EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137076 (Gene tree)
Gene ID: 7094
Gene Symbol: TLN1
Alias: ILWEQ|TLN
Full Name: talin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 35,448 bases
Position: chr9:35,696,948-35,732,395
Accession: 11845
RBP type: non-canonical RBP
Summary: This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
20728432	Vinculin activates inside-out signaling of integrin αIIbβ3 in Chinese hamster ovary cells.	Biochem Biophys Res Commun	2010 Sep 24	Ohmori T	doi: 10.1016/j.bbrc.2010.08.056

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000466916	TLN1-205	446	-	-	- (aa)	-	-
ENST00000486788	TLN1-206	551	-	-	- (aa)	-	-
ENST00000314888	TLN1-201	8823	-	ENSP00000316029	2541 (aa)	-	Q9Y490
ENST00000465002	TLN1-204	543	-	-	- (aa)	-	-
ENST00000378192	TLN1-202	1693	-	-	- (aa)	-	-
ENST00000489255	TLN1-207	798	-	-	- (aa)	-	-
ENST00000464379	TLN1-203	814	-	-	- (aa)	-	-
ENST00000495712	TLN1-208	370	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137076's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04015	Rap1 signaling pathway	KEGG
hsa04510	Focal adhesion	KEGG
hsa04611	Platelet activation	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137076	Asthma	8E-6	23967269
ENSG00000137076	Immunoglobulin E	8E-6	23967269

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137076	rs4879926	9	35700840	?	IgE levels in asthmatics	23967269			EFO_0004579\|EFO_0000270
ENSG00000137076	rs2737273	9	35716069	C	Platelet distribution width	27863252	[0.017-0.032] unit increase	0.02451837	EFO_0007984
ENSG00000137076	rs7873822	9	35726824	?	Heel bone mineral density	30048462	[0.0099-0.0187] unit increase	0.0143036	EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137076's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137076	TLN1	100	98.741	ENSMUSG00000028465	Tln1	99	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	ISS	Component
GO:0001786	phosphatidylserine binding	-	IEA	Function
GO:0002576	platelet degranulation	-	TAS	Process
GO:0005178	integrin binding	12473654.	IPI	Function
GO:0005200	structural constituent of cytoskeleton	10610730.	NAS	Function
GO:0005515	protein binding	11279249.16273093.16546176.18342854.19608030.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005856	cytoskeleton	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	-	ISS	Component
GO:0005925	focal adhesion	10610730.	NAS	Component
GO:0006936	muscle contraction	-	TAS	Process
GO:0007016	cytoskeletal anchoring at plasma membrane	10610730.	NAS	Process
GO:0007043	cell-cell junction assembly	15494027.	TAS	Process
GO:0007044	cell-substrate junction assembly	-	IEA	Process
GO:0007229	integrin-mediated signaling pathway	-	IEA	Process
GO:0009986	cell surface	-	IEA	Component
GO:0016032	viral process	-	IEA	Process
GO:0017166	vinculin binding	15070891.	IPI	Function
GO:0030274	LIM domain binding	10320340.	IPI	Function
GO:0030866	cortical actin cytoskeleton organization	-	IEA	Process
GO:0032587	ruffle membrane	-	IEA	Component
GO:0033622	integrin activation	-	IEA	Process
GO:0035091	phosphatidylinositol binding	-	IEA	Function
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0051015	actin filament binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.21362503.23533145.	HDA	Component
GO:0070527	platelet aggregation	23382103.	HMP	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
23722670	miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1.	Int J Mol Med	2013 Aug	Tang H	doi: 10.3892/ijmm.2013.1400
24891603	Talin regulates moesin-NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis.	J Cell Biol	2014 Jun 9	Beaty BT	doi: 10.1083/jcb.201312046
23204516	Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells.	J Biol Chem	2013 Jan 25	Jevnikar Z	doi: 10.1074/jbc.M112.436394
