EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136381 (Gene tree)
Gene ID: 3658
Gene Symbol: IREB2
Alias: IRP2
Full Name: iron responsive element binding protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 64,026 bases
Position: chr15:78,437,431-78,501,456
Accession: 6115
RBP type: canonical RBP
Summary: The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000258886	Aconitase	PF00330.20	1.6e-150	1	2
ENSP00000258886	Aconitase	PF00330.20	1.6e-150	2	2
ENSP00000452938	Aconitase	PF00330.20	1.1e-53	1	2
ENSP00000452938	Aconitase	PF00330.20	1.1e-53	2	2
ENSP00000258886	Aconitase_C	PF00694.19	1.5e-41	1	1
ENSP00000453863	Aconitase_C	PF00694.19	4.9e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9988751	Hypoxia post-translationally activates iron-regulatory protein 2.	J Biol Chem	1999 Feb 19	Hanson ES	-
8961933	Expression and biochemical characterization of iron regulatory proteins 1 and 2 in Saccharomyces cerevisiae.	Biochemistry	1996 Dec 10	Phillips JD	-
7665579	Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome.	J Biol Chem	1995 Sep 15	Guo B	-
12855587	Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.	Blood	2003 Nov 1	Schneider BD	-
19223469	Cysteine oxidation regulates the RNA-binding activity of iron regulatory protein 2.	Mol Cell Biol	2009 Apr	Zumbrennen KB	doi: 10.1128/MCB.00004-09
18574241	Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.	J Biol Chem	2008 Aug 29	Wallander ML	doi: 10.1074/jbc.M803005200
25120486	The IRP/IRE system in vivo: insights from mouse models.	Front Pharmacol	2014 Jul 28	Wilkinson N	doi: 10.3389/fphar.2014.00176
8633068	Differences in the RNA binding sites of iron regulatory proteins and potential target diversity.	Proc Natl Acad Sci U S A	1996 Apr 30	Butt J	-
9516462	Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation.	J Biol Chem	1998 Mar 27	Hanson ES	-
16914832	Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease.	J Alzheimers Dis	2006 Aug	Coon KD	-
28287180	Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue.	Sci Rep	2017 Mar 13	Morrow JD	doi: 10.1038/srep44232.
8710843	Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.	Proc Natl Acad Sci U S A	1996 Aug 6	Hentze MW	-
7890603	Translational repressor activity is equivalent and is quantitatively predicted by in vitro RNA binding for two iron-responsive element-binding proteins, IRP1 and IRP2.	J Biol Chem	1995 Mar 10	Kim HY	-
12572672	Role of nitric oxide in cellular iron metabolism.	Biometals	2003 Mar	Kim S	-
12547230	Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis.	Blood Cells Mol Dis	2002 Nov-Dec	Kim S	-
10692416	Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2.	J Biol Chem	2000 Mar 3	Kim S	-
14726953	Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.	EMBO J	2004 Jan 28	Meyron-Holtz EG	-
19021541	Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease.	Biochem Soc Trans	2008 Dec	Rogers JT	doi: 10.1042/BST0361282.
25548934	Electrophoretic mobility shift assay (EMSA) for the study of RNA-protein interactions: the IRE/IRP example.	J Vis Exp	2014 Dec 3	Fillebeen C	doi: 10.3791/52230.
7544791	Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron. IRP-2 inactivation requires translation of another protein.	J Biol Chem	1995 Sep 1	Henderson BR	-
7489724	Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.	EMBO J	1995 Nov 1	Iwai K	-
10095770	Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption.	Eur J Biochem	1999 Mar	Schumann K	-
9867873	Thioredoxin activation of iron regulatory proteins. Redox regulation of RNA binding after exposure to nitric oxide.	J Biol Chem	1999 Jan 1	Oliveira L	-
9868172	Iron regulatory proteins, iron responsive elements and iron homeostasis.	J Nutr	1998 Dec	Eisenstein RS	-
9545264	Converse modulation of IRP1 and IRP2 by immunological stimuli in murine RAW 264.7 macrophages.	J Biol Chem	1998 Apr 17	Bouton C	-
9482759	Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver.	J Nutr	1998 Mar	Chen OS	-
9242665	Redox modulation of iron regulatory proteins by peroxynitrite.	J Biol Chem	1997 Aug 8	Bouton C	-
10440237	Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.	Gene Expr	1999	Hanson ES	-
9039823	Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver.	J Nutr	1997 Feb	Chen OS	-
8994263	Interaction between iron-regulatory proteins and their RNA target sequences, iron-responsive elements.	Prog Mol Subcell Biol	1997	Henderson BR	-
8977218	Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13.	J Immunol	1997 Jan 1	Weiss G	-
8617762	Iron regulatory proteins 1 and 2 bind distinct sets of RNA target sequences.	J Biol Chem	1996 Mar 1	Henderson BR	-
8639920	Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells.	Blood	1996 Apr 1	Phillips JD	-
7622457	Characterization and expression of iron regulatory protein 2 (IRP2). Presence of multiple IRP2 transcripts regulated by intracellular iron levels.	J Biol Chem	1995 Jul 14	Guo B	-
12592010	A high-capacity RNA affinity column for the purification of human IRP1 and IRP2 overexpressed in Pichia pastoris.	RNA	2003 Mar	Allerson CR	-
16511074	Crystallization and preliminary X-ray diffraction data for the aconitase form of human iron-regulatory protein 1.	Acta Crystallogr Sect F Struct Biol Cryst Commun	2005 May 1	Dupuy J	-
16479012	Sodium nitroprusside promotes IRP2 degradation via an increase in intracellular iron and in the absence of S nitrosylation at C178.	Mol Cell Biol	2006 Mar	Wang J	-
11969379	Role of hypolipidemic drug clofibrate in altering iron regulatory proteins IRP1 and IRP2 activities and hepatic iron metabolism in rats fed a low-iron diet.	Toxicol Appl Pharmacol	2002 Apr 15	Huang HL	-
11807826	Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE-expressing cells.	J Cell Physiol	2002 Feb	Roy CN	-
10816424	Oxalomalate, a competitive inhibitor of aconitase, modulates the RNA-binding activity of iron-regulatory proteins.	Biochem J	2000 Jun 1	Festa M	-
16819431	[The role of iron regulatory proteins (IRPs) in the regulation of systemic iron homeostasis: lessons from studies on IRP1 and IRP2 knock out mice].	Postepy Hig Med Dosw (Online)	2006	Lipinski P	-
15604406	Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.	Science	2004 Dec 17	Meyron-Holtz EG	-
15178542	Influence of gestational age and fetal iron status on IRP activity and iron transporter protein expression in third-trimester human placenta.	Am J Physiol Regul Integr Comp Physiol	2004 Oct	Bradley J	-
16737972	Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression.	J Biol Chem	2006 Aug 11	Harrison-Findik DD	-
19945401	How iron controls iron.	Cell Metab	2009 Dec	Kuhn LC	doi: 10.1016/j.cmet.2009.11.005.
17822790	HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells.	Biochim Biophys Acta	2008 Feb	Zumbrennen KB	-
17760563	Human iron regulatory protein 2 is easily cleaved in its specific domain: consequences for the haem binding properties of the protein.	Biochem J	2007 Dec 15	Dycke C	-
21333694	2,3,7,8-Tetrachlorodibenzo-p-dioxin impairs iron homeostasis by modulating iron-related proteins expression and increasing the labile iron pool in mammalian cells.	Biochim Biophys Acta	2011 May	Santamaria R	doi: 10.1016/j.bbamcr.2011.02.003
20558735	Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1.	J Biol Chem	2010 Oct 8	Cho HH	doi: 10.1074/jbc.M110.149161
23520538	2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes BHV-1 infection in mammalian cells by interfering with iron homeostasis regulation.	PLoS One	2013	Fiorito F	doi: 10.1371/journal.pone.0058845
28768766	A synergistic role of IRP1 and FBXL5 proteins in coordinating iron metabolism during cell proliferation.	J Biol Chem	2017 Sep 22	Johnson NB	doi: 10.1074/jbc.M117.785741
28939752	Checks and balances for the iron bank.	J Biol Chem	2017 Sep 22	Outten CE	doi: 10.1074/jbc.H117.785741.
9657110	Lack of coordinate control of ferritin and transferrin receptor expression during rat liver regeneration.	Hepatology	1998 Jul	Cairo G	-
19800271	A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.	Blood Cells Mol Dis	2010 Jan 15	Cao W	doi: 10.1016/j.bcmd.2009.09.003
20214491	Iron regulatory proteins: from molecular mechanisms to drug development.	Antioxid Redox Signal	2010 Nov 15	Recalcati S	doi: 10.1089/ars.2009.2983.
