EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000137996 (Gene tree)
Gene ID: 8634
Gene Symbol: RTCA
Alias: RPC|RTC1|RTCD1
Full Name: RNA 3'-terminal phosphate cyclase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,612 bases
Position: chr1:100,266,158-100,292,769
Accession: 17981
RBP type: canonical RBP
Summary: This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359146	RTC	PF01137.21	4.4e-86	1	1
ENSP00000260563	RTC	PF01137.21	2.4e-80	1	1
ENSP00000359144	RTC	PF01137.21	2.6e-12	1	1
ENSP00000359146	RTC_insert	PF05189.13	6.7e-24	1	1
ENSP00000260563	RTC_insert	PF05189.13	7.2e-24	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25161314	Structure of RNA 3'-phosphate cyclase bound to substrate RNA.	RNA	2014 Oct	Desai KK	doi: 10.1261/rna.045823.114
19690099	Structure-activity relationships in human RNA 3'-phosphate cyclase.	RNA	2009 Oct	Tanaka N	doi: 10.1261/rna.1771509

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000370126	RTCA-202	538	-	ENSP00000359144	49 (aa)	-	A6NIC1
ENST00000483474	RTCA-204	683	-	-	- (aa)	-	-
ENST00000498617	RTCA-205	731	-	-	- (aa)	-	-
ENST00000370128	RTCA-203	2535	XM_005271298	ENSP00000359146	366 (aa)	XP_005271355	O00442
ENST00000260563	RTCA-201	1534	-	ENSP00000260563	379 (aa)	-	O00442

Gene Model

Click here to download ENSG00000137996's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000137996	rs143453921	1	100281785	C	Interferon gamma-induced protein 10 levels	27989323	[0.59-1.49] SD units decrease	1.0402	EFO_0008056

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000137996's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000137996	RTCA	99	71.745	ENSAPOG00000001345	rtca	98	71.745	Acanthochromis_polyacanthus
ENSG00000137996	RTCA	73	94.052	ENSAMEG00000008855	RTCA	100	94.052	Ailuropoda_melanoleuca
ENSG00000137996	RTCA	99	71.745	ENSACIG00000019643	rtca	99	71.745	Amphilophus_citrinellus
ENSG00000137996	RTCA	100	71.038	ENSAOCG00000014979	rtca	99	71.038	Amphiprion_ocellaris
ENSG00000137996	RTCA	100	71.038	ENSAPEG00000006945	rtca	99	71.038	Amphiprion_percula
ENSG00000137996	RTCA	96	71.795	ENSATEG00000006315	rtca	96	71.795	Anabas_testudineus
ENSG00000137996	RTCA	96	80.508	ENSAPLG00000015430	RTCA	100	80.508	Anas_platyrhynchos
ENSG00000137996	RTCA	96	87.234	ENSACAG00000003290	RTCA	94	85.455	Anolis_carolinensis
ENSG00000137996	RTCA	100	97.268	ENSANAG00000025446	RTCA	100	97.268	Aotus_nancymaae
ENSG00000137996	RTCA	100	70.492	ENSACLG00000020770	rtca	99	70.492	Astatotilapia_calliptera
ENSG00000137996	RTCA	100	73.224	ENSAMXG00000043271	rtca	100	73.224	Astyanax_mexicanus
ENSG00000137996	RTCA	100	97.959	ENSBTAG00000006321	RTCA	100	95.628	Bos_taurus
ENSG00000137996	RTCA	100	100.000	ENSCJAG00000003398	RTCA	100	97.814	Callithrix_jacchus
ENSG00000137996	RTCA	100	95.918	ENSCAFG00000020010	RTCA	68	95.628	Canis_familiaris
ENSG00000137996	RTCA	100	95.918	ENSCAFG00020011528	RTCA	57	95.628	Canis_lupus_dingo
