EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136271 (Gene tree)
Gene ID: 54606
Gene Symbol: DDX56
Alias: NOH61
Full Name: DEAD-box helicase 56
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 9,635 bases
Position: chr7:44,565,417-44,575,051
Accession: 18193
RBP type: canonical RBP
Summary: This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene shows ATPase activity in the presence of polynucleotides and associates with nucleoplasmic 65S preribosomal particles. This gene may be involved in ribosome synthesis, most likely during assembly of the large 60S ribosomal subunit. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000393488	ResIII	PF04851.15	1.8e-07	1	1
ENSP00000258772	ResIII	PF04851.15	2e-07	1	1
ENSP00000393488	DEAD	PF00270.29	3e-38	1	1
ENSP00000258772	DEAD	PF00270.29	3.4e-38	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15165181	Interaction of the plant glycine-rich RNA-binding protein MA16 with a novel nucleolar DEAD box RNA helicase protein from Zea mays.	Plant J	2004 Jun	Gendra E	-
9883581	RNA-binding proteins in mouse oocytes and embryos: expression of genes encoding Y box, DEAD box RNA helicase, and polyA binding proteins.	Dev Genet	1998	Paynton BV	-
8627691	The QRxGRxGRxxxG motif of the vaccinia virus DExH box RNA helicase NPH-II is required for ATP hydrolysis and RNA unwinding but not for RNA binding.	J Virol	1996 Mar	Gross CH	-
8413273	The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.	Mol Cell Biol	1993 Nov	Pause A	-
18335541	MBNL1 associates with YB-1 in cytoplasmic stress granules.	J Neurosci Res	2008 Jul	Onishi H	doi: 10.1002/jnr.21655.
24863059	A DEAD-box RNA helicase produces two forms of transcript that differentially respond to cold stress in a cryophyte (Chorispora bungeana).	Planta	2014 Aug	Yang Y	doi: 10.1007/s00425-014-2091-5
21126315	Analysis of the RNA degradosome complex in Vibrio angustum S14.	FEBS J	2010 Dec	Erce MA	doi: 10.1111/j.1742-4658.2010.07934.x.
24019147	Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification.	Mol Cell Proteomics	2013 Dec	Wang C	doi: 10.1074/mcp.M113.029256
18184816	Cooperative binding of ATP and RNA induces a closed conformation in a DEAD box RNA helicase.	Proc Natl Acad Sci U S A	2008 Jan 15	Theissen B	doi: 10.1073/pnas.0705488105
21277973	(-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68.	Free Radic Biol Med	2011 May 15	Tanaka T	doi: 10.1016/j.freeradbiomed.2011.01.024
26876600	Recruitment, Duplex Unwinding and Protein-Mediated Inhibition of the Dead-Box RNA Helicase Dbp2 at Actively Transcribed Chromatin.	J Mol Biol	2016 Mar 27	Ma WK	doi: 10.1016/j.jmb.2016.02.005
9732274	Ribonuclease E organizes the protein interactions in the Escherichia coli RNA degradosome.	Genes Dev	1998 Sep 1	Vanzo NF	-
16556597	A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes.	J Biol Chem	2006 May 19	Nashchekin D	-
12054531	Two-hybrid cloning and characterization of OSH3, a yeast oxysterol-binding protein homolog.	Biochem Biophys Res Commun	2002 May 3	Park YU	-
11418588	Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.	J Biol Chem	2001 Aug 17	Rogers GW Jr	-
16030146	Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.	Proc Natl Acad Sci U S A	2005 Jul 26	Bordeleau ME	-
15654752	Equilibrium and kinetic analysis of nucleotide binding to the DEAD-box RNA helicase DbpA.	Biochemistry	2005 Jan 25	Talavera MA	-
18367715	Cap-dependent eukaryotic initiation factor-mRNA interactions probed by cross-linking.	RNA	2008 May	Lindqvist L	doi: 10.1261/rna.971208
20217243	Identification of Fe-excess-induced genes in rice shoots reveals a WRKY transcription factor responsive to Fe, drought and senescence.	Mol Biol Rep	2010 Dec	Ricachenevsky FK	doi: 10.1007/s11033-010-0027-0
25496916	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	Retrovirology	2014 Dec 14	Lin MH	doi: 10.1186/s12977-014-0121-9.
