EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137710 (Gene tree)
Gene ID: 5962
Gene Symbol: RDX
Alias: DFNB24
Full Name: radixin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 432,428 bases
Position: chr11:109,864,295-110,296,722
Accession: 9944
RBP type: non-canonical RBP
Summary: Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10385389	Estrogen receptor regulation of the Na+/H+ exchange regulatory factor.	Endocrinology	1999 Jul	Ediger TR	-
16339744	Estrogen regulation of the rat anterior pituitary gland proteome.	Exp Biol Med (Maywood)	2005 Dec	Blake CA	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000530749	RDX-211	2558	-	ENSP00000437301	604 (aa)	-	P35241
ENST00000533961	RDX-215	771	-	-	- (aa)	-	-
ENST00000530131	RDX-209	1911	-	ENSP00000432829	52 (aa)	-	E9PNP4
ENST00000533991	RDX-216	544	-	ENSP00000432572	116 (aa)	-	E9PQ82
ENST00000645312	RDX-220	1036	-	ENSP00000494060	152 (aa)	-	A0A2R8Y4H6
ENST00000527537	RDX-203	3403	-	-	- (aa)	-	-
ENST00000533678	RDX-214	531	-	ENSP00000435930	44 (aa)	-	E9PRS5
ENST00000645527	RDX-222	3239	-	ENSP00000496121	534 (aa)	-	A0A2R8Y7M3
ENST00000647231	RDX-224	2663	-	ENSP00000496414	604 (aa)	-	P35241
ENST00000646663	RDX-223	2633	-	ENSP00000494693	590 (aa)	-	A0A2R8Y5S7
ENST00000530085	RDX-208	793	-	-	- (aa)	-	-
ENST00000530301	RDX-210	1549	-	ENSP00000436277	200 (aa)	-	P35241
ENST00000532118	RDX-212	536	-	ENSP00000437140	148 (aa)	-	E9PNV3
ENST00000343115	RDX-201	4500	-	ENSP00000342830	583 (aa)	-	P35241
ENST00000645495	RDX-221	4383	-	ENSP00000496503	583 (aa)	-	P35241
ENST00000528900	RDX-206	1814	-	ENSP00000433580	257 (aa)	-	P35241
ENST00000532461	RDX-213	3286	-	-	- (aa)	-	-
ENST00000529774	RDX-207	512	-	-	- (aa)	-	-
ENST00000528556	RDX-205	803	-	ENSP00000434881	50 (aa)	-	E9PN07
ENST00000528498	RDX-204	2511	-	ENSP00000432112	604 (aa)	-	P35241
ENST00000544551	RDX-218	4117	-	ENSP00000445826	447 (aa)	-	P35241
ENST00000642511	RDX-219	501	-	ENSP00000494706	115 (aa)	-	A0A2R8Y5P0
ENST00000405097	RDX-202	2761	-	ENSP00000384136	604 (aa)	-	P35241
ENST00000534683	RDX-217	562	-	ENSP00000431560	51 (aa)	-	E9PKN5

Gene Model

Click here to download ENSG00000137710's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05205	Proteoglycans in cancer	KEGG
hsa05206	MicroRNAs in cancer	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137710	Hip	6.63524216521065E-5	17903296
ENSG00000137710	Hip	5.53041871555646E-5	17903296
ENSG00000137710	Myocardial Infarction	6.2764139E-004	-
ENSG00000137710	Myocardial Infarction	2.0972092E-005	-
ENSG00000137710	Arteries	3.6610000E-005	-
ENSG00000137710	Platelet Function Tests	3.1400000E-006	-
ENSG00000137710	Cognition	7E-6	24684796

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137710	rs144471255	11	110058188	A	Late-onset Alzheimer's disease	27770636	[0.17-0.45] unit increase	0.31	EFO_1001870
ENSG00000137710	rs4561177	11	110091706	A	Psoriasis vulgaris	26626624	NR	1.139	EFO_1001494
ENSG00000137710	rs17110679	11	110061343	?	Antibody status in Tripanosoma cruzi seropositivity	24324551			EFO_0004556\|EFO_0005530
ENSG00000137710	rs4561177	11	110091706	A	Psoriasis	23143594		1.14	EFO_0000676
ENSG00000137710	rs746463	11	110125219	?	Exercise treadmill test traits	17903301			EFO_0004328
ENSG00000137710	rs661171	11	110145794	G	Plasma parathyroid hormone levels	30134803	[0.12-0.28] unit increase	0.2	EFO_0004752
ENSG00000137710	rs10789752	11	110109220	T	High density lipoprotein cholesterol levels	29507422	unit increase	0.018	EFO_0004612
ENSG00000137710	rs661171	11	110145794	?	Lipid traits (pleiotropy) (HIPO component 1)	30289880			EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137710's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137710	RDX	100	89.655	ENSG00000147065	MSN	100	88.350	Homo_sapiens
ENSG00000137710	RDX	100	84.483	ENSG00000092820	EZR	100	76.280	Homo_sapiens
