EuRBPDB

Description

Ensembl ID: ENSG00000137055 (Gene tree)
Gene ID: 9373
Gene Symbol: PLAA
Alias: PLAP|PLA2P|FLJ11281|FLJ12699|DOA1
Full Name: phospholipase A2 activating protein
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 44,101 bases
Position: chr9:26,903,370-26,947,470
Accession: 9043
RBP type: non-canonical RBP
Summary: (Phospholipase A2 Activating Protein) is a Protein Coding gene. Diseases associated with PLAA include Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies and Spasticity. Among its related pathways are Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include binding and phospholipase A2 activator activity.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000520641	PLAA-204	471	-	-	- (aa)	-	-
ENST00000523212	PLAA-207	730	-	ENSP00000428111	244 (aa)	-	H0YAU9
ENST00000397292	PLAA-201	4234	-	ENSP00000380460	795 (aa)	-	Q9Y263
ENST00000521968	PLAA-206	457	-	-	- (aa)	-	-
ENST00000520884	PLAA-205	2041	XM_011518072	ENSP00000429372	609 (aa)	XP_011516374	E5RIM3
ENST00000517642	PLAA-203	868	-	ENSP00000430447	290 (aa)	-	H0YBW4
ENST00000487173	PLAA-202	625	-	ENSP00000430734	136 (aa)	-	H0YC16

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137055	Schizophrenia	2E-6	20185149

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137055	rs7045881	9	26935998	?	Schizophrenia	20185149	[NR]	1.16	EFO_0000692

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137055	PLAA	95	42.241	FBgn0024314	Plap	96	36.875	Drosophila_melanogaster

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	18775313.22190034.25416956.27753622.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	28007986.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	27753622.28007986.	IDA	Component
GO:0006644	phospholipid metabolic process	9931468.	TAS	Process
GO:0006693	prostaglandin metabolic process	-	ISS	Process
GO:0006954	inflammatory response	-	IEA	Process
GO:0007165	signal transduction	9931468.	TAS	Process
GO:0010992	ubiquitin recycling	21873635.	IBA	Process
GO:0016005	phospholipase A2 activator activity	-	IEA	Function
GO:0016236	macroautophagy	27753622.	IMP	Process
GO:0030054	cell junction	-	IEA	Component
GO:0032430	positive regulation of phospholipase A2 activity	28007986.	IMP	Process
GO:0043130	ubiquitin binding	21873635.	IBA	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	21873635.	IBA	Process
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	-	ISS	Process
GO:0045202	synapse	-	ISS	Component
GO:0070062	extracellular exosome	17076679.	IDA	Component
GO:0071222	cellular response to lipopolysaccharide	28007986.	IMP	Process
GO:1900045	negative regulation of protein K63-linked ubiquitination	-	ISS	Process
GO:1903423	positive regulation of synaptic vesicle recycling	-	ISS	Process
GO:1903861	positive regulation of dendrite extension	-	ISS	Process
GO:2001224	positive regulation of neuron migration	-	ISS	Process