EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138095 (Gene tree)
Gene ID: 10128
Gene Symbol: LRPPRC
Alias: GP130|LRP130|LSFC
Full Name: leucine rich pentatricopeptide repeat containing
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 109,782 bases
Position: chr2:43,886,224-43,996,005
Accession: 15714
RBP type: canonical RBP
Summary: This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. [provided by RefSeq, Mar 2012]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000260665	PPR	PF01535.20	3.1e-29	1	6
ENSP00000260665	PPR	PF01535.20	3.1e-29	2	6
ENSP00000260665	PPR	PF01535.20	3.1e-29	3	6
ENSP00000260665	PPR	PF01535.20	3.1e-29	4	6
ENSP00000260665	PPR	PF01535.20	3.1e-29	5	6
ENSP00000260665	PPR	PF01535.20	3.1e-29	6	6
ENSP00000403637	PPR	PF01535.20	1e-15	1	3
ENSP00000403637	PPR	PF01535.20	1e-15	2	3
ENSP00000403637	PPR	PF01535.20	1e-15	3	3
ENSP00000386562	PPR	PF01535.20	3.3e-15	1	3
ENSP00000386562	PPR	PF01535.20	3.3e-15	2	3
ENSP00000386562	PPR	PF01535.20	3.3e-15	3	3
ENSP00000386234	PPR	PF01535.20	3.6e-15	1	3
ENSP00000386234	PPR	PF01535.20	3.6e-15	2	3
ENSP00000386234	PPR	PF01535.20	3.6e-15	3	3

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23118342	Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model.	Dis Model Mech	2013 Jan	Llamusi B	doi: 10.1242/dmm.009563
27353330	SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.	Nucleic Acids Res	2016 Aug 19	Spahr H	doi: 10.1093/nar/gkw575
12832482	LRP130, a pentatricopeptide motif protein with a noncanonical RNA-binding domain, is bound in vivo to mitochondrial and nuclear RNAs.	Mol Cell Biol	2003 Jul	Mili S	-
11585913	Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA.	Mol Cell Biol	2001 Nov	Mili S	-
15081402	LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo.	Biochem Biophys Res Commun	2004 May 7	Tsuchiya N	-
20633537	LRPPRC is a mitochondrial matrix protein that is conserved in metazoans.	Biochem Biophys Res Commun	2010 Aug 6	Sterky FH	doi: 10.1016/j.bbrc.2010.07.019
20200222	LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria.	Mol Biol Cell	2010 Apr 15	Sasarman F	doi: 10.1091/mbc.E10-01-0047
25428350	Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.	Nucleic Acids Res	2014 Dec 16	Baggio F	doi: 10.1093/nar/gku1132
25214534	Tissue-specific responses to the LRPPRC founder mutation in French Canadian Leigh Syndrome.	Hum Mol Genet	2015 Jan 15	Sasarman F	doi: 10.1093/hmg/ddu468
25008111	A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.	Hum Mol Genet	2014 Dec 1	Wilson WC	doi: 10.1093/hmg/ddu352

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000409659	LRPPRC-202	1610	-	ENSP00000386562	504 (aa)	-	B8ZZ38
ENST00000419884	LRPPRC-204	888	-	ENSP00000414207	77 (aa)	-	H7C3W8
ENST00000260665	LRPPRC-201	6335	XM_006711915	ENSP00000260665	1394 (aa)	XP_006711978	P42704
ENST00000409946	LRPPRC-203	1848	-	ENSP00000386234	531 (aa)	-	A0A0C4DG06
ENST00000483489	LRPPRC-209	564	-	-	- (aa)	-	-
ENST00000463456	LRPPRC-206	3549	-	-	- (aa)	-	-
ENST00000472420	LRPPRC-208	694	-	-	- (aa)	-	-
ENST00000447246	LRPPRC-205	1209	-	ENSP00000403637	359 (aa)	-	C9JCA9
ENST00000467058	LRPPRC-207	557	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138095's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138095	Body Weight	6.46942529539519E-5	17903300
ENSG00000138095	Body Weight	4.40768165814054E-5	17903300
ENSG00000138095	Cholesterol, HDL	7.84783516712504E-5	17903299
ENSG00000138095	Blood Glucose	7.9570000E-005	-
ENSG00000138095	Platelet Function Tests	1.0855100E-005	-
ENSG00000138095	Platelet Function Tests	1.0845900E-005	-
ENSG00000138095	Child Development Disorders, Pervasive	2.3762000E-005	-
ENSG00000138095	Intelligence	9E-6	23358156

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138095	rs13387221	2	43908175	A	Intelligence (childhood)	23358156	[0.035-0.093] unit increase	0.064	EFO_0004337
ENSG00000138095	rs4347883	2	43957990	T	Cognitive performance	30038396	[0.01-0.022] unit decrease	0.016	EFO_0008354
ENSG00000138095	rs13017251	2	43994021	A	Hand grip strength	29691431	[0.0014-0.0026] unit increase	0.002	EFO_0006941
ENSG00000138095	rs2955280	2	43889697	T	Intelligence	29942086	z-score decrease	5.455	EFO_0004337
ENSG00000138095	rs1136998	2	43888044	A	Smoking status (ever vs never smokers)	30643258	[0.014-0.026] unit decrease	0.020011662	EFO_0004318