26797126	Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.	J Biol Chem	2016 Mar 25	Okazaki F	doi: 10.1074/jbc.M115.713412
25771171	Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.	Neurobiol Dis	2015 Sep	Ghosh MC	doi: 10.1016/j.nbd.2015.02.026

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560454	IREB2-209	545	-	-	- (aa)	-	-
ENST00000560440	IREB2-208	4396	-	ENSP00000452938	343 (aa)	-	P48200
ENST00000558570	IREB2-203	2917	-	ENSP00000454063	220 (aa)	-	H0YNL8
ENST00000559427	IREB2-206	608	-	-	- (aa)	-	-
ENST00000559091	IREB2-204	268	-	ENSP00000453863	89 (aa)	-	H0YN46
ENST00000559215	IREB2-205	572	-	ENSP00000453532	46 (aa)	-	H0YMA8
ENST00000558525	IREB2-202	865	-	ENSP00000453058	51 (aa)	-	H0YL48
ENST00000258886	IREB2-201	6354	-	ENSP00000258886	963 (aa)	-	UPI0004620DD2
ENST00000560840	IREB2-210	558	-	ENSP00000453172	38 (aa)	-	H0YLE0
ENST00000559676	IREB2-207	973	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136381's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136381	Smoking	1.1700000E-008	-
ENSG00000136381	Airway Obstruction	1.8460000E-006	22837378
ENSG00000136381	Airway Obstruction	1.8030000E-006	22837378
ENSG00000136381	Airway Obstruction	1.7910000E-006	22837378
ENSG00000136381	Airway Obstruction	1.9950000E-006	22837378
ENSG00000136381	Airway Obstruction	1.7410000E-006	22837378
ENSG00000136381	Bronchodilator Agents	8E-8	26634245
ENSG00000136381	Forced Expiratory Volume	8E-8	26634245
ENSG00000136381	Bronchodilator Agents	7E-8	26634245
ENSG00000136381	Lung Volume Measurements	7E-8	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Lung Volume Measurements	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	8E-8	26634245
ENSG00000136381	Lung Volume Measurements	8E-8	26634245
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Lung Volume Measurements	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-10	26634245
ENSG00000136381	Lung Volume Measurements	3E-10	26634245
ENSG00000136381	Bronchodilator Agents	2E-10	26634245
ENSG00000136381	Lung Volume Measurements	2E-10	26634245
ENSG00000136381	Bronchodilator Agents	4E-7	26634245
ENSG00000136381	Forced Expiratory Volume	4E-7	26634245
ENSG00000136381	Bronchodilator Agents	4E-9	26634245
ENSG00000136381	Forced Expiratory Volume	4E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-6	26634245
ENSG00000136381	Forced Expiratory Volume	1E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Forced Expiratory Volume	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	8E-10	26634245
ENSG00000136381	Forced Expiratory Volume	8E-10	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	1E-6	22080838
ENSG00000136381	Bronchodilator Agents	1E-6	26634245
ENSG00000136381	Lung Volume Measurements	1E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-12	26634245
ENSG00000136381	Lung Volume Measurements	1E-12	26634245
ENSG00000136381	Bronchodilator Agents	1E-8	26634245
ENSG00000136381	Forced Expiratory Volume	1E-8	26634245
ENSG00000136381	Bronchodilator Agents	6E-8	26634245
ENSG00000136381	Lung Volume Measurements	6E-8	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Forced Expiratory Volume	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	8E-7	26634245
ENSG00000136381	Forced Expiratory Volume	8E-7	26634245
ENSG00000136381	Bronchodilator Agents	1E-8	26634245
ENSG00000136381	Lung Volume Measurements	1E-8	26634245
ENSG00000136381	Bronchodilator Agents	9E-8	26634245
ENSG00000136381	Lung Volume Measurements	9E-8	26634245
ENSG00000136381	Bronchodilator Agents	2E-13	26634245
ENSG00000136381	Forced Expiratory Volume	2E-13	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Lung Volume Measurements	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	1E-13	26634245
ENSG00000136381	Forced Expiratory Volume	1E-13	26634245
ENSG00000136381	Forced Expiratory Volume	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	5E-9	26634245
ENSG00000136381	Forced Expiratory Volume	5E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-13	26634245
ENSG00000136381	Forced Expiratory Volume	2E-13	26634245
ENSG00000136381	Bronchodilator Agents	6E-8	26634245
ENSG00000136381	Lung Volume Measurements	6E-8	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Forced Expiratory Volume	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-14	26634245
ENSG00000136381	Forced Expiratory Volume	2E-14	26634245
ENSG00000136381	Bronchodilator Agents	5E-7	26634245
ENSG00000136381	Forced Expiratory Volume	5E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Forced Expiratory Volume	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	9E-9	26634245
ENSG00000136381	Forced Expiratory Volume	9E-9	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Forced Expiratory Volume	4E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-9	26634245
ENSG00000136381	Lung Volume Measurements	4E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	6E-7	26634245
ENSG00000136381	Forced Expiratory Volume	6E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-8	26634245
ENSG00000136381	Lung Volume Measurements	7E-8	26634245
ENSG00000136381	Bronchodilator Agents	6E-9	26634245
ENSG00000136381	Lung Volume Measurements	6E-9	26634245
ENSG00000136381	Bronchodilator Agents	5E-8	26634245
ENSG00000136381	Lung Volume Measurements	5E-8	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Forced Expiratory Volume	4E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Lung Volume Measurements	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-7	26634245
ENSG00000136381	Forced Expiratory Volume	7E-7	26634245
ENSG00000136381	Bronchodilator Agents	4E-9	26634245
ENSG00000136381	Forced Expiratory Volume	4E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-8	26634245
ENSG00000136381	Lung Volume Measurements	4E-8	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	5E-13	26634245
ENSG00000136381	Lung Volume Measurements	5E-13	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-8	26634245
ENSG00000136381	Forced Expiratory Volume	4E-8	26634245
ENSG00000136381	Bronchodilator Agents	5E-7	26634245
ENSG00000136381	Forced Expiratory Volume	5E-7	26634245
ENSG00000136381	Bronchodilator Agents	3E-10	26634245
ENSG00000136381	Lung Volume Measurements	3E-10	26634245
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Lung Volume Measurements	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-9	26634245
ENSG00000136381	Lung Volume Measurements	4E-9	26634245
ENSG00000136381	Forced Expiratory Volume	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-7	26634245
ENSG00000136381	Forced Expiratory Volume	7E-7	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	7E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-9	26634245
ENSG00000136381	Forced Expiratory Volume	7E-9	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Lung Volume Measurements	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	8E-9	26634245
ENSG00000136381	Forced Expiratory Volume	8E-9	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-8	20173748
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Lung Volume Measurements	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-10	26634245
ENSG00000136381	Lung Volume Measurements	7E-10	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Lung Volume Measurements	2E-12	26634245
ENSG00000136381	Forced Expiratory Volume	7E-8	26634245
ENSG00000136381	Bronchodilator Agents	1E-10	26634245
ENSG00000136381	Forced Expiratory Volume	1E-10	26634245
ENSG00000136381	Bronchodilator Agents	8E-7	26634245
ENSG00000136381	Forced Expiratory Volume	8E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-10	26634245
ENSG00000136381	Lung Volume Measurements	2E-10	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	6E-9	26634245
ENSG00000136381	Forced Expiratory Volume	6E-9	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	5E-9	26634245
ENSG00000136381	Forced Expiratory Volume	5E-9	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Lung Volume Measurements	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	7E-7	26634245
ENSG00000136381	Forced Expiratory Volume	7E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Lung Volume Measurements	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-10	26634245
ENSG00000136381	Lung Volume Measurements	2E-10	26634245
ENSG00000136381	Bronchodilator Agents	9E-7	26634245
ENSG00000136381	Forced Expiratory Volume	9E-7	26634245
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Lung Volume Measurements	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Forced Expiratory Volume	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	6E-7	26634245
ENSG00000136381	Forced Expiratory Volume	6E-7	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Longevity	5E-6	27015805
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Forced Expiratory Volume	5E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	6E-7	26634245
ENSG00000136381	Forced Expiratory Volume	6E-7	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	5E-8	25241909
ENSG00000136381	Bronchodilator Agents	2E-13	26634245
ENSG00000136381	Forced Expiratory Volume	2E-13	26634245
ENSG00000136381	Bronchodilator Agents	1E-12	26634245
ENSG00000136381	Forced Expiratory Volume	1E-12	26634245
ENSG00000136381	Bronchodilator Agents	9E-11	26634245
ENSG00000136381	Forced Expiratory Volume	9E-11	26634245
ENSG00000136381	Bronchodilator Agents	1E-8	26634245