25479428	Utilization of inherent miRNAs in functional analyses of Toxoplasma gondii genes.	J Microbiol Methods	2015 Jan	Crater AK	doi: 10.1016/j.mimet.2014.11.014
24312670	Mak5 and Ebp2 act together on early pre-60S particles and their reduced functionality bypasses the requirement for the essential pre-60S factor Nsa1.	PLoS One	2013 Dec 2	Pratte D	doi: 10.1371/journal.pone.0082741
24035833	The DEAD-box RNA helicase DDX5 acts as a positive regulator of Japanese encephalitis virus replication by binding to viral 3' UTR.	Antiviral Res	2013 Nov	Li C	doi: 10.1016/j.antiviral.2013.09.002
28757063	ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.	Bioorg Med Chem Lett	2017 Sep 1	Tillotson J	doi: 10.1016/j.bmcl.2017.07.045

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479440	DDX56-210	599	-	-	- (aa)	-	-
ENST00000431640	DDX56-204	1554	-	ENSP00000393488	507 (aa)	-	Q9NY93
ENST00000258772	DDX56-201	2336	-	ENSP00000258772	547 (aa)	-	Q9NY93
ENST00000421223	DDX56-203	3028	-	ENSP00000392139	375 (aa)	-	G3V0G3
ENST00000433257	DDX56-205	1682	-	ENSP00000411456	396 (aa)	-	H7C3E9
ENST00000467318	DDX56-208	1665	-	-	- (aa)	-	-
ENST00000473924	DDX56-209	385	-	-	- (aa)	-	-
ENST00000485367	DDX56-212	1781	-	-	- (aa)	-	-
ENST00000448192	DDX56-207	691	-	ENSP00000390553	182 (aa)	-	H7BZN7
ENST00000415758	DDX56-202	1287	-	ENSP00000388310	103 (aa)	-	F8WEI3
ENST00000446987	DDX56-206	1853	-	ENSP00000402989	185 (aa)	-	F8WDT8
ENST00000479602	DDX56-211	440	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136271's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136271	Arteries	1.1950000E-005	-
ENSG00000136271	Arteries	1.1950000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136271	rs217373	7	44572855	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000136271	rs217381	7	44566618	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.026	EFO_0004611
ENSG00000136271	rs217381	7	44566618	C	Low density lipoprotein cholesterol levels	29507422	unit increase	0.027	EFO_0004611
ENSG00000136271	rs217381	7	44566618	C	Total cholesterol levels	29507422	unit increase	0.021	EFO_0004574

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136271's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000136271	DDX56	97	30.081	ENSG00000088205	DDX18	52	32.133
ENSG00000136271	DDX56	96	39.326	ENSG00000123064	DDX54	89	39.691
ENSG00000136271	DDX56	95	35.196	ENSG00000110367	DDX6	74	31.915
ENSG00000136271	DDX56	96	32.203	ENSG00000156976	EIF4A2	83	37.755
ENSG00000136271	DDX56	96	31.111	ENSG00000064703	DDX20	52	34.722
ENSG00000136271	DDX56	95	49.180	ENSG00000079785	DDX1	54	49.180
ENSG00000136271	DDX56	88	35.366	ENSG00000123136	DDX39A	77	34.337
ENSG00000136271	DDX56	74	36.842	ENSG00000178105	DDX10	53	30.518
ENSG00000136271	DDX56	63	33.846	ENSG00000183258	DDX41	57	33.333
ENSG00000136271	DDX56	91	33.333	ENSG00000215301	DDX3X	73	31.161
ENSG00000136271	DDX56	97	40.556	ENSG00000124228	DDX27	87	35.102
ENSG00000136271	DDX56	90	32.370	ENSG00000168872	DDX19A	87	30.328
ENSG00000136271	DDX56	94	30.110	ENSG00000109832	DDX25	91	39.344
ENSG00000136271	DDX56	96	34.066	ENSG00000161960	EIF4A1	99	35.862
ENSG00000136271	DDX56	96	30.055	ENSG00000108654	DDX5	83	47.368
ENSG00000136271	DDX56	85	33.728	ENSG00000067048	DDX3Y	52	30.571