ENSG00000137996	RTCA	100	97.959	ENSCHIG00000018937	RTCA	100	95.355	Capra_hircus
ENSG00000137996	RTCA	100	93.878	ENSTSYG00000011305	RTCA	100	92.896	Carlito_syrichta
ENSG00000137996	RTCA	100	95.918	ENSCPOG00000009296	-	99	97.122	Cavia_porcellus
ENSG00000137996	RTCA	100	100.000	ENSCCAG00000021844	RTCA	100	97.541	Cebus_capucinus
ENSG00000137996	RTCA	100	98.681	ENSCATG00000019364	RTCA	100	98.681	Cercocebus_atys
ENSG00000137996	RTCA	87	95.584	ENSCLAG00000006125	RTCA	100	95.584	Chinchilla_lanigera
ENSG00000137996	RTCA	100	100.000	ENSCSAG00000001509	RTCA	100	98.907	Chlorocebus_sabaeus
ENSG00000137996	RTCA	100	93.878	ENSCHOG00000005211	RTCA	100	93.443	Choloepus_hoffmanni
ENSG00000137996	RTCA	100	83.880	ENSCPBG00000026658	RTCA	100	83.880	Chrysemys_picta_bellii
ENSG00000137996	RTCA	98	56.233	ENSCING00000007875	-	98	56.233	Ciona_intestinalis
ENSG00000137996	RTCA	98	53.889	ENSCSAVG00000007269	-	98	53.889	Ciona_savignyi
ENSG00000137996	RTCA	100	100.000	ENSCANG00000040106	RTCA	100	98.681	Colobus_angolensis_palliatus
ENSG00000137996	RTCA	100	93.878	ENSCGRG00001001848	-	83	91.089	Cricetulus_griseus_chok1gshd
ENSG00000137996	RTCA	73	90.706	ENSCGRG00001013163	Rtca	85	90.706	Cricetulus_griseus_chok1gshd
ENSG00000137996	RTCA	100	93.878	ENSCGRG00000002803	-	76	91.919	Cricetulus_griseus_crigri
ENSG00000137996	RTCA	99	68.493	ENSCSEG00000000530	rtca	98	68.493	Cynoglossus_semilaevis
ENSG00000137996	RTCA	100	69.388	ENSCVAG00000021809	rtca	100	58.470	Cyprinodon_variegatus
ENSG00000137996	RTCA	100	74.317	ENSDARG00000002215	rtca	100	74.317	Danio_rerio
ENSG00000137996	RTCA	100	93.989	ENSDNOG00000000456	RTCA	100	93.989	Dasypus_novemcinctus
ENSG00000137996	RTCA	100	95.918	ENSDORG00000005448	Rtca	100	92.350	Dipodomys_ordii
ENSG00000137996	RTCA	88	62.791	FBgn0025630	Rtca	98	38.547	Drosophila_melanogaster
ENSG00000137996	RTCA	100	64.000	ENSEBUG00000008556	rtca	97	54.237	Eptatretus_burgeri
ENSG00000137996	RTCA	100	95.918	ENSEASG00005015926	RTCA	100	94.536	Equus_asinus_asinus
ENSG00000137996	RTCA	100	95.918	ENSECAG00000019831	RTCA	100	94.536	Equus_caballus
ENSG00000137996	RTCA	98	95.833	ENSEEUG00000001165	RTCA	100	82.659	Erinaceus_europaeus
ENSG00000137996	RTCA	99	71.745	ENSELUG00000003741	rtca	99	71.745	Esox_lucius
ENSG00000137996	RTCA	100	95.918	ENSFCAG00000024460	RTCA	100	95.082	Felis_catus
ENSG00000137996	RTCA	100	81.633	ENSFALG00000002443	RTCA	90	84.384	Ficedula_albicollis
ENSG00000137996	RTCA	100	95.628	ENSFDAG00000012070	-	100	95.628	Fukomys_damarensis
ENSG00000137996	RTCA	100	75.510	ENSFDAG00000016084	-	100	75.138	Fukomys_damarensis
ENSG00000137996	RTCA	72	60.687	ENSFHEG00000002868	rtca	90	71.154	Fundulus_heteroclitus
ENSG00000137996	RTCA	100	69.126	ENSGMOG00000013264	rtca	100	69.126	Gadus_morhua
ENSG00000137996	RTCA	100	85.714	ENSGALG00000005277	RTCA	100	83.333	Gallus_gallus
ENSG00000137996	RTCA	100	71.038	ENSGAFG00000011853	rtca	99	71.038	Gambusia_affinis