24793790	Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis.	Oncogene	2015 Apr 2	Jin JK	doi: 10.1038/onc.2014.116
23479679	A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer.	Clin Cancer Res	2013 Apr 15	Singel SM	doi: 10.1158/1078-0432.CCR-13-0082
24761880	Talin-1 correlates with reduced invasion and migration in human hepatocellular carcinoma cells.	Asian Pac J Cancer Prev	2014	Fang KP	-

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr9	35720209	Silent	novel	L432L	0.23
ACC	chr9	35716440	Missense_Mutation	novel	A859T	0.86
ACC	chr9	35715148	Missense_Mutation	rs749822890	R889W	0.06
BLCA	chr9	35714612	Nonsense_Mutation	novel	Q983*	0.45
BLCA	chr9	35706195	Splice_Site	novel	X1787_splice	0.36
BLCA	chr9	35697857	Silent	NA	K2520K	0.17
BLCA	chr9	35698828	Missense_Mutation	NA	E2369Q	0.35
BLCA	chr9	35725309	Missense_Mutation	novel	G48E	0.25
BLCA	chr9	35700253	Missense_Mutation	novel	D2200N	0.43
BLCA	chr9	35705824	Missense_Mutation	novel	E1847Q	0.24
BLCA	chr9	35698320	Splice_Region	novel		0.11
BLCA	chr9	35703796	Nonsense_Mutation	novel	W2112*	0.26
BLCA	chr9	35700305	Silent	NA	I2182I	0.07
BLCA	chr9	35720217	Missense_Mutation	novel	S429L	0.32
BLCA	chr9	35710626	Missense_Mutation	novel	E1421K	0.09
BLCA	chr9	35720451	Missense_Mutation	novel	D422G	0.49
BLCA	chr9	35713031	Missense_Mutation	rs763888196	R1122Q	0.43
BLCA	chr9	35714251	Silent	rs376495117	T1036T	0.09
BLCA	chr9	35714021	Missense_Mutation	novel	E1061Q	0.68
BLCA	chr9	35717695	Missense_Mutation	rs762426705	S696L	0.15
BLCA	chr9	35716482	Missense_Mutation	NA	E845K	0.06
BLCA	chr9	35722216	Missense_Mutation	novel	K284R	0.24
BLCA	chr9	35717152	Missense_Mutation	novel	D818N	0.1
BLCA	chr9	35724037	Missense_Mutation	novel	D233H	0.08
BLCA	chr9	35707205	Missense_Mutation	novel	E1608K	0.36
BRCA	chr9	35703999	Nonsense_Mutation	novel	E2075*	0.4
BRCA	chr9	35698402	Frame_Shift_Del	NA	*V2431Efs23**	0.21
BRCA	chr9	35724603	Missense_Mutation	novel	K160N	0.04
BRCA	chr9	35707174	Missense_Mutation	rs780560798	R1618Q	0.42
BRCA	chr9	35713257	Silent	NA	A1097A	0.44
BRCA	chr9	35711753	Missense_Mutation	rs770655381	R1241W	0.61
BRCA	chr9	35700201	Missense_Mutation	rs769841997	R2217Q	0.23
BRCA	chr9	35714851	Nonsense_Mutation	NA	S927*	0.4
BRCA	chr9	35718826	Missense_Mutation	novel	D661N	0.07
BRCA	chr9	35711072	Missense_Mutation	NA	D1344N	0.15
BRCA	chr9	35724270	Silent	NA	L192L	0.38
BRCA	chr9	35705646	Missense_Mutation	NA	E1880Q	0.15
BRCA	chr9	35722143	Nonsense_Mutation	NA	Y308*	0.15
BRCA	chr9	35722144	Missense_Mutation	NA	Y308C	0.15
BRCA	chr9	35706353	Missense_Mutation	rs775801466	A1735V	0.18
BRCA	chr9	35697746	3'UTR	rs776130687		0.19
BRCA	chr9	35724612	Missense_Mutation	novel	K157N	0.1
BRCA	chr9	35722180	Missense_Mutation	NA	V296A	0.19
BRCA	chr9	35724878	Missense_Mutation	novel	D104N	0.05
BRCA	chr9	35707385	Missense_Mutation	novel	P1579L	0.24
BRCA	chr9	35713280	Missense_Mutation	NA	D1090N	0.29
BRCA	chr9	35714769	Missense_Mutation	NA	Q954H	0.5
BRCA	chr9	35723957	Silent	rs755633555	F259F	0.13
BRCA	chr9	35704105	Silent	NA	G2039G	0.35
BRCA	chr9	35711761	Missense_Mutation	NA	A1238G	0.69
BRCA	chr9	35714651	Missense_Mutation	rs371183695	V970I	0.46
BRCA	chr9	35710575	Missense_Mutation	NA	E1438K	0.1
BRCA	chr9	35720066	Missense_Mutation	NA	Q479H	0.86
BRCA	chr9	35708479	Silent	NA	A1444A	0.38
BRCA	chr9	35717231	Silent	NA	G791G	0.15
CESC	chr9	35717359	Missense_Mutation	rs746904145	G749S	0.33
CESC	chr9	35704816	Splice_Site	NA	X1912_splice	0.47
CESC	chr9	35719570	Missense_Mutation	novel	Q546E	0.38
CESC	chr9	35707748	Missense_Mutation	rs151033435	L1539V	0.18
CESC	chr9	35697718	3'UTR	novel		0.23
CESC	chr9	35715142	Missense_Mutation	rs770307539	R891W	0.55
CESC	chr9	35717212	Missense_Mutation	novel	Y798H	0.45
CESC	chr9	35717721	Missense_Mutation	NA	K687N	0.15
