EuRBPDB

Description

Ensembl ID: ENSG00000138073 (Gene tree)
Gene ID: 10113
Gene Symbol: PREB
Alias: SEC12
Full Name: prolactin regulatory element binding
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 3,920 bases
Position: chr2:27,130,756-27,134,675
Accession: 9356
RBP type: non-canonical RBP
Summary: This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26739056	Prolactin Regulatory Element Binding Protein Is Involved in Hepatitis C Virus Replication by Interaction with NS4B.	J Virol	2016 Jan 6	Kong L	doi: 10.1128/JVI.01540-15.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000416802	PREB-203	564	-	-	- (aa)	-	-
ENST00000260643	PREB-201	2166	-	ENSP00000260643	417 (aa)	-	Q9HCU5
ENST00000444452	PREB-206	2030	-	ENSP00000416103	50 (aa)	-	F8WCS5
ENST00000468045	PREB-208	3057	-	-	- (aa)	-	-
ENST00000406567	PREB-202	1910	-	ENSP00000384032	359 (aa)	-	B5MC98
ENST00000474802	PREB-209	1283	-	-	- (aa)	-	-
ENST00000430533	PREB-204	615	-	ENSP00000407036	106 (aa)	-	H7C2N7
ENST00000441451	PREB-205	351	-	ENSP00000391894	22 (aa)	-	H7BZX0
ENST00000456259	PREB-207	1105	-	ENSP00000397036	176 (aa)	-	H7C0W3

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0003400	regulation of COPII vesicle coating	21873635.	IBA	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0005085	guanyl-nucleotide exchange factor activity	-	TAS	Function
GO:0005090	Sar guanyl-nucleotide exchange factor activity	21873635.	IBA	Function
GO:0005090	Sar guanyl-nucleotide exchange factor activity	-	ISS	Function
GO:0005096	GTPase activator activity	21873635.	IBA	Function
GO:0005515	protein binding	25202031.27170179.	IPI	Function
GO:0005634	nucleus	10194769.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006888	ER to Golgi vesicle-mediated transport	-	ISS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0009306	protein secretion	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0030176	integral component of endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0030176	integral component of endoplasmic reticulum membrane	-	ISS	Component
GO:0032527	protein exit from endoplasmic reticulum	25202031.	IMP	Process
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0043547	positive regulation of GTPase activity	-	IEA	Process
GO:0048208	COPII vesicle coating	-	ISS	Process
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0051020	GTPase binding	21873635.	IBA	Function
GO:0070971	endoplasmic reticulum exit site	25202031.27170179.28442536.	IDA	Component