EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137628 (Gene tree)
Gene ID: 55601
Gene Symbol: DDX60
Alias: FLJ20035
Full Name: DExD/H-box helicase 60
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 102,517 bases
Position: chr4:168,216,291-168,318,807
Accession: 25942
RBP type: canonical RBP
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular procsses involving RNA binding and alteration of RNA secondary structure. This gene encodes a DEXD/H box RNA helicase that functions as an antiviral factor and promotes RIG-I-like receptor-mediated signaling. [provided by RefSeq, Apr 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000377344	ResIII	PF04851.15	3.3e-12	1	1
ENSP00000377344	DEAD	PF00270.29	8e-17	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23449408	[Innate immune responses against viral infection and its suppression by viral proteins].	Yakugaku Zasshi	2013	Oshiumi H	-
21791617	DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.	Mol Cell Biol	2011 Sep	Miyashita M	doi: 10.1128/MCB.01368-10

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505393	DDX60-202	745	-	-	- (aa)	-	-
ENST00000513997	DDX60-205	542	-	ENSP00000423678	104 (aa)	-	H0Y9B2
ENST00000507815	DDX60-203	548	-	-	- (aa)	-	-
ENST00000511317	DDX60-204	618	-	ENSP00000422669	191 (aa)	-	H0Y8Z7
ENST00000514995	DDX60-206	534	-	ENSP00000423647	119 (aa)	-	D6R944
ENST00000393743	DDX60-201	6071	XM_011532103	ENSP00000377344	1712 (aa)	XP_011530405	Q8IY21

Gene Model

Click here to download ENSG00000137628's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137628's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000137628	DDX60	95	80.531	ENSG00000181381	DDX60L	95	79.661

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137628	DDX60	99	80.583	ENSAMEG00000013429	DDX60	99	80.458	Ailuropoda_melanoleuca
ENSG00000137628	DDX60	99	60.577	ENSAPLG00000007120	DDX60	100	57.022	Anas_platyrhynchos
ENSG00000137628	DDX60	92	66.364	ENSACAG00000016010	DDX60	97	57.986	Anolis_carolinensis
ENSG00000137628	DDX60	100	90.713	ENSANAG00000030883	DDX60	100	92.259	Aotus_nancymaae
ENSG00000137628	DDX60	100	91.530	ENSCJAG00000004726	DDX60	100	93.040	Callithrix_jacchus
ENSG00000137628	DDX60	100	78.634	ENSCAFG00000009003	DDX60	100	78.634	Canis_familiaris
ENSG00000137628	DDX60	95	86.726	ENSTSYG00000011545	-	99	81.529	Carlito_syrichta
ENSG00000137628	DDX60	95	67.129	ENSCAPG00000006504	DDX60	100	65.908	Cavia_aperea
ENSG00000137628	DDX60	99	77.670	ENSCPOG00000008326	DDX60	96	75.439	Cavia_porcellus
ENSG00000137628	DDX60	100	90.718	ENSCCAG00000034674	DDX60	100	90.718	Cebus_capucinus
ENSG00000137628	DDX60	100	97.479	ENSCATG00000038859	DDX60	100	96.145	Cercocebus_atys
ENSG00000137628	DDX60	99	79.612	ENSCLAG00000015332	DDX60	99	74.634	Chinchilla_lanigera
ENSG00000137628	DDX60	99	98.058	ENSCSAG00000003155	DDX60	100	96.028	Chlorocebus_sabaeus
ENSG00000137628	DDX60	99	61.165	ENSCPBG00000001510	-	99	61.237	Chrysemys_picta_bellii
ENSG00000137628	DDX60	88	73.333	ENSCPBG00000027534	DDX60	95	60.968	Chrysemys_picta_bellii
ENSG00000137628	DDX60	100	96.145	ENSCANG00000032267	DDX60	100	96.145	Colobus_angolensis_palliatus
ENSG00000137628	DDX60	100	77.311	ENSCGRG00001018201	Ddx60	100	74.562	Cricetulus_griseus_chok1gshd
ENSG00000137628	DDX60	100	78.151	ENSCGRG00000005295	Ddx60	100	74.562	Cricetulus_griseus_crigri
ENSG00000137628	DDX60	95	83.186	ENSDNOG00000008454	DDX60	99	78.174	Dasypus_novemcinctus
ENSG00000137628	DDX60	93	88.288	ENSEASG00005021849	DDX60	99	80.704	Equus_asinus_asinus
ENSG00000137628	DDX60	93	90.090	ENSECAG00000024167	DDX60	95	79.711	Equus_caballus
ENSG00000137628	DDX60	99	54.369	ENSECAG00000032492	-	94	54.589	Equus_caballus
ENSG00000137628	DDX60	100	61.098	ENSEEUG00000010236	DDX60	100	61.098	Erinaceus_europaeus
ENSG00000137628	DDX60	99	79.015	ENSFCAG00000010766	DDX60	99	79.015	Felis_catus