ENSG00000137710	RDX	100	100.000	ENSMUSG00000032050	Rdx	100	98.456	Mus_musculus
ENSG00000137710	RDX	100	88.793	ENSMUSG00000031207	Msn	100	81.132	Mus_musculus
ENSG00000137710	RDX	100	84.314	ENSMUSG00000052397	Ezr	100	75.768	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001726	ruffle	-	IEA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	17825285.	IDA	Function
GO:0005515	protein binding	10806479.17321526.21148287.23414517.26496610.29568061.	IPI	Function
GO:0005615	extracellular space	16502470.	HDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0005886	plasma membrane	-	ISS	Component
GO:0005902	microvillus	-	ISS	Component
GO:0005913	cell-cell adherens junction	-	IEA	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0005925	focal adhesion	21282464.	IDA	Component
GO:0008360	regulation of cell shape	22467863.	IMP	Process
GO:0008361	regulation of cell size	22467863.	IGI	Process
GO:0010628	positive regulation of gene expression	23264465.	IGI	Process
GO:0010737	protein kinase A signaling	-	ISS	Process
GO:0016324	apical plasma membrane	17825285.	IDA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0030027	lamellipodium	-	ISS	Component
GO:0030033	microvillus assembly	-	IEA	Process
GO:0030175	filopodium	-	ISS	Component
GO:0030315	T-tubule	-	IEA	Component
GO:0030335	positive regulation of cell migration	22467863.	IMP	Process
GO:0030496	midbody	-	IEA	Component
GO:0030864	cortical actin cytoskeleton	-	ISS	Component
GO:0032154	cleavage furrow	-	IEA	Component
GO:0032231	regulation of actin filament bundle assembly	22467863.	IMP	Process
GO:0032420	stereocilium	-	IEA	Component
GO:0032487	regulation of Rap protein signal transduction	-	ISS	Process
GO:0034111	negative regulation of homotypic cell-cell adhesion	22467863.	IMP	Process
GO:0034260	negative regulation of GTPase activity	22467863.	IMP	Process
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IEA	Process
GO:0042803	protein homodimerization activity	16582480.	ISS	Function
GO:0043087	regulation of GTPase activity	22467863.	IGI	Process
GO:0045176	apical protein localization	-	IEA	Process
GO:0045184	establishment of protein localization	-	ISS	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0045792	negative regulation of cell size	22467863.	IMP	Process
GO:0051016	barbed-end actin filament capping	-	IEA	Process
GO:0051018	protein kinase A binding	-	ISS	Function
GO:0051117	ATPase binding	17825285.	IPI	Function
GO:0051286	cell tip	-	IEA	Component
GO:0061028	establishment of endothelial barrier	23264465.	IGI	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component
GO:0071944	cell periphery	22291017.	IDA	Component
GO:0072659	protein localization to plasma membrane	17825285.	IMP	Process
GO:0097067	cellular response to thyroid hormone stimulus	-	ISS	Process
GO:1900027	regulation of ruffle assembly	22467863.	IMP	Process
GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	-	ISS	Process
GO:1902115	regulation of organelle assembly	21148287.	IGI	Process
GO:1902966	positive regulation of protein localization to early endosome	21148287.	IGI	Process
GO:1903364	positive regulation of cellular protein catabolic process	21148287.	IGI	Process
GO:1903392	negative regulation of adherens junction organization	22467863.	IMP	Process
GO:2000643	positive regulation of early endosome to late endosome transport	21148287.	IGI	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21352885	ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.	Biochimie	2011 May	Ou-Yang M	doi: 10.1016/j.biochi.2011.01.017
24380686	Concomitant microRNA-31 downregulation and radixin upregulation predicts advanced tumor progression and unfavorable prognosis in patients with gliomas.	J Neurol Sci	2014 Mar 15	Wang S	doi: 10.1016/j.jns.2013.12.019
27793041	CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.	Oncotarget	2016 Nov 29	Riecken LB	doi: 10.18632/oncotarget.12919.
