EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137760 (Gene tree)
Gene ID: 91801
Gene Symbol: ALKBH8
Alias: MGC10235|TRM9|TRMT9A
Full Name: alkB homolog 8, tRNA methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 63,021 bases
Position: chr11:107,502,726-107,565,746
Accession: 25189
RBP type: canonical RBP
Summary: (AlkB Homolog 8, TRNA Methyltransferase) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is TRMT9B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000391225	RRM_1	PF00076.22	0.00018	1	1
ENSP00000374219	2OG-FeII_Oxy_2	PF13532.6	1.1e-19	1	1
ENSP00000415885	2OG-FeII_Oxy_2	PF13532.6	1.1e-19	1	1
ENSP00000397673	2OG-FeII_Oxy_2	PF13532.6	1.1e-19	1	1
ENSP00000374219	Methyltransf_8	PF05148.15	0.00033	1	1
ENSP00000415885	Methyltransf_8	PF05148.15	0.00033	1	1
ENSP00000397673	Methyltransf_8	PF05148.15	0.00033	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
22065580	Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.	J Biol Chem	2012 Jan 13	Pastore C	doi: 10.1074/jbc.M111.286187
17979886	Expression and sub-cellular localization of human ABH family molecules.	J Cell Mol Med	2007 Sep-Oct	Tsujikawa K	-
30338756	ALKB-8, a 2-Oxoglutarate-Dependent Dioxygenase and S-Adenosine Methionine-Dependent Methyltransferase Modulates Metabolic Events Linked to Lysosome-Related Organelles and Aging in C. elegans.	Folia Biol (Praha)	2018	Kollarova J	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000417449	ALKBH8-204	2114	XM_017018553	ENSP00000397673	667 (aa)	XP_016874042	Q96BT7
ENST00000393100	ALKBH8-203	999	-	ENSP00000376812	144 (aa)	-	C9JQN2
ENST00000389568	ALKBH8-202	2491	-	ENSP00000374219	664 (aa)	-	Q96BT7
ENST00000530933	ALKBH8-207	594	-	-	- (aa)	-	-
ENST00000429370	ALKBH8-206	2296	-	ENSP00000391225	224 (aa)	-	Q96BT7
ENST00000428149	ALKBH8-205	4079	XM_005271728	ENSP00000415885	664 (aa)	XP_005271785	Q96BT7
ENST00000260318	ALKBH8-201	1684	-	ENSP00000260318	238 (aa)	-	Q96BT7

Gene Model

Click here to download ENSG00000137760's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137760's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137760	ALKBH8	97	68.889	ENSAPOG00000000864	alkbh8	88	68.889	Acanthochromis_polyacanthus
ENSG00000137760	ALKBH8	100	86.134	ENSAMEG00000002177	ALKBH8	99	82.353	Ailuropoda_melanoleuca
ENSG00000137760	ALKBH8	97	55.255	ENSACIG00000003562	alkbh8	99	54.125	Amphilophus_citrinellus
ENSG00000137760	ALKBH8	98	54.217	ENSAOCG00000017691	alkbh8	99	50.593	Amphiprion_ocellaris
ENSG00000137760	ALKBH8	98	54.217	ENSAPEG00000016243	alkbh8	99	50.461	Amphiprion_percula
ENSG00000137760	ALKBH8	98	55.488	ENSATEG00000008092	alkbh8	98	55.623	Anabas_testudineus
ENSG00000137760	ALKBH8	99	67.311	ENSAPLG00000015851	ALKBH8	99	67.311	Anas_platyrhynchos
ENSG00000137760	ALKBH8	100	94.880	ENSANAG00000027895	ALKBH8	100	94.880	Aotus_nancymaae
ENSG00000137760	ALKBH8	98	66.667	ENSACLG00000022770	alkbh8	89	66.667	Astatotilapia_calliptera
ENSG00000137760	ALKBH8	99	57.991	ENSAMXG00000036006	alkbh8	98	57.991	Astyanax_mexicanus