ENSG00000137628	DDX60	99	59.615	ENSGALG00000009639	DDX60	93	54.567	Gallus_gallus
ENSG00000137628	DDX60	100	98.319	ENSGGOG00000012801	DDX60	100	99.692	Gorilla_gorilla
ENSG00000137628	DDX60	99	78.641	ENSHGLG00000013790	DDX60	99	75.388	Heterocephalus_glaber_female
ENSG00000137628	DDX60	99	78.641	ENSHGLG00100002763	-	99	75.599	Heterocephalus_glaber_male
ENSG00000137628	DDX60	99	73.786	ENSSTOG00000016257	DDX60	100	79.186	Ictidomys_tridecemlineatus
ENSG00000137628	DDX60	99	58.491	ENSLACG00000017399	DDX60	99	55.901	Latimeria_chalumnae
ENSG00000137628	DDX60	100	96.639	ENSMFAG00000016136	DDX60	100	96.379	Macaca_fascicularis
ENSG00000137628	DDX60	100	96.639	ENSMMUG00000001880	DDX60	100	96.437	Macaca_mulatta
ENSG00000137628	DDX60	100	96.639	ENSMNEG00000030573	DDX60	100	93.003	Macaca_nemestrina
ENSG00000137628	DDX60	99	96.117	ENSMLEG00000030919	DDX60	100	95.910	Mandrillus_leucophaeus
ENSG00000137628	DDX60	99	58.654	ENSMGAG00000002432	DDX60	100	54.481	Meleagris_gallopavo
ENSG00000137628	DDX60	95	80.531	ENSMAUG00000016664	Ddx60	99	74.649	Mesocricetus_auratus
ENSG00000137628	DDX60	99	78.378	ENSMICG00000013542	DDX60	100	78.378	Microcebus_murinus
ENSG00000137628	DDX60	95	76.991	ENSMOCG00000007646	-	99	72.876	Microtus_ochrogaster
ENSG00000137628	DDX60	95	77.876	ENSMOCG00000008571	-	99	70.433	Microtus_ochrogaster
ENSG00000137628	DDX60	100	68.067	ENSMODG00000002645	DDX60	99	62.252	Monodelphis_domestica
ENSG00000137628	DDX60	95	80.531	MGP_CAROLIEiJ_G0031080	Ddx60	99	75.513	Mus_caroli
ENSG00000137628	DDX60	95	82.301	ENSMUSG00000037921	Ddx60	99	75.220	Mus_musculus
ENSG00000137628	DDX60	99	81.114	ENSMPUG00000007710	DDX60	99	81.114	Mustela_putorius_furo
ENSG00000137628	DDX60	99	82.524	ENSMLUG00000007300	DDX60	99	80.177	Myotis_lucifugus
ENSG00000137628	DDX60	100	96.639	ENSNLEG00000006542	DDX60	100	96.203	Nomascus_leucogenys
ENSG00000137628	DDX60	99	58.095	ENSOANG00000028702	-	99	50.165	Ornithorhynchus_anatinus
ENSG00000137628	DDX60	99	63.107	ENSOANG00000007454	DDX60	99	61.628	Ornithorhynchus_anatinus
ENSG00000137628	DDX60	99	56.364	ENSOCUG00000022101	-	100	52.376	Oryctolagus_cuniculus
ENSG00000137628	DDX60	99	51.818	ENSOCUG00000020913	-	99	52.301	Oryctolagus_cuniculus
ENSG00000137628	DDX60	95	84.956	ENSOCUG00000006355	DDX60	99	78.266	Oryctolagus_cuniculus
ENSG00000137628	DDX60	99	100.000	ENSPPAG00000040254	-	99	98.743	Pan_paniscus
ENSG00000137628	DDX60	100	79.697	ENSPPRG00000009286	DDX60	100	79.697	Panthera_pardus
ENSG00000137628	DDX60	100	79.755	ENSPTIG00000022042	DDX60	100	79.755	Panthera_tigris_altaica
ENSG00000137628	DDX60	100	99.124	ENSPTRG00000016581	DDX60	100	99.124	Pan_troglodytes
ENSG00000137628	DDX60	100	98.319	ENSPANG00000019535	DDX60	100	96.671	Papio_anubis
ENSG00000137628	DDX60	97	66.957	ENSPSIG00000004307	DDX60	100	60.292	Pelodiscus_sinensis
ENSG00000137628	DDX60	95	82.301	ENSPEMG00000023735	-	99	70.316	Peromyscus_maniculatus_bairdii
ENSG00000137628	DDX60	100	97.479	ENSPPYG00000015184	DDX60	99	94.626	Pongo_abelii
ENSG00000137628	DDX60	99	75.728	ENSPCAG00000002661	-	83	77.778	Procavia_capensis
ENSG00000137628	DDX60	99	65.049	ENSPCAG00000000925	-	92	62.346	Procavia_capensis
ENSG00000137628	DDX60	95	84.956	ENSPCOG00000008412	DDX60	98	79.612	Propithecus_coquereli
ENSG00000137628	DDX60	99	82.524	ENSPVAG00000011428	DDX60	99	76.040	Pteropus_vampyrus
ENSG00000137628	DDX60	99	69.903	ENSRNOG00000059097	AABR07025140.1	99	73.012	Rattus_norvegicus
ENSG00000137628	DDX60	100	96.639	ENSRBIG00000034414	DDX60	100	96.759	Rhinopithecus_bieti
ENSG00000137628	DDX60	100	97.479	ENSRROG00000030767	DDX60	100	96.028	Rhinopithecus_roxellana
ENSG00000137628	DDX60	99	90.678	ENSSBOG00000024856	DDX60	100	88.009	Saimiri_boliviensis_boliviensis
ENSG00000137628	DDX60	99	65.714	ENSSHAG00000016219	DDX60	99	63.829	Sarcophilus_harrisii
