EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137574 (Gene tree)
Gene ID: 96764
Gene Symbol: TGS1
Alias: PIMT|NCOA6IP
Full Name: trimethylguanosine synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 52,307 bases
Position: chr8:55,773,142-55,825,448
Accession: 17843
RBP type: canonical RBP
Summary: (Trimethylguanosine Synthase 1) is a Protein Coding gene. Among its related pathways are Developmental Biology and Metabolism. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and RNA trimethylguanosine synthase activity.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000260129	Methyltransf_15	PF09445.10	7.3e-42	1	1
ENSP00000260129	UPF0020	PF01170.18	4.7e-05	1	1
ENSP00000260129	Met_10	PF02475.16	2.6e-05	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22982455	Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.	Mech Dev	2012 Sep-Dec	Jia Y	doi: 10.1016/j.mod.2012.08.002
15684427	DTL, the Drosophila homolog of PIMT/Tgs1 nuclear receptor coactivator-interacting protein/RNA methyltransferase, has an essential role in development.	J Biol Chem	2005 Apr 1	Komonyi O	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000260129	TGS1-201	3782	XM_005251328	ENSP00000260129	853 (aa)	XP_006716548	Q96RS0
ENST00000523948	TGS1-203	3159	-	ENSP00000430467	53 (aa)	-	E5RJW7
ENST00000519494	TGS1-202	550	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137574's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137574's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137574	TGS1	100	81.374	ENSAMEG00000001781	TGS1	100	81.607	Ailuropoda_melanoleuca
ENSG00000137574	TGS1	97	36.836	ENSAOCG00000022799	lyn	96	36.628	Amphiprion_ocellaris
ENSG00000137574	TGS1	76	40.348	ENSAPEG00000019723	TGS1	96	40.552	Amphiprion_percula
ENSG00000137574	TGS1	92	35.301	ENSATEG00000005927	lyn	91	35.422	Anabas_testudineus
ENSG00000137574	TGS1	77	51.213	ENSAPLG00000006073	-	100	51.498	Anas_platyrhynchos
ENSG00000137574	TGS1	99	49.835	ENSACAG00000017988	TGS1	92	50.384	Anolis_carolinensis
ENSG00000137574	TGS1	99	81.754	ENSANAG00000035525	TGS1	100	80.819	Aotus_nancymaae
ENSG00000137574	TGS1	98	39.150	ENSAMXG00000014086	lyn	98	38.691	Astyanax_mexicanus
ENSG00000137574	TGS1	100	73.396	ENSBTAG00000005898	TGS1	100	73.629	Bos_taurus
ENSG00000137574	TGS1	99	88.655	ENSCJAG00000016657	TGS1	98	88.772	Callithrix_jacchus
ENSG00000137574	TGS1	100	80.792	ENSCAFG00000007011	TGS1	100	81.141	Canis_familiaris
ENSG00000137574	TGS1	100	79.837	ENSCAFG00020015485	TGS1	100	80.186	Canis_lupus_dingo
ENSG00000137574	TGS1	100	72.960	ENSCHIG00000013976	TGS1	100	73.310	Capra_hircus
ENSG00000137574	TGS1	100	82.126	ENSTSYG00000000171	TGS1	100	82.593	Carlito_syrichta
ENSG00000137574	TGS1	96	68.116	ENSCAPG00000013732	TGS1	99	67.840	Cavia_aperea
ENSG00000137574	TGS1	100	73.690	ENSCPOG00000009713	TGS1	99	74.040	Cavia_porcellus
ENSG00000137574	TGS1	99	90.665	ENSCCAG00000030476	TGS1	99	91.015	Cebus_capucinus
ENSG00000137574	TGS1	100	93.216	ENSCATG00000035375	TGS1	100	93.567	Cercocebus_atys
ENSG00000137574	TGS1	100	76.752	ENSCLAG00000009468	TGS1	99	77.220	Chinchilla_lanigera