22631643	Knockdown of radixin by RNA interference suppresses the growth of human pancreatic cancer cells in vitro and in vivo.	Asian Pac J Cancer Prev	2012	Chen SD	-
22179828	MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers.	Oncogene	2012 Oct 18	Zheng B	doi: 10.1038/onc.2011.581
19152423	Proteomic profiling in pancreatic cancer with and without lymph node metastasis.	Int J Cancer	2009 Apr 1	Cui Y	doi: 10.1002/ijc.24163.
26209696	Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.	FASEB J	2015 Nov	Adada MM	doi: 10.1096/fj.15-274340

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr11	110258168	Silent	NA	L163L	0.24
BLCA	chr11	110233437	Missense_Mutation	novel	L463V	0.15
BLCA	chr11	110264193	Missense_Mutation	NA	F78L	0.4
BLCA	chr11	110233478	Missense_Mutation	novel	A449D	0.1
BLCA	chr11	110254007	Missense_Mutation	NA	I300V	0.24
BRCA	chr11	110264083	Missense_Mutation	NA	I115T	0.42
BRCA	chr11	110233329	Missense_Mutation	NA	E499Q	0.18
BRCA	chr11	110255351	Missense_Mutation	novel	I245F	0.28
BRCA	chr11	110233421	Missense_Mutation	novel	S468F	0.05
BRCA	chr11	110264175	Missense_Mutation	NA	F84L	0.27
BRCA	chr11	110264073	Silent	rs144543614	P118P	0.35
CESC	chr11	110253967	Missense_Mutation	NA	K313T	0.12
CESC	chr11	110264835	Missense_Mutation	NA	G46R	0.35
CESC	chr11	110231915	Missense_Mutation	rs780179741	R569Q	0.24
CESC	chr11	110233455	Missense_Mutation	novel	E457K	0.4
CESC	chr11	110264222	Missense_Mutation	rs750130636	D69Y	0.16
CESC	chr11	110229451	3'UTR	novel		0.3
CESC	chr11	110230028	3'UTR	novel		0.27
CHOL	chr11	110254097	Missense_Mutation	novel	Y270N	0.46
COAD	chr11	110237713	Intron	novel		0.39
COAD	chr11	110258108	Missense_Mutation	NA	L183F	0.18
COAD	chr11	110272614	Silent	rs193206883	N6N	0.16
COAD	chr11	110253972	Silent	NA	E311E	0.13
COAD	chr11	110233461	Missense_Mutation	novel	D455Y	0.08
COAD	chr11	110247769	Missense_Mutation	NA	R342C	0.2
COAD	chr11	110264783	Missense_Mutation	novel	K63T	0.23
COAD	chr11	110236267	Intron	novel		0.23
COAD	chr11	110233412	Frame_Shift_Del	NA	*P471Lfs35**	0.37
COAD	chr11	110236190	Missense_Mutation	rs200525150	A418V	0.36
COAD	chr11	110255389	Splice_Region	NA		0.41
COAD	chr11	110264836	Frame_Shift_Del	NA	*F45Lfs6**	0.23
COAD	chr11	110237565	Missense_Mutation	rs764536750	R393H	0.26
COAD	chr11	110231601	3'UTR	novel		0.73
COAD	chr11	110254033	Missense_Mutation	NA	Y291C	0.19
COAD	chr11	110264057	Missense_Mutation	NA	L124I	0.12
COAD	chr11	110257829	Frame_Shift_Del	novel	*G213Efs6**	0.09
COAD	chr11	110233411	Frame_Shift_Ins	rs780998172	*P472Sfs16**	0.21
COAD	chr11	110264132	Missense_Mutation	novel	Q99K	0.1
COAD	chr11	110255389	Splice_Region	NA		0.34
ESCA	chr11	110233341	Missense_Mutation	novel	E495Q	0.17
ESCA	chr11	110236181	Missense_Mutation	novel	L421R	0.34
