EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000136875 (Gene tree)
Gene ID: 9128
Gene Symbol: PRPF4
Alias: Prp4p|HPRP4|HPRP4P|PRP4|SNRNP60
Full Name: pre-mRNA processing factor 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,572 bases
Position: chr9:113,275,343-113,293,914
Accession: 17349
RBP type: canonical RBP
Summary: The protein encoded by this gene is part of a heteromeric complex that binds U4, U5, and U6 small nuclear RNAs and is involved in pre-mRNA splicing. The encoded protein also is a mitotic checkpoint protein and a regulator of chemoresistance in human ovarian cancer. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000363315	PRP4	PF08799.11	1.8e-13	1	1
ENSP00000363313	PRP4	PF08799.11	1.8e-13	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
2145195	Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo.	Genes Dev	1990 Jul	Bordonne R	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488937	PRPF4-203	567	-	-	- (aa)	-	-
ENST00000374199	PRPF4-202	3212	-	ENSP00000363315	521 (aa)	-	O43172
ENST00000374198	PRPF4-201	2787	-	ENSP00000363313	522 (aa)	-	O43172

Gene Model

Click here to download ENSG00000136875's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000136875	rs10733604	9	113279983	?	White matter growth	29682794			EFO_0009335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000136875's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000136875	PRPF4	96	76.987	ENSAPOG00000014132	prpf4	98	76.987	Acanthochromis_polyacanthus
ENSG00000136875	PRPF4	100	99.424	ENSAMEG00000013048	PRPF4	98	99.424	Ailuropoda_melanoleuca
ENSG00000136875	PRPF4	96	77.183	ENSACIG00000005579	prpf4	99	77.183	Amphilophus_citrinellus
ENSG00000136875	PRPF4	96	76.832	ENSAOCG00000005457	prpf4	99	76.832	Amphiprion_ocellaris
ENSG00000136875	PRPF4	96	76.634	ENSAPEG00000000776	prpf4	99	76.634	Amphiprion_percula
ENSG00000136875	PRPF4	96	76.587	ENSATEG00000023013	prpf4	99	76.587	Anabas_testudineus
ENSG00000136875	PRPF4	100	89.060	ENSAPLG00000006534	PRPF4	96	90.253	Anas_platyrhynchos
ENSG00000136875	PRPF4	100	90.249	ENSACAG00000015110	PRPF4	100	90.249	Anolis_carolinensis
ENSG00000136875	PRPF4	100	99.616	ENSANAG00000022464	PRPF4	96	99.616	Aotus_nancymaae
ENSG00000136875	PRPF4	96	76.984	ENSACLG00000019031	prpf4	99	76.984	Astatotilapia_calliptera
ENSG00000136875	PRPF4	97	61.228	ENSAMXG00000006756	prpf4	99	73.663	Astyanax_mexicanus
ENSG00000136875	PRPF4	100	98.656	ENSBTAG00000004571	PRPF4	100	98.656	Bos_taurus
ENSG00000136875	PRPF4	87	45.254	WBGene00007972	prp-4	91	45.254	Caenorhabditis_elegans
ENSG00000136875	PRPF4	100	99.617	ENSCJAG00000017856	PRPF4	100	99.617	Callithrix_jacchus
ENSG00000136875	PRPF4	100	99.424	ENSCAFG00000003224	PRPF4	97	99.424	Canis_familiaris
ENSG00000136875	PRPF4	100	99.424	ENSCAFG00020022637	PRPF4	100	99.424	Canis_lupus_dingo
ENSG00000136875	PRPF4	100	99.042	ENSCHIG00000024648	-	100	99.042	Capra_hircus