ENSG00000136271	DDX56	96	36.111	ENSG00000105671	DDX49	78	38.298
ENSG00000136271	DDX56	88	35.976	ENSG00000198563	DDX39B	81	32.821
ENSG00000136271	DDX56	99	38.919	ENSG00000213782	DDX47	70	45.000
ENSG00000136271	DDX56	88	33.728	ENSG00000157349	DDX19B	76	30.412
ENSG00000136271	DDX56	92	30.114	ENSG00000111364	DDX55	87	31.361
ENSG00000136271	DDX56	92	36.364	ENSG00000278053	DDX52	57	33.146

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136271	DDX56	98	68.132	ENSAPOG00000017113	ddx56	98	64.505	Acanthochromis_polyacanthus
ENSG00000136271	DDX56	100	93.600	ENSAMEG00000017711	DDX56	100	91.225	Ailuropoda_melanoleuca
ENSG00000136271	DDX56	98	67.403	ENSACIG00000013747	ddx56	98	66.667	Amphilophus_citrinellus
ENSG00000136271	DDX56	98	67.956	ENSAOCG00000018059	ddx56	99	64.140	Amphiprion_ocellaris
ENSG00000136271	DDX56	98	67.956	ENSAOCG00000015447	-	87	67.008	Amphiprion_ocellaris
ENSG00000136271	DDX56	98	67.582	ENSAPEG00000007267	ddx56	99	63.685	Amphiprion_percula
ENSG00000136271	DDX56	98	68.132	ENSATEG00000005279	ddx56	98	64.493	Anabas_testudineus
ENSG00000136271	DDX56	98	67.403	ENSACLG00000020113	ddx56	98	64.685	Astatotilapia_calliptera
ENSG00000136271	DDX56	97	65.193	ENSAMXG00000019357	ddx56	99	60.541	Astyanax_mexicanus
ENSG00000136271	DDX56	100	95.467	ENSBTAG00000010602	DDX56	100	93.053	Bos_taurus
ENSG00000136271	DDX56	98	43.377	WBGene00016073	C24H12.4	86	41.324	Caenorhabditis_elegans
ENSG00000136271	DDX56	100	97.867	ENSCJAG00000012233	DDX56	100	97.623	Callithrix_jacchus
ENSG00000136271	DDX56	84	91.541	ENSCAFG00000029295	DDX56	100	90.157	Canis_familiaris
ENSG00000136271	DDX56	100	91.733	ENSCAFG00020019695	DDX56	100	86.861	Canis_lupus_dingo
ENSG00000136271	DDX56	100	95.200	ENSCHIG00000014261	DDX56	100	92.687	Capra_hircus
ENSG00000136271	DDX56	100	97.600	ENSTSYG00000008048	DDX56	100	96.344	Carlito_syrichta
ENSG00000136271	DDX56	90	91.036	ENSCAPG00000006286	DDX56	100	89.641	Cavia_aperea
ENSG00000136271	DDX56	100	93.600	ENSCPOG00000003359	DDX56	100	90.128	Cavia_porcellus
ENSG00000136271	DDX56	100	97.333	ENSCCAG00000025303	DDX56	100	96.709	Cebus_capucinus
ENSG00000136271	DDX56	100	98.933	ENSCATG00000039389	DDX56	100	98.720	Cercocebus_atys
ENSG00000136271	DDX56	100	95.733	ENSCLAG00000007666	DDX56	100	92.687	Chinchilla_lanigera
ENSG00000136271	DDX56	100	98.933	ENSCSAG00000015636	DDX56	100	98.903	Chlorocebus_sabaeus
ENSG00000136271	DDX56	96	74.576	ENSCPBG00000024556	DDX56	97	69.301	Chrysemys_picta_bellii
ENSG00000136271	DDX56	98	57.333	ENSCING00000005185	-	97	56.548	Ciona_intestinalis
ENSG00000136271	DDX56	100	54.427	ENSCSAVG00000011266	-	99	54.455	Ciona_savignyi
ENSG00000136271	DDX56	100	98.933	ENSCANG00000028187	DDX56	100	98.422	Colobus_angolensis_palliatus
ENSG00000136271	DDX56	100	93.600	ENSCGRG00001019019	Ddx56	100	90.494	Cricetulus_griseus_chok1gshd
ENSG00000136271	DDX56	100	93.600	ENSCGRG00000011870	Ddx56	100	90.494	Cricetulus_griseus_crigri
ENSG00000136271	DDX56	98	71.978	ENSCSEG00000008368	ddx56	98	64.568	Cynoglossus_semilaevis
ENSG00000136271	DDX56	98	68.681	ENSCVAG00000006499	ddx56	98	64.674	Cyprinodon_variegatus
ENSG00000136271	DDX56	99	65.574	ENSDARG00000020913	ddx56	98	64.364	Danio_rerio
ENSG00000136271	DDX56	90	91.597	ENSDNOG00000036526	DDX56	99	90.909	Dasypus_novemcinctus