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138095's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138095	LRPPRC	94	58.390	ENSAPLG00000008902	LRPPRC	99	58.390	Anas_platyrhynchos
ENSG00000138095	LRPPRC	99	80.871	ENSBTAG00000016368	LRPPRC	99	80.532	Bos_taurus
ENSG00000138095	LRPPRC	99	81.214	ENSCAFG00000002527	LRPPRC	99	79.813	Canis_familiaris
ENSG00000138095	LRPPRC	99	81.690	ENSCAFG00020025995	LRPPRC	99	79.023	Canis_lupus_dingo
ENSG00000138095	LRPPRC	93	87.164	ENSTSYG00000013197	LRPPRC	96	83.631	Carlito_syrichta
ENSG00000138095	LRPPRC	97	66.479	ENSCPBG00000005446	LRPPRC	99	62.955	Chrysemys_picta_bellii
ENSG00000138095	LRPPRC	87	45.714	FBgn0284256	bsf	66	42.723	Drosophila_melanogaster
ENSG00000138095	LRPPRC	97	85.632	ENSEASG00005003715	LRPPRC	99	82.268	Equus_asinus_asinus
ENSG00000138095	LRPPRC	99	83.106	ENSECAG00000023814	LRPPRC	95	82.539	Equus_caballus
ENSG00000138095	LRPPRC	91	65.152	ENSGALG00000009967	LRPPRC	98	57.447	Gallus_gallus
ENSG00000138095	LRPPRC	100	62.740	ENSGAGG00000020227	LRPPRC	98	63.307	Gopherus_agassizii
ENSG00000138095	LRPPRC	99	91.887	ENSMLEG00000043673	LRPPRC	99	91.887	Mandrillus_leucophaeus
ENSG00000138095	LRPPRC	96	57.797	ENSMGAG00000010201	LRPPRC	100	57.797	Meleagris_gallopavo
ENSG00000138095	LRPPRC	100	75.036	MGP_CAROLIEiJ_G0021927	Lrpprc	100	75.036	Mus_caroli
ENSG00000138095	LRPPRC	100	75.251	ENSMUSG00000024120	Lrpprc	100	75.251	Mus_musculus
ENSG00000138095	LRPPRC	100	76.255	MGP_PahariEiJ_G0020917	Lrpprc	100	76.255	Mus_pahari
ENSG00000138095	LRPPRC	100	75.251	MGP_SPRETEiJ_G0022843	Lrpprc	100	75.251	Mus_spretus
ENSG00000138095	LRPPRC	81	85.294	ENSMEUG00000004430	-	88	85.294	Notamacropus_eugenii
ENSG00000138095	LRPPRC	99	78.212	ENSPEMG00000022720	Lrpprc	100	75.610	Peromyscus_maniculatus_bairdii
ENSG00000138095	LRPPRC	95	74.499	ENSPCIG00000006872	LRPPRC	99	67.906	Phascolarctos_cinereus
ENSG00000138095	LRPPRC	99	84.034	ENSPCOG00000001309	LRPPRC	99	83.992	Propithecus_coquereli
ENSG00000138095	LRPPRC	97	93.333	ENSRROG00000038362	-	87	88.793	Rhinopithecus_roxellana
ENSG00000138095	LRPPRC	89	60.654	ENSSPUG00000005188	LRPPRC	99	60.654	Sphenodon_punctatus
ENSG00000138095	LRPPRC	78	75.000	ENSTBEG00000011055	-	66	80.090	Tupaia_belangeri
ENSG00000138095	LRPPRC	99	82.576	ENSUAMG00000022940	LRPPRC	100	80.717	Ursus_americanus
ENSG00000138095	LRPPRC	99	82.765	ENSUMAG00000012801	LRPPRC	100	80.860	Ursus_maritimus
ENSG00000138095	LRPPRC	99	81.214	ENSVVUG00000002339	LRPPRC	99	78.879	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000794	condensed nuclear chromosome	12762840.	IDA	Component
GO:0000961	negative regulation of mitochondrial RNA catabolic process	-	IEA	Process
GO:0003697	single-stranded DNA binding	-	IEA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	12832482.	NAS	Function
GO:0005515	protein binding	15907802.17050673.19262567.22045337.26496610.	IPI	Function
GO:0005634	nucleus	12762840.12832482.	IDA	Component
GO:0005637	nuclear inner membrane	-	IEA	Component
GO:0005640	nuclear outer membrane	-	IEA	Component
GO:0005654	nucleoplasm	-	IEA	Component
GO:0005739	mitochondrion	12832482.	IDA	Component
GO:0005739	mitochondrion	12762840.	IDA	Component
GO:0005856	cytoskeleton	12762840.	IDA	Component
GO:0005874	microtubule	21525035.	IDA	Component
GO:0008017	microtubule binding	12762840.	TAS	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0031625	ubiquitin protein ligase binding	19725078.	IPI	Function
GO:0042645	mitochondrial nucleoid	18063578.	IDA	Component
GO:0047497	mitochondrion transport along microtubule	12762840.	TAS	Process
GO:0048471	perinuclear region of cytoplasm	12762840.	IDA	Component
GO:0048487	beta-tubulin binding	12762840.	IDA	Function
GO:0051015	actin filament binding	12762840.	IDA	Function
GO:0051028	mRNA transport	-	IEA	Process
GO:0070129	regulation of mitochondrial translation	-	IEA	Process
GO:1990904	ribonucleoprotein complex	-	IEA	Component