EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136810 (Gene tree)
Gene ID: 7295
Gene Symbol: TXN
Alias: TRX
Full Name: thioredoxin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 12,830 bases
Position: chr9:110,243,811-110,256,640
Accession: 12435
RBP type: non-canonical RBP
Summary: The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26327811	Effects of Mild Chronic Intermittent Cold Exposure on Rat Organs.	Int J Biol Sci	2015 Aug 8	Wang X	doi: 10.7150/ijbs.12161
16513844	Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18.	Nucleic Acids Res	2006 Mar 2	Yang R	-
9867873	Thioredoxin activation of iron regulatory proteins. Redox regulation of RNA binding after exposure to nitric oxide.	J Biol Chem	1999 Jan 1	Oliveira L	-
15696199	Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells.	J Clin Invest	2005 Mar	Yamawaki H	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000374517	TXN-202	869	-	ENSP00000363641	105 (aa)	-	P10599
ENST00000374515	TXN-201	635	-	ENSP00000363639	85 (aa)	-	P10599
ENST00000487892	TXN-203	540	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136810's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04621	NOD-like receptor signaling pathway	KEGG
hsa05418	Fluid shear stress and atherosclerosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136810	alpha-Linolenic Acid	4.9460000E-006	21829377

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136810's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136810	TXN	98	89.320	ENSMUSG00000028367	Txn1	98	89.320	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000122	negative regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004791	thioredoxin-disulfide reductase activity	-	TAS	Function
GO:0005515	protein binding	10814541.11118054.15480426.15657067.17557078.17606900.19690162.19805025.20029029.21771788.21988832.24658140.24976139.25402766.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006662	glycerol ether metabolic process	-	IEA	Process
GO:0007165	signal transduction	10947064.	TAS	Process
GO:0007267	cell-cell signaling	10947064.	TAS	Process
GO:0008283	cell proliferation	3170595.	TAS	Process
GO:0009314	response to radiation	11118054.	IDA	Process
GO:0015035	protein disulfide oxidoreductase activity	-	IEA	Function
GO:0015037	peptide disulfide oxidoreductase activity	-	IEA	Function
GO:0032148	activation of protein kinase B activity	22492997.	IC	Process
GO:0033138	positive regulation of peptidyl-serine phosphorylation	22492997.	IGI	Process
GO:0043388	positive regulation of DNA binding	11118054.	IDA	Process
GO:0045454	cell redox homeostasis	-	IEA	Process
GO:0046826	negative regulation of protein export from nucleus	-	IEA	Process
GO:0051897	positive regulation of protein kinase B signaling	22492997.	IC	Process
GO:0055114	oxidation-reduction process	11118054.	IDA	Process
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:0098869	cellular oxidant detoxification	-	IEA	Process
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	22492997.	IGI	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19799607	Expression of thioredoxin during progression of hamster and human cholangiocarcinoma.	Cancer Sci	2010 Jan	Yoon BI	doi: 10.1111/j.1349-7006.2009.01353.x
24720336	Hyperglycemia regulates TXNIP/TRX/ROS axis via p38 MAPK and ERK pathways in pancreatic cancer.	Curr Cancer Drug Targets	2014	Li W	-
14703116	Preferential elevation of Prx I and Trx expression in lung cancer cells following hypoxia and in human lung cancer tissues.	Cell Biol Toxicol	2003 Oct	Kim HJ	-
25174623	Thioredoxin 1 as a serum marker for ovarian cancer and its use in combination with CA125 for improving the sensitivity of ovarian cancer diagnoses.	Biomarkers	2014 Nov	Park BJ	doi: 10.3109/1354750X.2014.956793
26334622	Diagnostic and prognostic value of serum thioredoxin and DJ-1 in non-small cell lung carcinoma patients.	Tumour Biol	2016 Feb	Fan J	doi: 10.1007/s13277-015-3994-x
24962940	An investigation into the serum thioredoxin, superoxide dismutase, malondialdehyde, and advanced oxidation protein products in patients with breast cancer.	Ann Surg Oncol	2014 Dec	Kilic N	doi: 10.1245/s10434-014-3859-3
28411237	Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy.	J Biol Chem	2017 Jun 2	Lou M	doi: 10.1074/jbc.M117.783365
26460805	Down-Regulation of Thioredoxin1 Is Involved in Death of Calu-6 Lung Cancer Cells Treated With Suberoyl Bishydroxamic Acid.	J Cell Biochem	2016 May	You BR	doi: 10.1002/jcb.25409
23133653	Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.	PLoS One	2012	M??plan C	doi: 10.1371/journal.pone.0048709
19723146	Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation.	Histopathology	2009 Sep	Fernandes AP	doi: 10.1111/j.1365-2559.2009.03381.x.
17949784	Increased expression of thioredoxin-1, vascular endothelial growth factor, and redox factor-1 is associated with poor prognosis in patients with liver metastasis from colorectal cancer.	Hum Pathol	2008 Feb	Noike T	-
25483731	Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines.	Oncol Rep	2015 Feb	Wang F	doi: 10.3892/or.2014.3652
20955789	Thioredoxin 1 as a subcellular biomarker of redox imbalance in human prostate cancer progression.	Free Radic Biol Med	2010 Dec 15	Shan W	doi: 10.1016/j.freeradbiomed.2010.10.691
21963718	Thioredoxin stimulates MMP-9 expression, de-regulates the MMP-9/TIMP-1 equilibrium and promotes MMP-9 dependent invasion in human MDA-MB-231 breast cancer cells.	FEBS Lett	2011 Oct 20	Farina AR	doi: 10.1016/j.febslet.2011.09.023
23112551	Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence.	World J Gastroenterol	2012 Oct 21	Lim JY	doi: 10.3748/wjg.v18.i39.5581.
12878985	Increased expression of thioredoxin-1 in human colorectal cancer is associated with decreased patient survival.	J Lab Clin Med	2003 Jul	Raffel J	-
12189205	The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin.	Proc Natl Acad Sci U S A	2002 Sep 3	Butler LM	-
19773351	The cyclin-dependent kinase inhibitor, p21(WAF1), promotes angiogenesis by repressing gene transcription of thioredoxin-binding protein 2 in cancer cells.	Carcinogenesis	2009 Nov	Kuljaca S	doi: 10.1093/carcin/bgp225
28483515	Thioredoxin-1 promotes colorectal cancer invasion and metastasis through crosstalk with S100P.	Cancer Lett	2017 Aug 10	Lin F	doi: 10.1016/j.canlet.2017.04.036
29053012	The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer.	Biomark Med	2017 Dec	Chang LC	doi: 10.2217/bmm-2017-0107
27779244	Predictive value of ATP7b, BRCA1, BRCA2, PARP1, UIMC1 (RAP80), HOXA9, DAXX, TXN (TRX1), THBS1 (TSP1) and PRR13 (TXR1) genes in patients with epithelial ovarian cancer who received platinum-taxane first-line therapy.	Pharmacogenomics J	2017 Dec	Pontikakis S	doi: 10.1038/tpj.2016.63
29089489	Thioredoxin-1 protects against androgen receptor-induced redox vulnerability in castration-resistant prostate cancer.	Nat Commun	2017 Oct 31	Samaranayake GJ	doi: 10.1038/s41467-017-01269-x.
30911354	Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer.	Oxid Med Cell Longev	2019 Feb 18	Shang W	doi: 10.1155/2019/9291683