ENSG00000137760	ALKBH8	100	86.975	ENSBTAG00000010642	ALKBH8	100	85.542	Bos_taurus
ENSG00000137760	ALKBH8	97	35.015	WBGene00007581	alkb-8	97	35.015	Caenorhabditis_elegans
ENSG00000137760	ALKBH8	100	89.496	ENSCJAG00000009957	ALKBH8	100	86.446	Callithrix_jacchus
ENSG00000137760	ALKBH8	100	86.555	ENSCAFG00000014696	ALKBH8	98	82.681	Canis_familiaris
ENSG00000137760	ALKBH8	100	86.555	ENSCAFG00020008876	ALKBH8	98	82.681	Canis_lupus_dingo
ENSG00000137760	ALKBH8	100	86.975	ENSCHIG00000008649	ALKBH8	100	86.145	Capra_hircus
ENSG00000137760	ALKBH8	98	89.270	ENSTSYG00000007339	ALKBH8	100	86.898	Carlito_syrichta
ENSG00000137760	ALKBH8	98	76.824	ENSCAPG00000006447	ALKBH8	99	83.264	Cavia_aperea
ENSG00000137760	ALKBH8	100	94.277	ENSCCAG00000036485	ALKBH8	100	94.277	Cebus_capucinus
ENSG00000137760	ALKBH8	100	95.536	ENSCATG00000035864	ALKBH8	100	95.536	Cercocebus_atys
ENSG00000137760	ALKBH8	100	96.386	ENSCSAG00000003027	ALKBH8	100	96.386	Chlorocebus_sabaeus
ENSG00000137760	ALKBH8	100	60.084	ENSCHOG00000011491	ALKBH8	100	71.348	Choloepus_hoffmanni
ENSG00000137760	ALKBH8	99	70.982	ENSCPBG00000018611	ALKBH8	95	70.982	Chrysemys_picta_bellii
ENSG00000137760	ALKBH8	96	38.820	ENSCING00000009639	-	97	38.729	Ciona_intestinalis
ENSG00000137760	ALKBH8	100	38.039	ENSCSAVG00000000631	-	100	38.039	Ciona_savignyi
ENSG00000137760	ALKBH8	100	96.875	ENSCANG00000030900	ALKBH8	100	96.875	Colobus_angolensis_palliatus
ENSG00000137760	ALKBH8	100	77.711	ENSCGRG00001011248	Alkbh8	100	77.711	Cricetulus_griseus_chok1gshd
ENSG00000137760	ALKBH8	98	50.633	ENSCSEG00000018513	alkbh8	98	50.633	Cynoglossus_semilaevis
ENSG00000137760	ALKBH8	99	53.912	ENSCVAG00000006951	alkbh8	99	54.339	Cyprinodon_variegatus
ENSG00000137760	ALKBH8	98	57.727	ENSDARG00000060256	alkbh8	97	57.727	Danio_rerio
ENSG00000137760	ALKBH8	100	78.346	ENSDNOG00000035970	ALKBH8	100	78.261	Dasypus_novemcinctus
ENSG00000137760	ALKBH8	100	79.518	ENSDORG00000008596	Alkbh8	97	79.518	Dipodomys_ordii
ENSG00000137760	ALKBH8	94	43.125	FBgn0034748	CG17807	93	43.349	Drosophila_melanogaster
ENSG00000137760	ALKBH8	98	47.713	ENSEBUG00000004016	alkbh8	97	47.713	Eptatretus_burgeri
ENSG00000137760	ALKBH8	100	86.975	ENSEASG00005011010	ALKBH8	99	86.657	Equus_asinus_asinus
ENSG00000137760	ALKBH8	100	87.395	ENSECAG00000019425	ALKBH8	100	87.349	Equus_caballus
ENSG00000137760	ALKBH8	70	67.167	ENSEEUG00000015594	-	100	67.167	Erinaceus_europaeus
ENSG00000137760	ALKBH8	94	56.000	ENSELUG00000012168	alkbh8	77	62.476	Esox_lucius
ENSG00000137760	ALKBH8	94	83.736	ENSFCAG00000033583	ALKBH8	99	83.736	Felis_catus
ENSG00000137760	ALKBH8	99	67.665	ENSFALG00000000478	ALKBH8	99	67.665	Ficedula_albicollis
ENSG00000137760	ALKBH8	100	81.777	ENSFDAG00000010504	ALKBH8	100	81.777	Fukomys_damarensis
ENSG00000137760	ALKBH8	99	51.494	ENSFHEG00000003699	alkbh8	99	51.746	Fundulus_heteroclitus
ENSG00000137760	ALKBH8	98	53.464	ENSGMOG00000002720	alkbh8	98	53.614	Gadus_morhua
ENSG00000137760	ALKBH8	99	67.115	ENSGALG00000017170	ALKBH8	99	67.115	Gallus_gallus
ENSG00000137760	ALKBH8	99	53.779	ENSGAFG00000009655	alkbh8	99	53.924	Gambusia_affinis