ENSG00000136271	DDX56	100	95.676	ENSDORG00000026173	-	100	95.676	Dipodomys_ordii
ENSG00000136271	DDX56	99	50.806	FBgn0001565	Hlc	89	49.605	Drosophila_melanogaster
ENSG00000136271	DDX56	97	63.802	ENSETEG00000019559	-	100	60.842	Echinops_telfairi
ENSG00000136271	DDX56	99	80.054	ENSETEG00000002969	-	83	81.034	Echinops_telfairi
ENSG00000136271	DDX56	99	60.836	ENSEBUG00000009986	ddx56	99	59.528	Eptatretus_burgeri
ENSG00000136271	DDX56	100	96.267	ENSEASG00005017795	DDX56	100	93.784	Equus_asinus_asinus
ENSG00000136271	DDX56	100	96.000	ENSECAG00000019897	DDX56	100	93.688	Equus_caballus
ENSG00000136271	DDX56	90	93.838	ENSEEUG00000004849	DDX56	100	91.966	Erinaceus_europaeus
ENSG00000136271	DDX56	99	68.267	ENSELUG00000004150	ddx56	97	65.876	Esox_lucius
ENSG00000136271	DDX56	100	94.133	ENSFCAG00000010261	DDX56	99	90.842	Felis_catus
ENSG00000136271	DDX56	100	94.667	ENSFDAG00000007128	DDX56	100	91.956	Fukomys_damarensis
ENSG00000136271	DDX56	99	66.844	ENSFHEG00000018008	ddx56	95	68.273	Fundulus_heteroclitus
ENSG00000136271	DDX56	98	68.132	ENSGAFG00000006906	ddx56	97	62.152	Gambusia_affinis
ENSG00000136271	DDX56	98	72.283	ENSGAGG00000006789	DDX56	93	71.098	Gopherus_agassizii
ENSG00000136271	DDX56	100	100.000	ENSGGOG00000012031	DDX56	100	100.000	Gorilla_gorilla
ENSG00000136271	DDX56	99	65.873	ENSHBUG00000015246	ddx56	92	62.209	Haplochromis_burtoni
ENSG00000136271	DDX56	100	94.133	ENSHGLG00000017271	DDX56	100	91.590	Heterocephalus_glaber_female
ENSG00000136271	DDX56	100	94.133	ENSHGLG00100015731	DDX56	100	91.590	Heterocephalus_glaber_male
ENSG00000136271	DDX56	98	68.132	ENSHCOG00000001685	ddx56	97	64.325	Hippocampus_comes
ENSG00000136271	DDX56	99	65.027	ENSIPUG00000006602	ddx56	97	61.939	Ictalurus_punctatus
ENSG00000136271	DDX56	100	94.400	ENSSTOG00000000464	DDX56	100	92.505	Ictidomys_tridecemlineatus
ENSG00000136271	DDX56	100	93.600	ENSJJAG00000014269	Ddx56	100	91.160	Jaculus_jaculus
ENSG00000136271	DDX56	97	68.156	ENSKMAG00000016611	ddx56	98	64.973	Kryptolebias_marmoratus
ENSG00000136271	DDX56	96	68.927	ENSLBEG00000026281	ddx56	98	63.738	Labrus_bergylta
ENSG00000136271	DDX56	96	71.348	ENSLACG00000015551	DDX56	97	66.969	Latimeria_chalumnae
ENSG00000136271	DDX56	98	69.613	ENSLOCG00000015185	ddx56	99	63.958	Lepisosteus_oculatus
ENSG00000136271	DDX56	99	95.161	ENSLAFG00000018206	DDX56	99	92.066	Loxodonta_africana
ENSG00000136271	DDX56	100	98.933	ENSMFAG00000041001	DDX56	100	98.537	Macaca_fascicularis
ENSG00000136271	DDX56	100	98.667	ENSMMUG00000002645	DDX56	100	98.355	Macaca_mulatta
ENSG00000136271	DDX56	100	98.933	ENSMNEG00000028492	DDX56	100	98.355	Macaca_nemestrina
ENSG00000136271	DDX56	100	98.933	ENSMLEG00000043591	DDX56	100	98.720	Mandrillus_leucophaeus
ENSG00000136271	DDX56	99	66.667	ENSMAMG00000007776	ddx56	98	64.568	Mastacembelus_armatus
ENSG00000136271	DDX56	98	67.403	ENSMZEG00005009813	ddx56	98	64.685	Maylandia_zebra
ENSG00000136271	DDX56	80	86.585	ENSMAUG00000019569	-	89	91.026	Mesocricetus_auratus
ENSG00000136271	DDX56	100	97.067	ENSMICG00000005550	DDX56	100	95.464	Microcebus_murinus
ENSG00000136271	DDX56	100	94.595	ENSMOCG00000016782	Ddx56	100	91.042	Microtus_ochrogaster
ENSG00000136271	DDX56	97	68.715	ENSMMOG00000009654	ddx56	94	68.400	Mola_mola