ENSG00000136875	PRPF4	100	99.232	ENSTSYG00000010366	PRPF4	100	99.232	Carlito_syrichta
ENSG00000136875	PRPF4	88	88.305	ENSCAPG00000008935	PRPF4	97	88.305	Cavia_aperea
ENSG00000136875	PRPF4	100	92.514	ENSCPOG00000014729	-	100	92.514	Cavia_porcellus
ENSG00000136875	PRPF4	100	98.848	ENSCPOG00000010747	-	100	98.848	Cavia_porcellus
ENSG00000136875	PRPF4	100	99.424	ENSCCAG00000028990	PRPF4	100	99.424	Cebus_capucinus
ENSG00000136875	PRPF4	100	99.232	ENSCATG00000021552	PRPF4	100	99.232	Cercocebus_atys
ENSG00000136875	PRPF4	100	99.040	ENSCLAG00000013448	PRPF4	100	99.040	Chinchilla_lanigera
ENSG00000136875	PRPF4	87	95.796	ENSCHOG00000007233	PRPF4	100	95.796	Choloepus_hoffmanni
ENSG00000136875	PRPF4	99	91.262	ENSCPBG00000019136	PRPF4	74	91.262	Chrysemys_picta_bellii
ENSG00000136875	PRPF4	96	59.055	ENSCING00000001299	-	97	58.416	Ciona_intestinalis
ENSG00000136875	PRPF4	96	57.341	ENSCSAVG00000009178	-	99	58.874	Ciona_savignyi
ENSG00000136875	PRPF4	100	99.424	ENSCANG00000003246	PRPF4	100	99.424	Colobus_angolensis_palliatus
ENSG00000136875	PRPF4	100	99.232	ENSCGRG00001016992	Prpf4	100	99.232	Cricetulus_griseus_chok1gshd
ENSG00000136875	PRPF4	100	99.232	ENSCGRG00000017560	Prpf4	100	99.232	Cricetulus_griseus_crigri
ENSG00000136875	PRPF4	97	75.644	ENSCSEG00000020451	prpf4	99	75.644	Cynoglossus_semilaevis
ENSG00000136875	PRPF4	97	80.000	ENSDARG00000067639	prpf4	99	80.000	Danio_rerio
ENSG00000136875	PRPF4	100	98.851	ENSDNOG00000013203	PRPF4	100	98.851	Dasypus_novemcinctus
ENSG00000136875	PRPF4	100	99.232	ENSDORG00000026275	Prpf4	100	99.232	Dipodomys_ordii
ENSG00000136875	PRPF4	87	56.674	FBgn0036733	U4-U6-60K	99	50.547	Drosophila_melanogaster
ENSG00000136875	PRPF4	100	97.323	ENSETEG00000020389	PRPF4	100	97.323	Echinops_telfairi
ENSG00000136875	PRPF4	95	73.272	ENSEBUG00000015229	prpf4	86	73.733	Eptatretus_burgeri
ENSG00000136875	PRPF4	100	99.616	ENSEASG00005022678	PRPF4	100	99.616	Equus_asinus_asinus
ENSG00000136875	PRPF4	100	99.616	ENSECAG00000007072	PRPF4	100	99.616	Equus_caballus
ENSG00000136875	PRPF4	100	78.384	ENSEEUG00000007480	PRPF4	100	78.384	Erinaceus_europaeus
ENSG00000136875	PRPF4	97	80.990	ENSELUG00000007510	prpf4	99	80.990	Esox_lucius
ENSG00000136875	PRPF4	100	99.617	ENSFCAG00000005514	PRPF4	100	99.617	Felis_catus
ENSG00000136875	PRPF4	98	88.117	ENSFALG00000005423	PRPF4	90	85.376	Ficedula_albicollis
ENSG00000136875	PRPF4	100	98.848	ENSFDAG00000005839	PRPF4	100	98.848	Fukomys_damarensis
ENSG00000136875	PRPF4	96	76.190	ENSFHEG00000001300	prpf4	99	76.190	Fundulus_heteroclitus
ENSG00000136875	PRPF4	98	90.020	ENSGALG00000008857	PRPF4	96	89.669	Gallus_gallus
ENSG00000136875	PRPF4	65	71.471	ENSGAFG00000012164	prpf4	70	71.471	Gambusia_affinis
ENSG00000136875	PRPF4	96	70.040	ENSGACG00000015476	prpf4	99	69.246	Gasterosteus_aculeatus
ENSG00000136875	PRPF4	99	91.068	ENSGAGG00000025029	PRPF4	96	90.909	Gopherus_agassizii
ENSG00000136875	PRPF4	100	100.000	ENSGGOG00000006943	PRPF4	100	100.000	Gorilla_gorilla
