EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137802 (Gene tree)
Gene ID: 23005
Gene Symbol: MAPKBP1
Alias: KIAA0596
Full Name: mitogen-activated protein kinase binding protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 53,422 bases
Position: chr15:41,774,434-41,827,855
Accession: 29536
RBP type: canonical RBP
Summary: This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000422132	eIF2A	PF08662.11	0.00085	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000505061	MAPKBP1-206	5931	-	-	- (aa)	-	-
ENST00000515164	MAPKBP1-216	677	-	-	- (aa)	-	-
ENST00000457542	MAPKBP1-202	7232	XM_006720438	ENSP00000397570	1508 (aa)	XP_006720501	O60336
ENST00000512970	MAPKBP1-214	4804	-	ENSP00000427582	331 (aa)	-	D6RHX7
ENST00000510535	MAPKBP1-212	908	-	ENSP00000422132	156 (aa)	-	D6R9F7
ENST00000505373	MAPKBP1-207	4695	-	ENSP00000421891	69 (aa)	-	D6RAI2
ENST00000512433	MAPKBP1-213	603	-	-	- (aa)	-	-
ENST00000502695	MAPKBP1-204	577	-	-	- (aa)	-	-
ENST00000503526	MAPKBP1-205	460	-	-	- (aa)	-	-
ENST00000506301	MAPKBP1-208	563	-	-	- (aa)	-	-
ENST00000514566	MAPKBP1-215	5394	-	ENSP00000426154	1231 (aa)	-	O60336
ENST00000507147	MAPKBP1-209	334	-	-	- (aa)	-	-
ENST00000456763	MAPKBP1-201	7158	XM_011521383	ENSP00000393099	1514 (aa)	XP_011519685	O60336
ENST00000508050	MAPKBP1-211	605	-	-	- (aa)	-	-
ENST00000627631	MAPKBP1-217	210	-	ENSP00000487189	69 (aa)	-	D6RAI2
ENST00000502292	MAPKBP1-203	2509	-	-	- (aa)	-	-
ENST00000507762	MAPKBP1-210	544	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000137802's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000137802	Platelet Function Tests	1.9918300E-005	-
ENSG00000137802	Education	7E-6	25201988

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137802	rs1105881	15	41780332	C	Educational attainment	25201988	[NR] unit increase	0.02	EFO_0004784
ENSG00000137802	rs8035855	15	41785763	A	Urinary albumin excretion	30220432	[0.0089-0.0157] unit increase	0.01227	EFO_0004285
ENSG00000137802	rs2695165	15	41781199	?	Lung function (FVC)	30595370			EFO_0004312
ENSG00000137802	rs11855017	15	41803948	?	Body mass index	30595370			EFO_0004340
ENSG00000137802	rs1105881	15	41780332	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000137802	rs11855017	15	41803948	?	Fat-free mass	30593698	[0.097-0.21] unit increase	0.15353	EFO_0004995
ENSG00000137802	rs4923910	15	41794142	G	Diastolic blood pressure	27841878	unit decrease	0.178	EFO_0006336
ENSG00000137802	rs3959569	15	41823549	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.0084-0.0198] unit increase	0.0141	EFO_0007788
ENSG00000137802	rs3959569	15	41823549	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.011-0.023] unit increase	0.0173	EFO_0007788
ENSG00000137802	rs3959569	15	41823549	C	Waist-to-hip ratio adjusted for BMI (additive genetic model)	30778226	[0.01-0.027] unit increase	0.0187	EFO_0007788

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137802's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137802	MAPKBP1	100	93.590	ENSAPLG00000009844	MAPKBP1	99	64.633	Anas_platyrhynchos
ENSG00000137802	MAPKBP1	100	99.094	ENSANAG00000036484	MAPKBP1	100	99.094	Aotus_nancymaae
ENSG00000137802	MAPKBP1	100	98.489	ENSCJAG00000020630	MAPKBP1	100	98.489	Callithrix_jacchus
ENSG00000137802	MAPKBP1	100	99.094	ENSCATG00000022303	MAPKBP1	100	99.094	Cercocebus_atys
ENSG00000137802	MAPKBP1	100	93.590	ENSFALG00000006019	MAPKBP1	99	61.027	Ficedula_albicollis
ENSG00000137802	MAPKBP1	100	92.949	ENSGALG00000052873	MAPKBP1	99	61.329	Gallus_gallus
ENSG00000137802	MAPKBP1	100	91.667	ENSGAGG00000023865	MAPKBP1	99	61.641	Gopherus_agassizii
ENSG00000137802	MAPKBP1	100	96.795	ENSJJAG00000016314	-	100	97.248	Jaculus_jaculus
ENSG00000137802	MAPKBP1	100	99.094	ENSMFAG00000042257	MAPKBP1	100	99.094	Macaca_fascicularis
ENSG00000137802	MAPKBP1	100	99.094	ENSMLEG00000027137	MAPKBP1	100	99.094	Mandrillus_leucophaeus
ENSG00000137802	MAPKBP1	87	90.476	ENSMGAG00000011295	MAPKBP1	100	64.628	Meleagris_gallopavo
ENSG00000137802	MAPKBP1	100	98.718	ENSNGAG00000002712	-	100	96.997	Nannospalax_galili
ENSG00000137802	MAPKBP1	100	92.308	ENSPSIG00000014182	MAPKBP1	96	75.921	Pelodiscus_sinensis
ENSG00000137802	MAPKBP1	100	99.094	ENSRBIG00000033176	MAPKBP1	100	99.094	Rhinopithecus_bieti
ENSG00000137802	MAPKBP1	100	99.094	ENSRROG00000038701	MAPKBP1	100	99.094	Rhinopithecus_roxellana
ENSG00000137802	MAPKBP1	100	91.667	ENSSPUG00000018500	-	91	89.820	Sphenodon_punctatus
ENSG00000137802	MAPKBP1	87	92.014	ENSTGUG00000010931	MAPKBP1	99	72.894	Taeniopygia_guttata
ENSG00000137802	MAPKBP1	88	74.658	ENSTNIG00000000627	-	96	70.000	Tetraodon_nigroviridis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	22700971.25416956.28089251.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	28089251.	IDA	Component
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	22700971.	IMP	Process
GO:0097431	mitotic spindle pole	28089251.	IDA	Component
GO:1900425	negative regulation of defense response to bacterium	22700971.	IMP	Process
GO:2000483	negative regulation of interleukin-8 secretion	22700971.	IMP	Process