ENSG00000137628	DDX60	92	79.817	ENSSARG00000002474	-	91	64.387	Sorex_araneus
ENSG00000137628	DDX60	91	67.593	ENSSPUG00000019257	DDX60	95	70.062	Sphenodon_punctatus
ENSG00000137628	DDX60	99	78.052	ENSSSCG00000009720	DDX60	99	78.052	Sus_scrofa
ENSG00000137628	DDX60	99	69.903	ENSTTRG00000016129	DDX60	88	78.893	Tursiops_truncatus
ENSG00000137628	DDX60	99	83.495	ENSUMAG00000020219	DDX60	99	80.318	Ursus_maritimus
ENSG00000137628	DDX60	99	78.641	ENSVVUG00000023953	DDX60	99	78.332	Vulpes_vulpes
ENSG00000137628	DDX60	99	57.282	ENSXETG00000031597	-	99	49.855	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003690	double-stranded DNA binding	21791617.	IDA	Function
GO:0003725	double-stranded RNA binding	21791617.	IDA	Function
GO:0003727	single-stranded RNA binding	21791617.	IDA	Function
GO:0004386	helicase activity	-	IEA	Function
GO:0005515	protein binding	21791617.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005737	cytoplasm	21791617.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0009615	response to virus	21791617.	IDA	Process
GO:0045087	innate immune response	-	IEA	Process
GO:0045111	intermediate filament cytoskeleton	-	IDA	Component
GO:0051607	defense response to virus	-	IEA	Process
GO:1900245	positive regulation of MDA-5 signaling pathway	21791617.	IMP	Process
GO:1900246	positive regulation of RIG-I signaling pathway	21791617.	IMP	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr4	168255738	Missense_Mutation	novel	K1177R	0.72
BLCA	chr4	168275351	Silent	rs139888899	T766T	0.42
BLCA	chr4	168302417	Splice_Site	novel	X203_splice	0.5
BLCA	chr4	168293927	Missense_Mutation	NA	L248V	0.2
BLCA	chr4	168216997	Missense_Mutation	novel	D1692V	0.19
BLCA	chr4	168275408	Silent	NA	L747L	0.53
BLCA	chr4	168287172	Missense_Mutation	NA	M405I	0.16
BLCA	chr4	168308136	Nonsense_Mutation	novel	S45*	0.19
BLCA	chr4	168236370	Nonsense_Mutation	novel	S1472*	0.22
BLCA	chr4	168276155	Missense_Mutation	NA	A669T	0.17
BLCA	chr4	168283486	Nonsense_Mutation	NA	S561*	0.52
BRCA	chr4	168262042	Missense_Mutation	NA	K1077N	0.22
BRCA	chr4	168274082	Missense_Mutation	NA	R769Q	0.55	ResIII
BRCA	chr4	168283555	Missense_Mutation	novel	F538S	0.1
BRCA	chr4	168284853	Missense_Mutation	NA	D510H	0.55
BRCA	chr4	168306623	Missense_Mutation	NA	T121R	0.64
BRCA	chr4	168280533	Missense_Mutation	NA	E594K	0.09
BRCA	chr4	168274047	Missense_Mutation	novel	A781T	0.05	ResIII
BRCA	chr4	168268930	Nonsense_Mutation	NA	E904*	0.19	ResIII
BRCA	chr4	168283515	Silent	rs753639974	S551S	0.18
BRCA	chr4	168285412	Missense_Mutation	novel	D476Y	0.05
BRCA	chr4	168251022	Missense_Mutation	novel	H1264Y	0.08
BRCA	chr4	168225628	In_Frame_Ins	novel	E1527_Y1528insAA	0.08
CESC	chr4	168237361	Nonsense_Mutation	NA	E1446*	0.45
CESC	chr4	168248226	Missense_Mutation	NA	Q1309E	0.4
CESC	chr4	168276095	Missense_Mutation	NA	E689Q	0.46
CESC	chr4	168220632	Intron	novel		0.07
CESC	chr4	168275500	Missense_Mutation	NA	A717T	0.29
CESC	chr4	168251073	Missense_Mutation	NA	E1247Q	0.32
CESC	chr4	168246492	Missense_Mutation	rs774054777	L1364F	0.31
COAD	chr4	168221792	Silent	NA	L1638L	0.3
COAD	chr4	168306689	Missense_Mutation	novel	E99V	0.31
COAD	chr4	168283457	Missense_Mutation	NA	K571E	0.21
COAD	chr4	168288203	Missense_Mutation	NA	A385D	0.36
COAD	chr4	168288281	Missense_Mutation	rs551895137	I359T	0.09
COAD	chr4	168216954	Missense_Mutation	NA	W1706C	0.25
COAD	chr4	168248274	Missense_Mutation	novel	T1293P	0.15
COAD	chr4	168276171	Silent	rs745578311	T663T	0.16
COAD	chr4	168252634	Frame_Shift_Del	NA	*T1194Pfs8**	0.22
COAD	chr4	168275466	Missense_Mutation	novel	K728T	0.19
COAD	chr4	168275439	Missense_Mutation	rs574811561	R737Q	0.59
COAD	chr4	168283503	Silent	NA	V555V	0.3
COAD	chr4	168267923	Silent	rs148195164	T949T	0.24
COAD	chr4	168276135	Silent	novel	R675R	0.34
COAD	chr4	168274024	Silent	novel	S788S	0.15