ENSG00000136271	DDX56	100	76.268	ENSMODG00000016137	DDX56	100	76.268	Monodelphis_domestica
ENSG00000136271	DDX56	98	68.306	ENSMALG00000016910	ddx56	99	64.706	Monopterus_albus
ENSG00000136271	DDX56	100	94.054	MGP_CAROLIEiJ_G0016069	Ddx56	100	90.859	Mus_caroli
ENSG00000136271	DDX56	100	93.514	ENSMUSG00000004393	Ddx56	100	90.859	Mus_musculus
ENSG00000136271	DDX56	100	93.514	MGP_PahariEiJ_G0016822	Ddx56	100	90.676	Mus_pahari
ENSG00000136271	DDX56	100	93.514	MGP_SPRETEiJ_G0016911	Ddx56	100	90.859	Mus_spretus
ENSG00000136271	DDX56	100	92.533	ENSMPUG00000018196	DDX56	88	90.311	Mustela_putorius_furo
ENSG00000136271	DDX56	100	94.400	ENSMLUG00000003509	DDX56	100	91.956	Myotis_lucifugus
ENSG00000136271	DDX56	100	94.667	ENSNGAG00000018785	Ddx56	100	92.139	Nannospalax_galili
ENSG00000136271	DDX56	98	67.403	ENSNBRG00000002656	ddx56	92	67.015	Neolamprologus_brichardi
ENSG00000136271	DDX56	100	99.029	ENSNLEG00000003816	DDX56	100	99.029	Nomascus_leucogenys
ENSG00000136271	DDX56	100	83.243	ENSMEUG00000006788	DDX56	100	77.823	Notamacropus_eugenii
ENSG00000136271	DDX56	100	91.351	ENSOPRG00000000292	-	100	90.494	Ochotona_princeps
ENSG00000136271	DDX56	100	95.467	ENSODEG00000014807	DDX56	100	95.467	Octodon_degus
ENSG00000136271	DDX56	99	66.577	ENSONIG00000011509	ddx56	98	65.736	Oreochromis_niloticus
ENSG00000136271	DDX56	68	82.900	ENSOANG00000010592	-	99	82.900	Ornithorhynchus_anatinus
ENSG00000136271	DDX56	67	88.406	ENSOANG00000020827	-	100	74.312	Ornithorhynchus_anatinus
ENSG00000136271	DDX56	99	71.850	ENSOANG00000015987	-	95	71.240	Ornithorhynchus_anatinus
ENSG00000136271	DDX56	89	87.273	ENSOANG00000006320	-	100	70.544	Ornithorhynchus_anatinus
ENSG00000136271	DDX56	100	91.467	ENSOCUG00000022918	DDX56	100	91.042	Oryctolagus_cuniculus
ENSG00000136271	DDX56	99	68.351	ENSORLG00000001434	ddx56	97	66.300	Oryzias_latipes
ENSG00000136271	DDX56	99	68.351	ENSORLG00020015718	ddx56	95	65.642	Oryzias_latipes_hni
ENSG00000136271	DDX56	99	68.351	ENSORLG00015003004	ddx56	93	66.300	Oryzias_latipes_hsok
ENSG00000136271	DDX56	99	68.617	ENSOMEG00000022072	ddx56	97	65.996	Oryzias_melastigma
ENSG00000136271	DDX56	100	95.200	ENSOGAG00000009981	DDX56	100	94.333	Otolemur_garnettii
ENSG00000136271	DDX56	100	95.200	ENSOARG00000015240	DDX56	100	92.870	Ovis_aries
ENSG00000136271	DDX56	100	99.029	ENSPPAG00000029147	DDX56	100	99.029	Pan_paniscus
ENSG00000136271	DDX56	100	78.689	ENSPPAG00000031263	-	100	78.506	Pan_paniscus
ENSG00000136271	DDX56	100	93.600	ENSPPRG00000014594	DDX56	99	90.316	Panthera_pardus
ENSG00000136271	DDX56	90	89.916	ENSPTIG00000019500	DDX56	92	88.559	Panthera_tigris_altaica
ENSG00000136271	DDX56	94	80.888	ENSPTRG00000052765	-	100	80.695	Pan_troglodytes
ENSG00000136271	DDX56	100	99.634	ENSPTRG00000019147	DDX56	100	99.634	Pan_troglodytes
ENSG00000136271	DDX56	100	98.933	ENSPANG00000002446	DDX56	100	98.355	Papio_anubis
ENSG00000136271	DDX56	99	66.048	ENSPKIG00000018998	ddx56	98	64.545	Paramormyrops_kingsleyae
ENSG00000136271	DDX56	98	66.851	ENSPMGG00000017421	ddx56	99	64.432	Periophthalmus_magnuspinnatus
ENSG00000136271	DDX56	99	84.783	ENSPEMG00000018351	-	96	88.163	Peromyscus_maniculatus_bairdii
ENSG00000136271	DDX56	100	88.267	ENSPCIG00000009336	DDX56	100	84.783	Phascolarctos_cinereus