ENSG00000136381	Forced Expiratory Volume	1E-8	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	8E-11	26634245
ENSG00000136381	Forced Expiratory Volume	8E-11	26634245
ENSG00000136381	Bronchodilator Agents	8E-13	26634245
ENSG00000136381	Lung Volume Measurements	8E-13	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Lung Volume Measurements	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	9E-8	26634245
ENSG00000136381	Lung Volume Measurements	9E-8	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	9E-7	26634245
ENSG00000136381	Forced Expiratory Volume	9E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-8	26634245
ENSG00000136381	Lung Volume Measurements	7E-8	26634245
ENSG00000136381	Bronchodilator Agents	7E-9	26634245
ENSG00000136381	Forced Expiratory Volume	7E-9	26634245
ENSG00000136381	Bronchodilator Agents	4E-7	26634245
ENSG00000136381	Forced Expiratory Volume	4E-7	26634245
ENSG00000136381	Bronchodilator Agents	4E-7	26634245
ENSG00000136381	Lung Volume Measurements	4E-7	26634245
ENSG00000136381	Bronchodilator Agents	4E-12	26634245
ENSG00000136381	Forced Expiratory Volume	4E-12	26634245
ENSG00000136381	Bronchodilator Agents	7E-10	26634245
ENSG00000136381	Lung Volume Measurements	7E-10	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Lung Volume Measurements	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Lung Volume Measurements	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Lung Volume Measurements	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	6E-9	26634245
ENSG00000136381	Forced Expiratory Volume	6E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Lung Volume Measurements	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Forced Expiratory Volume	4E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-9	26634245
ENSG00000136381	Forced Expiratory Volume	1E-9	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-10	26634245
ENSG00000136381	Lung Volume Measurements	2E-10	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-10	26634245
ENSG00000136381	Lung Volume Measurements	3E-10	26634245
ENSG00000136381	Bronchodilator Agents	5E-7	26634245
ENSG00000136381	Forced Expiratory Volume	5E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-8	26634245
ENSG00000136381	Lung Volume Measurements	7E-8	26634245
ENSG00000136381	Bronchodilator Agents	1E-12	26634245
ENSG00000136381	Forced Expiratory Volume	1E-12	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Forced Expiratory Volume	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	6E-9	26634245
ENSG00000136381	Forced Expiratory Volume	6E-9	26634245
ENSG00000136381	Forced Expiratory Volume	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	4E-9	26634245
ENSG00000136381	Forced Expiratory Volume	4E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	9E-7	26634245
ENSG00000136381	Forced Expiratory Volume	9E-7	26634245
ENSG00000136381	Bronchodilator Agents	7E-7	26634245
ENSG00000136381	Forced Expiratory Volume	7E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-12	26634245
ENSG00000136381	Lung Volume Measurements	2E-12	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Forced Expiratory Volume	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	5E-6	26634245
ENSG00000136381	Lung Volume Measurements	5E-6	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	7E-9	26634245
ENSG00000136381	Forced Expiratory Volume	7E-9	26634245
ENSG00000136381	Bronchodilator Agents	3E-10	26634245
ENSG00000136381	Lung Volume Measurements	3E-10	26634245
ENSG00000136381	Bronchodilator Agents	5E-7	26634245
ENSG00000136381	Forced Expiratory Volume	5E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	4E-10	26634245
ENSG00000136381	Lung Volume Measurements	4E-10	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Lung Volume Measurements	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-13	26634245
ENSG00000136381	Forced Expiratory Volume	3E-13	26634245
ENSG00000136381	Bronchodilator Agents	4E-6	26634245
ENSG00000136381	Lung Volume Measurements	4E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-12	26634245
ENSG00000136381	Lung Volume Measurements	3E-12	26634245
ENSG00000136381	Bronchodilator Agents	1E-7	26634245
ENSG00000136381	Forced Expiratory Volume	1E-7	26634245
ENSG00000136381	Bronchodilator Agents	6E-9	26634245
ENSG00000136381	Forced Expiratory Volume	6E-9	26634245
ENSG00000136381	Bronchodilator Agents	7E-7	26634245
ENSG00000136381	Forced Expiratory Volume	7E-7	26634245
ENSG00000136381	Bronchodilator Agents	6E-8	26634245
ENSG00000136381	Lung Volume Measurements	6E-8	26634245
ENSG00000136381	Bronchodilator Agents	7E-9	26634245
ENSG00000136381	Forced Expiratory Volume	7E-9	26634245
ENSG00000136381	Bronchodilator Agents	9E-7	26634245
ENSG00000136381	Forced Expiratory Volume	9E-7	26634245
ENSG00000136381	Bronchodilator Agents	1E-9	26634245
ENSG00000136381	Lung Volume Measurements	1E-9	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Forced Expiratory Volume	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	3E-6	26634245
ENSG00000136381	Bronchodilator Agents	1E-13	26634245
ENSG00000136381	Forced Expiratory Volume	1E-13	26634245
ENSG00000136381	Bronchodilator Agents	1E-6	26634245
ENSG00000136381	Lung Volume Measurements	1E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	1E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-13	26634245
ENSG00000136381	Forced Expiratory Volume	3E-13	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-7	26634245
ENSG00000136381	Forced Expiratory Volume	2E-7	26634245
ENSG00000136381	Pulmonary Artery	2E-8	25101718
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-8	25101718
ENSG00000136381	Bronchodilator Agents	1E-11	26634245
ENSG00000136381	Lung Volume Measurements	1E-11	26634245
ENSG00000136381	Bronchodilator Agents	4E-7	26634245
ENSG00000136381	Forced Expiratory Volume	4E-7	26634245
ENSG00000136381	Bronchodilator Agents	2E-6	26634245
ENSG00000136381	Lung Volume Measurements	2E-6	26634245
ENSG00000136381	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000136381	Bronchodilator Agents	3E-6	26634245
ENSG00000136381	Lung Volume Measurements	3E-6	26634245

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136381	rs12592111	15	78475004	?	Parental longevity (combined parental age at death)	27015805	[0.02-0.05] unit increase	0.03526	EFO_0007796
ENSG00000136381	rs11858836	15	78490935	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17483929	15	78450034	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs72738736	15	78472780	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs55983731	15	78442927	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2568494	15	78448622	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs72738718	15	78443096	C	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17405217	15	78438807	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2656065	15	78458207	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17483548	15	78437971	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit decrease	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2089162	15	78447421	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17484524	15	78480334	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs56219465	15	78450237	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs7181486	15	78449276	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2009746	15	78461760	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs1504550	15	78473908	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17484235	15	78469072	C	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2656052	15	78448590	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2938670	15	78448346	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs72738732	15	78459846	C	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17483721	15	78441389	T	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs17483686	15	78441048	A	Post bronchodilator FEV1/FVC ratio in COPD	26634245	NR unit increase	0.012	GO_0097366\|EFO_0000341\|EFO_0004713
ENSG00000136381	rs2568494	15	78448622		Pre bronchodilator FEV1	26634245	unit decrease	0.07201	EFO_0004314
ENSG00000136381	rs2656065	15	78458207		Pre bronchodilator FEV1	26634245	unit decrease	0.07111	EFO_0004314
ENSG00000136381	rs17483721	15	78441389		Pre bronchodilator FEV1	26634245	unit decrease	0.07077	EFO_0004314
ENSG00000136381	rs17483929	15	78450034		Pre bronchodilator FEV1	26634245	unit decrease	0.07044	EFO_0004314