CESC	chr9	35713254	Silent	NA	V1098V	0.33
CHOL	chr9	35698457	Missense_Mutation	novel	A2413T	0.29
CHOL	chr9	35704684	Silent	novel	R1955R	0.45
COAD	chr9	35721670	Missense_Mutation	NA	A361V	0.43
COAD	chr9	35714666	Silent	NA	L965L	0.18
COAD	chr9	35707805	Missense_Mutation	NA	T1520A	0.26
COAD	chr9	35699369	Silent	novel	A2287A	0.29
COAD	chr9	35710885	Missense_Mutation	rs752281502	T1372M	0.13
COAD	chr9	35725632	Silent	rs760882744	P21P	0.32
COAD	chr9	35704004	Missense_Mutation	novel	D2073V	0.45
COAD	chr9	35716394	Missense_Mutation	novel	A874V	0.3
COAD	chr9	35697804	Missense_Mutation	novel	R2538Q	0.12
COAD	chr9	35697748	3'UTR	novel		0.4
COAD	chr9	35724211	Missense_Mutation	novel	L212P	0.09
COAD	chr9	35708373	Missense_Mutation	NA	S1480G	0.18
COAD	chr9	35698486	Missense_Mutation	NA	A2403V	0.27
COAD	chr9	35700076	Silent	novel	A2222A	0.35
COAD	chr9	35725729	Splice_Site	novel		0.1
COAD	chr9	35722875	Missense_Mutation	NA	R277C	0.18
COAD	chr9	35723860	Intron	novel		0.3
COAD	chr9	35712993	Missense_Mutation	rs146392528	A1135T	0.45
COAD	chr9	35720890	Silent	novel	G376G	0.13
COAD	chr9	35712974	Missense_Mutation	NA	L1141P	0.39
COAD	chr9	35711389	Missense_Mutation	NA	Q1295H	0.13
COAD	chr9	35717753	Missense_Mutation	novel	S677R	0.07
COAD	chr9	35711657	Nonsense_Mutation	rs769049864	R1273*	0.37
COAD	chr9	35720503	Frame_Shift_Del	NA	*S405Afs84**	0.3
COAD	chr9	35725283	Frame_Shift_Ins	NA	*K57Qfs48**	0.22
COAD	chr9	35715086	Silent	NA	I909I	0.12
COAD	chr9	35719518	Splice_Site	NA	X563_splice	0.33
COAD	chr9	35713286	Missense_Mutation	novel	T1088A	0.19
COAD	chr9	35704342	Missense_Mutation	rs144809355	A2013T	0.62
COAD	chr9	35707144	Frame_Shift_Del	NA	*P1628Rfs20**	0.44
COAD	chr9	35725279	Frame_Shift_Del	novel	*K58Rfs31**	0.09
COAD	chr9	35704345	Missense_Mutation	NA	F2012V	0.23
COAD	chr9	35707796	Missense_Mutation	NA	R1523C	0.35
COAD	chr9	35717762	Missense_Mutation	novel	A674S	0.43
COAD	chr9	35717708	Missense_Mutation	rs774077967	R692W	0.47
COAD	chr9	35698845	Missense_Mutation	rs763897212	A2363V	0.13
COAD	chr9	35711000	Missense_Mutation	NA	R1368W	0.36
COAD	chr9	35711724	Missense_Mutation	NA	N1250K	0.39
COAD	chr9	35698422	In_Frame_Ins	novel	L2424_I2425insETY	0.09
COAD	chr9	35705813	Silent	rs748787321	F1850F	0.21
COAD	chr9	35706352	Silent	rs535930797	A1735A	0.23
DLBC	chr9	35720847	Missense_Mutation	NA	L391F	0.15
DLBC	chr9	35704402	Missense_Mutation	rs149639715	D1993N	0.11
DLBC	chr9	35724046	Missense_Mutation	novel	V230I	0.11
ESCA	chr9	35697468	3'UTR	novel		0.25
ESCA	chr9	35700021	Missense_Mutation	rs750965317	R2241W	0.33
ESCA	chr9	35700262	Missense_Mutation	rs761387809	R2197C	0.12
ESCA	chr9	35703900	Missense_Mutation	novel	V2078M	0.32
ESCA	chr9	35713965	Silent	novel	L1079L	0.31
ESCA	chr9	35700038	Missense_Mutation	rs752190315	R2235Q	0.56
ESCA	chr9	35707167	Silent	rs554877602	L1620L	0.14
GBM	chr9	35717701	Missense_Mutation	novel	E694G	0.14
GBM	chr9	35724076	Nonsense_Mutation	novel	R220*	0.32
GBM	chr9	35725591	Missense_Mutation	rs192509639	R35Q	0.06
GBM	chr9	35699133	Missense_Mutation	novel	D2300Y	0.23
GBM	chr9	35710804	Missense_Mutation	novel	N1399T	0.04
GBM	chr9	35698160	Missense_Mutation	rs762166245	A2462T	0.48
GBM	chr9	35698330	Missense_Mutation	novel	R2455Q	0.12
GBM	chr9	35699392	Missense_Mutation	rs780974070	V2280I	0.16
GBM	chr9	35699987	Missense_Mutation	novel	D2252G	0.32
GBM	chr9	35710675	Silent	rs774522280	G1404G	0.15
GBM	chr9	35719257	Silent	rs780691721	T571T	0.12
GBM	chr9	35717670	Silent	novel	A704A	0.05
GBM	chr9	35697840	Missense_Mutation	NA	R2526Q	0.04
GBM	chr9	35714673	Missense_Mutation	novel	Q962H	0.18
GBM	chr9	35712976	Silent	novel	A1140A	0.43
GBM	chr9	35714077	Missense_Mutation	novel	Q1042R	0.11
GBM	chr9	35715074	Frame_Shift_Ins	novel	*V914Gfs65**	0.07
GBM	chr9	35723919	Intron	novel		0.1
