EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138231 (Gene tree)
Gene ID: 51163
Gene Symbol: DBR1
Alias: N
Full Name: debranching RNA lariats 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 13,962 bases
Position: chr3:138,160,988-138,174,949
Accession: 15594
RBP type: canonical RBP
Summary: The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000260803	DBR1	PF05011.13	2e-34	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23104007	Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.	Nat Genet	2012 Dec	Armakola M	doi: 10.1038/ng.2434
26797105	In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity.	Sci Rep	2016 Jan 22	Pires DE	doi: 10.1038/srep19848.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000260803	DBR1-201	2666	-	ENSP00000260803	544 (aa)	-	Q9UK59
ENST00000463982	DBR1-203	623	-	-	- (aa)	-	-
ENST00000477557	DBR1-204	838	-	ENSP00000417262	118 (aa)	-	F8WAY1
ENST00000460271	DBR1-202	572	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138231's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138231's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138231	DBR1	94	79.279	ENSAPOG00000004318	dbr1	98	56.801	Acanthochromis_polyacanthus
ENSG00000138231	DBR1	97	89.662	ENSAMEG00000006272	DBR1	98	89.662	Ailuropoda_melanoleuca
ENSG00000138231	DBR1	99	75.000	ENSACIG00000020512	dbr1	98	55.575	Amphilophus_citrinellus
ENSG00000138231	DBR1	94	79.279	ENSAOCG00000008060	dbr1	98	56.985	Amphiprion_ocellaris
ENSG00000138231	DBR1	94	79.279	ENSAPEG00000021944	dbr1	98	56.985	Amphiprion_percula
ENSG00000138231	DBR1	99	76.667	ENSATEG00000019673	dbr1	98	57.358	Anabas_testudineus
ENSG00000138231	DBR1	94	77.679	ENSACAG00000016760	DBR1	98	66.851	Anolis_carolinensis
ENSG00000138231	DBR1	97	96.226	ENSANAG00000028952	DBR1	98	98.788	Aotus_nancymaae
ENSG00000138231	DBR1	94	79.279	ENSACLG00000024027	dbr1	98	56.757	Astatotilapia_calliptera
ENSG00000138231	DBR1	94	80.180	ENSAMXG00000030736	dbr1	98	55.062	Astyanax_mexicanus
ENSG00000138231	DBR1	94	94.595	ENSBTAG00000019949	DBR1	98	88.411	Bos_taurus
ENSG00000138231	DBR1	93	68.182	WBGene00000937	dbr-1	85	44.522	Caenorhabditis_elegans
ENSG00000138231	DBR1	98	95.685	ENSCJAG00000002433	DBR1	98	95.685	Callithrix_jacchus
ENSG00000138231	DBR1	93	96.364	ENSCAFG00000007501	DBR1	98	90.093	Canis_familiaris
ENSG00000138231	DBR1	94	95.495	ENSCAFG00020008060	DBR1	98	90.093	Canis_lupus_dingo
ENSG00000138231	DBR1	99	88.192	ENSCHIG00000026937	DBR1	98	88.224	Capra_hircus
ENSG00000138231	DBR1	100	86.679	ENSTSYG00000005317	DBR1	98	87.896	Carlito_syrichta
ENSG00000138231	DBR1	91	98.131	ENSCPOG00000006179	DBR1	98	86.168	Cavia_porcellus
ENSG00000138231	DBR1	98	95.497	ENSCCAG00000025708	DBR1	98	95.497	Cebus_capucinus
ENSG00000138231	DBR1	99	98.529	ENSCATG00000032054	DBR1	100	98.529	Cercocebus_atys
ENSG00000138231	DBR1	93	95.455	ENSCLAG00000001800	DBR1	98	88.972	Chinchilla_lanigera
ENSG00000138231	DBR1	99	98.162	ENSCSAG00000010977	DBR1	100	98.162	Chlorocebus_sabaeus
ENSG00000138231	DBR1	89	96.078	ENSCHOG00000000730	DBR1	88	96.078	Choloepus_hoffmanni
ENSG00000138231	DBR1	94	85.586	ENSCPBG00000007633	DBR1	89	73.184	Chrysemys_picta_bellii
ENSG00000138231	DBR1	94	67.568	ENSCING00000011388	-	100	53.182	Ciona_intestinalis