ENSG00000136381	rs11858836	15	78490935	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs17405217	15	78438807	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs17483548	15	78437971	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs17483929	15	78450034	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs72738736	15	78472780	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs55983731	15	78442927	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs72738718	15	78443096	C	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656065	15	78458207	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2568494	15	78448622	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs12904234	15	78487042	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs12592111	15	78475004	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656071	15	78453001	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2568488	15	78444251	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2568485	15	78459772	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs11637656	15	78459619	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs4299116	15	78473852	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs12910910	15	78475508	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs1504549	15	78474287	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs1062980	15	78500185	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs36146269	15	78487168	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs8042238	15	78481929	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs4887059	15	78489753	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs965604	15	78496881	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs13180	15	78497146	T	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs924840	15	78439466	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs10851906	15	78482334	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2958719	15	78450687	A	Post bronchodilator FEV1/FVC ratio	26634245	unit decrease	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs4887057	15	78468576	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.009	GO_0097366\|EFO_0004713
ENSG00000136381	rs1964678	15	78461658	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs8043227	15	78476529	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs12593229	15	78472948	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs8042260	15	78482032	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs12899351	15	78500056	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs12916801	15	78476788	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2036533	15	78489345	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2938671	15	78440412	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2938674	15	78465571	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2568490	15	78446028	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656073	15	78449934	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656074	15	78449042	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.01	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656052	15	78448590	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2938670	15	78448346	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs12903295	15	78486630	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs12903285	15	78486611	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs958025	15	78467006	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs7174348	15	78500097	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs2915695	15	78447129	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs16969894	15	78484114	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.011	GO_0097366\|EFO_0004713
ENSG00000136381	rs17483721	15	78441389	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs56219465	15	78450237	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs7181486	15	78449276	T	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs17483686	15	78441048	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.012	GO_0097366\|EFO_0004713
ENSG00000136381	rs2009746	15	78461760	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.013	GO_0097366\|EFO_0004713
ENSG00000136381	rs17484524	15	78480334	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs1504550	15	78473908	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs17484235	15	78469072	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs72738732	15	78459846	C	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs2089162	15	78447421	A	Post bronchodilator FEV1/FVC ratio	26634245	unit increase	0.015	GO_0097366\|EFO_0004713
ENSG00000136381	rs2656065	15	78458207	A	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.046	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs2568494	15	78448622	A	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.044	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs72738718	15	78443096	C	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.044	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs17483929	15	78450034	A	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.044	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs56219465	15	78450237	A	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs7181486	15	78449276	T	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.044	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs2656052	15	78448590	A	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs2938670	15	78448346	T	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.045	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs2009746	15	78461760	A	Post bronchodilator FEV1 in COPD	26634245	NR unit increase	0.046	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000136381	rs7181486	15	78449276	C	Pulmonary artery enlargement in chronic obstructive pulmonary disease	25101718	[1.20-1.45]	1.32	EFO_0006347\|EFO_0000341
ENSG00000136381	rs8042238	15	78481929	T	Chronic obstructive pulmonary disease	25241909	[1.16-1.37]	1.26	EFO_0000341
ENSG00000136381	rs13180	15	78497146	?	Chronic obstructive pulmonary disease	20173748	[1.18-1.43]	1.3	EFO_0000341
ENSG00000136381	rs11858836	15	78490935	A	Current cigarettes per day in chronic obstructive pulmonary disease	29767774	[NR] unit increase	0.1	EFO_0000341\|EFO_0005671
ENSG00000136381	rs17405217	15	78438807	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.074	EFO_0004314\|GO_0097366
ENSG00000136381	rs17483548	15	78437971	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.074	EFO_0004314\|GO_0097366
ENSG00000136381	rs11858836	15	78490935	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.074	EFO_0004314\|GO_0097366
ENSG00000136381	rs72738736	15	78472780	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs17483929	15	78450034	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs55983731	15	78442927	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs72738718	15	78443096	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656065	15	78458207	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.062	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568494	15	78448622	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.062	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656071	15	78453001	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.059	EFO_0004314\|GO_0097366
ENSG00000136381	rs12904234	15	78487042	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568488	15	78444251	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568485	15	78459772	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs10851906	15	78482334	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs924840	15	78439466	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs12592111	15	78475004	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.057	EFO_0004314\|GO_0097366
ENSG00000136381	rs28602670	15	78475825	C	Post bronchodilator FEV1	26634245	NR unit decrease	0.056	EFO_0004314\|GO_0097366
ENSG00000136381	rs28480606	15	78469971	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.055	EFO_0004314\|GO_0097366
ENSG00000136381	rs1062980	15	78500185	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2958719	15	78450687	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656069	15	78453365	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs8042238	15	78481929	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs36146269	15	78487168	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs4887059	15	78489753	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs4299116	15	78473852	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs11637656	15	78459619	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568493	15	78447891	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568483	15	78460001	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs1504549	15	78474287	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs13180	15	78497146	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs965604	15	78496881	A	Post bronchodilator FEV1	26634245	NR unit decrease	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs12910910	15	78475508	T	Post bronchodilator FEV1	26634245	NR unit decrease	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs4887057	15	78468576	A	Post bronchodilator FEV1	26634245	NR unit increase	0.049	EFO_0004314\|GO_0097366
ENSG00000136381	rs12593229	15	78472948	T	Post bronchodilator FEV1	26634245	NR unit increase	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs12899351	15	78500056	T	Post bronchodilator FEV1	26634245	NR unit increase	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs8043227	15	78476529	C	Post bronchodilator FEV1	26634245	NR unit increase	0.052	EFO_0004314\|GO_0097366
ENSG00000136381	rs1964678	15	78461658	A	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs8042260	15	78482032	A	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs12916801	15	78476788	A	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs11072766	15	78479204	T	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs7174190	15	78471275	T	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs12101809	15	78487459	T	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs28511883	15	78491341	T	Post bronchodilator FEV1	26634245	NR unit increase	0.053	EFO_0004314\|GO_0097366