ENSG00000137574	TGS1	93	91.970	ENSCSAG00000014611	TGS1	99	92.346	Chlorocebus_sabaeus
ENSG00000137574	TGS1	100	75.846	ENSCHOG00000001462	TGS1	100	76.313	Choloepus_hoffmanni
ENSG00000137574	TGS1	99	54.813	ENSCPBG00000004958	TGS1	99	55.832	Chrysemys_picta_bellii
ENSG00000137574	TGS1	100	93.216	ENSCANG00000041389	TGS1	100	93.567	Colobus_angolensis_palliatus
ENSG00000137574	TGS1	100	74.446	ENSCGRG00001019470	Tgs1	99	74.562	Cricetulus_griseus_chok1gshd
ENSG00000137574	TGS1	100	74.622	ENSCGRG00000008981	Tgs1	99	75.204	Cricetulus_griseus_crigri
ENSG00000137574	TGS1	98	38.550	ENSDARG00000107511	lyn	99	73.333	Danio_rerio
ENSG00000137574	TGS1	99	78.880	ENSDNOG00000008353	TGS1	99	78.996	Dasypus_novemcinctus
ENSG00000137574	TGS1	100	75.613	ENSDORG00000012484	Tgs1	100	75.846	Dipodomys_ordii
ENSG00000137574	TGS1	75	80.488	ENSETEG00000005126	TGS1	85	70.175	Echinops_telfairi
ENSG00000137574	TGS1	93	80.779	ENSEASG00005016371	TGS1	95	81.281	Equus_asinus_asinus
ENSG00000137574	TGS1	100	81.956	ENSECAG00000019399	TGS1	99	82.538	Equus_caballus
ENSG00000137574	TGS1	71	91.803	ENSEEUG00000001735	TGS1	71	94.118	Erinaceus_europaeus
ENSG00000137574	TGS1	99	38.322	ENSELUG00000012537	lyn	99	39.091	Esox_lucius
ENSG00000137574	TGS1	100	81.002	ENSFCAG00000011478	TGS1	100	81.235	Felis_catus
ENSG00000137574	TGS1	89	49.875	ENSFALG00000010249	TGS1	99	50.313	Ficedula_albicollis
ENSG00000137574	TGS1	100	77.726	ENSFDAG00000011405	TGS1	100	77.726	Fukomys_damarensis
ENSG00000137574	TGS1	97	50.685	ENSGALG00000015340	TGS1	97	51.139	Gallus_gallus
ENSG00000137574	TGS1	99	55.431	ENSGAGG00000019590	TGS1	99	56.103	Gopherus_agassizii
ENSG00000137574	TGS1	100	98.246	ENSGGOG00000008624	TGS1	100	98.246	Gorilla_gorilla
ENSG00000137574	TGS1	91	83.333	ENSHGLG00000000284	TGS1	100	83.333	Heterocephalus_glaber_female
ENSG00000137574	TGS1	98	38.051	ENSHCOG00000014161	lyn	98	37.703	Hippocampus_comes
ENSG00000137574	TGS1	77	41.772	ENSIPUG00000002294	tgs1	98	37.954	Ictalurus_punctatus
ENSG00000137574	TGS1	100	79.953	ENSSTOG00000009597	TGS1	100	80.536	Ictidomys_tridecemlineatus
ENSG00000137574	TGS1	99	71.864	ENSJJAG00000016239	Tgs1	100	72.098	Jaculus_jaculus
ENSG00000137574	TGS1	97	38.123	ENSKMAG00000019371	-	96	37.835	Kryptolebias_marmoratus
ENSG00000137574	TGS1	99	36.897	ENSLBEG00000027341	-	98	37.225	Labrus_bergylta
ENSG00000137574	TGS1	99	47.463	ENSLACG00000008074	TGS1	100	47.914	Latimeria_chalumnae
ENSG00000137574	TGS1	99	40.914	ENSLOCG00000005492	lyn	95	46.120	Lepisosteus_oculatus
ENSG00000137574	TGS1	100	75.058	ENSLAFG00000015386	TGS1	100	75.406	Loxodonta_africana
ENSG00000137574	TGS1	100	93.677	ENSMFAG00000029838	TGS1	100	93.911	Macaca_fascicularis
ENSG00000137574	TGS1	100	92.398	ENSMMUG00000005478	TGS1	100	92.749	Macaca_mulatta
ENSG00000137574	TGS1	100	93.794	ENSMNEG00000023719	TGS1	100	94.028	Macaca_nemestrina
ENSG00000137574	TGS1	100	93.216	ENSMLEG00000034807	TGS1	100	93.567	Mandrillus_leucophaeus
ENSG00000137574	TGS1	98	38.983	ENSMAMG00000009542	TGS1	91	42.341	Mastacembelus_armatus