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr9	110256507	5'UTR	novel		0.33
BRCA	chr9	110244183	Missense_Mutation	NA	E98K	0.35
COAD	chr9	110244804	Missense_Mutation	novel	F77L	0.07
COAD	chr9	110251357	Splice_Site	NA	X43_splice	0.2
HNSC	chr9	110244158	Silent	novel	*106*	0.18
HNSC	chr9	110256492	5'UTR	novel		0.6
HNSC	chr9	110251398	Missense_Mutation	rs547387406	T30M	0.28
KIRC	chr9	110256431	Missense_Mutation	novel	V2E	0.29
KIRC	chr9	110244787	Missense_Mutation	NA	K82N	0.16
KIRP	chr9	110251415	Silent	NA	V24V	0.27
PAAD	chr9	110244180	Missense_Mutation	novel	A99S	0.25
STAD	chr9	110251413	Missense_Mutation	NA	V25A	0.33
UCEC	chr9	110244108	3'UTR	novel		0.13
UCEC	chr9	110251406	Silent	NA	F27F	0.24
UCEC	chr9	110244043	3'UTR	novel		0.45
UCEC	chr9	110244086	3'UTR	novel		0.25
UCEC	chr9	110244052	3'UTR	novel		0.4
UCEC	chr9	110256454	5'UTR	novel		0.19
UCS	chr9	110250858	Missense_Mutation	novel	N51D	0.17

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3529	0.11788
CHOL	DEL	0.4722	0.067545
LAML	DEL	0.0105	0.24147
LIHC	DEL	0.2703	0.12467
PRAD	AMP	0.0772	0.059049
THCA	DEL	0.0401	0.24038
THYM	DEL	0.0081	0.022012
UCS	DEL	0.6071	0.089783

Survival Analysis

Cancer	P-value	Q-value
MESO	0.0058	Kaplan-Meier Survival Analysis
ACC	0.0017	Kaplan-Meier Survival Analysis
UCS	0.004	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
BRCA	0.037	Kaplan-Meier Survival Analysis
ESCA	0.039	Kaplan-Meier Survival Analysis
KIRP	0.042	Kaplan-Meier Survival Analysis
PAAD	0.0046	Kaplan-Meier Survival Analysis
UCEC	0.00023	Kaplan-Meier Survival Analysis
GBM	0.0014	Kaplan-Meier Survival Analysis
LIHC	0.02	Kaplan-Meier Survival Analysis
LGG	0.0003	Kaplan-Meier Survival Analysis
LUAD	0.0044	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742