GBM	chr9	35712093	Missense_Mutation	rs765433665	R1198H	0.18
GBM	chr9	35714571	Splice_Region	rs763048749		0.12
GBM	chr9	35715149	Silent	NA	Q888Q	0.11
GBM	chr9	35722875	Missense_Mutation	NA	R277C	0.23
GBM	chr9	35703625	Missense_Mutation	novel	D2137H	0.05
GBM	chr9	35711326	Silent	novel	L1316L	0.33
HNSC	chr9	35712952	Missense_Mutation	novel	Q1148H	0.23
HNSC	chr9	35706788	Missense_Mutation	rs768245253	R1690C	0.27
HNSC	chr9	35720088	Missense_Mutation	rs144393265	Q472R	0.28
HNSC	chr9	35707193	Missense_Mutation	novel	G1612R	0.18
HNSC	chr9	35716454	Missense_Mutation	novel	R854L	0.2
HNSC	chr9	35724891	Silent	rs748628195	T99T	0.09
HNSC	chr9	35698092	Missense_Mutation	novel	E2484D	0.16
HNSC	chr9	35724575	Missense_Mutation	NA	E170Q	0.58
HNSC	chr9	35711045	Missense_Mutation	novel	C1353G	0.53
HNSC	chr9	35707798	Missense_Mutation	novel	K1522M	0.34
HNSC	chr9	35706342	Missense_Mutation	novel	E1739Q	0.19
HNSC	chr9	35715168	Missense_Mutation	novel	D882A	0.29
HNSC	chr9	35716475	Missense_Mutation	rs755083449	E847G	0.04
HNSC	chr9	35720908	Missense_Mutation	novel	F370L	0.08
HNSC	chr9	35714270	Missense_Mutation	rs764011686	A1030V	0.34
HNSC	chr9	35720838	Missense_Mutation	novel	G394S	0.11
HNSC	chr9	35704670	Missense_Mutation	novel	K1960M	0.22
HNSC	chr9	35717219	Silent	novel	A795A	0.3
HNSC	chr9	35715169	Missense_Mutation	novel	D882N	0.1
HNSC	chr9	35717421	Missense_Mutation	novel	S728I	0.73
HNSC	chr9	35720455	Missense_Mutation	novel	E421Q	0.08
HNSC	chr9	35707820	Missense_Mutation	novel	R1515G	0.1
HNSC	chr9	35725713	5'UTR	novel		0.27
HNSC	chr9	35720094	Missense_Mutation	rs148182997	P470L	0.44
KIRC	chr9	35718907	Missense_Mutation	NA	R634S	0.17
KIRC	chr9	35714324	Missense_Mutation	NA	Q1012P	0.65
KIRC	chr9	35698345	Missense_Mutation	NA	S2450L	0.14
KIRP	chr9	35706218	Missense_Mutation	NA	K1780R	0.23
KIRP	chr9	35698172	Missense_Mutation	NA	A2458P	0.16
KIRP	chr9	35697813	Nonsense_Mutation	novel	S2535*	0.54
KIRP	chr9	35711019	Silent	rs780092147	K1361K	0.25
KIRP	chr9	35699408	Missense_Mutation	NA	K2274N	0.31
KIRP	chr9	35714848	Missense_Mutation	novel	A928D	0.29
KIRP	chr9	35699094	Frame_Shift_Del	novel	*G2311Qfs11**	0.23
KIRP	chr9	35711279	Missense_Mutation	NA	K1332M	0.35
KIRP	chr9	35698342	Missense_Mutation	NA	E2451A	0.09
LAML	chr9	35719749	Silent	novel	G523G	0.19
LAML	chr9	35717320	Nonsense_Mutation	novel	Q762*	0.07
LAML	chr9	35706033	Missense_Mutation	novel	L1814V	0.13
LGG	chr9	35706487	Missense_Mutation	rs202143177	N1718S	0.2
LGG	chr9	35717310	Missense_Mutation	rs752009662	R765Q	0.21
LGG	chr9	35714766	Missense_Mutation	NA	S955R	0.05
LGG	chr9	35720839	Silent	rs749192861	A393A	0.2
LIHC	chr9	35705591	Missense_Mutation	rs779743307	S1898L	0.46
LIHC	chr9	35697840	Missense_Mutation	NA	R2526Q	0.35
LIHC	chr9	35707198	Missense_Mutation	novel	A1610D	0.2
LIHC	chr9	35724959	Missense_Mutation	NA	D77Y	0.34
LIHC	chr9	35703659	Silent	NA	V2125V	0.41
LIHC	chr9	35707457	Missense_Mutation	novel	R1555L	0.49
LIHC	chr9	35717325	Missense_Mutation	novel	D760V	0.49
LIHC	chr9	35703776	Missense_Mutation	novel	K2119R	0.31
LUAD	chr9	35711081	Missense_Mutation	novel	A1341S	0.5
LUAD	chr9	35720895	Missense_Mutation	NA	D375H	0.29
LUAD	chr9	35722172	Missense_Mutation	NA	V299L	0.34
LUAD	chr9	35712919	Silent	NA	L1159L	0.44
LUAD	chr9	35714252	Missense_Mutation	novel	T1036M	0.27
LUAD	chr9	35718874	Missense_Mutation	NA	G645C	0.37
LUAD	chr9	35714847	Silent	novel	A928A	0.04
LUAD	chr9	35711748	Missense_Mutation	novel	L1242F	0.12
LUAD	chr9	35705821	In_Frame_Del	novel	E1847del	0.23
LUAD	chr9	35707220	Missense_Mutation	NA	A1603T	0.51
LUAD	chr9	35712047	Silent	novel	L1213L	0.15
LUAD	chr9	35710598	Missense_Mutation	NA	S1430L	0.33
LUAD	chr9	35706064	Missense_Mutation	NA	M1803I	0.13
LUAD	chr9	35699428	Nonsense_Mutation	NA	Q2268*	0.09
LUAD	chr9	35700305	Silent	NA	I2182I	0.22
