EuRBPDB

Description

Ensembl ID: ENSG00000136770 (Gene tree)
Gene ID: 64215
Gene Symbol: DNAJC1
Alias: DNAJL1|ERdj1|MTJ1
Full Name: DnaJ heat shock protein family (Hsp40) member C1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 247,233 bases
Position: chr10:21,756,537-22,003,769
Accession: 20090
RBP type: non-canonical RBP
Summary: The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000376946	DNAJC1-201	1013	-	-	- (aa)	-	-
ENST00000483085	DNAJC1-205	442	-	-	- (aa)	-	-
ENST00000476103	DNAJC1-204	682	-	ENSP00000431248	109 (aa)	-	Q5T1X2
ENST00000376980	DNAJC1-202	2106	XM_011519614	ENSP00000366179	554 (aa)	XP_011517916	Q96KC8
ENST00000447548	DNAJC1-203	363	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136770	Parkinson Disease	6.29E-7	17052657
ENSG00000136770	Parkinson Disease	9.679435E-8	17052657
ENSG00000136770	Neuropsychological Tests	1.05296962684943E-5	17903297
ENSG00000136770	Stroke	2.89024E-5	17434096
ENSG00000136770	Blood Pressure	8.8624536E-005	-
ENSG00000136770	Platelet Function Tests	2.8133800E-005	-
ENSG00000136770	Zeaxanthins	5.1920000E-005	-
ENSG00000136770	Zeaxanthins	9.1810000E-006	-
ENSG00000136770	3-hydroxy-1-methylpropylmercapturic acid	7E-7	26053186
ENSG00000136770	Smoking	7E-7	26053186
ENSG00000136770	Breast Neoplasms	9E-16	23535729
ENSG00000136770	Subcutaneous Fat	1E-8	26480920

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136770	rs7903144	10	21768476	A	Subcutaneous adipose tissue	26480920	[NR] unit decrease	249.29	EFO_0004766
ENSG00000136770	rs4364959	10	21996442	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423
ENSG00000136770	rs4748779	10	21999203	T	Smoking status (ever vs never smokers)	30643258	[0.0093-0.0181] unit decrease	0.013735452	EFO_0004318
ENSG00000136770	rs72806318	10	21863269	A	Breast cancer	29059683	[0.17-0.27] unit increase	0.2218	EFO_0000305

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136770	DNAJC1	100	84.173	ENSMUSG00000026740	Dnajc1	98	92.982	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001671	ATPase activator activity	14668352.	TAS	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	14668352.16271702.	IPI	Function
GO:0005783	endoplasmic reticulum	-	ISS	Component
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0006417	regulation of translation	-	IEA	Process
GO:0006457	protein folding	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0031965	nuclear membrane	-	IEA	Component
GO:0032781	positive regulation of ATPase activity	-	IEA	Process
GO:0045861	negative regulation of proteolysis	14668352.	TAS	Process
GO:0050708	regulation of protein secretion	14668352.	IDA	Process
GO:0051087	chaperone binding	-	IEA	Function