ENSG00000136381	rs2938674	15	78465571	A	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656072	15	78451950	A	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656073	15	78449934	T	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656074	15	78449042	T	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs2568490	15	78446028	T	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs35031105	15	78480464	T	Post bronchodilator FEV1	26634245	NR unit increase	0.054	EFO_0004314\|GO_0097366
ENSG00000136381	rs12903295	15	78486630	A	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs2915695	15	78447129	T	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs16969894	15	78484114	T	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs958025	15	78467006	T	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs2036533	15	78489345	A	Post bronchodilator FEV1	26634245	NR unit increase	0.058	EFO_0004314\|GO_0097366
ENSG00000136381	rs2938671	15	78440412	A	Post bronchodilator FEV1	26634245	NR unit increase	0.059	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656070	15	78437910	A	Post bronchodilator FEV1	26634245	NR unit increase	0.059	EFO_0004314\|GO_0097366
ENSG00000136381	rs12903285	15	78486611	A	Post bronchodilator FEV1	26634245	NR unit increase	0.06	EFO_0004314\|GO_0097366
ENSG00000136381	rs2938670	15	78448346	T	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000136381	rs2656052	15	78448590	A	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000136381	rs7174348	15	78500097	A	Post bronchodilator FEV1	26634245	NR unit increase	0.062	EFO_0004314\|GO_0097366
ENSG00000136381	rs7181486	15	78449276	T	Post bronchodilator FEV1	26634245	NR unit increase	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs56219465	15	78450237	A	Post bronchodilator FEV1	26634245	NR unit increase	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs17483686	15	78441048	A	Post bronchodilator FEV1	26634245	NR unit increase	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs17483721	15	78441389	T	Post bronchodilator FEV1	26634245	NR unit increase	0.064	EFO_0004314\|GO_0097366
ENSG00000136381	rs2009746	15	78461760	A	Post bronchodilator FEV1	26634245	NR unit increase	0.071	EFO_0004314\|GO_0097366
ENSG00000136381	rs2089162	15	78447421	A	Post bronchodilator FEV1	26634245	NR unit increase	0.073	EFO_0004314\|GO_0097366
ENSG00000136381	rs17484235	15	78469072	C	Post bronchodilator FEV1	26634245	NR unit increase	0.074	EFO_0004314\|GO_0097366
ENSG00000136381	rs72738732	15	78459846	C	Post bronchodilator FEV1	26634245	NR unit increase	0.074	EFO_0004314\|GO_0097366
ENSG00000136381	rs1504550	15	78473908	A	Post bronchodilator FEV1	26634245	NR unit increase	0.075	EFO_0004314\|GO_0097366
ENSG00000136381	rs17484524	15	78480334	A	Post bronchodilator FEV1	26634245	NR unit increase	0.076	EFO_0004314\|GO_0097366
ENSG00000136381	rs11858836	15	78490935	?	Chronic obstructive pulmonary disease	22080838	[1.13-1.47]	1.29	EFO_0000341

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136381's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000136381	IREB2	100	64.103	ENSG00000122729	ACO1	99	53.918

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136381	IREB2	97	72.973	ENSAPOG00000016684	ireb2	99	69.108	Acanthochromis_polyacanthus
ENSG00000136381	IREB2	97	72.973	ENSAPOG00000020564	ireb2	99	68.416	Acanthochromis_polyacanthus
ENSG00000136381	IREB2	97	72.973	ENSAPOG00000015501	-	99	68.416	Acanthochromis_polyacanthus
ENSG00000136381	IREB2	100	100.000	ENSAMEG00000012645	IREB2	100	92.946	Ailuropoda_melanoleuca
ENSG00000136381	IREB2	99	69.119	ENSACIG00000012557	ireb2	99	69.119	Amphilophus_citrinellus
ENSG00000136381	IREB2	97	75.676	ENSAOCG00000000407	ireb2	99	69.215	Amphiprion_ocellaris
ENSG00000136381	IREB2	97	75.676	ENSAPEG00000009121	ireb2	99	68.795	Amphiprion_percula
ENSG00000136381	IREB2	97	70.270	ENSATEG00000021145	ireb2	99	66.563	Anabas_testudineus
ENSG00000136381	IREB2	97	70.270	ENSATEG00000021210	ireb2	99	65.428	Anabas_testudineus
ENSG00000136381	IREB2	99	82.812	ENSAPLG00000016388	IREB2	99	82.812	Anas_platyrhynchos
ENSG00000136381	IREB2	100	100.000	ENSANAG00000021994	IREB2	100	97.614	Aotus_nancymaae
ENSG00000136381	IREB2	97	72.973	ENSACLG00000024688	ireb2	99	69.016	Astatotilapia_calliptera
ENSG00000136381	IREB2	100	71.053	ENSAMXG00000008756	ireb2	99	68.470	Astyanax_mexicanus
ENSG00000136381	IREB2	100	100.000	ENSBTAG00000002504	IREB2	100	96.162	Bos_taurus
ENSG00000136381	IREB2	100	97.718	ENSCJAG00000010259	IREB2	100	97.718	Callithrix_jacchus
ENSG00000136381	IREB2	100	97.368	ENSCAFG00000001766	IREB2	100	92.427	Canis_familiaris
ENSG00000136381	IREB2	100	97.368	ENSCAFG00020021072	IREB2	100	92.427	Canis_lupus_dingo
ENSG00000136381	IREB2	100	100.000	ENSCHIG00000023111	IREB2	100	96.058	Capra_hircus
ENSG00000136381	IREB2	100	100.000	ENSTSYG00000011729	IREB2	100	96.584	Carlito_syrichta
ENSG00000136381	IREB2	100	94.737	ENSCAPG00000011854	IREB2	99	85.461	Cavia_aperea
ENSG00000136381	IREB2	100	94.737	ENSCPOG00000013905	IREB2	100	94.465	Cavia_porcellus
ENSG00000136381	IREB2	100	100.000	ENSCCAG00000021202	IREB2	100	98.237	Cebus_capucinus
ENSG00000136381	IREB2	100	100.000	ENSCATG00000033462	IREB2	100	99.170	Cercocebus_atys
ENSG00000136381	IREB2	100	94.737	ENSCLAG00000008985	IREB2	100	92.635	Chinchilla_lanigera
ENSG00000136381	IREB2	100	100.000	ENSCSAG00000014904	IREB2	100	99.274	Chlorocebus_sabaeus
ENSG00000136381	IREB2	100	97.368	ENSCHOG00000004107	IREB2	99	92.050	Choloepus_hoffmanni
ENSG00000136381	IREB2	100	89.474	ENSCPBG00000024247	IREB2	99	86.667	Chrysemys_picta_bellii
ENSG00000136381	IREB2	100	100.000	ENSCANG00000029420	IREB2	100	99.066	Colobus_angolensis_palliatus
ENSG00000136381	IREB2	100	97.368	ENSCGRG00001019234	Ireb2	100	93.568	Cricetulus_griseus_chok1gshd
ENSG00000136381	IREB2	100	97.368	ENSCGRG00000016786	Ireb2	100	93.568	Cricetulus_griseus_crigri
ENSG00000136381	IREB2	97	70.270	ENSCSEG00000003080	ireb2	99	67.150	Cynoglossus_semilaevis
ENSG00000136381	IREB2	97	70.270	ENSCVAG00000010739	ireb2	97	68.087	Cyprinodon_variegatus
ENSG00000136381	IREB2	100	68.421	ENSDARG00000021466	ireb2	99	65.975	Danio_rerio
ENSG00000136381	IREB2	100	100.000	ENSDNOG00000009614	IREB2	100	94.522	Dasypus_novemcinctus
ENSG00000136381	IREB2	92	90.244	ENSDORG00000014339	Ireb2	100	80.793	Dipodomys_ordii
ENSG00000136381	IREB2	100	89.474	ENSETEG00000012717	IREB2	74	93.996	Echinops_telfairi
ENSG00000136381	IREB2	100	95.436	ENSEASG00005015622	IREB2	100	95.436	Equus_asinus_asinus
ENSG00000136381	IREB2	100	95.436	ENSECAG00000016731	IREB2	100	97.222	Equus_caballus
ENSG00000136381	IREB2	90	87.500	ENSEEUG00000007999	IREB2	99	84.045	Erinaceus_europaeus
ENSG00000136381	IREB2	100	71.053	ENSELUG00000023666	ireb2	99	68.459	Esox_lucius
ENSG00000136381	IREB2	100	92.739	ENSFCAG00000001921	IREB2	100	92.739	Felis_catus
ENSG00000136381	IREB2	100	81.579	ENSFALG00000010640	IREB2	99	72.897	Ficedula_albicollis
ENSG00000136381	IREB2	100	94.737	ENSFDAG00000009355	IREB2	100	92.324	Fukomys_damarensis
ENSG00000136381	IREB2	99	68.607	ENSFHEG00000017905	ireb2	96	69.322	Fundulus_heteroclitus
ENSG00000136381	IREB2	100	68.421	ENSGMOG00000009184	ireb2	99	65.321	Gadus_morhua
ENSG00000136381	IREB2	99	82.261	ENSGALG00000035462	IREB2	99	82.261	Gallus_gallus
ENSG00000136381	IREB2	97	75.676	ENSGAFG00000005145	ireb2	97	66.599	Gambusia_affinis
ENSG00000136381	IREB2	97	72.973	ENSGACG00000007341	ireb2	96	71.028	Gasterosteus_aculeatus
ENSG00000136381	IREB2	100	89.474	ENSGAGG00000006117	IREB2	96	84.959	Gopherus_agassizii
ENSG00000136381	IREB2	100	100.000	ENSGGOG00000015650	IREB2	100	99.688	Gorilla_gorilla
ENSG00000136381	IREB2	97	72.973	ENSHBUG00000007184	ireb2	99	68.912	Haplochromis_burtoni
ENSG00000136381	IREB2	100	94.737	ENSHGLG00000000783	Ireb2	100	92.842	Heterocephalus_glaber_female
ENSG00000136381	IREB2	100	94.737	ENSHGLG00100019429	Ireb2	100	92.842	Heterocephalus_glaber_male
ENSG00000136381	IREB2	100	71.053	ENSHCOG00000007424	ireb2	99	66.455	Hippocampus_comes
ENSG00000136381	IREB2	99	66.943	ENSIPUG00000014808	Ireb2	99	66.805	Ictalurus_punctatus
ENSG00000136381	IREB2	100	96.369	ENSSTOG00000009273	IREB2	100	96.369	Ictidomys_tridecemlineatus
ENSG00000136381	IREB2	100	100.000	ENSJJAG00000019768	Ireb2	99	87.164	Jaculus_jaculus
ENSG00000136381	IREB2	97	72.973	ENSKMAG00000016020	ireb2	97	67.946	Kryptolebias_marmoratus
ENSG00000136381	IREB2	97	78.378	ENSLBEG00000020371	ireb2	99	68.589	Labrus_bergylta
ENSG00000136381	IREB2	100	71.053	ENSLACG00000001182	IREB2	99	69.048	Latimeria_chalumnae
ENSG00000136381	IREB2	100	73.684	ENSLOCG00000015029	ireb2	99	71.146	Lepisosteus_oculatus
ENSG00000136381	IREB2	100	94.737	ENSLAFG00000012839	IREB2	100	95.431	Loxodonta_africana
ENSG00000136381	IREB2	100	100.000	ENSMFAG00000039630	IREB2	100	99.066	Macaca_fascicularis
ENSG00000136381	IREB2	100	100.000	ENSMMUG00000045680	IREB2	100	99.066	Macaca_mulatta
ENSG00000136381	IREB2	100	100.000	ENSMNEG00000039698	IREB2	100	95.954	Macaca_nemestrina
ENSG00000136381	IREB2	100	100.000	ENSMLEG00000031047	IREB2	100	99.170	Mandrillus_leucophaeus
ENSG00000136381	IREB2	97	72.973	ENSMAMG00000023095	ireb2	99	68.951	Mastacembelus_armatus
ENSG00000136381	IREB2	97	72.973	ENSMZEG00005010935	ireb2	99	69.016	Maylandia_zebra
ENSG00000136381	IREB2	99	82.102	ENSMGAG00000003688	IREB2	99	82.102	Meleagris_gallopavo
ENSG00000136381	IREB2	100	97.368	ENSMAUG00000020717	-	93	92.118	Mesocricetus_auratus
