EuRBPDB

Description

Ensembl ID: ENSG00000136709 (Gene tree)
Gene ID: 55339
Gene Symbol: WDR33
Alias: FLJ11294|WDC146|NET14
Full Name: WD repeat domain 33
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 110,166 bases
Position: chr2:127,701,022-127,811,187
Accession: 25651
RBP type: non-canonical RBP
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
29274231	Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.	Elife	2017 Dec 23	Clerici M	doi: 10.7554/eLife.33111.
25301781	Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.	Genes Dev	2014 Nov 1	Schonemann L	doi: 10.1101/gad.250985.114

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409658	WDR33-204	3104	-	ENSP00000387186	326 (aa)	-	Q9C0J8
ENST00000436787	WDR33-205	822	-	ENSP00000397547	205 (aa)	-	C9J8B4
ENST00000393006	WDR33-202	3574	XM_017004435	ENSP00000376730	257 (aa)	XP_016859924	Q9C0J8
ENST00000322313	WDR33-201	9471	XM_005263697	ENSP00000325377	1336 (aa)	XP_005263754	Q9C0J8
ENST00000408998	WDR33-203	583	-	ENSP00000386861	118 (aa)	-	B9A053

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136709	Vascular Calcification	6E-6	23870195
ENSG00000136709	Lung Volume Measurements	3E-6	24023788

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136709	rs13013415	2	127762223	?	Lung function (FEV1/FVC)	24023788			EFO_0004713
ENSG00000136709	rs17015535	2	127745011	A	Coronary artery calcification	23870195	[0.2-0.56] unit decrease	0.38	EFO_0004723
ENSG00000136709	rs2923	2	127706044	C	Coronary artery disease	29212778	[0.043-0.106] unit decrease	0.0743	EFO_0000378

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136709	WDR33	99	97.059	ENSDARG00000018272	wdr33	83	86.420	Danio_rerio
ENSG00000136709	WDR33	99	75.862	FBgn0046222	Wdr33	57	67.442	Drosophila_melanogaster
ENSG00000136709	WDR33	100	100.000	ENSMUSG00000024400	Wdr33	100	95.961	Mus_musculus
ENSG00000136709	WDR33	99	44.878	YNL317W		78	39.142	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0001650	fibrillar center	-	IDA	Component
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005581	collagen trimer	-	IEA	Component
GO:0005634	nucleus	11162572.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	21873635.	IBA	Component
GO:0006301	postreplication repair	11162572.	NAS	Process
GO:0006369	termination of RNA polymerase II transcription	-	TAS	Process
GO:0006378	mRNA polyadenylation	21873635.	IBA	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0007283	spermatogenesis	11162572.	NAS	Process
GO:0031124	mRNA 3'-end processing	-	TAS	Process