ENSG00000136271	DDX56	98	68.508	ENSPFOG00000018658	ddx56	97	64.909	Poecilia_formosa
ENSG00000136271	DDX56	98	68.508	ENSPLAG00000019208	ddx56	97	64.909	Poecilia_latipinna
ENSG00000136271	DDX56	98	68.508	ENSPMEG00000001775	ddx56	97	64.909	Poecilia_mexicana
ENSG00000136271	DDX56	99	66.935	ENSPREG00000015142	ddx56	97	64.498	Poecilia_reticulata
ENSG00000136271	DDX56	100	99.200	ENSPPYG00000017591	DDX56	100	99.086	Pongo_abelii
ENSG00000136271	DDX56	97	91.927	ENSPCAG00000011499	DDX56	100	90.512	Procavia_capensis
ENSG00000136271	DDX56	100	97.333	ENSPCOG00000024864	DDX56	100	96.252	Propithecus_coquereli
ENSG00000136271	DDX56	100	91.892	ENSPVAG00000000791	DDX56	88	93.023	Pteropus_vampyrus
ENSG00000136271	DDX56	98	66.851	ENSPNYG00000019212	ddx56	98	64.505	Pundamilia_nyererei
ENSG00000136271	DDX56	99	64.973	ENSPNAG00000025446	ddx56	99	64.126	Pygocentrus_nattereri
ENSG00000136271	DDX56	100	94.595	ENSRNOG00000004670	Ddx56	100	91.408	Rattus_norvegicus
ENSG00000136271	DDX56	100	98.933	ENSRBIG00000030140	DDX56	100	98.720	Rhinopithecus_bieti
ENSG00000136271	DDX56	100	98.400	ENSRROG00000044428	DDX56	100	98.355	Rhinopithecus_roxellana
ENSG00000136271	DDX56	96	46.083	YLR276C	-	98	42.295	Saccharomyces_cerevisiae
ENSG00000136271	DDX56	100	97.600	ENSSBOG00000034339	DDX56	100	97.075	Saimiri_boliviensis_boliviensis
ENSG00000136271	DDX56	90	85.714	ENSSHAG00000016615	DDX56	98	84.797	Sarcophilus_harrisii
ENSG00000136271	DDX56	99	65.957	ENSSFOG00015012795	ddx56	98	65.209	Scleropages_formosus
ENSG00000136271	DDX56	98	68.508	ENSSMAG00000011280	ddx56	98	64.493	Scophthalmus_maximus
ENSG00000136271	DDX56	98	69.613	ENSSDUG00000023597	ddx56	98	64.991	Seriola_dumerili
ENSG00000136271	DDX56	98	69.613	ENSSLDG00000018369	ddx56	98	64.991	Seriola_lalandi_dorsalis
ENSG00000136271	DDX56	75	90.286	ENSSARG00000014363	DDX56	79	88.950	Sorex_araneus
ENSG00000136271	DDX56	99	69.892	ENSSPUG00000000784	DDX56	96	68.670	Sphenodon_punctatus
ENSG00000136271	DDX56	98	67.582	ENSSPAG00000009392	ddx56	96	66.541	Stegastes_partitus
ENSG00000136271	DDX56	100	94.164	ENSSSCG00000016745	DDX56	100	92.532	Sus_scrofa
ENSG00000136271	DDX56	66	69.118	ENSTGUG00000016252	-	99	69.118	Taeniopygia_guttata
ENSG00000136271	DDX56	98	68.681	ENSTRUG00000018623	ddx56	99	64.404	Takifugu_rubripes
ENSG00000136271	DDX56	98	67.582	ENSTNIG00000013593	ddx56	99	62.100	Tetraodon_nigroviridis
ENSG00000136271	DDX56	100	94.667	ENSTBEG00000007119	DDX56	100	92.870	Tupaia_belangeri
ENSG00000136271	DDX56	90	92.997	ENSTTRG00000010552	DDX56	100	91.543	Tursiops_truncatus
ENSG00000136271	DDX56	100	93.867	ENSUAMG00000014194	DDX56	100	91.590	Ursus_americanus
ENSG00000136271	DDX56	100	93.867	ENSUMAG00000009666	DDX56	100	91.590	Ursus_maritimus
ENSG00000136271	DDX56	72	97.297	ENSVPAG00000000136	-	58	97.297	Vicugna_pacos
ENSG00000136271	DDX56	100	92.267	ENSVVUG00000011905	DDX56	100	90.128	Vulpes_vulpes
ENSG00000136271	DDX56	99	67.380	ENSXETG00000019000	ddx56	99	66.849	Xenopus_tropicalis
ENSG00000136271	DDX56	98	68.508	ENSXCOG00000017413	ddx56	97	64.165	Xiphophorus_couchianus