ENSG00000136381	IREB2	100	100.000	ENSMICG00000005757	IREB2	100	96.680	Microcebus_murinus
ENSG00000136381	IREB2	100	94.737	ENSMOCG00000010784	Ireb2	100	92.946	Microtus_ochrogaster
ENSG00000136381	IREB2	97	75.676	ENSMMOG00000001385	ireb2	97	68.737	Mola_mola
ENSG00000136381	IREB2	92	53.659	ENSMODG00000021441	-	100	61.538	Monodelphis_domestica
ENSG00000136381	IREB2	100	89.637	ENSMODG00000011768	IREB2	100	89.637	Monodelphis_domestica
ENSG00000136381	IREB2	95	72.222	ENSMALG00000015314	ireb2	99	66.149	Monopterus_albus
ENSG00000136381	IREB2	100	97.368	MGP_CAROLIEiJ_G0032235	Ireb2	99	93.562	Mus_caroli
ENSG00000136381	IREB2	100	97.368	ENSMUSG00000032293	Ireb2	99	93.666	Mus_musculus
ENSG00000136381	IREB2	100	94.737	MGP_PahariEiJ_G0015103	Ireb2	99	93.146	Mus_pahari
ENSG00000136381	IREB2	100	97.368	MGP_SPRETEiJ_G0033375	Ireb2	99	93.666	Mus_spretus
ENSG00000136381	IREB2	100	100.000	ENSMPUG00000010978	IREB2	95	92.596	Mustela_putorius_furo
ENSG00000136381	IREB2	100	87.629	ENSMLUG00000006783	IREB2	100	87.629	Myotis_lucifugus
ENSG00000136381	IREB2	100	100.000	ENSNGAG00000017333	Ireb2	100	94.295	Nannospalax_galili
ENSG00000136381	IREB2	97	72.973	ENSNBRG00000017676	ireb2	99	71.582	Neolamprologus_brichardi
ENSG00000136381	IREB2	100	100.000	ENSNLEG00000008549	IREB2	100	99.378	Nomascus_leucogenys
ENSG00000136381	IREB2	78	94.444	ENSMEUG00000001630	-	78	94.444	Notamacropus_eugenii
ENSG00000136381	IREB2	100	100.000	ENSOPRG00000000340	IREB2	100	86.307	Ochotona_princeps
ENSG00000136381	IREB2	100	92.012	ENSODEG00000015993	IREB2	100	92.012	Octodon_degus
ENSG00000136381	IREB2	97	72.973	ENSONIG00000012838	ireb2	99	68.976	Oreochromis_niloticus
ENSG00000136381	IREB2	96	88.235	ENSOANG00000003852	-	95	92.593	Ornithorhynchus_anatinus
ENSG00000136381	IREB2	100	89.474	ENSOANG00000013218	-	99	88.150	Ornithorhynchus_anatinus
ENSG00000136381	IREB2	100	100.000	ENSOCUG00000009907	IREB2	100	93.157	Oryctolagus_cuniculus
ENSG00000136381	IREB2	99	68.601	ENSORLG00000001943	ireb2	91	68.601	Oryzias_latipes
ENSG00000136381	IREB2	99	68.601	ENSORLG00020000623	ireb2	96	68.601	Oryzias_latipes_hni
ENSG00000136381	IREB2	99	68.563	ENSORLG00015014057	ireb2	97	68.563	Oryzias_latipes_hsok
ENSG00000136381	IREB2	99	68.601	ENSOMEG00000005120	ireb2	97	68.601	Oryzias_melastigma
ENSG00000136381	IREB2	100	92.658	ENSOGAG00000010622	IREB2	100	92.658	Otolemur_garnettii
ENSG00000136381	IREB2	100	100.000	ENSOARG00000000881	IREB2	100	95.773	Ovis_aries
ENSG00000136381	IREB2	100	99.585	ENSPPAG00000038956	IREB2	100	99.585	Pan_paniscus
ENSG00000136381	IREB2	100	92.739	ENSPPRG00000003145	IREB2	100	92.739	Panthera_pardus
ENSG00000136381	IREB2	100	92.105	ENSPTIG00000021418	IREB2	86	92.484	Panthera_tigris_altaica
ENSG00000136381	IREB2	100	99.585	ENSPTRG00000007342	IREB2	100	99.585	Pan_troglodytes
ENSG00000136381	IREB2	100	100.000	ENSPANG00000015813	IREB2	100	99.170	Papio_anubis
ENSG00000136381	IREB2	100	68.421	ENSPKIG00000012755	ireb2	99	68.607	Paramormyrops_kingsleyae
ENSG00000136381	IREB2	84	93.750	ENSPSIG00000009905	IREB2	98	85.434	Pelodiscus_sinensis
ENSG00000136381	IREB2	97	78.378	ENSPMGG00000016828	ireb2	99	68.054	Periophthalmus_magnuspinnatus
ENSG00000136381	IREB2	100	94.737	ENSPEMG00000020204	Ireb2	100	93.776	Peromyscus_maniculatus_bairdii
ENSG00000136381	IREB2	100	89.474	ENSPCIG00000019022	IREB2	88	88.808	Phascolarctos_cinereus
ENSG00000136381	IREB2	97	72.973	ENSPFOG00000014509	ireb2	97	68.191	Poecilia_formosa
ENSG00000136381	IREB2	97	72.973	ENSPLAG00000002220	ireb2	97	68.295	Poecilia_latipinna
ENSG00000136381	IREB2	97	75.676	ENSPMEG00000010284	ireb2	98	68.571	Poecilia_mexicana
ENSG00000136381	IREB2	97	75.676	ENSPREG00000012857	ireb2	97	68.087	Poecilia_reticulata
ENSG00000136381	IREB2	92	98.780	ENSPPYG00000006696	-	100	99.646	Pongo_abelii
ENSG00000136381	IREB2	100	97.368	ENSPCAG00000001992	IREB2	90	95.926	Procavia_capensis
ENSG00000136381	IREB2	100	100.000	ENSPCOG00000021988	IREB2	100	96.680	Propithecus_coquereli
ENSG00000136381	IREB2	100	100.000	ENSPVAG00000014630	IREB2	87	88.776	Pteropus_vampyrus
ENSG00000136381	IREB2	97	72.973	ENSPNYG00000008976	ireb2	99	68.905	Pundamilia_nyererei
ENSG00000136381	IREB2	100	68.421	ENSPNAG00000027252	ireb2	99	68.182	Pygocentrus_nattereri
ENSG00000136381	IREB2	100	94.737	ENSRNOG00000013271	Ireb2	99	93.769	Rattus_norvegicus
ENSG00000136381	IREB2	100	100.000	ENSRBIG00000033855	IREB2	100	99.170	Rhinopithecus_bieti
ENSG00000136381	IREB2	100	100.000	ENSRROG00000001424	IREB2	100	99.170	Rhinopithecus_roxellana
ENSG00000136381	IREB2	100	100.000	ENSSBOG00000030803	IREB2	100	97.896	Saimiri_boliviensis_boliviensis
ENSG00000136381	IREB2	92	87.805	ENSSHAG00000017480	-	100	92.337	Sarcophilus_harrisii
ENSG00000136381	IREB2	100	86.842	ENSSHAG00000017490	-	99	86.994	Sarcophilus_harrisii
ENSG00000136381	IREB2	100	68.421	ENSSFOG00015022085	ireb2	95	68.998	Scleropages_formosus
ENSG00000136381	IREB2	97	72.973	ENSSMAG00000005657	ireb2	99	68.219	Scophthalmus_maximus
ENSG00000136381	IREB2	97	75.676	ENSSDUG00000023484	ireb2	99	68.486	Seriola_dumerili
ENSG00000136381	IREB2	97	75.676	ENSSLDG00000001705	ireb2	99	68.692	Seriola_lalandi_dorsalis
ENSG00000136381	IREB2	100	97.368	ENSSARG00000001203	IREB2	99	89.946	Sorex_araneus
ENSG00000136381	IREB2	99	83.817	ENSSPUG00000006298	IREB2	99	83.817	Sphenodon_punctatus
ENSG00000136381	IREB2	97	78.378	ENSSPAG00000000877	ireb2	99	69.295	Stegastes_partitus
ENSG00000136381	IREB2	100	97.368	ENSSSCG00000001756	IREB2	100	96.058	Sus_scrofa
ENSG00000136381	IREB2	99	80.689	ENSTGUG00000003332	IREB2	99	80.689	Taeniopygia_guttata
ENSG00000136381	IREB2	97	72.973	ENSTRUG00000015902	ireb2	99	67.459	Takifugu_rubripes
ENSG00000136381	IREB2	97	72.973	ENSTNIG00000008450	-	96	58.436	Tetraodon_nigroviridis
ENSG00000136381	IREB2	100	100.000	ENSTBEG00000010922	IREB2	94	96.154	Tupaia_belangeri
ENSG00000136381	IREB2	100	92.105	ENSTTRG00000000698	IREB2	100	84.336	Tursiops_truncatus
ENSG00000136381	IREB2	100	100.000	ENSUAMG00000017908	IREB2	100	94.481	Ursus_americanus
ENSG00000136381	IREB2	100	100.000	ENSUMAG00000011242	IREB2	100	92.012	Ursus_maritimus
ENSG00000136381	IREB2	100	100.000	ENSVPAG00000008245	IREB2	100	94.775	Vicugna_pacos
ENSG00000136381	IREB2	100	97.368	ENSVVUG00000007811	IREB2	100	93.488	Vulpes_vulpes
ENSG00000136381	IREB2	99	62.391	ENSXETG00000009774	ireb2	99	60.207	Xenopus_tropicalis
ENSG00000136381	IREB2	97	75.676	ENSXCOG00000020858	ireb2	97	67.913	Xiphophorus_couchianus
ENSG00000136381	IREB2	97	75.676	ENSXMAG00000002195	ireb2	97	67.913	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001069	regulatory region RNA binding	21873635.	IBA	Function
GO:0003723	RNA binding	7983023.	IDA	Function
GO:0003723	RNA binding	9924025.	TAS	Function
GO:0003994	aconitate hydratase activity	21873635.	IBA	Function
GO:0005515	protein binding	19762596.19762597.23891004.	IPI	Function
GO:0005737	cytoplasm	7983023.	NAS	Component
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006099	tricarboxylic acid cycle	21873635.	IBA	Process
GO:0006101	citrate metabolic process	21873635.	IBA	Process
GO:0006417	regulation of translation	21873635.	IBA	Process
GO:0006782	protoporphyrinogen IX biosynthetic process	21873635.	IBA	Process
GO:0006826	iron ion transport	9924025.	TAS	Process
GO:0006879	cellular iron ion homeostasis	21873635.	IBA	Process
GO:0006879	cellular iron ion homeostasis	-	TAS	Process
GO:0007420	brain development	21873635.	IBA	Process
GO:0007568	aging	21873635.	IBA	Process
GO:0009791	post-embryonic development	21873635.	IBA	Process
GO:0010040	response to iron(II) ion	21873635.	IBA	Process
GO:0010041	response to iron(III) ion	21873635.	IBA	Process
GO:0010043	response to zinc ion	21873635.	IBA	Process
GO:0014732	skeletal muscle atrophy	21873635.	IBA	Process
GO:0014823	response to activity	21873635.	IBA	Process
GO:0017148	negative regulation of translation	21873635.	IBA	Process
GO:0030316	osteoclast differentiation	21873635.	IBA	Process
GO:0030350	iron-responsive element binding	21873635.	IBA	Function
GO:0030350	iron-responsive element binding	23891004.	IMP	Function
GO:0030350	iron-responsive element binding	9924025.	TAS	Function
GO:0030371	translation repressor activity	-	IEA	Function
GO:0030424	axon	21873635.	IBA	Component
GO:0032526	response to retinoic acid	21873635.	IBA	Process
GO:0034101	erythrocyte homeostasis	21873635.	IBA	Process
GO:0046688	response to copper ion	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0051539	4 iron, 4 sulfur cluster binding	21873635.	IBA	Function
GO:0071283	cellular response to iron(III) ion	21873635.	IBA	Process
GO:0071287	cellular response to manganese ion	21873635.	IBA	Process
GO:0071300	cellular response to retinoic acid	21873635.	IBA	Process
GO:0071364	cellular response to epidermal growth factor stimulus	21873635.	IBA	Process
GO:0071456	cellular response to hypoxia	21873635.	IBA	Process
GO:0072705	cellular response to mercaptoethanol	21873635.	IBA	Process
GO:0090650	cellular response to oxygen-glucose deprivation	21873635.	IBA	Process
GO:1904373	response to kainic acid	21873635.	IBA	Process
GO:1990910	response to hypobaric hypoxia	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24285726	IRP2 regulates breast tumor growth.	Cancer Res	2014 Jan 15	Wang W	doi: 10.1158/0008-5472.CAN-13-1224
26310313	Susceptibility loci in lung cancer and COPD: association of IREB2 and FAM13A with pulmonary diseases.	Sci Rep	2015 Aug 27	Zi??kowska-Suchanek I	doi: 10.1038/srep13502.