LUAD	chr9	35700307	Missense_Mutation	NA	I2182F	0.21
LUAD	chr9	35719535	Silent	novel	V557V	0.44
LUAD	chr9	35707128	Silent	NA	L1633L	0.76
LUAD	chr9	35714080	Missense_Mutation	novel	A1041V	0.26
LUAD	chr9	35707114	Frame_Shift_Ins	novel	*R1638Pfs25**	0.1
LUAD	chr9	35704726	Silent	NA	P1941P	0.12
LUSC	chr9	35720149	Missense_Mutation	NA	I452V	0.25
LUSC	chr9	35706852	Silent	novel	L1668L	0.12
LUSC	chr9	35698065	Silent	novel	K2493K	0.21
LUSC	chr9	35699977	Silent	novel	L2255L	0.43
LUSC	chr9	35717269	Missense_Mutation	novel	N779H	0.37
LUSC	chr9	35706816	Silent	rs762759883	L1680L	0.2
LUSC	chr9	35722864	Silent	rs777906241	F280F	0.59
LUSC	chr9	35699043	Missense_Mutation	NA	A2330P	0.39
LUSC	chr9	35720480	Missense_Mutation	NA	E412D	0.4
LUSC	chr9	35699407	Missense_Mutation	rs773118269	R2275C	0.15
LUSC	chr9	35708462	Missense_Mutation	NA	S1450F	0.65
LUSC	chr9	35703859	Silent	novel	L2091L	0.31
LUSC	chr9	35697664	3'UTR	novel		0.33
LUSC	chr9	35697665	3'UTR	novel		0.31
LUSC	chr9	35720191	Missense_Mutation	novel	R438W	0.05
LUSC	chr9	35719215	Silent	novel	T585T	0.39
LUSC	chr9	35707123	Missense_Mutation	novel	G1635A	0.57
LUSC	chr9	35705580	Missense_Mutation	rs770507067	P1902S	0.11
LUSC	chr9	35697720	3'UTR	novel		0.15
LUSC	chr9	35712076	Missense_Mutation	NA	P1204S	0.19
LUSC	chr9	35697717	3'UTR	novel		0.56
LUSC	chr9	35710638	Missense_Mutation	NA	G1417R	0.14
LUSC	chr9	35706775	Missense_Mutation	NA	S1694F	0.25
MESO	chr9	35717159	Silent	novel	S815S	0.35
MESO	chr9	35707829	Missense_Mutation	novel	A1512P	0.08
MESO	chr9	35714264	Missense_Mutation	rs373243370	A1032G	0.26
OV	chr9	35699453	Missense_Mutation	NA	Q2259H	0.16
OV	chr9	35724627	Silent	NA	L152L	0.26
OV	chr9	35705962	Splice_Region	novel	Q1837Q	0.48
OV	chr9	35698044	Missense_Mutation	novel	Q2500H	0.06
OV	chr9	35711644	Frame_Shift_Ins	novel	*D1277Afs54**	0.12
OV	chr9	35707731	Missense_Mutation	novel	K1544N	0.1
OV	chr9	35703780	Missense_Mutation	novel	A2118P	0.08
OV	chr9	35699406	Missense_Mutation	rs73438721	R2275H	0.36
OV	chr9	35699389	Missense_Mutation	novel	T2281S	0.07
OV	chr9	35712017	Silent	novel	L1223L	0.1
OV	chr9	35698465	Missense_Mutation	novel	A2410V	0.09
OV	chr9	35711351	Missense_Mutation	novel	I1308T	0.14
PAAD	chr9	35699044	Silent	novel	R2329R	0.1
PAAD	chr9	35699413	Missense_Mutation	novel	S2273A	0.04
PAAD	chr9	35705573	Missense_Mutation	rs373819052	A1904V	0.2
PAAD	chr9	35707250	Missense_Mutation	rs267602229	R1593W	0.13
PAAD	chr9	35708474	Missense_Mutation	novel	L1446P	0.15
PAAD	chr9	35714816	Missense_Mutation	novel	A939P	0.14
PAAD	chr9	35715100	Missense_Mutation	novel	A905T	0.18
PAAD	chr9	35715142	Missense_Mutation	rs770307539	R891W	0.16
PAAD	chr9	35725688	Missense_Mutation	novel	A3T	0.15
PAAD	chr9	35700283	Missense_Mutation	rs758160563	V2190I	0.04
PCPG	chr9	35700008	Missense_Mutation	rs368513332	N2245S	0.39
PRAD	chr9	35697768	3'UTR	novel		0.35
PRAD	chr9	35711268	Missense_Mutation	NA	A1336S	0.1
PRAD	chr9	35700344	Silent	novel	T2169T	0.49
PRAD	chr9	35703885	Missense_Mutation	rs761961290	A2083T	0.11
PRAD	chr9	35707459	Silent	rs781565789	N1554N	0.42
PRAD	chr9	35716545	Nonsense_Mutation	novel	R824*	0.41
PRAD	chr9	35725565	Missense_Mutation	rs543841478	P44S	0.34
READ	chr9	35716495	Silent	NA	I840I	0.24
READ	chr9	35706490	Missense_Mutation	novel	A1717V	0.31
READ	chr9	35698640	Missense_Mutation	novel	W2389G	0.58
READ	chr9	35699393	Silent	NA	S2279S	0.32
READ	chr9	35714270	Missense_Mutation	rs764011686	A1030V	0.36
READ	chr9	35717174	Missense_Mutation	novel	E810D	0.42
READ	chr9	35711693	Missense_Mutation	novel	R1261W	0.16
READ	chr9	35717157	Missense_Mutation	novel	M816T	0.36
SARC	chr9	35704733	Missense_Mutation	novel	C1939Y	0.09
SARC	chr9	35705600	Missense_Mutation	rs567336438	R1895H	0.36
SKCM	chr9	35706004	Silent	rs149087654	V1823V	0.37
SKCM	chr9	35705817	Missense_Mutation	NA	S1849F	0.53
