG00000032499	SETDB2	100	97.171	Rhinopithecus_roxellana
ENSG00000136169	SETDB2	100	92.221	ENSSBOG00000023249	SETDB2	100	92.221	Saimiri_boliviensis_boliviensis
ENSG00000136169	SETDB2	100	55.292	ENSSHAG00000007281	SETDB2	100	55.432	Sarcophilus_harrisii
ENSG00000136169	SETDB2	75	40.123	ENSSFOG00015008204	-	90	40.123	Scleropages_formosus
ENSG00000136169	SETDB2	67	52.874	ENSSDUG00000002987	-	74	52.874	Seriola_dumerili
ENSG00000136169	SETDB2	67	54.023	ENSSLDG00000015081	-	73	54.023	Seriola_lalandi_dorsalis
ENSG00000136169	SETDB2	100	72.458	ENSSARG00000009926	SETDB2	100	72.458	Sorex_araneus
ENSG00000136169	SETDB2	66	53.247	ENSSPAG00000006869	-	81	53.247	Stegastes_partitus
ENSG00000136169	SETDB2	100	80.905	ENSSSCG00000009395	SETDB2	100	80.905	Sus_scrofa
ENSG00000136169	SETDB2	67	51.337	ENSTGUG00000012159	SETDB2	92	51.337	Taeniopygia_guttata
ENSG00000136169	SETDB2	86	94.872	ENSTBEG00000008013	SETDB2	90	94.872	Tupaia_belangeri
ENSG00000136169	SETDB2	100	78.784	ENSTTRG00000012932	SETDB2	100	78.784	Tursiops_truncatus
ENSG00000136169	SETDB2	100	82.320	ENSUMAG00000018406	SETDB2	100	82.320	Ursus_maritimus
ENSG00000136169	SETDB2	100	77.247	ENSVPAG00000012019	SETDB2	100	77.247	Vicugna_pacos
ENSG00000136169	SETDB2	87	79.412	ENSVVUG00000028174	SETDB2	91	77.647	Vulpes_vulpes
ENSG00000136169	SETDB2	82	66.279	ENSXETG00000015666	setdb2	95	41.071	Xenopus_tropicalis
ENSG00000136169	SETDB2	55	44.030	ENSXMAG00000006323	-	69	44.030	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000278	mitotic cell cycle	20404330.	IMP	Process
GO:0001947	heart looping	-	ISS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005634	nucleus	20404330.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0007059	chromosome segregation	20404330.	IMP	Process
GO:0008270	zinc ion binding	-	IEA	Function
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	Process
GO:0046974	histone methyltransferase activity (H3-K9 specific)	20404330.	IDA	Function
GO:0051301	cell division	-	IEA	Process
GO:0051567	histone H3-K9 methylation	20404330.	IDA	Process
GO:0070986	left/right axis specification	-	ISS	Process