ENSG00000137996	RTCA	100	69.399	ENSGACG00000013497	rtca	100	69.399	Gasterosteus_aculeatus
ENSG00000137996	RTCA	100	83.673	ENSGAGG00000023306	RTCA	100	84.983	Gopherus_agassizii
ENSG00000137996	RTCA	100	100.000	ENSGGOG00000009546	-	100	99.472	Gorilla_gorilla
ENSG00000137996	RTCA	100	100.000	ENSGGOG00000044018	-	100	98.634	Gorilla_gorilla
ENSG00000137996	RTCA	100	70.219	ENSHBUG00000002114	rtca	99	70.219	Haplochromis_burtoni
ENSG00000137996	RTCA	100	95.918	ENSHGLG00000002617	RTCA	100	94.262	Heterocephalus_glaber_female
ENSG00000137996	RTCA	100	95.918	ENSHGLG00100006056	RTCA	100	94.262	Heterocephalus_glaber_male
ENSG00000137996	RTCA	100	67.347	ENSHCOG00000020628	rtca	89	64.754	Hippocampus_comes
ENSG00000137996	RTCA	100	73.497	ENSIPUG00000024803	rtca	100	73.497	Ictalurus_punctatus
ENSG00000137996	RTCA	100	83.106	ENSSTOG00000033099	-	100	83.106	Ictidomys_tridecemlineatus
ENSG00000137996	RTCA	100	88.251	ENSSTOG00000013528	-	100	88.251	Ictidomys_tridecemlineatus
ENSG00000137996	RTCA	100	95.918	ENSJJAG00000016178	Rtca	100	66.393	Jaculus_jaculus
ENSG00000137996	RTCA	100	71.429	ENSKMAG00000006651	rtca	98	72.022	Kryptolebias_marmoratus
ENSG00000137996	RTCA	88	68.536	ENSLBEG00000002448	-	99	68.536	Labrus_bergylta
ENSG00000137996	RTCA	99	69.252	ENSLBEG00000028971	rtca	99	69.252	Labrus_bergylta
ENSG00000137996	RTCA	100	78.142	ENSLACG00000013666	RTCA	100	78.142	Latimeria_chalumnae
ENSG00000137996	RTCA	100	73.224	ENSLOCG00000000093	rtca	99	73.224	Lepisosteus_oculatus
ENSG00000137996	RTCA	100	93.878	ENSLAFG00000001473	RTCA	100	93.443	Loxodonta_africana
ENSG00000137996	RTCA	100	100.000	ENSMFAG00000034132	RTCA	100	98.945	Macaca_fascicularis
ENSG00000137996	RTCA	100	100.000	ENSMMUG00000019105	RTCA	100	98.417	Macaca_mulatta
ENSG00000137996	RTCA	84	98.706	ENSMNEG00000037163	RTCA	100	98.706	Macaca_nemestrina
ENSG00000137996	RTCA	100	100.000	ENSMLEG00000042151	RTCA	100	81.530	Mandrillus_leucophaeus
ENSG00000137996	RTCA	100	73.224	ENSMAMG00000016536	rtca	100	73.224	Mastacembelus_armatus
ENSG00000137996	RTCA	100	70.492	ENSMZEG00005017945	rtca	99	70.492	Maylandia_zebra
ENSG00000137996	RTCA	87	81.818	ENSMGAG00000006892	RTCA	100	81.250	Meleagris_gallopavo
ENSG00000137996	RTCA	100	95.918	ENSMAUG00000008488	Rtca	100	91.530	Mesocricetus_auratus
ENSG00000137996	RTCA	84	96.117	ENSMICG00000008643	RTCA	100	96.117	Microcebus_murinus
ENSG00000137996	RTCA	100	93.878	ENSMOCG00000016660	Rtca	100	91.803	Microtus_ochrogaster
ENSG00000137996	RTCA	84	71.521	ENSMMOG00000007750	rtca	100	71.521	Mola_mola
ENSG00000137996	RTCA	100	93.878	ENSMODG00000003557	RTCA	100	90.164	Monodelphis_domestica
ENSG00000137996	RTCA	100	72.678	ENSMALG00000020844	rtca	100	72.678	Monopterus_albus
ENSG00000137996	RTCA	100	93.878	MGP_CAROLIEiJ_G0025565	Rtca	100	91.257	Mus_caroli
ENSG00000137996	RTCA	100	93.878	ENSMUSG00000000339	Rtca	100	90.710	Mus_musculus
ENSG00000137996	RTCA	100	93.878	MGP_PahariEiJ_G0027011	Rtca	100	90.984	Mus_pahari