SKCM	chr9	35714012	Silent	NA	L1064L	0.36
SKCM	chr9	35711306	Missense_Mutation	NA	S1323F	0.26
SKCM	chr9	35704689	Missense_Mutation	NA	A1954S	0.48
SKCM	chr9	35707820	Missense_Mutation	rs758176386	R1515C	0.06
SKCM	chr9	35710669	Silent	novel	A1406A	0.38
SKCM	chr9	35700226	Missense_Mutation	novel	R2209C	0.11
SKCM	chr9	35700227	Silent	novel	S2208S	0.11
SKCM	chr9	35712050	Silent	novel	A1212A	0.33
SKCM	chr9	35710881	Silent	NA	V1373V	0.29
SKCM	chr9	35700366	Missense_Mutation	NA	S2162F	0.43
SKCM	chr9	35699388	Missense_Mutation	NA	T2281I	0.31
SKCM	chr9	35713968	Silent	NA	P1078P	0.31
SKCM	chr9	35714782	Missense_Mutation	NA	P950L	0.29
SKCM	chr9	35697779	3'UTR	novel		0.38
SKCM	chr9	35724064	Frame_Shift_Ins	novel	*L224Tfs10**	0.19
SKCM	chr9	35724066	Frame_Shift_Ins	novel	*I223Nfs21**	0.19
SKCM	chr9	35705813	Silent	rs748787321	F1850F	0.39
SKCM	chr9	35707808	Missense_Mutation	NA	P1519S	0.23
SKCM	chr9	35711669	Nonsense_Mutation	NA	R1269*	0.29
SKCM	chr9	35699394	Missense_Mutation	NA	S2279F	0.71
SKCM	chr9	35717708	Missense_Mutation	rs774077967	R692W	0.62
SKCM	chr9	35722161	Silent	novel	A302A	0.93
SKCM	chr9	35706308	Missense_Mutation	NA	S1750F	0.8
SKCM	chr9	35710654	Silent	NA	S1411S	0.94
SKCM	chr9	35719226	Missense_Mutation	NA	S582P	0.66
SKCM	chr9	35703633	Missense_Mutation	NA	A2134V	0.12
SKCM	chr9	35719782	Silent	NA	T512T	0.42
SKCM	chr9	35714782	Missense_Mutation	NA	P950L	0.24
SKCM	chr9	35700342	Missense_Mutation	NA	S2170F	0.15
SKCM	chr9	35697645	3'UTR	novel		0.78
SKCM	chr9	35724287	Missense_Mutation	novel	E187K	0.26
STAD	chr9	35719100	Missense_Mutation	rs373629805	R624C	0.16
STAD	chr9	35722159	Missense_Mutation	rs773595542	R303H	0.35
STAD	chr9	35724277	Missense_Mutation	rs769874189	T190M	0.37
STAD	chr9	35704047	Missense_Mutation	rs757869013	A2059T	0.18
STAD	chr9	35713201	Missense_Mutation	novel	Y1116F	0.13
STAD	chr9	35713996	Missense_Mutation	NA	A1069V	0.1
STAD	chr9	35714792	Missense_Mutation	rs570598486	G947S	0.61
STAD	chr9	35705805	Missense_Mutation	novel	Y1853C	0.39
STAD	chr9	35713242	Silent	rs778146857	I1102I	0.29
STAD	chr9	35720040	Missense_Mutation	NA	L488P	0.28
STAD	chr9	35704435	Missense_Mutation	novel	A1982T	0.44
STAD	chr9	35711735	Missense_Mutation	novel	A1247T	0.41
STAD	chr9	35721735	Silent	novel	R339R	0.05
STAD	chr9	35725617	Silent	rs755651034	Y26Y	0.36
STAD	chr9	35717229	Missense_Mutation	NA	A792V	0.11
STAD	chr9	35711381	Missense_Mutation	rs189605894	R1298Q	0.29
STAD	chr9	35711595	Splice_Region	NA	P1293P	0.32
STAD	chr9	35711656	Missense_Mutation	rs747462166	R1273Q	0.28
STAD	chr9	35725616	Missense_Mutation	novel	D27N	0.09
STAD	chr9	35714860	Missense_Mutation	NA	A924V	0.31
STAD	chr9	35720503	Frame_Shift_Del	NA	*S405Afs84**	0.28
STAD	chr9	35716446	Missense_Mutation	NA	L857V	0.11
STAD	chr9	35706865	Missense_Mutation	rs766069516	A1664V	0.28
STAD	chr9	35697861	Missense_Mutation	NA	R2519Q	0.39
STAD	chr9	35700203	Silent	novel	L2216L	0.14
STAD	chr9	35715066	Missense_Mutation	rs760405428	R916H	0.15
STAD	chr9	35707796	Missense_Mutation	NA	R1523C	0.14
STAD	chr9	35719205	Missense_Mutation	rs759490877	R589C	0.21
STAD	chr9	35719123	Missense_Mutation	rs756483237	A616V	0.27
STAD	chr9	35717292	Missense_Mutation	novel	A771V	0.24
STAD	chr9	35706105	Missense_Mutation	rs754790750	A1790T	0.14
STAD	chr9	35707153	Missense_Mutation	NA	R1625Q	0.18
STAD	chr9	35723940	Intron	novel		0.2
STAD	chr9	35708387	Missense_Mutation	NA	Q1475R	0.35
THYM	chr9	35724313	Missense_Mutation	rs767796509	R178Q	0.2
UCEC	chr9	35714255	Missense_Mutation	NA	R1035Q	0.16
UCEC	chr9	35698621	Missense_Mutation	NA	S2395Y	0.3
UCEC	chr9	35707753	Missense_Mutation	NA	A1537V	0.35
UCEC	chr9	35711753	Missense_Mutation	rs770655381	R1241W	0.31
UCEC	chr9	35724593	Missense_Mutation	NA	K164E	0.29
UCEC	chr9	35717314	Missense_Mutation	novel	L764V	0.22
