EuRBPDB

Description

Ensembl ID: ENSG00000136448 (Gene tree)
Gene ID: 4836
Gene Symbol: NMT1
Alias: NMT
Full Name: N-myristoyltransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 57,407 bases
Position: chr17:45,051,610-45,109,016
Accession: 7857
RBP type: non-canonical RBP
Summary: Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26074144	N-Myristoyltransferase 1 enhances human immunodeficiency virus replication through regulation of viral RNA expression level.	Biochem Biophys Res Commun	2015 Aug 7	Ohta H	doi: 10.1016/j.bbrc.2015.06.047

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000590310	NMT1-210	704	-	-	- (aa)	-	-
ENST00000592654	NMT1-212	558	-	ENSP00000466827	72 (aa)	-	K7EN82
ENST00000591931	NMT1-211	748	-	-	- (aa)	-	-
ENST00000587670	NMT1-206	537	-	-	- (aa)	-	-
ENST00000588975	NMT1-208	183	-	-	- (aa)	-	-
ENST00000590114	NMT1-209	666	-	-	- (aa)	-	-
ENST00000592782	NMT1-213	4999	-	ENSP00000468424	496 (aa)	-	P30419
ENST00000588455	NMT1-207	585	-	-	- (aa)	-	-
ENST00000543908	NMT1-202	1066	-	ENSP00000439263	137 (aa)	-	B7Z8J4
ENST00000587120	NMT1-205	573	-	-	- (aa)	-	-
ENST00000585561	NMT1-203	807	-	ENSP00000466777	88 (aa)	-	K7EN42
ENST00000258960	NMT1-201	4879	-	ENSP00000258960	496 (aa)	-	P30419
ENST00000587014	NMT1-204	773	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136448	rs7213273	17	45078546	A	Systolic blood pressure	27618452	[0.28-0.54] mm Hg decrease	0.413	EFO_0006335
ENSG00000136448	rs7213273	17	45078546	A	Diastolic blood pressure	27618452	[0.1-0.27] mm Hg decrease	0.185	EFO_0006336
ENSG00000136448	rs7222240	17	45058827	G	Craniofacial microsomia	26853712	[1.36-2.20]	1.73	Orphanet_141136
ENSG00000136448	rs2301597	17	45095905	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000136448	rs77981506	17	45078579	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000136448	rs2301597	17	45095905	?	Cardiovascular disease	30595370			EFO_0000319
ENSG00000136448	rs12951622	17	45069108	G	Pulse pressure	30578418	[0.29-0.51] mmHg decrease	0.4001	EFO_0005763
ENSG00000136448	rs6503413	17	45063974	T	Systolic blood pressure	30578418	[0.19-0.32] mmHg decrease	0.2513	EFO_0006335

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136448	NMT1	79	57.215	WBGene00020549	nmt-1	88	57.215	Caenorhabditis_elegans
ENSG00000136448	NMT1	80	65.000	FBgn0020392	Nmt	84	65.000	Drosophila_melanogaster
ENSG00000136448	NMT1	100	98.611	ENSMUSG00000020936	Nmt1	100	97.379	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	21873635.	IBA	Function
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity	25255805.	IDA	Function
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9353336.9506952.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006499	N-terminal protein myristoylation	-	TAS	Process
GO:0018008	N-terminal peptidyl-glycine N-myristoylation	21873635.	IBA	Process
GO:0018008	N-terminal peptidyl-glycine N-myristoylation	25255805.	IDA	Process
GO:0019107	myristoyltransferase activity	22865860.	IDA	Function
GO:0019107	myristoyltransferase activity	-	TAS	Function
GO:0019898	extrinsic component of membrane	9506952.	IDA	Component
GO:0022400	regulation of rhodopsin mediated signaling pathway	-	TAS	Process
GO:0042180	cellular ketone metabolic process	22865860.	IDA	Process
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process