ENSG00000136271	DDX56	98	68.508	ENSXMAG00000018749	ddx56	97	64.126	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004004	ATP-dependent RNA helicase activity	10749921.	TAS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005730	nucleolus	-	IDA	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0010976	positive regulation of neuron projection development	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr7	44570780	Nonsense_Mutation	novel	R329_G330ins*	0.26
BRCA	chr7	44572593	Missense_Mutation	NA	E179Q	0.27	ResIII
BRCA	chr7	44566476	Missense_Mutation	NA	K513R	0.11
BRCA	chr7	44572407	Silent	rs144360195	L195L	0.34
BRCA	chr7	44571704	Silent	rs767650743	P226P	0.23
CESC	chr7	44565936	3'UTR	novel		0.32
CESC	chr7	44569894	Silent	rs151083458	R378R	0.32
COAD	chr7	44568965	Missense_Mutation	NA	A441T	0.27
COAD	chr7	44569138	Missense_Mutation	NA	R429C	0.36
COAD	chr7	44569894	Silent	rs151083458	R378R	0.27
COAD	chr7	44574017	5'Flank	novel		0.38
COAD	chr7	44572427	Missense_Mutation	rs62459150	R189W	0.33	ResIII
COAD	chr7	44572942	Frame_Shift_Del	NA	*R111Gfs21**	0.38	ResIII
COAD	chr7	44569887	Missense_Mutation	novel	N381D	0.24
COAD	chr7	44571499	Missense_Mutation	rs200177535	R295C	0.14
COAD	chr7	44573732	Silent	novel	L25L	0.13
ESCA	chr7	44571556	Missense_Mutation	novel	L276V	0.17
ESCA	chr7	44573838	Missense_Mutation	novel	Q20E	0.19
GBM	chr7	44572375	Missense_Mutation	NA	A206V	0.26	ResIII
GBM	chr7	44570780	Missense_Mutation	novel	G330R	0.08
GBM	chr7	44572609	Silent	novel	S173S	0.16
GBM	chr7	44572603	Silent	novel	G175G	0.08
GBM	chr7	44568917	Missense_Mutation	novel	S457P	0.09
GBM	chr7	44571676	Frame_Shift_Ins	novel	*V236Mfs22**	0.08
GBM	chr7	44569843	Silent	novel	F395F	0.65
GBM	chr7	44571505	Missense_Mutation	novel	P293S	0.15
GBM	chr7	44570011	Splice_Region	novel		0.18
GBM	chr7	44570009	Splice_Region	novel		0.06
GBM	chr7	44571563	Silent	NA	R273R	0.11
HNSC	chr7	44572941	Missense_Mutation	rs759267727	R111Q	0.3	ResIII
HNSC	chr7	44570776	Missense_Mutation	rs770985431	R331Q	0.3
HNSC	chr7	44569816	Silent	novel	L404L	0.48
HNSC	chr7	44569137	Missense_Mutation	novel	R429L	0.44
KICH	chr7	44574037	5'Flank	novel		0.21
KIRP	chr7	44568198	Missense_Mutation	NA	D470A	0.16
LGG	chr7	44568959	Missense_Mutation	NA	R443W	0.25
LGG	chr7	44572426	Missense_Mutation	rs140918826	R189Q	0.32	ResIII
LIHC	chr7	44572658	Missense_Mutation	NA	R157L	0.23	ResIII
LIHC	chr7	44570041	Silent	NA	P366P	0.33
LIHC	chr7	44573945	5'UTR	rs761331041		0.28
LUAD	chr7	44573922	5'UTR	novel		0.13
LUAD	chr7	44570825	Frame_Shift_Del	novel	*T315Lfs35**	0.49
LUSC	chr7	44572629	Missense_Mutation	NA	E167K	0.22	ResIII
LUSC	chr7	44573595	Silent	NA	L70L	0.29
OV	chr7	44572896	Missense_Mutation	novel	S126F	0.23	ResIII
OV	chr7	44573756	Intron	novel		0.04
OV	chr7	44573014	Missense_Mutation	novel	V87F	0.05	ResIII
OV	chr7	44570029	Missense_Mutation	novel	I370M	0.73
OV	chr7	44570768	Missense_Mutation	novel	K334E	0.29
OV	chr7	44569860	Frame_Shift_Ins	novel	*L390Tfs12**	0.04
OV	chr7	44569821	Missense_Mutation	novel	L403V	0.26
OV	chr7	44568957	Silent	novel	R443R	0.16
PAAD	chr7	44571646	Missense_Mutation	novel	L246I	0.16
PAAD	chr7	44572647	Missense_Mutation	novel	E161K	0.18	ResIII
PRAD	chr7	44571560	Silent	novel	L274L	0.34
PRAD	chr7	44572426	Missense_Mutation	rs140918826	R189Q	0.08	ResIII
PRAD	chr7	44572697	Missense_Mutation	NA	R144H	0.57	ResIII
READ	chr7	44572729	Missense_Mutation	NA	E133D	0.49	ResIII