ESCA	chr11	110199651	Silent	novel	F592F	0.52
ESCA	chr11	110229778	3'UTR	novel		0.35
ESCA	chr11	110231718	3'UTR	novel		0.2
ESCA	chr11	110229454	3'UTR	novel		0.32
ESCA	chr11	110264191	Missense_Mutation	novel	K79T	0.33
GBM	chr11	110233461	Missense_Mutation	novel	D455Y	0.23
GBM	chr11	110263997	Missense_Mutation	novel	P144T	0.49
HNSC	chr11	110237489	Splice_Region	novel		0.65
HNSC	chr11	110232034	Splice_Site	novel	X530_splice	0.15
HNSC	chr11	110233276	Silent	novel	T516T	0.39
KIRC	chr11	110237670	Intron	novel		0.37
KIRP	chr11	110231796	3'UTR	novel		0.38
LGG	chr11	110231876	Missense_Mutation	rs757290634	A582V	0.08
LGG	chr11	110253956	Nonsense_Mutation	novel	Q317*	0.44
LGG	chr11	110254087	Missense_Mutation	rs142346566	R273H	0.5
LGG	chr11	110257851	Missense_Mutation	novel	Y205C	0.06
LGG	chr11	110264160	Silent	NA	V89V	0.12
LIHC	chr11	110233412	Frame_Shift_Del	NA	*P471Lfs35**	0.43
LIHC	chr11	110237745	Intron	novel		0.29
LUAD	chr11	110231943	Missense_Mutation	novel	D560Y	0.32
LUAD	chr11	110257772	Missense_Mutation	novel	D231E	0.12
LUAD	chr11	110236150	Silent	NA	L431L	0.09
LUAD	chr11	110237517	Missense_Mutation	NA	D409V	0.25
LUSC	chr11	110255347	Missense_Mutation	NA	R246K	0.33
LUSC	chr11	110264193	Missense_Mutation	novel	F78L	0.22
LUSC	chr11	110233415	In_Frame_Ins	novel	P470delinsHS	0.04
LUSC	chr11	110258103	Splice_Region	novel		0.44
LUSC	chr11	110233447	Frame_Shift_Del	novel	*E461Kfs3**	0.12
LUSC	chr11	110264212	Missense_Mutation	NA	K72I	0.21
LUSC	chr11	110254035	Silent	novel	L290L	0.32
MESO	chr11	110255362	Missense_Mutation	NA	P241L	0.12
MESO	chr11	110255363	Missense_Mutation	novel	P241S	0.12
OV	chr11	110264015	Missense_Mutation	novel	N138Y	0.12
OV	chr11	110257842	Missense_Mutation	novel	I208R	0.15
OV	chr11	110233260	Missense_Mutation	rs753458211	E522K	0.04
OV	chr11	110231764	3'UTR	novel		0.72
PAAD	chr11	110237608	Nonsense_Mutation	NA	R379*	0.08
PAAD	chr11	110254003	Missense_Mutation	novel	E301G	0.18
PAAD	chr11	110257819	Missense_Mutation	novel	L216V	0.2
PAAD	chr11	110237602	Nonsense_Mutation	novel	R381*	0.07
PRAD	chr11	110254028	Nonsense_Mutation	NA	R293*	0.08
READ	chr11	110237580	Missense_Mutation	NA	R388Q	0.26
READ	chr11	110254069	Missense_Mutation	rs150863373	R279Q	0.28
READ	chr11	110254087	Missense_Mutation	rs142346566	R273H	0.38
READ	chr11	110233356	Missense_Mutation	rs34471100	D490N	0.1
READ	chr11	110264219	Missense_Mutation	novel	V70F	0.12
SARC	chr11	110231695	3'UTR	novel		0.21
SARC	chr11	110255378	Missense_Mutation	novel	P236S	0.07
SKCM	chr11	110264175	Silent	rs768173454	F84F	0.96
SKCM	chr11	110279723	5'UTR	novel		0.16
SKCM	chr11	110233412	Missense_Mutation	rs754733997	P471L	0.34
SKCM	chr11	110233413	Missense_Mutation	rs138560358	P471S	0.35
SKCM	chr11	110263970	Silent	rs757046736	L153L	0.59