ENSG00000136875	PRPF4	96	76.786	ENSHBUG00000000562	prpf4	99	76.786	Haplochromis_burtoni
ENSG00000136875	PRPF4	100	80.230	ENSHGLG00000003838	-	100	80.230	Heterocephalus_glaber_female
ENSG00000136875	PRPF4	100	98.848	ENSHGLG00000015191	PRPF4	100	98.848	Heterocephalus_glaber_female
ENSG00000136875	PRPF4	100	81.836	ENSHGLG00000016628	-	100	82.600	Heterocephalus_glaber_female
ENSG00000136875	PRPF4	100	80.230	ENSHGLG00100005571	-	100	80.230	Heterocephalus_glaber_male
ENSG00000136875	PRPF4	97	79.010	ENSIPUG00000017956	PRPF4	99	79.010	Ictalurus_punctatus
ENSG00000136875	PRPF4	100	99.040	ENSSTOG00000027833	PRPF4	100	99.040	Ictidomys_tridecemlineatus
ENSG00000136875	PRPF4	100	99.232	ENSJJAG00000008838	Prpf4	100	99.232	Jaculus_jaculus
ENSG00000136875	PRPF4	96	76.190	ENSKMAG00000013236	prpf4	99	76.190	Kryptolebias_marmoratus
ENSG00000136875	PRPF4	96	75.697	ENSLBEG00000020611	prpf4	99	75.697	Labrus_bergylta
ENSG00000136875	PRPF4	99	80.539	ENSLACG00000016317	PRPF4	99	80.539	Latimeria_chalumnae
ENSG00000136875	PRPF4	97	81.584	ENSLOCG00000000581	prpf4	99	81.584	Lepisosteus_oculatus
ENSG00000136875	PRPF4	100	98.659	ENSLAFG00000018225	PRPF4	100	98.659	Loxodonta_africana
ENSG00000136875	PRPF4	100	99.040	ENSMFAG00000039397	PRPF4	100	99.040	Macaca_fascicularis
ENSG00000136875	PRPF4	100	99.232	ENSMMUG00000005844	PRPF4	100	99.232	Macaca_mulatta
ENSG00000136875	PRPF4	100	88.868	ENSMNEG00000033737	PRPF4	100	88.868	Macaca_nemestrina
ENSG00000136875	PRPF4	100	99.232	ENSMLEG00000040284	PRPF4	100	99.232	Mandrillus_leucophaeus
ENSG00000136875	PRPF4	97	76.134	ENSMAMG00000020141	prpf4	99	76.134	Mastacembelus_armatus
ENSG00000136875	PRPF4	96	76.984	ENSMZEG00005023205	prpf4	99	76.984	Maylandia_zebra
ENSG00000136875	PRPF4	99	88.292	ENSMGAG00000001796	PRPF4	97	88.292	Meleagris_gallopavo
ENSG00000136875	PRPF4	100	98.656	ENSMAUG00000018022	Prpf4	100	98.656	Mesocricetus_auratus
ENSG00000136875	PRPF4	100	98.467	ENSMICG00000015022	PRPF4	100	98.467	Microcebus_murinus
ENSG00000136875	PRPF4	100	98.656	ENSMOCG00000018273	Prpf4	100	98.656	Microtus_ochrogaster
ENSG00000136875	PRPF4	97	74.851	ENSMMOG00000021177	prpf4	99	74.851	Mola_mola
ENSG00000136875	PRPF4	100	94.837	ENSMODG00000004444	-	100	94.837	Monodelphis_domestica
ENSG00000136875	PRPF4	100	95.029	ENSMODG00000025096	-	97	95.029	Monodelphis_domestica
ENSG00000136875	PRPF4	96	76.587	ENSMALG00000013624	prpf4	99	76.587	Monopterus_albus
ENSG00000136875	PRPF4	100	99.040	MGP_CAROLIEiJ_G0026078	Prpf4	100	99.040	Mus_caroli
ENSG00000136875	PRPF4	100	99.040	ENSMUSG00000066148	Prpf4	100	99.040	Mus_musculus
ENSG00000136875	PRPF4	100	98.848	MGP_PahariEiJ_G0028413	Prpf4	100	98.848	Mus_pahari
ENSG00000136875	PRPF4	100	99.040	MGP_SPRETEiJ_G0027042	Prpf4	100	99.040	Mus_spretus
ENSG00000136875	PRPF4	100	99.424	ENSMPUG00000007883	PRPF4	100	99.424	Mustela_putorius_furo
ENSG00000136875	PRPF4	100	99.040	ENSMLUG00000015309	-	97	99.040	Myotis_lucifugus
ENSG00000136875	PRPF4	100	97.121	ENSMLUG00000008626	-	97	97.121	Myotis_lucifugus