COAD	chr4	168220678	Frame_Shift_Del	novel	*F1672Lfs25**	0.08
COAD	chr4	168288243	Missense_Mutation	rs142942424	L372I	0.35
COAD	chr4	168237741	Missense_Mutation	novel	D1407Y	0.12
COAD	chr4	168255747	Missense_Mutation	rs768211946	R1174Q	0.04
COAD	chr4	168217027	Missense_Mutation	novel	S1682F	0.29
COAD	chr4	168251107	Splice_Site	NA	X1236_splice	0.11
COAD	chr4	168267587	Missense_Mutation	novel	D1012Y	0.06
COAD	chr4	168306393	Missense_Mutation	NA	I198L	0.31
COAD	chr4	168311050	Missense_Mutation	NA	T8A	0.1
COAD	chr4	168220712	Missense_Mutation	NA	N1661T	0.41
COAD	chr4	168224351	Silent	rs375521196	L1572L	0.26
COAD	chr4	168276171	Silent	rs745578311	T663T	0.3
COAD	chr4	168262033	Missense_Mutation	novel	L1080F	0.08
COAD	chr4	168252633	Missense_Mutation	rs775193865	T1194N	0.17
COAD	chr4	168273352	Missense_Mutation	novel	K834R	0.36	ResIII
COAD	chr4	168275357	Silent	NA	P764P	0.13
DLBC	chr4	168291807	Missense_Mutation	novel	A328P	0.44
ESCA	chr4	168216942	Missense_Mutation	novel	N1710K	0.14
ESCA	chr4	168246536	Missense_Mutation	novel	K1349R	0.14
ESCA	chr4	168276160	Missense_Mutation	novel	S667I	0.32
GBM	chr4	168306614	Missense_Mutation	novel	S124W	0.2
GBM	chr4	168306661	Frame_Shift_Del	novel	*L109Ffs35**	0.04
GBM	chr4	168275440	Missense_Mutation	rs767373127	R737W	0.25
GBM	chr4	168225588	Missense_Mutation	rs374855681	R1541Q	0.39
GBM	chr4	168246592	Silent	rs767917539	G1330G	0.41
GBM	chr4	168275424	Missense_Mutation	novel	Y742S	0.19
GBM	chr4	168280479	Silent	novel	L612L	0.22
GBM	chr4	168283539	Silent	novel	G543G	0.28
GBM	chr4	168308019	Missense_Mutation	novel	I84R	0.06
GBM	chr4	168217023	Silent	novel	L1683L	0.61
GBM	chr4	168306613	Silent	rs200721426	S124S	0.1
GBM	chr4	168255787	Frame_Shift_Ins	novel	K1161*	0.17
HNSC	chr4	168224247	Missense_Mutation	novel	N1607S	0.25
HNSC	chr4	168252594	Missense_Mutation	novel	H1207R	0.26
HNSC	chr4	168276058	Missense_Mutation	novel	Y701F	0.22
HNSC	chr4	168267601	Missense_Mutation	novel	A1007V	0.31
HNSC	chr4	168236356	Missense_Mutation	rs751155591	Q1477E	0.12
HNSC	chr4	168293865	Silent	novel	C268C	0.17
HNSC	chr4	168283570	Frame_Shift_Ins	novel	*Q533Pfs31**	0.11
HNSC	chr4	168236310	Missense_Mutation	novel	G1492V	0.22
HNSC	chr4	168280569	Missense_Mutation	novel	A582S	0.26
HNSC	chr4	168280440	Missense_Mutation	novel	D625Y	0.13
HNSC	chr4	168216956	Missense_Mutation	novel	W1706G	0.35
HNSC	chr4	168306559	Silent	novel	F142F	0.28
KIRP	chr4	168250970	Missense_Mutation	NA	R1281K	0.25
LAML	chr4	168275371	Nonsense_Mutation	rs780328856	Q760*	0.09
LGG	chr4	168251095	Missense_Mutation	novel	K1239N	0.41
LGG	chr4	168262690	Missense_Mutation	rs751465372	R1046Q	0.39
LGG	chr4	168274008	Missense_Mutation	novel	A794S	0.39	ResIII
LGG	chr4	168224283	Missense_Mutation	novel	N1595S	0.31
LIHC	chr4	168216896	3'UTR	novel		0.3
LIHC	chr4	168216880	3'UTR	novel		0.4
LIHC	chr4	168280356	Missense_Mutation	NA	E653Q	0.59
LIHC	chr4	168287145	Silent	rs144769993	T414T	0.36
LIHC	chr4	168288254	Missense_Mutation	novel	N368S	0.38
LUAD	chr4	168284819	Splice_Site	novel	X521_splice	0.38
LUAD	chr4	168287075	Missense_Mutation	novel	L438I	0.12
LUAD	chr4	168287130	Silent	NA	V419V	0.15
LUAD	chr4	168224371	Missense_Mutation	novel	E1566K	0.13
LUAD	chr4	168225669	Missense_Mutation	novel	L1514R	0.1
LUAD	chr4	168237750	Nonsense_Mutation	novel	R1404*	0.2
LUAD	chr4	168237346	Missense_Mutation	NA	V1451F	0.24
LUAD	chr4	168251094	Missense_Mutation	novel	V1240I	0.22
LUAD	chr4	168225676	Missense_Mutation	novel	V1512L	0.66
LUAD	chr4	168225677	Splice_Site	novel	X1512_splice	0.66
LUAD	chr4	168280373	Missense_Mutation	rs137933604	C647F	0.09
LUAD	chr4	168275429	Silent	NA	L740L	0.29
LUAD	chr4	168225528	Splice_Site	novel	X1561_splice	0.38
LUAD	chr4	168280381	Missense_Mutation	NA	L644F	0.35
LUAD	chr4	168291879	Nonsense_Mutation	NA	E304*	0.44
LUAD	chr4	168311271	5'UTR	novel		0.15
LUAD	chr4	168306454	Silent	novel	G177G	0.11