SKCM	chr11	110263971	Silent	novel	L152L	0.57
SKCM	chr11	110233380	Missense_Mutation	NA	T482A	0.47
SKCM	chr11	110254004	Missense_Mutation	NA	E301K	0.74
STAD	chr11	110257799	Silent	NA	A222A	0.37
STAD	chr11	110237565	Missense_Mutation	rs764536750	R393H	0.33
STAD	chr11	110237566	Missense_Mutation	rs750035123	R393C	0.37
STAD	chr11	110255311	Missense_Mutation	NA	K258T	0.17
STAD	chr11	110236190	Missense_Mutation	rs200525150	A418V	0.29
STAD	chr11	110231825	3'UTR	novel		0.14
STAD	chr11	110237675	Intron	novel		0.25
STAD	chr11	110231895	Missense_Mutation	NA	R576C	0.07
THYM	chr11	110279688	Missense_Mutation	rs763518071	P2L	0.09
UCEC	chr11	110237580	Missense_Mutation	NA	R388Q	0.32
UCEC	chr11	110254027	Missense_Mutation	rs759389484	R293Q	0.28
UCEC	chr11	110264105	Nonsense_Mutation	NA	E108*	0.21
UCEC	chr11	110257837	Missense_Mutation	NA	N210H	0.34
UCEC	chr11	110279727	5'UTR	novel		0.3
UCEC	chr11	110233306	Missense_Mutation	novel	M506I	0.07
UCEC	chr11	110264061	Silent	novel	A122A	0.45
UCEC	chr11	110231928	Silent	novel	L565L	0.51
UCEC	chr11	110236232	Intron	novel		0.43
UCEC	chr11	110237516	Silent	NA	D409D	0.46
UCEC	chr11	110230772	3'UTR	novel		0.56
UCEC	chr11	110230730	3'UTR	novel		0.23
UCEC	chr11	110237562	Missense_Mutation	rs780679073	R394Q	0.43
UCEC	chr11	110264141	Nonsense_Mutation	NA	E96*	0.6
UCEC	chr11	110231693	3'UTR	novel		0.69
UCEC	chr11	110257881	Frame_Shift_Ins	novel	*A195Dfs7**	0.07
UCEC	chr11	110257882	Frame_Shift_Ins	novel	*A195Tfs14**	0.04
UCEC	chr11	110230786	3'UTR	rs114509945		0.14
UCEC	chr11	110237634	Missense_Mutation	NA	R370Q	0.43
UCEC	chr11	110229645	3'UTR	novel		0.33
UCEC	chr11	110237753	Intron	novel		0.34
UCEC	chr11	110279706	5'UTR	novel		0.32
UCEC	chr11	110233472	Missense_Mutation	novel	A451V	0.48
UCEC	chr11	110236168	Silent	novel	T425T	0.51
UCEC	chr11	110272613	Missense_Mutation	rs142539598	V7I	0.46
UCEC	chr11	110247809	Missense_Mutation	novel	K328N	0.33
UCEC	chr11	110247777	Missense_Mutation	NA	R339I	0.44
UCEC	chr11	110255373	Missense_Mutation	NA	K237N	0.22
UCEC	chr11	110264105	Missense_Mutation	NA	E108K	0.11
UCEC	chr11	110279752	5'UTR	novel		0.21
UCEC	chr11	110255323	Missense_Mutation	NA	K254T	0.4
UCEC	chr11	110236308	Intron	novel		0.17
UCEC	chr11	110264836	Frame_Shift_Del	NA	*F45Lfs6**	0.12
UCEC	chr11	110247821	Missense_Mutation	novel	E324D	0.37
UCEC	chr11	110230806	3'UTR	novel		0.35
UCEC	chr11	110247748	Missense_Mutation	rs773878373	E349K	0.39
UCEC	chr11	110229715	3'UTR	novel		0.23
UCEC	chr11	110229901	3'UTR	novel		0.39
UCEC	chr11	110254087	Missense_Mutation	rs142346566	R273H	0.44
UCEC	chr11	110230806	3'UTR	novel		0.43
UCEC	chr11	110233412	Frame_Shift_Del	NA	*P471Lfs35**	0.48
UCEC	chr11	110272613	Missense_Mutation	rs142539598	V7I	0.31