ENSG00000138231	DBR1	94	70.270	ENSCSAVG00000007545	-	100	56.464	Ciona_savignyi
ENSG00000138231	DBR1	99	98.152	ENSCANG00000024237	DBR1	99	98.152	Colobus_angolensis_palliatus
ENSG00000138231	DBR1	94	96.396	ENSCGRG00001018497	Dbr1	98	87.896	Cricetulus_griseus_chok1gshd
ENSG00000138231	DBR1	99	81.685	ENSCGRG00000005958	Dbr1	98	81.937	Cricetulus_griseus_crigri
ENSG00000138231	DBR1	94	77.477	ENSCSEG00000002813	dbr1	98	54.676	Cynoglossus_semilaevis
ENSG00000138231	DBR1	94	80.180	ENSCVAG00000019969	dbr1	99	56.295	Cyprinodon_variegatus
ENSG00000138231	DBR1	94	80.180	ENSDARG00000056923	dbr1	98	56.250	Danio_rerio
ENSG00000138231	DBR1	94	95.495	ENSDNOG00000043630	DBR1	98	88.972	Dasypus_novemcinctus
ENSG00000138231	DBR1	93	68.182	FBgn0035838	ldbr	78	50.239	Drosophila_melanogaster
ENSG00000138231	DBR1	94	94.595	ENSETEG00000011830	DBR1	78	97.761	Echinops_telfairi
ENSG00000138231	DBR1	94	85.586	ENSEBUG00000007494	dbr1	99	46.503	Eptatretus_burgeri
ENSG00000138231	DBR1	98	90.467	ENSEASG00005003788	DBR1	98	90.654	Equus_asinus_asinus
ENSG00000138231	DBR1	98	90.654	ENSECAG00000013920	DBR1	98	90.841	Equus_caballus
ENSG00000138231	DBR1	99	79.889	ENSEEUG00000007059	DBR1	98	80.000	Erinaceus_europaeus
ENSG00000138231	DBR1	94	78.378	ENSELUG00000005587	dbr1	98	56.909	Esox_lucius
ENSG00000138231	DBR1	98	90.841	ENSFCAG00000002229	DBR1	98	91.028	Felis_catus
ENSG00000138231	DBR1	94	84.685	ENSFALG00000013467	DBR1	85	72.491	Ficedula_albicollis
ENSG00000138231	DBR1	94	95.495	ENSFDAG00000009524	DBR1	98	89.346	Fukomys_damarensis
ENSG00000138231	DBR1	94	79.279	ENSFHEG00000001743	dbr1	98	54.464	Fundulus_heteroclitus
ENSG00000138231	DBR1	94	80.180	ENSGMOG00000006925	dbr1	99	54.611	Gadus_morhua
ENSG00000138231	DBR1	99	64.273	ENSGALG00000043797	DBR1	98	64.739	Gallus_gallus
ENSG00000138231	DBR1	94	79.279	ENSGAFG00000001046	dbr1	98	55.535	Gambusia_affinis
ENSG00000138231	DBR1	94	76.577	ENSGACG00000009122	dbr1	99	55.154	Gasterosteus_aculeatus
ENSG00000138231	DBR1	94	85.586	ENSGAGG00000001244	DBR1	99	73.184	Gopherus_agassizii
ENSG00000138231	DBR1	100	94.495	ENSGGOG00000004564	DBR1	100	94.495	Gorilla_gorilla
ENSG00000138231	DBR1	94	79.279	ENSHBUG00000000882	dbr1	98	56.757	Haplochromis_burtoni
ENSG00000138231	DBR1	91	98.131	ENSHGLG00000014529	Dbr1	98	90.075	Heterocephalus_glaber_female
ENSG00000138231	DBR1	91	98.131	ENSHGLG00100013202	Dbr1	98	90.075	Heterocephalus_glaber_male
ENSG00000138231	DBR1	94	79.279	ENSHCOG00000004179	dbr1	98	56.147	Hippocampus_comes
ENSG00000138231	DBR1	99	77.500	ENSIPUG00000023749	dbr1	99	54.145	Ictalurus_punctatus
ENSG00000138231	DBR1	94	96.396	ENSSTOG00000007122	DBR1	98	90.841	Ictidomys_tridecemlineatus
ENSG00000138231	DBR1	94	96.396	ENSJJAG00000017080	Dbr1	98	88.827	Jaculus_jaculus
ENSG00000138231	DBR1	94	78.378	ENSKMAG00000004869	dbr1	99	54.098	Kryptolebias_marmoratus
ENSG00000138231	DBR1	94	79.279	ENSLBEG00000021307	dbr1	98	56.940	Labrus_bergylta
ENSG00000138231	DBR1	94	80.180	ENSLACG00000005547	DBR1	99	69.444	Latimeria_chalumnae
ENSG00000138231	DBR1	94	80.180	ENSLOCG00000004160	dbr1	98	59.091	Lepisosteus_oculatus
ENSG00000138231	DBR1	94	96.396	ENSLAFG00000005827	DBR1	98	91.386	Loxodonta_africana
ENSG00000138231	DBR1	99	98.529	ENSMFAG00000043642	DBR1	100	98.529	Macaca_fascicularis