ENSG00000137996	RTCA	100	93.878	MGP_SPRETEiJ_G0026515	Rtca	100	90.984	Mus_spretus
ENSG00000137996	RTCA	100	95.355	ENSMPUG00000012119	RTCA	100	95.355	Mustela_putorius_furo
ENSG00000137996	RTCA	100	87.466	ENSMLUG00000009922	RTCA	100	87.466	Myotis_lucifugus
ENSG00000137996	RTCA	100	95.918	ENSNGAG00000011540	Rtca	99	91.803	Nannospalax_galili
ENSG00000137996	RTCA	100	70.492	ENSNBRG00000003062	rtca	99	70.492	Neolamprologus_brichardi
ENSG00000137996	RTCA	100	100.000	ENSNLEG00000031426	RTCA	100	99.472	Nomascus_leucogenys
ENSG00000137996	RTCA	98	91.667	ENSMEUG00000010030	-	77	72.727	Notamacropus_eugenii
ENSG00000137996	RTCA	73	87.361	ENSOPRG00000012092	RTCA	71	87.361	Ochotona_princeps
ENSG00000137996	RTCA	95	94.828	ENSODEG00000006990	RTCA	96	94.872	Octodon_degus
ENSG00000137996	RTCA	100	70.492	ENSONIG00000007753	rtca	99	70.492	Oreochromis_niloticus
ENSG00000137996	RTCA	87	87.066	ENSOANG00000012055	RTCA	98	87.066	Ornithorhynchus_anatinus
ENSG00000137996	RTCA	100	95.628	ENSOCUG00000014247	RTCA	100	95.628	Oryctolagus_cuniculus
ENSG00000137996	RTCA	100	70.492	ENSORLG00000013605	rtca	100	70.492	Oryzias_latipes
ENSG00000137996	RTCA	100	70.492	ENSORLG00020001904	rtca	100	70.492	Oryzias_latipes_hni
ENSG00000137996	RTCA	100	70.492	ENSORLG00015021064	rtca	100	70.492	Oryzias_latipes_hsok
ENSG00000137996	RTCA	100	71.311	ENSOMEG00000000756	rtca	100	71.311	Oryzias_melastigma
ENSG00000137996	RTCA	98	93.750	ENSOGAG00000005627	RTCA	100	85.246	Otolemur_garnettii
ENSG00000137996	RTCA	87	94.340	ENSOARG00000018122	RTCA	100	94.340	Ovis_aries
ENSG00000137996	RTCA	100	98.945	ENSPPAG00000035119	RTCA	100	99.029	Pan_paniscus
ENSG00000137996	RTCA	100	95.918	ENSPPRG00000000350	RTCA	100	95.082	Panthera_pardus
ENSG00000137996	RTCA	100	95.918	ENSPTIG00000012816	RTCA	100	94.809	Panthera_tigris_altaica
ENSG00000137996	RTCA	100	98.945	ENSPTRG00000001004	RTCA	100	99.029	Pan_troglodytes
ENSG00000137996	RTCA	100	98.087	ENSPANG00000000346	RTCA	100	98.087	Papio_anubis
ENSG00000137996	RTCA	100	74.317	ENSPKIG00000001653	rtca	100	74.317	Paramormyrops_kingsleyae
ENSG00000137996	RTCA	100	84.426	ENSPSIG00000011408	RTCA	100	84.426	Pelodiscus_sinensis
ENSG00000137996	RTCA	82	62.500	ENSPMGG00000022529	rtca	98	61.039	Periophthalmus_magnuspinnatus
ENSG00000137996	RTCA	100	93.878	ENSPEMG00000018582	Rtca	100	90.984	Peromyscus_maniculatus_bairdii
ENSG00000137996	RTCA	96	65.957	ENSPMAG00000009110	rtca	99	59.178	Petromyzon_marinus
ENSG00000137996	RTCA	100	93.878	ENSPCIG00000007684	RTCA	100	90.437	Phascolarctos_cinereus
ENSG00000137996	RTCA	100	71.390	ENSPFOG00000004824	rtca	100	71.390	Poecilia_formosa
ENSG00000137996	RTCA	100	71.585	ENSPLAG00000011753	rtca	99	71.585	Poecilia_latipinna
ENSG00000137996	RTCA	100	71.585	ENSPMEG00000020469	rtca	99	71.585	Poecilia_mexicana
ENSG00000137996	RTCA	100	72.404	ENSPREG00000001365	rtca	99	72.404	Poecilia_reticulata