ENSG00000137574	TGS1	78	51.433	ENSMGAG00000010966	TGS1	90	52.199	Meleagris_gallopavo
ENSG00000137574	TGS1	100	75.087	ENSMAUG00000009875	Tgs1	99	75.553	Mesocricetus_auratus
ENSG00000137574	TGS1	100	83.781	ENSMICG00000011199	TGS1	100	84.014	Microcebus_murinus
ENSG00000137574	TGS1	99	71.813	ENSMOCG00000019560	Tgs1	99	72.281	Microtus_ochrogaster
ENSG00000137574	TGS1	86	66.844	ENSMODG00000009174	TGS1	98	67.244	Monodelphis_domestica
ENSG00000137574	TGS1	99	73.536	MGP_CAROLIEiJ_G0025779	-	99	73.536	Mus_caroli
ENSG00000137574	TGS1	99	66.859	MGP_CAROLIEiJ_G0025780	-	98	66.859	Mus_caroli
ENSG00000137574	TGS1	99	73.653	ENSMUSG00000028233	Tgs1	99	73.653	Mus_musculus
ENSG00000137574	TGS1	99	67.396	MGP_PahariEiJ_G0023902	-	98	67.281	Mus_pahari
ENSG00000137574	TGS1	99	74.065	MGP_PahariEiJ_G0023901	-	99	73.949	Mus_pahari
ENSG00000137574	TGS1	57	84.332	MGP_SPRETEiJ_G0026726	-	94	84.332	Mus_spretus
ENSG00000137574	TGS1	99	73.536	MGP_SPRETEiJ_G0026727	-	99	73.536	Mus_spretus
ENSG00000137574	TGS1	93	79.874	ENSMPUG00000010475	TGS1	99	80.377	Mustela_putorius_furo
ENSG00000137574	TGS1	100	76.573	ENSMLUG00000014857	TGS1	100	76.923	Myotis_lucifugus
ENSG00000137574	TGS1	100	77.273	ENSNGAG00000019532	Tgs1	99	77.273	Nannospalax_galili
ENSG00000137574	TGS1	100	96.725	ENSNLEG00000001101	TGS1	100	96.725	Nomascus_leucogenys
ENSG00000137574	TGS1	93	63.716	ENSMEUG00000001697	TGS1	99	64.090	Notamacropus_eugenii
ENSG00000137574	TGS1	91	69.014	ENSODEG00000002948	TGS1	100	69.398	Octodon_degus
ENSG00000137574	TGS1	78	38.316	ENSONIG00000006339	lyn	94	39.691	Oreochromis_niloticus
ENSG00000137574	TGS1	89	62.117	ENSOANG00000021853	TGS1	98	62.500	Ornithorhynchus_anatinus
ENSG00000137574	TGS1	100	78.738	ENSOCUG00000017522	TGS1	100	79.089	Oryctolagus_cuniculus
ENSG00000137574	TGS1	63	74.419	ENSORLG00020004200	lyn	93	34.413	Oryzias_latipes_hni
ENSG00000137574	TGS1	76	39.035	ENSOMEG00000020174	lyn	96	35.581	Oryzias_melastigma
ENSG00000137574	TGS1	100	81.395	ENSOGAG00000012572	TGS1	100	81.279	Otolemur_garnettii
ENSG00000137574	TGS1	100	72.822	ENSOARG00000014613	TGS1	100	73.055	Ovis_aries
ENSG00000137574	TGS1	100	98.012	ENSPPAG00000039058	TGS1	100	98.012	Pan_paniscus
ENSG00000137574	TGS1	100	80.070	ENSPPRG00000000677	TGS1	100	80.420	Panthera_pardus
ENSG00000137574	TGS1	100	80.186	ENSPTIG00000005122	TGS1	100	80.536	Panthera_tigris_altaica
ENSG00000137574	TGS1	100	98.246	ENSPTRG00000020262	TGS1	100	98.246	Pan_troglodytes
ENSG00000137574	TGS1	100	93.450	ENSPANG00000018910	TGS1	100	93.801	Papio_anubis
ENSG00000137574	TGS1	77	43.008	ENSPKIG00000005454	lyn	68	42.667	Paramormyrops_kingsleyae
ENSG00000137574	TGS1	99	53.889	ENSPSIG00000014983	TGS1	100	54.333	Pelodiscus_sinensis
ENSG00000137574	TGS1	65	56.352	ENSPMGG00000012711	lyn	81	71.429	Periophthalmus_magnuspinnatus
ENSG00000137574	TGS1	100	73.979	ENSPEMG00000007957	Tgs1	99	74.679	Peromyscus_maniculatus_bairdii
ENSG00000137574	TGS1	99	66.513	ENSPCIG00000016232	TGS1	99	66.859	Phascolarctos_cinereus
ENSG00000137574	TGS1	76	39.376	ENSPFOG00000001545	-	99	39.227	Poecilia_formosa
ENSG00000137574	TGS1	92	32.807	ENSPREG00000012261	-	99	32.928	Poecilia_reticulata
