EuRBPDB

Description

Ensembl ID: ENSG00000138029 (Gene tree)
Gene ID: 3032
Gene Symbol: HADHB
Alias: MTPB
Full Name: hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 47,299 bases
Position: chr2:26,243,170-26,290,468
Accession: 4803
RBP type: non-canonical RBP
Summary: This gene encodes the beta subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the beta subunit catalyzing the 3-ketoacyl-CoA thiolase activity. The encoded protein can also bind RNA and decreases the stability of some mRNAs. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. Mutations in this gene result in trifunctional protein deficiency. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000405867	HADHB-202	1588	-	ENSP00000385411	351 (aa)	-	B5MD38
ENST00000545822	HADHB-209	1870	XM_024452831	ENSP00000442665	452 (aa)	XP_024308599	P55084
ENST00000412805	HADHB-203	574	-	ENSP00000413103	84 (aa)	-	C9K0M0
ENST00000494615	HADHB-207	2883	-	-	- (aa)	-	-
ENST00000425035	HADHB-204	696	-	ENSP00000404633	175 (aa)	-	C9JE81
ENST00000448743	HADHB-205	557	-	ENSP00000415300	149 (aa)	-	C9JEY0
ENST00000317799	HADHB-201	2044	XM_011532803	ENSP00000325136	474 (aa)	XP_011531105	P55084
ENST00000537713	HADHB-208	2142	-	ENSP00000444295	459 (aa)	-	F5GZQ3
ENST00000479347	HADHB-206	670	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00062	Fatty acid elongation	KEGG
hsa00071	Fatty acid degradation	KEGG
hsa00280	Valine, leucine and isoleucine degradation	KEGG
hsa01100	Metabolic pathways	KEGG
hsa01212	Fatty acid metabolism	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138029	Carcinoma, Non-Small-Cell Lung	4E-6	23144319

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138029	HADHB	95	62.413	WBGene00015125	B0303.3	99	60.879	Caenorhabditis_elegans
ENSG00000138029	HADHB	94	70.258	FBgn0025352	Thiolase	95	67.849	Drosophila_melanogaster
ENSG00000138029	HADHB	92	30.260	FBgn0035203	CG9149	99	30.260	Drosophila_melanogaster
ENSG00000138029	HADHB	93	30.445	FBgn0040064	yip2	98	30.445	Drosophila_melanogaster
ENSG00000138029	HADHB	98	31.544	ENSG00000075239	ACAT1	96	31.544	Homo_sapiens
ENSG00000138029	HADHB	93	34.033	ENSG00000167315	ACAA2	99	34.038	Homo_sapiens
ENSG00000138029	HADHB	99	95.588	ENSMUSG00000059447	Hadhb	99	91.121	Mus_musculus
ENSG00000138029	HADHB	95	34.416	ENSMUSG00000036138	Acaa1a	96	34.416	Mus_musculus
ENSG00000138029	HADHB	93	31.860	YPL028W	ERG10	99	31.860	Saccharomyces_cerevisiae
ENSG00000138029	HADHB	95	30.365	YIL160C	POT1	94	30.365	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity	1550553.	TAS	Function
GO:0003988	acetyl-CoA C-acyltransferase activity	21873635.	IBA	Function
GO:0004300	enoyl-CoA hydratase activity	21873635.	IBA	Function
GO:0005515	protein binding	20562859.21527675.	IPI	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	7958339.	NAS	Component
GO:0005740	mitochondrial envelope	1550553.	TAS	Component
GO:0005741	mitochondrial outer membrane	21527675.	IDA	Component
GO:0005743	mitochondrial inner membrane	21527675.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005783	endoplasmic reticulum	21527675.	IDA	Component
GO:0006635	fatty acid beta-oxidation	21873635.	IBA	Process
GO:0006635	fatty acid beta-oxidation	-	IEA	Process
GO:0006635	fatty acid beta-oxidation	-	TAS	Process
GO:0016508	long-chain-enoyl-CoA hydratase activity	21873635.	IBA	Function
GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity	21873635.	IBA	Function
GO:0035965	cardiolipin acyl-chain remodeling	-	TAS	Process
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component