LUAD	chr4	168268902	Missense_Mutation	NA	P913L	0.27	ResIII
LUAD	chr4	168293890	Missense_Mutation	NA	R260L	0.22
LUAD	chr4	168283521	Silent	novel	V549V	0.36
LUAD	chr4	168262084	Silent	novel	V1063V	0.09
LUAD	chr4	168252515	Missense_Mutation	novel	D1233E	0.8
LUAD	chr4	168273377	Missense_Mutation	NA	A826S	0.29	ResIII
LUSC	chr4	168268887	Missense_Mutation	NA	S918L	0.11	ResIII
LUSC	chr4	168274014	Missense_Mutation	novel	T792A	0.22	ResIII
LUSC	chr4	168306642	Missense_Mutation	novel	T115A	0.26
LUSC	chr4	168276077	Missense_Mutation	NA	I695V	0.72
LUSC	chr4	168276144	Silent	NA	V672V	0.15
LUSC	chr4	168236270	Silent	rs768206791	F1505F	0.07
LUSC	chr4	168248261	Missense_Mutation	novel	G1297V	0.26
LUSC	chr4	168237768	Silent	rs766452761	L1398L	0.52
LUSC	chr4	168273955	Silent	rs138638907	V811V	0.08
LUSC	chr4	168306720	Missense_Mutation	NA	D89Y	0.28
LUSC	chr4	168276162	Missense_Mutation	NA	L666F	0.2
LUSC	chr4	168260948	Missense_Mutation	novel	L1105F	0.15
LUSC	chr4	168262745	Missense_Mutation	novel	R1028G	0.13
LUSC	chr4	168275352	Missense_Mutation	novel	T766K	0.36
LUSC	chr4	168246460	Silent	novel	L1374L	0.33
LUSC	chr4	168273306	Silent	novel	E849E	0.32
LUSC	chr4	168252572	Silent	NA	L1214L	0.46
LUSC	chr4	168275383	Missense_Mutation	novel	D756Y	0.23
OV	chr4	168272133	In_Frame_Ins	novel	L860_I861insP	0.13	ResIII
OV	chr4	168272134	Frame_Shift_Ins	novel	*L860Qfs23**	0.13	ResIII
OV	chr4	168283513	Missense_Mutation	novel	K552T	0.07
OV	chr4	168306506	Missense_Mutation	novel	F160C	0.1
OV	chr4	168262712	Missense_Mutation	NA	Q1039E	0.4
OV	chr4	168217023	Nonsense_Mutation	novel	*R1684Cfs3**	0.05
PAAD	chr4	168273295	Missense_Mutation	novel	D853A	0.2	ResIII
PAAD	chr4	168308061	Missense_Mutation	rs747328711	R70H	0.18
PAAD	chr4	168285477	Missense_Mutation	novel	P454R	0.04
PRAD	chr4	168252576	Missense_Mutation	NA	C1213Y	0.39
PRAD	chr4	168275440	Missense_Mutation	rs767373127	R737W	0.27
PRAD	chr4	168283511	Missense_Mutation	novel	I553V	0.13
PRAD	chr4	168306451	Silent	NA	Q178Q	0.1
PRAD	chr4	168288274	Silent	novel	T361T	0.18
PRAD	chr4	168306706	Silent	rs140161501	A93A	0.46
PRAD	chr4	168308061	Missense_Mutation	rs747328711	R70H	0.39
READ	chr4	168291870	Missense_Mutation	novel	D307Y	0.08
READ	chr4	168246610	Silent	NA	G1324G	0.26
READ	chr4	168237335	Silent	novel	S1454S	0.38
READ	chr4	168251079	Missense_Mutation	NA	K1245Q	0.38
READ	chr4	168255753	Missense_Mutation	novel	K1172T	0.32
READ	chr4	168280346	Missense_Mutation	rs780985010	R656Q	0.41
READ	chr4	168306531	Missense_Mutation	rs545288798	D152N	0.46
READ	chr4	168216868	3'UTR	novel		0.14
SARC	chr4	168275439	Missense_Mutation	rs574811561	R737Q	0.3
SARC	chr4	168275446	Missense_Mutation	novel	P735T	0.16
SARC	chr4	168306609	Missense_Mutation	novel	C126R	0.09
SKCM	chr4	168216981	Silent	NA	A1697A	0.41
SKCM	chr4	168273966	Missense_Mutation	rs144653089	D808N	0.41	ResIII
SKCM	chr4	168267912	Missense_Mutation	NA	R953K	0.29
SKCM	chr4	168306531	Missense_Mutation	rs545288798	D152N	0.32
SKCM	chr4	168237405	Missense_Mutation	novel	N1431T	0.36
SKCM	chr4	168283534	Missense_Mutation	novel	S545L	0.62
SKCM	chr4	168260941	Missense_Mutation	novel	E1108K	0.2
SKCM	chr4	168255731	Silent	NA	S1179S	0.26
SKCM	chr4	168237760	Missense_Mutation	novel	F1400L	0.22
SKCM	chr4	168287159	Missense_Mutation	NA	Y410N	0.28
SKCM	chr4	168224263	Nonsense_Mutation	novel	R1602*	0.3
SKCM	chr4	168236296	Missense_Mutation	novel	P1497S	0.32
SKCM	chr4	168274025	Missense_Mutation	novel	S788F	0.07	ResIII
SKCM	chr4	168225579	Missense_Mutation	NA	S1544F	0.28
SKCM	chr4	168262128	Missense_Mutation	NA	E1049K	0.3
SKCM	chr4	168280524	Missense_Mutation	NA	E597K	0.24
SKCM	chr4	168262076	Missense_Mutation	NA	K1066M	0.17
SKCM	chr4	168291768	Missense_Mutation	novel	M341V	0.27
SKCM	chr4	168283521	Silent	NA	V549V	0.29
SKCM	chr4	168306612	Missense_Mutation	NA	R125G	0.24