ENSG00000137574	TGS1	100	95.897	ENSPPYG00000018597	TGS1	100	95.897	Pongo_abelii
ENSG00000137574	TGS1	100	73.131	ENSPCAG00000000143	TGS1	100	73.014	Procavia_capensis
ENSG00000137574	TGS1	100	84.481	ENSPCOG00000013537	TGS1	100	84.714	Propithecus_coquereli
ENSG00000137574	TGS1	100	74.707	ENSPVAG00000016399	TGS1	100	74.707	Pteropus_vampyrus
ENSG00000137574	TGS1	99	40.023	ENSPNAG00000022249	lyn	99	40.753	Pygocentrus_nattereri
ENSG00000137574	TGS1	99	72.664	ENSRNOG00000008156	Tgs1	99	72.547	Rattus_norvegicus
ENSG00000137574	TGS1	100	90.409	ENSRBIG00000041893	TGS1	100	90.994	Rhinopithecus_bieti
ENSG00000137574	TGS1	100	93.567	ENSRROG00000035127	TGS1	100	93.918	Rhinopithecus_roxellana
ENSG00000137574	TGS1	96	89.596	ENSSBOG00000024469	TGS1	99	89.351	Saimiri_boliviensis_boliviensis
ENSG00000137574	TGS1	99	64.638	ENSSHAG00000012878	TGS1	99	65.212	Sarcophilus_harrisii
ENSG00000137574	TGS1	97	38.138	ENSSFOG00015001308	tgs1	96	38.408	Scleropages_formosus
ENSG00000137574	TGS1	76	40.719	ENSSMAG00000019469	lyn	96	38.215	Scophthalmus_maximus
ENSG00000137574	TGS1	81	69.792	ENSSPAG00000002170	lyn	77	72.527	Stegastes_partitus
ENSG00000137574	TGS1	90	70.930	ENSSSCG00000006251	TGS1	98	71.576	Sus_scrofa
ENSG00000137574	TGS1	97	51.679	ENSTGUG00000011050	TGS1	100	52.205	Taeniopygia_guttata
ENSG00000137574	TGS1	75	37.963	ENSTRUG00000009532	lyn	65	67.907	Takifugu_rubripes
ENSG00000137574	TGS1	89	36.937	ENSTNIG00000018133	lyn	99	37.070	Tetraodon_nigroviridis
ENSG00000137574	TGS1	85	98.361	ENSTBEG00000010953	TGS1	85	98.361	Tupaia_belangeri
ENSG00000137574	TGS1	100	70.746	ENSTTRG00000017239	TGS1	100	71.096	Tursiops_truncatus
ENSG00000137574	TGS1	100	80.070	ENSUAMG00000027718	TGS1	100	80.303	Ursus_americanus
ENSG00000137574	TGS1	93	79.623	ENSUMAG00000009761	TGS1	99	79.874	Ursus_maritimus
ENSG00000137574	TGS1	84	69.806	ENSVPAG00000001166	TGS1	88	70.083	Vicugna_pacos
ENSG00000137574	TGS1	93	78.616	ENSVVUG00000017821	TGS1	99	78.994	Vulpes_vulpes
ENSG00000137574	TGS1	99	47.691	ENSXETG00000005648	tgs1	100	47.706	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000387	spliceosomal snRNP assembly	-	TAS	Process
GO:0005515	protein binding	21522132.	IPI	Function
GO:0005615	extracellular space	22664934.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	12943661.	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	12943661.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0008173	RNA methyltransferase activity	-	TAS	Function
GO:0009452	7-methylguanosine RNA capping	-	IEA	Process
GO:0015030	Cajal body	-	IEA	Component
GO:0019216	regulation of lipid metabolic process	-	TAS	Process
GO:0022613	ribonucleoprotein complex biogenesis	16687569.	IC	Process
GO:0030532	small nuclear ribonucleoprotein complex	16687569.	IC	Component
GO:0036261	7-methylguanosine cap hypermethylation	21873635.	IBA	Process
GO:0036261	7-methylguanosine cap hypermethylation	16687569.	IDA	Process
GO:0071164	RNA trimethylguanosine synthase activity	21873635.	IBA	Function
GO:0071164	RNA trimethylguanosine synthase activity	16687569.	IDA	Function