ENSG00000136875	PRPF4	100	93.858	ENSNGAG00000000468	Prpf4	100	93.858	Nannospalax_galili
ENSG00000136875	PRPF4	96	77.183	ENSNBRG00000007972	prpf4	99	77.183	Neolamprologus_brichardi
ENSG00000136875	PRPF4	100	99.616	ENSNLEG00000016647	PRPF4	100	99.616	Nomascus_leucogenys
ENSG00000136875	PRPF4	99	94.942	ENSMEUG00000013256	PRPF4	100	95.331	Notamacropus_eugenii
ENSG00000136875	PRPF4	100	98.851	ENSOPRG00000005302	PRPF4	100	98.851	Ochotona_princeps
ENSG00000136875	PRPF4	100	99.232	ENSODEG00000018147	PRPF4	100	99.232	Octodon_degus
ENSG00000136875	PRPF4	99	75.287	ENSONIG00000012671	prpf4	99	76.984	Oreochromis_niloticus
ENSG00000136875	PRPF4	100	99.424	ENSOCUG00000005046	PRPF4	100	99.424	Oryctolagus_cuniculus
ENSG00000136875	PRPF4	96	74.900	ENSORLG00000019641	prpf4	99	74.900	Oryzias_latipes
ENSG00000136875	PRPF4	96	74.900	ENSORLG00020019438	prpf4	99	74.900	Oryzias_latipes_hni
ENSG00000136875	PRPF4	96	74.737	ENSOMEG00000020941	prpf4	99	74.737	Oryzias_melastigma
ENSG00000136875	PRPF4	100	94.434	ENSOGAG00000007802	PRPF4	98	94.434	Otolemur_garnettii
ENSG00000136875	PRPF4	100	99.040	ENSOARG00000006319	PRPF4	97	99.040	Ovis_aries
ENSG00000136875	PRPF4	100	100.000	ENSPPAG00000041797	PRPF4	100	100.000	Pan_paniscus
ENSG00000136875	PRPF4	100	99.616	ENSPPRG00000014360	PRPF4	100	99.616	Panthera_pardus
ENSG00000136875	PRPF4	100	99.616	ENSPTIG00000009574	PRPF4	100	99.616	Panthera_tigris_altaica
ENSG00000136875	PRPF4	100	100.000	ENSPTRG00000021274	PRPF4	100	100.000	Pan_troglodytes
ENSG00000136875	PRPF4	100	99.040	ENSPANG00000025776	PRPF4	96	99.040	Papio_anubis
ENSG00000136875	PRPF4	97	81.386	ENSPKIG00000017259	prpf4	99	81.386	Paramormyrops_kingsleyae
ENSG00000136875	PRPF4	100	89.635	ENSPSIG00000010713	PRPF4	91	90.154	Pelodiscus_sinensis
ENSG00000136875	PRPF4	99	58.608	ENSPMGG00000000997	prpf4	99	58.716	Periophthalmus_magnuspinnatus
ENSG00000136875	PRPF4	100	99.232	ENSPEMG00000024115	Prpf4	100	99.232	Peromyscus_maniculatus_bairdii
ENSG00000136875	PRPF4	99	94.942	ENSPCIG00000003821	PRPF4	99	95.331	Phascolarctos_cinereus
ENSG00000136875	PRPF4	96	70.217	ENSPFOG00000013524	prpf4	98	73.292	Poecilia_formosa
ENSG00000136875	PRPF4	84	70.118	ENSPLAG00000011620	prpf4	96	72.360	Poecilia_latipinna
ENSG00000136875	PRPF4	92	74.398	ENSPMEG00000006813	prpf4	98	74.398	Poecilia_mexicana
ENSG00000136875	PRPF4	98	99.027	ENSPCAG00000002561	PRPF4	100	99.027	Procavia_capensis
ENSG00000136875	PRPF4	100	99.040	ENSPCOG00000011975	PRPF4	100	99.040	Propithecus_coquereli
ENSG00000136875	PRPF4	100	95.594	ENSPVAG00000004708	PRPF4	100	95.594	Pteropus_vampyrus
ENSG00000136875	PRPF4	96	76.984	ENSPNYG00000008013	prpf4	99	76.984	Pundamilia_nyererei
ENSG00000136875	PRPF4	97	80.594	ENSPNAG00000000697	prpf4	99	80.594	Pygocentrus_nattereri
ENSG00000136875	PRPF4	100	98.848	ENSRNOG00000014777	Prpf4	100	98.848	Rattus_norvegicus
ENSG00000136875	PRPF4	100	99.424	ENSRBIG00000040221	PRPF4	100	99.424	Rhinopithecus_bieti