UCEC	chr9	35718872	Silent	novel	G645G	0.4
UCEC	chr9	35706501	Silent	NA	I1713I	0.2
UCEC	chr9	35724070	Missense_Mutation	NA	D222N	0.23
UCEC	chr9	35706892	Missense_Mutation	novel	A1655D	0.29
UCEC	chr9	35717199	Missense_Mutation	novel	T802I	0.3
UCEC	chr9	35710847	Missense_Mutation	novel	N1385D	0.13
UCEC	chr9	35713011	Missense_Mutation	rs773838436	R1129W	0.53
UCEC	chr9	35720463	Missense_Mutation	novel	T418N	0.34
UCEC	chr9	35705814	Missense_Mutation	novel	F1850S	0.39
UCEC	chr9	35711740	Missense_Mutation	novel	A1245D	0.46
UCEC	chr9	35711623	Missense_Mutation	novel	A1284D	0.18
UCEC	chr9	35724960	Splice_Site	novel	X77_splice	0.44
UCEC	chr9	35697889	Missense_Mutation	novel	R2510W	0.51
UCEC	chr9	35704396	Missense_Mutation	NA	T1995A	0.2
UCEC	chr9	35708407	Silent	NA	A1468A	0.26
UCEC	chr9	35719100	Missense_Mutation	rs373629805	R624C	0.27
UCEC	chr9	35720096	Silent	NA	P469P	0.25
UCEC	chr9	35716424	Missense_Mutation	NA	A864V	0.16
UCEC	chr9	35704815	Missense_Mutation	NA	I1912L	0.47
UCEC	chr9	35698818	Missense_Mutation	novel	A2372V	0.38
UCEC	chr9	35697718	3'UTR	novel		0.07
UCEC	chr9	35698489	Missense_Mutation	rs200286479	A2402V	0.16
UCEC	chr9	35706004	Silent	rs149087654	V1823V	0.09
UCEC	chr9	35723789	Intron	novel		0.15
UCEC	chr9	35711788	Missense_Mutation	novel	P1229H	0.14
UCEC	chr9	35721804	Splice_Site	novel	X317_splice	0.16
UCEC	chr9	35723944	Splice_Region	novel		0.21
UCEC	chr9	35699449	Missense_Mutation	NA	P2261S	0.38
UCEC	chr9	35704064	Missense_Mutation	rs747900794	A2053V	0.52
UCEC	chr9	35714590	Missense_Mutation	NA	S990N	0.45
UCEC	chr9	35722178	Missense_Mutation	rs145146362	R297C	0.26
UCEC	chr9	35711019	Missense_Mutation	novel	K1361N	0.11
UCEC	chr9	35707833	Silent	novel	R1510R	0.09
UCEC	chr9	35711328	Missense_Mutation	novel	L1316I	0.5
UCEC	chr9	35719100	Missense_Mutation	rs373629805	R624C	0.19
UCEC	chr9	35722870	Missense_Mutation	novel	K278N	0.4
UCEC	chr9	35704146	Silent	novel	L2026L	0.35
UCEC	chr9	35697841	Missense_Mutation	novel	R2526W	0.38
UCEC	chr9	35700000	Silent	novel	L2248L	0.2
UCEC	chr9	35707185	Silent	rs748947958	I1614I	0.33
UCEC	chr9	35707458	Missense_Mutation	rs796217856	R1555C	0.3
UCEC	chr9	35714002	Missense_Mutation	novel	V1067A	0.28
UCEC	chr9	35724629	Silent	novel	L152L	0.22
UCEC	chr9	35697902	Missense_Mutation	NA	Q2505H	0.18
UCEC	chr9	35707144	Frame_Shift_Del	NA	*P1628Rfs20**	0.44
UCEC	chr9	35704457	Silent	rs140702228	G1974G	0.25
UCEC	chr9	35704363	Missense_Mutation	novel	R2006C	0.33
UCEC	chr9	35707796	Missense_Mutation	NA	R1523C	0.43
UCEC	chr9	35711302	Silent	rs774589019	T1324T	0.48
UCEC	chr9	35724277	Missense_Mutation	rs769874189	T190M	0.45
UCEC	chr9	35700352	Missense_Mutation	novel	A2167T	0.27
UCEC	chr9	35704744	Silent	rs370400484	G1935G	0.42
UCEC	chr9	35707192	Missense_Mutation	novel	G1612E	0.52
UCEC	chr9	35721670	Missense_Mutation	NA	A361V	0.44
UCEC	chr9	35697805	Nonsense_Mutation	NA	R2538*	0.36
UCEC	chr9	35706503	Missense_Mutation	NA	I1713V	0.52
UCEC	chr9	35704007	Frame_Shift_Ins	novel	*E2072Afs11**	0.05
UCEC	chr9	35697902	Missense_Mutation	NA	Q2505H	0.17
UCEC	chr9	35718870	Missense_Mutation	novel	Q646L	0.06
UCEC	chr9	35704407	Missense_Mutation	novel	D1991G	0.1
UCEC	chr9	35698489	Missense_Mutation	rs200286479	A2402V	0.31
UCEC	chr9	35721670	Missense_Mutation	NA	A361V	0.49
UCEC	chr9	35724675	Missense_Mutation	novel	E136D	0.3
UCEC	chr9	35706491	Missense_Mutation	rs544636956	A1717T	0.31
UCEC	chr9	35697447	3'UTR	novel		0.5
UCEC	chr9	35707224	Silent	novel	I1601I	0.31
UCEC	chr9	35711328	Missense_Mutation	NA	L1316F	0.11
UCEC	chr9	35704479	Missense_Mutation	novel	A1967V	0.09
UCEC	chr9	35707834	Missense_Mutation	rs756002749	R1510H	0.4
UCEC	chr9	35714573	Splice_Site	novel	X995_splice	0.27
UCEC	chr9	35722875	Missense_Mutation	NA	R277C	0.31
UCEC	chr9	35719770	Silent	novel	F516F	0.56