SKCM	chr4	168311038	Missense_Mutation	NA	E12K	0.57
SKCM	chr4	168273966	Missense_Mutation	rs144653089	D808N	0.35	ResIII
SKCM	chr4	168293787	Splice_Region	rs138547096	Q294Q	0.21
SKCM	chr4	168217010	Missense_Mutation	NA	E1688K	0.49
SKCM	chr4	168246492	Missense_Mutation	rs774054777	L1364F	0.61
SKCM	chr4	168216986	Silent	novel	L1696L	0.69
SKCM	chr4	168267628	In_Frame_Del	novel	C991_I998del	0.1
SKCM	chr4	168221756	Silent	NA	S1650S	0.39
SKCM	chr4	168267934	Missense_Mutation	NA	E946K	0.53
SKCM	chr4	168237354	Missense_Mutation	NA	S1448F	0.29
SKCM	chr4	168237762	Missense_Mutation	NA	F1400I	0.23
SKCM	chr4	168273362	Missense_Mutation	rs778806064	R831C	0.24	ResIII
SKCM	chr4	168306698	Missense_Mutation	NA	N96I	0.42
SKCM	chr4	168216898	3'UTR	novel		0.14
SKCM	chr4	168280427	Missense_Mutation	NA	S629F	0.1
SKCM	chr4	168285499	Splice_Site	NA	X447_splice	0.45
SKCM	chr4	168284870	Missense_Mutation	NA	S504F	0.24
SKCM	chr4	168306386	Missense_Mutation	novel	S200F	0.3
SKCM	chr4	168255748	Nonsense_Mutation	rs776523299	R1174*	0.22
SKCM	chr4	168291807	Missense_Mutation	NA	A328T	0.39
SKCM	chr4	168246495	Missense_Mutation	NA	P1363S	0.34
SKCM	chr4	168252633	Missense_Mutation	rs775193865	T1194I	0.18
SKCM	chr4	168285491	Silent	NA	S449S	0.75
SKCM	chr4	168267608	Missense_Mutation	NA	P1005S	0.24
SKCM	chr4	168221854	Missense_Mutation	rs367640779	R1618C	0.15
SKCM	chr4	168275394	Missense_Mutation	NA	R752K	0.46
SKCM	chr4	168276031	Missense_Mutation	NA	S710F	0.34
SKCM	chr4	168237415	Nonsense_Mutation	NA	Q1428*	0.74
SKCM	chr4	168306382	Nonsense_Mutation	novel	W201*	0.38
SKCM	chr4	168306383	Nonsense_Mutation	novel	W201*	0.4
SKCM	chr4	168284850	Missense_Mutation	NA	D511N	0.09
SKCM	chr4	168288186	Missense_Mutation	NA	E391K	0.14
SKCM	chr4	168283553	Nonsense_Mutation	NA	Q539*	0.26
SKCM	chr4	168250964	Missense_Mutation	NA	G1283E	0.51
SKCM	chr4	168255770	Silent	NA	A1166A	0.45
SKCM	chr4	168251035	Silent	rs778810404	R1259R	0.38
SKCM	chr4	168273362	Missense_Mutation	rs778806064	R831C	0.51	ResIII
SKCM	chr4	168284896	Missense_Mutation	novel	E495D	0.27
SKCM	chr4	168284898	Nonsense_Mutation	novel	E495*	0.25
SKCM	chr4	168273354	Silent	rs746559865	T833T	0.33
SKCM	chr4	168267687	Silent	NA	L978L	0.28
SKCM	chr4	168224319	Missense_Mutation	rs750654165	R1583K	0.33
SKCM	chr4	168255727	Missense_Mutation	NA	E1181K	0.19
SKCM	chr4	168308084	Silent	NA	L62L	0.18
SKCM	chr4	168280434	Silent	NA	L627L	0.66
SKCM	chr4	168255752	Silent	novel	K1172K	0.37
SKCM	chr4	168275480	Silent	NA	V723V	0.64
SKCM	chr4	168306693	Missense_Mutation	NA	P98S	0.47
SKCM	chr4	168283529	Missense_Mutation	novel	E547K	0.45
SKCM	chr4	168283562	Missense_Mutation	novel	H536Y	0.4
SKCM	chr4	168267901	Missense_Mutation	rs752328810	R957C	0.78
SKCM	chr4	168276171	Silent	rs745578311	T663T	0.75
SKCM	chr4	168291785	Missense_Mutation	novel	S335F	0.16
SKCM	chr4	168221875	Silent	NA	L1611L	0.12
SKCM	chr4	168268887	Missense_Mutation	NA	S918L	0.07	ResIII
STAD	chr4	168273280	Missense_Mutation	NA	Q858R	0.12	ResIII
STAD	chr4	168273349	Missense_Mutation	NA	N835I	0.26	ResIII
STAD	chr4	168252634	Frame_Shift_Del	NA	*T1194Pfs8**	0.23
STAD	chr4	168306614	Missense_Mutation	rs758196490	S124L	0.24
STAD	chr4	168220636	Intron	novel		0.33
STAD	chr4	168268856	Splice_Region	rs145361158	T928T	0.34
STAD	chr4	168273277	Splice_Site	NA	X858_splice	0.36
STAD	chr4	168276171	Silent	rs745578311	T663T	0.26
STAD	chr4	168273376	Missense_Mutation	novel	A826V	0.33	ResIII
STAD	chr4	168267943	In_Frame_Ins	novel	D942_K943insFL	0.08
STAD	chr4	168267944	Silent	novel	D942D	0.05
STAD	chr4	168311360	5'UTR	novel		0.13
STAD	chr4	168268909	Nonsense_Mutation	rs760941649	R911*	0.23	ResIII
STAD	chr4	168216999	Silent	rs372799055	D1691D	0.24
STAD	chr4	168221857	Missense_Mutation	novel	N1617D	0.25
STAD	chr4	168216877	3'UTR	novel		0.47
STAD	chr4	168306707	Missense_Mutation	rs750085737	A93V	0.4