ENSG00000137760	ALKBH8	100	52.367	ENSGACG00000008185	alkbh8	100	52.663	Gasterosteus_aculeatus
ENSG00000137760	ALKBH8	99	70.833	ENSGAGG00000024945	ALKBH8	99	70.833	Gopherus_agassizii
ENSG00000137760	ALKBH8	100	98.661	ENSGGOG00000015505	ALKBH8	100	98.661	Gorilla_gorilla
ENSG00000137760	ALKBH8	98	52.743	ENSHBUG00000011914	alkbh8	86	66.667	Haplochromis_burtoni
ENSG00000137760	ALKBH8	98	54.367	ENSHCOG00000015443	alkbh8	98	54.367	Hippocampus_comes
ENSG00000137760	ALKBH8	98	55.589	ENSIPUG00000009495	alkbh8	98	55.589	Ictalurus_punctatus
ENSG00000137760	ALKBH8	100	85.714	ENSSTOG00000024939	ALKBH8	99	85.822	Ictidomys_tridecemlineatus
ENSG00000137760	ALKBH8	99	80.182	ENSJJAG00000021066	Alkbh8	99	80.182	Jaculus_jaculus
ENSG00000137760	ALKBH8	99	52.039	ENSKMAG00000008461	alkbh8	99	52.247	Kryptolebias_marmoratus
ENSG00000137760	ALKBH8	99	52.180	ENSLBEG00000019152	alkbh8	99	52.180	Labrus_bergylta
ENSG00000137760	ALKBH8	99	64.232	ENSLACG00000008785	ALKBH8	100	63.529	Latimeria_chalumnae
ENSG00000137760	ALKBH8	97	60.802	ENSLOCG00000006833	alkbh8	94	60.942	Lepisosteus_oculatus
ENSG00000137760	ALKBH8	100	82.353	ENSLAFG00000017895	ALKBH8	99	80.241	Loxodonta_africana
ENSG00000137760	ALKBH8	100	97.289	ENSMFAG00000003178	ALKBH8	100	97.289	Macaca_fascicularis
ENSG00000137760	ALKBH8	89	97.210	ENSMMUG00000005437	ALKBH8	100	97.210	Macaca_mulatta
ENSG00000137760	ALKBH8	100	97.151	ENSMNEG00000041672	ALKBH8	100	97.151	Macaca_nemestrina
ENSG00000137760	ALKBH8	100	96.536	ENSMLEG00000029986	ALKBH8	100	96.536	Mandrillus_leucophaeus
ENSG00000137760	ALKBH8	98	65.909	ENSMAMG00000007121	alkbh8	89	63.043	Mastacembelus_armatus
ENSG00000137760	ALKBH8	98	66.667	ENSMZEG00005014129	alkbh8	89	66.667	Maylandia_zebra
ENSG00000137760	ALKBH8	99	67.761	ENSMGAG00000015156	ALKBH8	99	67.761	Meleagris_gallopavo
ENSG00000137760	ALKBH8	98	53.648	ENSMAUG00000022157	Alkbh8	87	67.635	Mesocricetus_auratus
ENSG00000137760	ALKBH8	100	88.235	ENSMICG00000001044	ALKBH8	99	88.084	Microcebus_murinus
ENSG00000137760	ALKBH8	100	75.602	ENSMOCG00000019349	Alkbh8	100	75.602	Microtus_ochrogaster
ENSG00000137760	ALKBH8	98	52.553	ENSMMOG00000011386	alkbh8	99	52.553	Mola_mola
ENSG00000137760	ALKBH8	99	74.213	ENSMODG00000014721	ALKBH8	99	74.213	Monodelphis_domestica
ENSG00000137760	ALKBH8	97	66.667	ENSMALG00000020225	alkbh8	88	66.667	Monopterus_albus
ENSG00000137760	ALKBH8	100	77.259	ENSMUSG00000025899	Alkbh8	100	77.259	Mus_musculus
ENSG00000137760	ALKBH8	98	78.308	MGP_PahariEiJ_G0014615	Alkbh8	100	78.422	Mus_pahari
ENSG00000137760	ALKBH8	98	78.000	MGP_SPRETEiJ_G0032856	Alkbh8	100	77.929	Mus_spretus
ENSG00000137760	ALKBH8	98	83.898	ENSMPUG00000006077	ALKBH8	99	79.310	Mustela_putorius_furo
ENSG00000137760	ALKBH8	61	83.498	ENSMLUG00000016822	ALKBH8	99	83.498	Myotis_lucifugus
ENSG00000137760	ALKBH8	100	79.940	ENSNGAG00000017423	Alkbh8	100	80.389	Nannospalax_galili
ENSG00000137760	ALKBH8	97	54.237	ENSNBRG00000014084	alkbh8	99	53.898	Neolamprologus_brichardi
ENSG00000137760	ALKBH8	100	97.892	ENSNLEG00000007217	ALKBH8	100	97.892	Nomascus_leucogenys