20405006	Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.	PLoS One	2010 Apr 13	Maffettone C	doi: 10.1371/journal.pone.0010163.
28404645	IRP2 as a potential modulator of cell proliferation, apoptosis and prognosis in nonsmall cell lung cancer.	Eur Respir J	2017 Apr 12	Khiroya H	doi: 10.1183/13993003.00711-2016

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr15	78439879	Missense_Mutation	novel	Y35C	0.08	Aconitase
BLCA	chr15	78466411	Missense_Mutation	NA	G184V	0.17
BLCA	chr15	78498141	Nonstop_Mutation	NA	964Qext12	0.13
BLCA	chr15	78490651	Missense_Mutation	novel	E738D	0.5
BLCA	chr15	78473381	Splice_Region	novel	K341K	0.28
BLCA	chr15	78490439	Nonsense_Mutation	novel	W698*	0.48
BLCA	chr15	78463022	Missense_Mutation	novel	W69C	0.52
BLCA	chr15	78490479	Missense_Mutation	novel	D712N	0.48
BLCA	chr15	78498067	Missense_Mutation	NA	S939L	0.14
BLCA	chr15	78488315	Missense_Mutation	NA	D644N	0.2
BLCA	chr15	78498056	Silent	NA	S935S	0.07
BLCA	chr15	78466313	Silent	NA	Q151Q	0.35
BLCA	chr15	78490712	Frame_Shift_Del	novel	*G759Efs13**	0.5
BRCA	chr15	78488249	Missense_Mutation	NA	R622C	0.22
BRCA	chr15	78498113	Missense_Mutation	NA	L954F	0.19
BRCA	chr15	78466312	Missense_Mutation	novel	Q151R	0.05
BRCA	chr15	78483434	Splice_Region	NA	K471K	0.36
BRCA	chr15	78497214	Missense_Mutation	NA	P895R	0.3
BRCA	chr15	78476270	Missense_Mutation	novel	T369S	0.1
BRCA	chr15	78494055	Missense_Mutation	rs200306100	T824M	0.48
BRCA	chr15	78473314	Missense_Mutation	NA	G319E	0.15
BRCA	chr15	78490658	Missense_Mutation	novel	H741N	0.13
BRCA	chr15	78490488	Missense_Mutation	novel	S715A	0.53
BRCA	chr15	78497179	Missense_Mutation	NA	L883F	0.18
BRCA	chr15	78463063	Missense_Mutation	NA	A83V	0.22
BRCA	chr15	78473474	Intron	novel		0.11
BRCA	chr15	78485813	Missense_Mutation	NA	G561A	0.28
BRCA	chr15	78490664	Missense_Mutation	rs755047367	L743V	0.12
BRCA	chr15	78498340	3'UTR	novel		0.2
BRCA	chr15	78465284	Missense_Mutation	NA	M102I	0.19
BRCA	chr15	78498078	Missense_Mutation	NA	D943N	0.03
CESC	chr15	78483335	Silent	NA	L438L	0.09
CESC	chr15	78465377	Silent	novel	D133D	0.49
CESC	chr15	78465343	Missense_Mutation	novel	T122R	0.07
CESC	chr15	78490720	Missense_Mutation	NA	I761M	0.22
CESC	chr15	78501387	3'UTR	novel		0.26
CESC	chr15	78493920	Missense_Mutation	novel	R779H	0.31
CESC	chr15	78498568	3'UTR	novel		0.34
COAD	chr15	78463066	Missense_Mutation	rs142659017	R84H	0.31
COAD	chr15	78488248	Silent	NA	V621V	0.27
COAD	chr15	78478356	Nonsense_Mutation	NA	R419*	0.34
COAD	chr15	78490659	Missense_Mutation	novel	H741R	0.09
COAD	chr15	78498200	3'UTR	novel		0.24
COAD	chr15	78478376	In_Frame_Del	novel	G426del	0.14
COAD	chr15	78490512	Frame_Shift_Del	novel	*F724Lfs48**	0.13
COAD	chr15	78473423	Intron	novel		0.08
COAD	chr15	78498264	3'UTR	novel		0.14
COAD	chr15	78487794	Missense_Mutation	rs746547492	A591T	0.37
COAD	chr15	78488249	Missense_Mutation	NA	R622C	0.26
COAD	chr15	78498235	3'UTR	novel		0.12
ESCA	chr15	78498068	Silent	rs144816277	S939S	0.13
ESCA	chr15	78470545	Silent	novel	L215L	0.1
ESCA	chr15	78483365	Frame_Shift_Del	novel	*R450Dfs8**	0.16
ESCA	chr15	78438239	5'UTR	novel		0.43
ESCA	chr15	78466290	Missense_Mutation	novel	N144Y	0.22
ESCA	chr15	78439819	Missense_Mutation	novel	E15G	0.42	Aconitase
GBM	chr15	78463035	Missense_Mutation	novel	S74R	0.32
GBM	chr15	78473384	Splice_Region	novel		0.22
HNSC	chr15	78487794	Missense_Mutation	rs746547492	A591S	0.17
HNSC	chr15	78476197	Nonsense_Mutation	novel	Q345*	0.09
HNSC	chr15	78488703	Missense_Mutation	novel	E670K	0.26
HNSC	chr15	78490720	Missense_Mutation	NA	I761M	0.36
HNSC	chr15	78490513	Missense_Mutation	novel	F723C	0.25
HNSC	chr15	78466478	Silent	novel	Q206Q	0.33
HNSC	chr15	78473264	Silent	novel	E302E	0.31
HNSC	chr15	78466297	Missense_Mutation	novel	G146A	0.11
KIRC	chr15	78485825	Missense_Mutation	NA	Y565C	0.07
KIRC	chr15	78465388	Nonsense_Mutation	novel	C137delins*	0.05
KIRC	chr15	78487750	Missense_Mutation	novel	Y576C	0.26
KIRC	chr15	78473328	Missense_Mutation	NA	G324W	0.31
KIRP	chr15	78473346	Missense_Mutation	NA	V330I	0.49
KIRP	chr15	78473347	Missense_Mutation	rs371991607	V330A	0.49
KIRP	chr15	78463014	Missense_Mutation	NA	L67I	0.42
KIRP	chr15	78498168	3'UTR	novel		0.35
LGG	chr15	78438350	Missense_Mutation	NA	K5E	0.42	Aconitase
LGG	chr15	78438341	Missense_Mutation	novel	D2N	0.56	Aconitase
LGG	chr15	78490694	Missense_Mutation	NA	D753N	0.36
LGG	chr15	78473414	Intron	novel		0.45
LIHC	chr15	78485799	Silent	rs747554380	Y556Y	0.18
LIHC	chr15	78490429	Missense_Mutation	novel	N695S	0.17
LIHC	chr15	78473320	Missense_Mutation	novel	E321V	0.18
LIHC	chr15	78439841	Missense_Mutation	novel	H22Q	0.26	Aconitase
LIHC	chr15	78466439	Silent	novel	Q193Q	0.1
LIHC	chr15	78476360	Splice_Site	novel	X399_splice	0.41
LUAD	chr15	78473470	Intron	novel		0.29
LUAD	chr15	78473510	Intron	novel		0.38
LUAD	chr15	78465340	Missense_Mutation	rs371029182	P121L	0.06
LUAD	chr15	78471918	Missense_Mutation	novel	G293W	0.13
LUAD	chr15	78498078	Missense_Mutation	novel	D943Y	0.14
LUAD	chr15	78484885	Missense_Mutation	NA	T513I	0.13
LUAD	chr15	78488254	Silent	novel	A623A	0.28
LUAD	chr15	78473338	Missense_Mutation	novel	N327I	0.45
LUAD	chr15	78438347	Missense_Mutation	rs751197364	P4T	0.19	Aconitase
LUSC	chr15	78478332	Missense_Mutation	rs144938417	Y411H	0.32
LUSC	chr15	78490660	Silent	NA	H741H	0.16
LUSC	chr15	78490724	Missense_Mutation	novel	R763G	0.09
LUSC	chr15	78490660	Silent	NA	H741H	0.29
LUSC	chr15	78463058	Silent	NA	F81F	0.37
LUSC	chr15	78490657	Silent	NA	A740A	0.23
LUSC	chr15	78471761	Silent	NA	K240K	0.31
LUSC	chr15	78478338	Nonsense_Mutation	novel	K413*	0.21