UCEC	chr9	35700292	Missense_Mutation	NA	A2187T	0.48
UCEC	chr9	35704363	Missense_Mutation	novel	R2006C	0.4
UCEC	chr9	35707796	Missense_Mutation	NA	R1523C	0.37
UCEC	chr9	35725648	Missense_Mutation	novel	T16M	0.26
UCEC	chr9	35698845	Missense_Mutation	rs763897212	A2363V	0.31
UCEC	chr9	35724277	Missense_Mutation	rs769874189	T190M	0.47
UCEC	chr9	35703886	Silent	rs11541906	N2082N	0.34
UCEC	chr9	35723846	Intron	novel		0.12
UCEC	chr9	35720490	Missense_Mutation	novel	F409C	0.06
UCEC	chr9	35698386	Silent	novel	A2436A	0.19
UCEC	chr9	35698899	Missense_Mutation	rs777100987	I2345T	0.29
UCEC	chr9	35703839	Missense_Mutation	rs149573730	T2098M	0.29
UCEC	chr9	35710842	Silent	novel	D1386D	0.24
UCEC	chr9	35713962	Silent	novel	P1080P	0.43
UCEC	chr9	35717366	Silent	rs776831566	A746A	0.24
UCEC	chr9	35725633	Missense_Mutation	rs764312097	P21L	0.48
UCEC	chr9	35712971	Missense_Mutation	rs778948183	T1142M	0.21
UCEC	chr9	35697817	Missense_Mutation	novel	P2534S	0.5
UCEC	chr9	35722172	Missense_Mutation	rs749761240	V299M	0.43
UCEC	chr9	35704696	Silent	novel	I1951I	0.07
UCEC	chr9	35704697	In_Frame_Ins	novel	L1950_I1951insT	0.07
UCEC	chr9	35707421	Missense_Mutation	novel	E1567G	0.28
UCEC	chr9	35700039	Nonsense_Mutation	NA	R2235*	0.08
UCEC	chr9	35724726	Splice_Site	novel	X120_splice	0.36
UCEC	chr9	35720094	Frame_Shift_Del	novel	*P470Lfs19**	0.23
UCEC	chr9	35706461	Silent	NA	L1727L	0.07
UCEC	chr9	35700373	Missense_Mutation	NA	F2160V	0.5
UCEC	chr9	35704159	Missense_Mutation	novel	K2021N	0.29
UCEC	chr9	35707084	Missense_Mutation	novel	I1648S	0.43
UCEC	chr9	35707406	Missense_Mutation	novel	L1572R	0.31
UCEC	chr9	35704695	Frame_Shift_Ins	novel	*E1952Pfs73**	0.04
UCEC	chr9	35704697	Frame_Shift_Ins	novel	*I1951Sfs9**	0.01
UCEC	chr9	35700359	Silent	NA	E2164E	0.53
UCEC	chr9	35704165	Silent	rs772238127	I2019I	0.4
UCEC	chr9	35707193	Missense_Mutation	novel	G1612R	0.3
UCEC	chr9	35714596	Missense_Mutation	novel	A988D	0.38
UCEC	chr9	35717178	Missense_Mutation	novel	T809N	0.49
UCEC	chr9	35721764	Silent	novel	L330L	0.16
UCEC	chr9	35724892	Missense_Mutation	NA	T99M	0.44
UCEC	chr9	35720438	Frame_Shift_Del	novel	*K428Sfs61**	0.35
UCEC	chr9	35697910	Missense_Mutation	rs148513341	A2503T	0.26
UCEC	chr9	35722876	Silent	novel	E276E	0.08
UCEC	chr9	35724892	Missense_Mutation	NA	T99M	0.31
UCEC	chr9	35707487	Missense_Mutation	novel	A1545V	0.44
UCEC	chr9	35698845	Missense_Mutation	rs763897212	A2363V	0.32
UCEC	chr9	35704154	Missense_Mutation	novel	A2023V	0.39
UCEC	chr9	35706865	Missense_Mutation	rs766069516	A1664V	0.35
UCEC	chr9	35712890	Missense_Mutation	rs552100458	A1169V	0.34
UCEC	chr9	35714046	Silent	novel	S1052S	0.43
UCEC	chr9	35717159	Silent	novel	S815S	0.29
UCEC	chr9	35725317	Silent	rs756421597	S45S	0.36
UCEC	chr9	35704154	Missense_Mutation	novel	A2023V	0.28
UCEC	chr9	35706358	Missense_Mutation	novel	Q1733H	0.27
UCEC	chr9	35718907	Missense_Mutation	rs776442599	R634C	0.39
UCEC	chr9	35724724	Missense_Mutation	novel	G120D	0.35
UCEC	chr9	35725301	Missense_Mutation	novel	L51M	0.13

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
HNSC	AMP	0.2299	6.4212e-14
LAML	DEL	0.0052	0.24147
LUSC	AMP	0.2315	1.2335e-10
PAAD	AMP	0.0924	1.193e-05
STAD	AMP	0.1565	0.00082114
TGCT	DEL	0.3267	7.3329e-05
THCA	DEL	0.0261	0.24038
THYM	DEL	0.0163	0.022012
UCS	DEL	0.5	0.089783

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00011	Kaplan-Meier Survival Analysis
SARC	0.048	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
ACC	0.00018	Kaplan-Meier Survival Analysis
UCS	0.043	Kaplan-Meier Survival Analysis
LUSC	0.046	Kaplan-Meier Survival Analysis
ESCA	0.036	Kaplan-Meier Survival Analysis
BLCA	0.016	Kaplan-Meier Survival Analysis
CESC	0.033	Kaplan-Meier Survival Analysis
LAML	0.00023	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742