STAD	chr4	168306706	Silent	rs140161501	A93A	0.14
STAD	chr4	168236370	Missense_Mutation	novel	S1472L	0.13
STAD	chr4	168252633	Frame_Shift_Ins	NA	*T1194Nfs11**	0.09
STAD	chr4	168225653	Missense_Mutation	NA	E1519D	0.23
STAD	chr4	168252634	Frame_Shift_Del	NA	*T1194Pfs8**	0.27
STAD	chr4	168311274	5'UTR	novel		0.21
STAD	chr4	168216994	Missense_Mutation	rs747089851	N1693S	0.49
TGCT	chr4	168225610	Missense_Mutation	novel	E1534K	0.12
THCA	chr4	168293839	Missense_Mutation	rs146995893	R277H	0.09
THCA	chr4	168287131	Missense_Mutation	novel	V419A	0.1
UCEC	chr4	168216737	3'UTR	novel		0.3
UCEC	chr4	168267901	Missense_Mutation	rs752328810	R957C	0.32
UCEC	chr4	168280556	Missense_Mutation	rs754680656	K586T	0.4
UCEC	chr4	168288211	Missense_Mutation	NA	K382N	0.28
UCEC	chr4	168302319	Missense_Mutation	novel	W235L	0.07
UCEC	chr4	168225550	Nonsense_Mutation	NA	Q1554*	0.54
UCEC	chr4	168251079	Missense_Mutation	NA	K1245Q	0.27
UCEC	chr4	168276141	Missense_Mutation	NA	M673I	0.32
UCEC	chr4	168280346	Missense_Mutation	rs780985010	R656Q	0.06
UCEC	chr4	168291860	Missense_Mutation	NA	K310T	0.3
UCEC	chr4	168293938	Missense_Mutation	novel	K244T	0.05
UCEC	chr4	168216848	3'UTR	novel		0.4
UCEC	chr4	168221742	Missense_Mutation	novel	V1655A	0.3
UCEC	chr4	168267652	Missense_Mutation	novel	V990A	0.6
UCEC	chr4	168272080	Missense_Mutation	novel	N878S	0.38	ResIII
UCEC	chr4	168276115	Missense_Mutation	novel	K682T	0.37
UCEC	chr4	168302398	Missense_Mutation	novel	D209Y	0.41
UCEC	chr4	168262128	Missense_Mutation	NA	E1049K	0.31
UCEC	chr4	168224291	Silent	rs143944090	L1592L	0.38
UCEC	chr4	168216992	Missense_Mutation	rs537859190	V1694I	0.39
UCEC	chr4	168246531	Missense_Mutation	novel	I1351L	0.48
UCEC	chr4	168268951	Nonsense_Mutation	NA	E897*	0.45	ResIII
UCEC	chr4	168276031	Missense_Mutation	NA	S710Y	0.16
UCEC	chr4	168283515	Silent	rs753639974	S551S	0.53
UCEC	chr4	168246545	Missense_Mutation	novel	K1346R	0.12
UCEC	chr4	168273973	Missense_Mutation	novel	E805D	0.32	ResIII
UCEC	chr4	168283445	Splice_Site	rs755907243	X574_splice	0.42
UCEC	chr4	168272115	Silent	rs763563943	C866C	0.07
UCEC	chr4	168273341	Missense_Mutation	NA	S838G	0.35	ResIII
UCEC	chr4	168275497	Nonsense_Mutation	NA	E718*	0.29
UCEC	chr4	168276167	Missense_Mutation	NA	D665Y	0.18
UCEC	chr4	168283445	Splice_Site	rs755907243	X574_splice	0.29
UCEC	chr4	168306454	Silent	novel	G177G	0.32
UCEC	chr4	168251078	Missense_Mutation	NA	K1245T	0.43
UCEC	chr4	168262092	Missense_Mutation	NA	K1061E	0.4
UCEC	chr4	168280473	Nonsense_Mutation	NA	E614*	0.44
UCEC	chr4	168267893	Silent	rs546918985	A959A	0.45
UCEC	chr4	168274082	Missense_Mutation	NA	R769Q	0.37	ResIII
UCEC	chr4	168276167	Missense_Mutation	NA	D665Y	0.41
UCEC	chr4	168216708	3'UTR	novel		0.36
UCEC	chr4	168220631	Intron	novel		0.16
UCEC	chr4	168225588	Missense_Mutation	rs374855681	R1541Q	0.36
UCEC	chr4	168246527	Missense_Mutation	novel	K1352T	0.45
UCEC	chr4	168285424	Missense_Mutation	novel	D472Y	0.14
UCEC	chr4	168220591	Intron	novel		0.21
UCEC	chr4	168276084	Silent	novel	R692R	0.26
UCEC	chr4	168291774	Missense_Mutation	novel	E339K	0.36
UCEC	chr4	168308158	Missense_Mutation	novel	F38I	0.17
UCEC	chr4	168306635	Missense_Mutation	novel	I117T	0.52
UCEC	chr4	168267971	Silent	rs556911957	S933S	0.42
UCEC	chr4	168273301	Missense_Mutation	rs559655221	R851H	0.36	ResIII
UCEC	chr4	168273970	Silent	rs147938217	S806S	0.29
UCEC	chr4	168291878	Missense_Mutation	novel	E304G	0.5
UCEC	chr4	168237774	Missense_Mutation	NA	S1396P	0.29
UCEC	chr4	168287080	Missense_Mutation	novel	C436S	0.42
UCEC	chr4	168246527	Missense_Mutation	novel	K1352T	0.33
UCEC	chr4	168273354	Silent	rs746559865	T833T	0.42
UCEC	chr4	168287067	Missense_Mutation	novel	K440N	0.19
UCEC	chr4	168220617	Intron	novel		0.45
UCEC	chr4	168251028	Nonsense_Mutation	rs756128279	G1262*	0.47
UCEC	chr4	168262748	Missense_Mutation	novel	P1027S	0.41