LUSC	chr15	78465345	Missense_Mutation	NA	D123H	0.16
OV	chr15	78483408	Missense_Mutation	rs141373267	D463N	0.34
PAAD	chr15	78488190	Missense_Mutation	novel	V602A	0.17
PRAD	chr15	78493995	Frame_Shift_Del	novel	*F805Lfs21**	0.37
PRAD	chr15	78484920	Missense_Mutation	novel	G525C	0.06
READ	chr15	78478357	Missense_Mutation	rs753403583	R419Q	0.07
READ	chr15	78483358	Missense_Mutation	novel	S446T	0.05
READ	chr15	78471846	Missense_Mutation	novel	D269Y	0.46
READ	chr15	78478357	Missense_Mutation	rs753403583	R419Q	0.39
READ	chr15	78497252	Nonsense_Mutation	novel	E908*	0.38
SARC	chr15	78498224	3'UTR	novel		0.24
SKCM	chr15	78478355	Missense_Mutation	novel	F418L	0.37
SKCM	chr15	78478356	Nonsense_Mutation	NA	R419*	0.37
SKCM	chr15	78490444	Missense_Mutation	NA	S700F	0.21
SKCM	chr15	78490647	Missense_Mutation	novel	I737S	0.29
SKCM	chr15	78493937	Missense_Mutation	NA	G785R	0.12
SKCM	chr15	78466384	Missense_Mutation	rs143720317	R175Q	0.42
SKCM	chr15	78485789	Missense_Mutation	NA	V553A	0.5
SKCM	chr15	78488727	Missense_Mutation	rs766036361	H678Y	0.42
SKCM	chr15	78483414	Nonsense_Mutation	NA	Q465*	0.16
SKCM	chr15	78488250	Missense_Mutation	rs777437554	R622H	0.08
SKCM	chr15	78466390	Missense_Mutation	novel	S177F	0.45
SKCM	chr15	78488231	Missense_Mutation	novel	R616C	0.27
SKCM	chr15	78465259	Missense_Mutation	NA	P94L	0.44
SKCM	chr15	78497262	Missense_Mutation	NA	S911F	0.14
SKCM	chr15	78497174	Missense_Mutation	rs772091594	H882Y	0.38
SKCM	chr15	78473268	Frame_Shift_Del	NA	*V304Lfs19**	0.53
SKCM	chr15	78488249	Missense_Mutation	NA	R622C	0.58
SKCM	chr15	78471915	Silent	NA	L292L	0.21
SKCM	chr15	78488660	Silent	rs183041930	T655T	0.37
SKCM	chr15	78488656	Missense_Mutation	NA	P654L	0.37
SKCM	chr15	78463044	Missense_Mutation	NA	E77K	0.21
SKCM	chr15	78478367	Silent	NA	Q422Q	0.26
SKCM	chr15	78493909	Splice_Region	novel	G775G	0.38
STAD	chr15	78462966	Nonsense_Mutation	novel	R51*	0.38
STAD	chr15	78476304	Silent	novel	A380A	0.26
STAD	chr15	78476205	Silent	novel	G347G	0.34
STAD	chr15	78465277	Missense_Mutation	NA	A100V	0.29
STAD	chr15	78487794	Missense_Mutation	rs746547492	A591T	0.15
STAD	chr15	78478356	Nonsense_Mutation	NA	R419*	0.29
STAD	chr15	78485740	Missense_Mutation	rs755226126	R537C	0.23
STAD	chr15	78471752	Silent	novel	R237R	0.19
STAD	chr15	78439800	Missense_Mutation	NA	A9T	0.13	Aconitase
STAD	chr15	78484792	Frame_Shift_Del	novel	*K483Nfs60**	0.45
STAD	chr15	78470593	Frame_Shift_Del	novel	*F232Lfs13**	0.24
STAD	chr15	78465345	Missense_Mutation	novel	D123Y	0.06
STAD	chr15	78473424	Intron	novel		0.25
STAD	chr15	78484908	Missense_Mutation	rs553171458	M521V	0.23
STAD	chr15	78498130	Missense_Mutation	rs375120202	R960Q	0.18
STAD	chr15	78470568	Silent	rs199867160	F222F	0.41
STAD	chr15	78439860	Missense_Mutation	NA	S29P	0.28	Aconitase
STAD	chr15	78439870	Missense_Mutation	NA	G32D	0.48	Aconitase
THCA	chr15	78498152	3'UTR	novel		0.08
THCA	chr15	78476306	Nonsense_Mutation	novel	L382*	0.09
THCA	chr15	78498152	3'UTR	novel		0.07
UCEC	chr15	78494055	Missense_Mutation	rs200306100	T824M	0.47
UCEC	chr15	78494211	Missense_Mutation	rs200881284	K848Q	0.32
UCEC	chr15	78497160	Missense_Mutation	NA	K877T	0.52
UCEC	chr15	78485794	Missense_Mutation	novel	H555Y	0.4
UCEC	chr15	78498603	3'UTR	novel		0.24
UCEC	chr15	78490484	Silent	novel	L713L	0.42
UCEC	chr15	78473485	Intron	novel		0.24
UCEC	chr15	78488713	Missense_Mutation	rs755759523	R673Q	0.27
UCEC	chr15	78476274	Silent	NA	T370T	0.41
UCEC	chr15	78438319	5'UTR	novel		0.22
UCEC	chr15	78439844	Missense_Mutation	NA	K23N	0.13	Aconitase
UCEC	chr15	78465292	Missense_Mutation	novel	A105V	0.17
UCEC	chr15	78498067	Missense_Mutation	NA	S939L	0.52
UCEC	chr15	78497228	Missense_Mutation	NA	D900N	0.35
UCEC	chr15	78471893	Silent	rs761406628	T284T	0.19
UCEC	chr15	78497254	Missense_Mutation	novel	E908D	0.33
UCEC	chr15	78488222	Missense_Mutation	novel	F613V	0.43
UCEC	chr15	78497312	Splice_Site	novel	X927_splice	0.32
UCEC	chr15	78493973	Missense_Mutation	novel	G797C	0.27
UCEC	chr15	78498056	Silent	NA	S935S	0.2
UCEC	chr15	78488216	Frame_Shift_Del	novel	*N612Ifs20**	0.24
UCEC	chr15	78488308	Silent	novel	V641V	0.65
UCEC	chr15	78501296	3'UTR	novel		0.46
UCEC	chr15	78501411	3'UTR	novel		0.25
UCEC	chr15	78494007	Missense_Mutation	novel	F808C	0.47
UCEC	chr15	78493908	Splice_Site	novel	X775_splice	0.43
UCEC	chr15	78498604	3'UTR	novel		0.48
UCEC	chr15	78463066	Missense_Mutation	rs142659017	R84H	0.29
UCEC	chr15	78490495	Missense_Mutation	NA	Y717C	0.31
UCEC	chr15	78473492	Intron	novel		0.2
UCEC	chr15	78484866	Missense_Mutation	novel	A507T	0.41
UCEC	chr15	78463053	Frame_Shift_Del	NA	*F81Sfs22**	0.26
UCEC	chr15	78478357	Missense_Mutation	rs753403583	R419Q	0.25
UCEC	chr15	78476185	Splice_Region	rs770551739		0.23
UCEC	chr15	78478356	Nonsense_Mutation	NA	R419*	0.16
UCEC	chr15	78498137	Missense_Mutation	novel	F962L	0.19
UCEC	chr15	78463066	Missense_Mutation	rs142659017	R84H	0.34
UCEC	chr15	78484805	Missense_Mutation	novel	D486E	0.33
UCEC	chr15	78463053	Frame_Shift_Del	NA	*F81Sfs22**	0.25
UCEC	chr15	78485707	Missense_Mutation	novel	L526I	0.55
UCEC	chr15	78439832	Silent	novel	D19D	0.24
UCEC	chr15	78498212	3'UTR	novel		0.38
UCEC	chr15	78473362	Missense_Mutation	novel	V335D	0.09
UCEC	chr15	78485721	Missense_Mutation	novel	K530N	0.38
UCEC	chr15	78493920	Missense_Mutation	novel	R779H	0.38
UCEC	chr15	78497310	Missense_Mutation	novel	Q927R	0.44
UCEC	chr15	78473481	Intron	novel		0.24
UCEC	chr15	78498067	Missense_Mutation	NA	S939L	0.41
UCEC	chr15	78478317	Missense_Mutation	rs142630681	E406K	0.34
UCEC	chr15	78470579	Missense_Mutation	novel