ENSG00000136875	PRPF4	100	99.424	ENSRROG00000040240	PRPF4	100	99.424	Rhinopithecus_roxellana
ENSG00000136875	PRPF4	100	95.411	ENSSHAG00000017658	PRPF4	100	95.411	Sarcophilus_harrisii
ENSG00000136875	PRPF4	97	82.178	ENSSFOG00015008963	prpf4	99	82.178	Scleropages_formosus
ENSG00000136875	PRPF4	96	75.595	ENSSMAG00000008889	prpf4	99	75.595	Scophthalmus_maximus
ENSG00000136875	PRPF4	96	73.506	ENSSDUG00000022083	prpf4	98	73.705	Seriola_dumerili
ENSG00000136875	PRPF4	96	73.705	ENSSLDG00000008115	prpf4	98	73.904	Seriola_lalandi_dorsalis
ENSG00000136875	PRPF4	100	90.787	ENSSPUG00000015582	PRPF4	100	90.787	Sphenodon_punctatus
ENSG00000136875	PRPF4	96	71.203	ENSSPAG00000011286	prpf4	99	71.203	Stegastes_partitus
ENSG00000136875	PRPF4	100	99.616	ENSSSCG00000024648	PRPF4	100	99.616	Sus_scrofa
ENSG00000136875	PRPF4	95	90.264	ENSTGUG00000002623	PRPF4	100	90.593	Taeniopygia_guttata
ENSG00000136875	PRPF4	97	75.494	ENSTRUG00000008853	prpf4	99	75.494	Takifugu_rubripes
ENSG00000136875	PRPF4	97	75.050	ENSTNIG00000013250	prpf4	99	75.050	Tetraodon_nigroviridis
ENSG00000136875	PRPF4	100	90.613	ENSTBEG00000000821	PRPF4	100	90.613	Tupaia_belangeri
ENSG00000136875	PRPF4	82	98.993	ENSTTRG00000003246	PRPF4	85	98.993	Tursiops_truncatus
ENSG00000136875	PRPF4	64	96.707	ENSUAMG00000018288	PRPF4	90	96.707	Ursus_americanus
ENSG00000136875	PRPF4	100	98.656	ENSUMAG00000019375	PRPF4	100	98.656	Ursus_maritimus
ENSG00000136875	PRPF4	100	99.234	ENSVPAG00000005281	PRPF4	100	99.234	Vicugna_pacos
ENSG00000136875	PRPF4	100	98.286	ENSVVUG00000002476	PRPF4	100	98.286	Vulpes_vulpes
ENSG00000136875	PRPF4	69	58.056	ENSXCOG00000006101	prpf4	93	59.653	Xiphophorus_couchianus
ENSG00000136875	PRPF4	88	64.629	ENSXMAG00000002750	prpf4	98	65.606	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000375	RNA splicing, via transesterification reactions	9328476.	NAS	Process
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0000398	mRNA splicing, via spliceosome	9570313.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	28781166.	IDA	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0005515	protein binding	9570313.19615732.22365833.23793891.25383878.29997244.	IPI	Function
GO:0005634	nucleus	28781166.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	9570313.	IC	Component
GO:0005681	spliceosomal complex	9328476.	NAS	Component
GO:0006396	RNA processing	9328476.	TAS	Process
GO:0008380	RNA splicing	9328476.	TAS	Process
GO:0015030	Cajal body	15257298.	IDA	Component
GO:0016607	nuclear speck	25383878.	IDA	Component
GO:0017070	U6 snRNA binding	21873635.	IBA	Function
GO:0030621	U4 snRNA binding	21873635.	IBA	Function
GO:0046540	U4/U6 x U5 tri-snRNP complex	21873635.	IBA	Component
GO:0046540	U4/U6 x U5 tri-snRNP complex	23793891.	IDA	Component
GO:0071001	U4/U6 snRNP	9570313.25383878.	IDA	Component
GO:0071005	U2-type precatalytic spliceosome	28781166.	IDA	Component
GO:0097525	spliceosomal snRNP complex	25383878.	IDA	Component