EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000136861 (Gene tree)
Gene ID: 55755
Gene Symbol: CDK5RAP2
Alias: C48|FLJ10867|CEP215|MCPH3
Full Name: CDK5 regulatory subunit associated protein 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 191,302 bases
Position: chr9:120,388,869-120,580,170
Accession: 18672
RBP type: non-canonical RBP
Summary: This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000468989	CDK5RAP2-207	577	-	-	- (aa)	-	-
ENST00000474262	CDK5RAP2-210	549	-	-	- (aa)	-	-
ENST00000425647	CDK5RAP2-205	2747	-	ENSP00000409941	903 (aa)	-	Q5JTU8
ENST00000491334	CDK5RAP2-218	546	-	-	- (aa)	-	-
ENST00000473282	CDK5RAP2-209	5956	-	ENSP00000419265	460 (aa)	-	F8WF55
ENST00000349780	CDK5RAP2-201	6228	XM_006717182	ENSP00000343818	1893 (aa)	XP_006717245	Q96SN8
ENST00000433194	CDK5RAP2-206	815	-	-	- (aa)	-	-
ENST00000484546	CDK5RAP2-217	1269	-	-	- (aa)	-	-
ENST00000479584	CDK5RAP2-211	611	-	-	- (aa)	-	-
ENST00000483412	CDK5RAP2-216	6235	-	-	- (aa)	-	-
ENST00000481266	CDK5RAP2-214	970	-	ENSP00000417925	275 (aa)	-	F8WBJ0
ENST00000472883	CDK5RAP2-208	389	-	-	- (aa)	-	-
ENST00000482047	CDK5RAP2-215	565	-	ENSP00000419640	133 (aa)	-	C9K0C9
ENST00000480112	CDK5RAP2-212	5826	-	ENSP00000418418	749 (aa)	-	F8WCI3
ENST00000495406	CDK5RAP2-219	635	-	-	- (aa)	-	-
ENST00000416449	CDK5RAP2-204	3902	XM_017014924	ENSP00000400395	1287 (aa)	XP_016870413	B1AMJ5
ENST00000360190	CDK5RAP2-202	5985	-	ENSP00000353317	1814 (aa)	-	Q96SN8
ENST00000360822	CDK5RAP2-203	5551	XM_006717185	ENSP00000354065	1663 (aa)	XP_006717248	A0A0A0MRG9
ENST00000480467	CDK5RAP2-213	931	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000136861's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000136861	Arthritis, Rheumatoid	1E-12	24782177
ENSG00000136861	Arthritis, Rheumatoid	1E-16	24782177

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136861	rs12379034	9	120400388	C	Rheumatoid arthritis	24782177	[NR]	1.489	EFO_0000685
ENSG00000136861	rs12379034	9	120400388	C	Rheumatoid arthritis	24782177	[NR]	1.336	EFO_0000685

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136861's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000086	G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0000132	establishment of mitotic spindle orientation	-	ISS	Process
GO:0000226	microtubule cytoskeleton organization	17959831.	IDA	Process
GO:0000242	pericentriolar material	17959831.	IDA	Component
GO:0000922	spindle pole	17959831.19282672.	IDA	Component
GO:0001578	microtubule bundle formation	19553473.	IDA	Process
GO:0005515	protein binding	17959831.19282672.19553473.20466722.25503564.26192437.26297806.26485573.29162697.	IPI	Function
GO:0005516	calmodulin binding	20466722.	IDA	Function
GO:0005737	cytoplasm	17959831.19282672.19553473.	IDA	Component
GO:0005794	Golgi apparatus	20466722.	IDA	Component
GO:0005813	centrosome	14654843.17959831.18042621.19282672.19543530.19553473.20466722.21399614.25657325.26485573.29162697.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	10721722.	NAS	Component
GO:0005874	microtubule	19553473.	IDA	Component
GO:0007059	chromosome segregation	19282672.	IMP	Process
GO:0007098	centrosome cycle	18042621.	IMP	Process
GO:0007099	centriole replication	26297806.	IMP	Process
GO:0007420	brain development	-	ISS	Process
GO:0007420	brain development	10915792.	NAS	Process
GO:0008017	microtubule binding	14654843.	IDA	Function
GO:0008274	gamma-tubulin ring complex	29162697.	IDA	Component
GO:0010389	regulation of G2/M transition of mitotic cell cycle	-	TAS	Process
GO:0015631	tubulin binding	17959831.	IPI	Function
GO:0019901	protein kinase binding	10721722.	IPI	Function
GO:0022008	neurogenesis	-	ISS	Process
GO:0030054	cell junction	-	IDA	Component
GO:0031023	microtubule organizing center organization	26485573.	IMP	Process
GO:0031116	positive regulation of microtubule polymerization	29162697.	IMP	Process
GO:0035371	microtubule plus-end	26485573.	IDA	Component
GO:0043015	gamma-tubulin binding	29162697.	IDA	Function
GO:0044212	transcription regulatory region DNA binding	19282672.	IDA	Function
GO:0045664	regulation of neuron differentiation	10721722.	NAS	Process
GO:0045665	negative regulation of neuron differentiation	-	IEA	Process
GO:0045893	positive regulation of transcription, DNA-templated	19282672.	IDA	Process
GO:0046600	negative regulation of centriole replication	-	ISS	Process
GO:0048471	perinuclear region of cytoplasm	17959831.	IDA	Component
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	19282672.	IDA	Process
GO:0097431	mitotic spindle pole	-	IEA	Component
GO:0097711	ciliary basal body-plasma membrane docking	-	TAS	Process