UCEC	chr4	168273362	Missense_Mutation	rs778806064	R831C	0.34	ResIII
UCEC	chr4	168276171	Silent	rs745578311	T663T	0.54
UCEC	chr4	168280473	Nonsense_Mutation	NA	E614*	0.37
UCEC	chr4	168308090	Missense_Mutation	novel	Q60H	0.37
UCEC	chr4	168311261	5'UTR	novel		0.32
UCEC	chr4	168306614	Missense_Mutation	rs758196490	S124L	0.43
UCEC	chr4	168216992	Missense_Mutation	NA	V1694F	0.45
UCEC	chr4	168255844	Missense_Mutation	rs373387038	A1142T	0.27
UCEC	chr4	168284899	Missense_Mutation	NA	K494N	0.32
UCEC	chr4	168306501	Missense_Mutation	novel	I162F	0.36
UCEC	chr4	168255844	Missense_Mutation	rs373387038	A1142T	0.45
UCEC	chr4	168308176	Missense_Mutation	novel	D32Y	0.39
UCEC	chr4	168216924	3'UTR	novel		0.28
UCEC	chr4	168273363	Silent	novel	N830N	0.06
UCEC	chr4	168250965	Nonsense_Mutation	novel	G1283*	0.16
UCEC	chr4	168251084	Missense_Mutation	novel	R1243Q	0.18
UCEC	chr4	168255716	Missense_Mutation	novel	K1184N	0.17
UCEC	chr4	168302417	Splice_Site	novel	X203_splice	0.21
UCEC	chr4	168260865	Frame_Shift_Del	rs778036194	*L1133Yfs4**	0.31
UCEC	chr4	168293790	Silent	rs768396338	Q293Q	0.74
UCEC	chr4	168216877	3'UTR	novel		0.27
UCEC	chr4	168285443	Silent	novel	V465V	0.42
UCEC	chr4	168311298	5'UTR	novel		0.31
UCEC	chr4	168308035	In_Frame_Del	novel	K78_G79delinsR	0.38
UCEC	chr4	168248247	Missense_Mutation	novel	C1302R	0.15
UCEC	chr4	168262738	Missense_Mutation	novel	S1030N	0.31
UCEC	chr4	168255828	Missense_Mutation	novel	S1147N	0.1
UCEC	chr4	168287095	Missense_Mutation	NA	R431I	0.29
UCEC	chr4	168220602	Intron	novel		0.08
UCEC	chr4	168275466	Missense_Mutation	novel	K728T	0.1
UCEC	chr4	168287126	Missense_Mutation	novel	D421Y	0.19
UCEC	chr4	168308046	Missense_Mutation	novel	L75P	0.29
UCEC	chr4	168273954	Missense_Mutation	novel	V812M	0.32	ResIII
UCEC	chr4	168275399	Silent	novel	D750D	0.24
UCEC	chr4	168262774	Missense_Mutation	NA	G1018E	0.19
UCEC	chr4	168293887	Missense_Mutation	rs371472482	R261H	0.33
UCEC	chr4	168260928	Missense_Mutation	novel	T1112I	0.45
UCEC	chr4	168274002	Missense_Mutation	novel	Y796H	0.09	ResIII
UCEC	chr4	168308093	Silent	NA	G59G	0.15
UCEC	chr4	168220671	Missense_Mutation	novel	T1675A	0.53
UCEC	chr4	168262748	Missense_Mutation	NA	P1027T	0.5
UCEC	chr4	168260865	Frame_Shift_Del	rs778036194	*L1133Yfs4**	0.42
UCEC	chr4	168276171	Silent	rs745578311	T663T	0.39
UCEC	chr4	168246588	Missense_Mutation	NA	D1332N	0.2
UCEC	chr4	168221825	Missense_Mutation	NA	Q1627H	0.48
UCEC	chr4	168251084	Missense_Mutation	novel	R1243Q	0.07
UCEC	chr4	168216738	3'UTR	novel		0.44
UCEC	chr4	168255747	Missense_Mutation	rs768211946	R1174Q	0.32
UCEC	chr4	168306714	Missense_Mutation	rs751474343	E91K	0.22
UCEC	chr4	168216850	3'UTR	novel		0.41
UCEC	chr4	168236269	Missense_Mutation	novel	E1506K	0.28
UCEC	chr4	168246528	Missense_Mutation	novel	K1352Q	0.33
UCEC	chr4	168262016	Frame_Shift_Del	novel	*N1086Mfs4**	0.1
UCEC	chr4	168217022	Missense_Mutation	rs766821714	R1684C	0.29
UCEC	chr4	168275402	Silent	novel	R749R	0.39
UCEC	chr4	168293839	Missense_Mutation	rs146995893	R277H	0.27
UCEC	chr4	168251058	Nonsense_Mutation	novel	E1252*	0.38
UCS	chr4	168280346	Missense_Mutation	rs780985010	R656Q	0.33

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1444	2.13e-13
DLBC	DEL	0.1042	0.037264
KIRC	DEL	0.108	0.0008848
MESO	DEL	0.3793	0.10007
PAAD	DEL	0.0978	0.027407
PCPG	DEL	0.0741	0.003794

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.012	Kaplan-Meier Survival Analysis
MESO	0.027	Kaplan-Meier Survival Analysis
ACC	0.013	Kaplan-Meier Survival Analysis
PAAD	0.00044	Kaplan-Meier Survival Analysis
READ	0.039	Kaplan-Meier Survival Analysis
CHOL	0.038	Kaplan-Meier Survival Analysis
THCA	0.04	Kaplan-Meier Survival Analysis
LUAD	0.011	Kaplan-Meier Survival Analysis
UVM	0.025	Kaplan-Meier Survival Analysis
OV	0.018	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742