UCEC	chr11	110253971	Missense_Mutation	novel	E312K	0.3
UCEC	chr11	110263961	Missense_Mutation	novel	R156C	0.23
UCEC	chr11	110230786	3'UTR	rs114509945		0.2
UCEC	chr11	110231924	Missense_Mutation	rs762658340	R566Q	0.22
UCEC	chr11	110255320	Missense_Mutation	novel	F255Y	0.28
UCEC	chr11	110230961	3'UTR	novel		0.13
UCEC	chr11	110264835	Frame_Shift_Ins	novel	*G46Wfs15**	0.18
UCEC	chr11	110231924	Missense_Mutation	rs762658340	R566Q	0.45
UCEC	chr11	110233273	Missense_Mutation	novel	E517D	0.39
UCEC	chr11	110255303	Missense_Mutation	novel	D261N	0.28
UCEC	chr11	110231992	Missense_Mutation	novel	K543N	0.41
UCEC	chr11	110230076	3'UTR	novel		0.36
UCEC	chr11	110232027	Missense_Mutation	novel	S532R	0.03
UCEC	chr11	110233440	Nonsense_Mutation	novel	E462*	0.04
UCEC	chr11	110237634	Missense_Mutation	NA	R370Q	0.24
UCEC	chr11	110229862	3'UTR	novel		0.25
UCEC	chr11	110230734	3'UTR	novel		0.54
UCEC	chr11	110231668	3'UTR	novel		0.5
UCEC	chr11	110231816	3'UTR	novel		0.58
UCEC	chr11	110236174	Missense_Mutation	NA	E423D	0.5
UCEC	chr11	110258143	Missense_Mutation	NA	I172L	0.44
UCEC	chr11	110272536	Splice_Region	NA	Q32Q	0.53
UCEC	chr11	110237555	Silent	NA	A396A	0.51
UCEC	chr11	110255305	Missense_Mutation	NA	I260T	0.09
UCEC	chr11	110236215	Intron	novel		0.43
UCEC	chr11	110236293	Intron	novel		0.17
UCEC	chr11	110264811	Missense_Mutation	NA	G54C	0.13
UCEC	chr11	110257881	Frame_Shift_Ins	novel	*A195Dfs7**	0.18
UCEC	chr11	110257882	In_Frame_Ins	novel	I194_A195insLIKLL	0.09
UCEC	chr11	110255287	Splice_Site	NA	X265_splice	0.31
UCEC	chr11	110258138	Missense_Mutation	novel	Q173H	0.2
UCEC	chr11	110264215	Missense_Mutation	novel	K71R	0.42
UCEC	chr11	110272563	Silent	novel	N23N	0.3
UCEC	chr11	110264780	Frame_Shift_Del	novel	*K64Rfs2**	0.32
UCEC	chr11	110229614	3'UTR	novel		0.5
UCEC	chr11	110279753	5'UTR	novel		0.23
UCEC	chr11	110231889	Missense_Mutation	rs121918379	D578N	0.45
UCS	chr11	110264094	Silent	novel	L111L	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.2892	0.00015732
BRCA	DEL	0.4491	7.1709e-58
CESC	DEL	0.4847	1.0762e-32
CHOL	DEL	0.3056	0.048655
ESCA	AMP	0.1141	0.018342
HNSC	DEL	0.4061	1.8879e-21
KIRP	DEL	0.1076	2.839e-05
LIHC	DEL	0.1946	0.00030497
LUAD	DEL	0.1783	4.2393e-06
MESO	DEL	0.1609	0.0023183
PRAD	DEL	0.0691	0.00026046
READ	DEL	0.2061	0.054114
SARC	DEL	0.4241	1.8105e-09
STAD	DEL	0.1519	8.3734e-05
TGCT	DEL	0.7533	0.21504
UCS	DEL	0.3929	0.086462

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
ACC	0.032	Kaplan-Meier Survival Analysis
SKCM	0.025	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
BRCA	0.0014	Kaplan-Meier Survival Analysis
BLCA	0.00076	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0038	Kaplan-Meier Survival Analysis
UVM	0.012	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742