SARC	chr7	44573719	Missense_Mutation	novel	R29Q	0.28
SKCM	chr7	44572381	Missense_Mutation	NA	V204A	0.26	ResIII
SKCM	chr7	44571593	Silent	novel	L263L	0.37
SKCM	chr7	44571499	Missense_Mutation	rs200177535	R295C	0.15
SKCM	chr7	44568174	Missense_Mutation	novel	L478P	0.08
SKCM	chr7	44569150	Missense_Mutation	novel	G425S	0.16
SKCM	chr7	44566010	Missense_Mutation	NA	P546S	0.08
SKCM	chr7	44572659	Missense_Mutation	NA	R157C	0.09	ResIII
SKCM	chr7	44569842	Missense_Mutation	novel	H396Y	0.44
STAD	chr7	44573019	Missense_Mutation	NA	G85D	0.12	ResIII
STAD	chr7	44573598	Silent	rs769845263	L69L	0.29
STAD	chr7	44570024	Missense_Mutation	rs144918436	R372Q	0.35
STAD	chr7	44573604	Missense_Mutation	novel	Q67H	0.36	ResIII
STAD	chr7	44573873	Missense_Mutation	novel	G8V	0.44
STAD	chr7	44572659	Missense_Mutation	NA	R157C	0.26	ResIII
STAD	chr7	44571495	Missense_Mutation	NA	S296Y	0.07
STAD	chr7	44568204	Missense_Mutation	NA	P468H	0.23
STAD	chr7	44570024	Missense_Mutation	novel	R372L	0.2
STAD	chr7	44571653	Silent	rs776086145	D243D	0.27
THCA	chr7	44568182	Silent	novel	R475R	0.07
THCA	chr7	44569000	Splice_Region	novel		0.1
UCEC	chr7	44566478	Missense_Mutation	novel	K512N	0.48
UCEC	chr7	44568183	Missense_Mutation	rs188954038	R475Q	0.42
UCEC	chr7	44569893	Missense_Mutation	NA	A379T	0.39
UCEC	chr7	44568225	Splice_Site	novel	X462_splice	0.33
UCEC	chr7	44568181	Missense_Mutation	novel	H476Y	0.12
UCEC	chr7	44572911	Missense_Mutation	novel	A121D	0.29	ResIII
UCEC	chr7	44570024	Missense_Mutation	rs144918436	R372Q	0.33
UCEC	chr7	44568982	Missense_Mutation	novel	R435H	0.44
UCEC	chr7	44571531	Missense_Mutation	novel	P284H	0.13
UCEC	chr7	44572659	Missense_Mutation	NA	R157C	0.44	ResIII
UCEC	chr7	44572391	Frame_Shift_Ins	novel	N201*	0.45	ResIII
UCEC	chr7	44566030	Missense_Mutation	novel	K539T	0.49
UCEC	chr7	44566032	Missense_Mutation	novel	K538N	0.18
UCEC	chr7	44566460	Silent	novel	C518C	0.14
UCEC	chr7	44572419	Nonsense_Mutation	novel	Y191*	0.27	ResIII
UCEC	chr7	44573707	Missense_Mutation	NA	I33S	0.4	ResIII
UCEC	chr7	44572659	Missense_Mutation	NA	R157C	0.08	ResIII
UCEC	chr7	44572939	Missense_Mutation	NA	D112Y	0.2	ResIII
UCEC	chr7	44569154	Silent	rs367859317	I423I	0.26
UCEC	chr7	44573650	Missense_Mutation	novel	R52H	0.22	ResIII
UCEC	chr7	44570094	Missense_Mutation	NA	I349V	0.31
UCEC	chr7	44569154	Silent	rs367859317	I423I	0.51
UCEC	chr7	44572889	Splice_Site	novel	X128_splice	0.35
UCS	chr7	44569138	Missense_Mutation	novel	R429S	0.21

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
THCA	DEL	0	0.27619

Survival Analysis

Cancer	P-value	Q-value
ACC	0.00014	Kaplan-Meier Survival Analysis
HNSC	0.0036	Kaplan-Meier Survival Analysis
SKCM	0.047	Kaplan-Meier Survival Analysis
PRAD	0.015	Kaplan-Meier Survival Analysis
LUSC	0.038	Kaplan-Meier Survival Analysis
TGCT	0.041	Kaplan-Meier Survival Analysis
COAD	0.038	Kaplan-Meier Survival Analysis
PAAD	0.0011	Kaplan-Meier Survival Analysis
KICH	0.043	Kaplan-Meier Survival Analysis
GBM	0.015	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
DLBC	0.015	Kaplan-Meier Survival Analysis
LGG	0.00061	Kaplan-Meier Survival Analysis
LUAD	0.00019	Kaplan-Meier Survival Analysis
UVM	0.00012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742