EuRBPDB

Description

Ensembl ID: ENSG00000136699 (Gene tree)
Gene ID: 55627
Gene Symbol: SMPD4
Alias: FLJ20297|FLJ20756|nSMase-3|KIAA1418|NSMASE3|NET13
Full Name: sphingomyelin phosphodiesterase 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 31,359 bases
Position: chr2:130,151,392-130,182,750
Accession: 32949
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000412570	SMPD4-203	3601	-	ENSP00000403002	57 (aa)	-	F2Z2W5
ENST00000482171	SMPD4-218	4298	-	-	- (aa)	-	-
ENST00000433118	SMPD4-206	3335	-	ENSP00000397278	56 (aa)	-	F2Z2I0
ENST00000491319	SMPD4-220	593	-	-	- (aa)	-	-
ENST00000451542	SMPD4-212	796	-	ENSP00000405363	265 (aa)	-	H7C2E2
ENST00000351288	SMPD4-201	3661	XM_011511444	ENSP00000259217	837 (aa)	XP_011509746	Q9NXE4
ENST00000409031	SMPD4-202	4896	XM_011511443	ENSP00000386531	866 (aa)	XP_011509745	Q9NXE4
ENST00000439886	SMPD4-209	3371	XM_011511445	ENSP00000401648	741 (aa)	XP_011509747	H7C1Q6
ENST00000455548	SMPD4-214	547	-	-	- (aa)	-	-
ENST00000454468	SMPD4-213	3586	-	ENSP00000407591	50 (aa)	-	F8WF03
ENST00000439029	SMPD4-208	566	-	ENSP00000416208	56 (aa)	-	F2Z2I0
ENST00000473720	SMPD4-217	555	-	-	- (aa)	-	-
ENST00000431183	SMPD4-205	3614	-	ENSP00000405187	764 (aa)	-	Q9NXE4
ENST00000457039	SMPD4-215	940	-	ENSP00000397078	313 (aa)	-	H7C0W5
ENST00000461187	SMPD4-216	659	-	-	- (aa)	-	-
ENST00000491128	SMPD4-219	2570	-	-	- (aa)	-	-
ENST00000449159	SMPD4-211	635	-	ENSP00000403915	211 (aa)	-	H7C235
ENST00000441135	SMPD4-210	699	-	ENSP00000406458	135 (aa)	-	C9J647
ENST00000430682	SMPD4-204	820	-	ENSP00000406325	274 (aa)	-	H7C2J2
ENST00000435455	SMPD4-207	842	-	ENSP00000393791	88 (aa)	-	F8WEQ5

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00600	Sphingolipid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0004767	sphingomyelin phosphodiesterase activity	-	IEA	Function
GO:0005783	endoplasmic reticulum	16517606.18505924.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	16517606.	IDA	Component
GO:0005802	trans-Golgi network	16517606.	IDA	Component
GO:0006685	sphingomyelin catabolic process	16517606.	IDA	Process
GO:0006687	glycosphingolipid metabolic process	-	TAS	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0046475	glycerophospholipid catabolic process	16517606.	IDA	Process
GO:0046513	ceramide biosynthetic process	16517606.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0050290	sphingomyelin phosphodiesterase D activity	16517606.	IDA	Function
GO:0071356	cellular response to tumor necrosis factor	16517606.	IDA	Process