ENSG00000137996	RTCA	100	100.000	ENSPPYG00000029514	-	96	100.000	Pongo_abelii
ENSG00000137996	RTCA	100	100.000	ENSPPYG00000001115	RTCA	100	99.180	Pongo_abelii
ENSG00000137996	RTCA	100	91.837	ENSPCAG00000005076	RTCA	100	90.710	Procavia_capensis
ENSG00000137996	RTCA	100	96.721	ENSPCOG00000005603	RTCA	100	96.721	Propithecus_coquereli
ENSG00000137996	RTCA	98	95.833	ENSPVAG00000009478	RTCA	100	92.876	Pteropus_vampyrus
ENSG00000137996	RTCA	100	70.492	ENSPNYG00000004722	rtca	99	70.492	Pundamilia_nyererei
ENSG00000137996	RTCA	100	73.224	ENSPNAG00000022270	rtca	100	73.224	Pygocentrus_nattereri
ENSG00000137996	RTCA	100	93.878	ENSRNOG00000014575	Rtca	100	90.984	Rattus_norvegicus
ENSG00000137996	RTCA	100	98.153	ENSRBIG00000041180	RTCA	100	98.153	Rhinopithecus_bieti
ENSG00000137996	RTCA	100	100.000	ENSRROG00000024929	RTCA	100	98.153	Rhinopithecus_roxellana
ENSG00000137996	RTCA	100	96.995	ENSSBOG00000028626	RTCA	100	96.995	Saimiri_boliviensis_boliviensis
ENSG00000137996	RTCA	100	93.878	ENSSHAG00000001758	RTCA	100	90.164	Sarcophilus_harrisii
ENSG00000137996	RTCA	98	69.167	ENSSMAG00000014680	rtca	97	69.167	Scophthalmus_maximus
ENSG00000137996	RTCA	98	71.667	ENSSDUG00000015585	rtca	97	71.667	Seriola_dumerili
ENSG00000137996	RTCA	96	71.795	ENSSLDG00000018985	rtca	95	71.795	Seriola_lalandi_dorsalis
ENSG00000137996	RTCA	87	85.804	ENSSARG00000013993	RTCA	100	85.804	Sorex_araneus
ENSG00000137996	RTCA	100	83.673	ENSSPUG00000016262	-	88	87.770	Sphenodon_punctatus
ENSG00000137996	RTCA	100	70.492	ENSSPAG00000011938	rtca	99	70.492	Stegastes_partitus
ENSG00000137996	RTCA	100	97.959	ENSSSCG00000006865	RTCA	100	94.809	Sus_scrofa
ENSG00000137996	RTCA	100	83.880	ENSTGUG00000005154	RTCA	100	83.880	Taeniopygia_guttata
ENSG00000137996	RTCA	73	69.444	ENSTRUG00000002431	-	95	66.892	Takifugu_rubripes
ENSG00000137996	RTCA	100	71.038	ENSTRUG00000008799	rtca	100	71.038	Takifugu_rubripes
ENSG00000137996	RTCA	100	73.469	ENSTNIG00000004725	rtca	100	71.038	Tetraodon_nigroviridis
ENSG00000137996	RTCA	98	89.583	ENSTBEG00000000943	RTCA	82	67.227	Tupaia_belangeri
ENSG00000137996	RTCA	98	100.000	ENSTTRG00000015327	RTCA	100	93.668	Tursiops_truncatus
ENSG00000137996	RTCA	100	93.878	ENSUAMG00000017265	RTCA	96	92.420	Ursus_americanus
ENSG00000137996	RTCA	100	94.262	ENSUMAG00000007881	RTCA	100	94.262	Ursus_maritimus
ENSG00000137996	RTCA	87	85.174	ENSVPAG00000001039	RTCA	87	85.152	Vicugna_pacos
ENSG00000137996	RTCA	100	95.918	ENSVVUG00000022041	RTCA	68	95.355	Vulpes_vulpes
ENSG00000137996	RTCA	96	74.468	ENSXETG00000031661	RTCA	99	64.850	Xenopus_tropicalis
ENSG00000137996	RTCA	100	69.388	ENSXCOG00000008002	rtca	100	62.022	Xiphophorus_couchianus
ENSG00000137996	RTCA	100	71.311	ENSXMAG00000005482	rtca	99	71.311	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003963	RNA-3'-phosphate cyclase activity	21873635.	IBA	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006396	RNA processing	-	IEA	Process