ENSG00000137760	ALKBH8	98	77.253	ENSMEUG00000015254	ALKBH8	88	79.876	Notamacropus_eugenii
ENSG00000137760	ALKBH8	100	68.908	ENSOPRG00000009592	ALKBH8	87	77.743	Ochotona_princeps
ENSG00000137760	ALKBH8	98	84.120	ENSODEG00000011567	ALKBH8	99	81.599	Octodon_degus
ENSG00000137760	ALKBH8	99	54.934	ENSONIG00000005062	alkbh8	99	54.934	Oreochromis_niloticus
ENSG00000137760	ALKBH8	99	70.871	ENSOANG00000010463	ALKBH8	99	70.871	Ornithorhynchus_anatinus
ENSG00000137760	ALKBH8	99	85.520	ENSOCUG00000011931	ALKBH8	99	85.520	Oryctolagus_cuniculus
ENSG00000137760	ALKBH8	99	54.328	ENSORLG00000010440	alkbh8	99	54.478	Oryzias_latipes
ENSG00000137760	ALKBH8	99	52.774	ENSORLG00020015934	alkbh8	99	52.916	Oryzias_latipes_hni
ENSG00000137760	ALKBH8	99	51.899	ENSORLG00015023296	alkbh8	99	52.617	Oryzias_latipes_hsok
ENSG00000137760	ALKBH8	99	53.846	ENSOMEG00000002376	alkbh8	99	54.351	Oryzias_melastigma
ENSG00000137760	ALKBH8	100	85.294	ENSOGAG00000004956	ALKBH8	99	84.012	Otolemur_garnettii
ENSG00000137760	ALKBH8	100	86.975	ENSOARG00000010464	ALKBH8	100	85.392	Ovis_aries
ENSG00000137760	ALKBH8	100	98.795	ENSPPAG00000012183	ALKBH8	100	98.795	Pan_paniscus
ENSG00000137760	ALKBH8	100	84.789	ENSPPRG00000017697	ALKBH8	100	84.789	Panthera_pardus
ENSG00000137760	ALKBH8	100	85.090	ENSPTIG00000011062	ALKBH8	100	85.090	Panthera_tigris_altaica
ENSG00000137760	ALKBH8	100	98.351	ENSPTRG00000004240	ALKBH8	100	98.351	Pan_troglodytes
ENSG00000137760	ALKBH8	100	96.252	ENSPANG00000010011	ALKBH8	100	96.252	Papio_anubis
ENSG00000137760	ALKBH8	99	57.121	ENSPKIG00000023662	alkbh8	99	55.724	Paramormyrops_kingsleyae
ENSG00000137760	ALKBH8	98	70.085	ENSPSIG00000011627	ALKBH8	82	74.952	Pelodiscus_sinensis
ENSG00000137760	ALKBH8	98	54.947	ENSPMGG00000011981	alkbh8	99	54.947	Periophthalmus_magnuspinnatus
ENSG00000137760	ALKBH8	100	78.561	ENSPEMG00000022020	Alkbh8	100	78.561	Peromyscus_maniculatus_bairdii
ENSG00000137760	ALKBH8	98	50.076	ENSPMAG00000004616	alkbh8	98	50.000	Petromyzon_marinus
ENSG00000137760	ALKBH8	99	53.779	ENSPFOG00000001533	alkbh8	99	53.779	Poecilia_formosa
ENSG00000137760	ALKBH8	99	53.634	ENSPLAG00000008535	alkbh8	99	54.070	Poecilia_latipinna
ENSG00000137760	ALKBH8	99	53.634	ENSPMEG00000016977	alkbh8	99	54.070	Poecilia_mexicana
ENSG00000137760	ALKBH8	87	51.645	ENSPREG00000020964	alkbh8	99	52.138	Poecilia_reticulata
ENSG00000137760	ALKBH8	100	97.590	ENSPPYG00000003834	ALKBH8	100	97.590	Pongo_abelii
ENSG00000137760	ALKBH8	97	81.897	ENSPCAG00000005589	ALKBH8	99	71.795	Procavia_capensis
ENSG00000137760	ALKBH8	99	80.694	ENSPCOG00000022645	ALKBH8	99	80.694	Propithecus_coquereli
ENSG00000137760	ALKBH8	100	80.572	ENSPVAG00000011970	ALKBH8	100	80.572	Pteropus_vampyrus
ENSG00000137760	ALKBH8	98	54.614	ENSPNYG00000015082	alkbh8	98	54.614	Pundamilia_nyererei
ENSG00000137760	ALKBH8	99	57.424	ENSPNAG00000020902	alkbh8	98	57.424	Pygocentrus_nattereri
ENSG00000137760	ALKBH8	100	76.807	ENSRNOG00000024525	Alkbh8	100	76.807	Rattus_norvegicus
ENSG00000137760	ALKBH8	100	97.440	ENSRBIG00000032575	ALKBH8	100	97.440	Rhinopithecus_bieti
ENSG00000137760	ALKBH8	100	97.440	ENSRROG00000039484	ALKBH8	100	97.440	Rhinopithecus_roxellana
ENSG00000137760	ALKBH8	100	94.428	ENSSBOG00000031504	ALKBH8	100	94.428	Saimiri_boliviensis_boliviensis
ENSG00000137760	ALKBH8	98	76.824	ENSSHAG00000014253	ALKBH8	99	74.218	Sarcophilus_harrisii
ENSG00000137760	ALKBH8	94	56.418	ENSSFOG00015003173	alkbh8	99	56.418	Scleropages_formosus
ENSG00000137760	ALKBH8	97	64.444	ENSSMAG00000018948	alkbh8	89	64.444	Scophthalmus_maximus
ENSG00000137760	ALKBH8	96	62.222	ENSSDUG00000001609	alkbh8	87	62.222	Seriola_dumerili
ENSG00000137760	ALKBH8	98	55.891	ENSSLDG00000002033	alkbh8	99	56.344	Seriola_lalandi_dorsalis
ENSG00000137760	ALKBH8	98	76.395	ENSSARG00000008350	ALKBH8	100	66.063	Sorex_araneus
ENSG00000137760	ALKBH8	97	71.245	ENSSPUG00000015167	ALKBH8	98	67.218	Sphenodon_punctatus
ENSG00000137760	ALKBH8	97	63.636	ENSSPAG00000012412	alkbh8	99	55.259	Stegastes_partitus
ENSG00000137760	ALKBH8	100	84.874	ENSSSCG00000024628	ALKBH8	92	84.982	Sus_scrofa
ENSG00000137760	ALKBH8	98	69.347	ENSTGUG00000012660	-	99	69.347	Taeniopygia_guttata
ENSG00000137760	ALKBH8	99	50.495	ENSTRUG00000006986	alkbh8	98	50.992	Takifugu_rubripes
ENSG00000137760	ALKBH8	98	53.323	ENSTNIG00000010286	alkbh8	98	53.323	Tetraodon_nigroviridis
ENSG00000137760	ALKBH8	97	76.899	ENSTBEG00000002728	ALKBH8	100	76.899	Tupaia_belangeri
ENSG00000137760	ALKBH8	100	78.163	ENSTTRG00000000238	ALKBH8	100	78.163	Tursiops_truncatus
ENSG00000137760	ALKBH8	98	87.124	ENSUMAG00000008743	ALKBH8	99	82.655	Ursus_maritimus
ENSG00000137760	ALKBH8	98	85.408	ENSVPAG00000004932	ALKBH8	99	76.471	Vicugna_pacos
ENSG00000137760	ALKBH8	100	86.134	ENSVVUG00000013994	ALKBH8	98	82.380	Vulpes_vulpes
ENSG00000137760	ALKBH8	98	62.979	ENSXETG00000014487	alkbh8	99	61.435	Xenopus_tropicalis
ENSG00000137760	ALKBH8	98	53.687	ENSXCOG00000010055	alkbh8	99	53.896	Xiphophorus_couchianus
ENSG00000137760	ALKBH8	99	54.360	ENSXMAG00000010877	alkbh8	99	54.506	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	21873635.	IBA	Function
GO:0000049	tRNA binding	22065580.	IDA	Function
GO:0002098	tRNA wobble uridine modification	21873635.	IBA	Process
GO:0002098	tRNA wobble uridine modification	21285950.	IDA	Process
GO:0005506	iron ion binding	-	ISS	Function
GO:0005515	protein binding	20123966.20308323.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	20308323.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	20308323.	IDA	Component
GO:0006974	cellular response to DNA damage stimulus	20308323.	IDA	Process
GO:0008270	zinc ion binding	22065580.	IDA	Function
GO:0016300	tRNA (uracil) methyltransferase activity	21873635.	IBA	Function
GO:0016300	tRNA (uracil) methyltransferase activity	20308323.	IDA	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	21873635.	IBA	Function
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors	21285950.	IDA	Function
GO:0030488	tRNA methylation	20308323.	IDA	Process
GO:0055114	oxidation-reduction process	21285950.	IDA	Process