ENSG00000138231	DBR1	99	98.346	ENSMMUG00000021284	DBR1	100	98.346	Macaca_mulatta
ENSG00000138231	DBR1	99	98.529	ENSMNEG00000041740	DBR1	100	98.529	Macaca_nemestrina
ENSG00000138231	DBR1	95	79.423	ENSMLEG00000034542	DBR1	95	83.128	Mandrillus_leucophaeus
ENSG00000138231	DBR1	94	78.378	ENSMAMG00000012205	dbr1	98	55.456	Mastacembelus_armatus
ENSG00000138231	DBR1	94	79.279	ENSMZEG00005021338	dbr1	98	56.757	Maylandia_zebra
ENSG00000138231	DBR1	80	69.266	ENSMGAG00000002142	DBR1	98	69.930	Meleagris_gallopavo
ENSG00000138231	DBR1	99	90.833	ENSMAUG00000010037	Dbr1	98	87.828	Mesocricetus_auratus
ENSG00000138231	DBR1	98	92.523	ENSMICG00000049533	DBR1	98	92.897	Microcebus_murinus
ENSG00000138231	DBR1	94	96.396	ENSMOCG00000018746	Dbr1	98	85.955	Microtus_ochrogaster
ENSG00000138231	DBR1	94	79.279	ENSMMOG00000000719	dbr1	98	56.810	Mola_mola
ENSG00000138231	DBR1	94	93.694	ENSMODG00000018554	DBR1	98	77.365	Monodelphis_domestica
ENSG00000138231	DBR1	99	74.167	ENSMALG00000022283	dbr1	96	56.373	Monopterus_albus
ENSG00000138231	DBR1	94	95.495	MGP_CAROLIEiJ_G0032564	Dbr1	100	98.773	Mus_caroli
ENSG00000138231	DBR1	94	95.495	ENSMUSG00000032469	Dbr1	100	98.773	Mus_musculus
ENSG00000138231	DBR1	94	95.495	MGP_PahariEiJ_G0015433	Dbr1	100	98.773	Mus_pahari
ENSG00000138231	DBR1	94	95.495	MGP_SPRETEiJ_G0033708	Dbr1	100	98.773	Mus_spretus
ENSG00000138231	DBR1	93	95.455	ENSMPUG00000009230	DBR1	98	90.093	Mustela_putorius_furo
ENSG00000138231	DBR1	94	94.595	ENSMLUG00000026117	DBR1	98	87.523	Myotis_lucifugus
ENSG00000138231	DBR1	93	95.455	ENSNGAG00000003518	Dbr1	98	89.533	Nannospalax_galili
ENSG00000138231	DBR1	94	79.279	ENSNBRG00000016318	dbr1	98	56.937	Neolamprologus_brichardi
ENSG00000138231	DBR1	99	98.711	ENSNLEG00000032263	DBR1	98	98.711	Nomascus_leucogenys
ENSG00000138231	DBR1	94	92.793	ENSMEUG00000009188	DBR1	99	76.438	Notamacropus_eugenii
ENSG00000138231	DBR1	92	75.248	ENSOPRG00000016510	DBR1	99	75.551	Ochotona_princeps
ENSG00000138231	DBR1	94	95.495	ENSODEG00000018178	DBR1	98	87.103	Octodon_degus
ENSG00000138231	DBR1	94	79.279	ENSONIG00000013801	dbr1	98	56.295	Oreochromis_niloticus
ENSG00000138231	DBR1	88	72.301	ENSOANG00000007783	DBR1	98	72.727	Ornithorhynchus_anatinus
ENSG00000138231	DBR1	93	88.998	ENSOCUG00000015129	DBR1	88	89.567	Oryctolagus_cuniculus
ENSG00000138231	DBR1	99	75.833	ENSORLG00015001112	dbr1	98	56.983	Oryzias_latipes_hsok
ENSG00000138231	DBR1	99	76.667	ENSOMEG00000000857	dbr1	98	57.435	Oryzias_melastigma
ENSG00000138231	DBR1	97	92.655	ENSOGAG00000033095	DBR1	98	92.884	Otolemur_garnettii
ENSG00000138231	DBR1	99	87.085	ENSOARG00000007589	DBR1	98	87.103	Ovis_aries
ENSG00000138231	DBR1	100	99.266	ENSPPAG00000031137	DBR1	100	99.266	Pan_paniscus
ENSG00000138231	DBR1	98	90.654	ENSPPRG00000013629	DBR1	98	90.841	Panthera_pardus
ENSG00000138231	DBR1	96	90.249	ENSPTIG00000012674	DBR1	96	90.440	Panthera_tigris_altaica
ENSG00000138231	DBR1	100	99.266	ENSPTRG00000015441	DBR1	100	99.266	Pan_troglodytes
ENSG00000138231	DBR1	99	98.346	ENSPANG00000012664	DBR1	100	98.346	Papio_anubis
ENSG00000138231	DBR1	94	79.279	ENSPKIG00000000310	dbr1	98	57.371	Paramormyrops_kingsleyae
ENSG00000138231	DBR1	87	71.698	ENSPSIG00000015486	DBR1	98	71.762	Pelodiscus_sinensis
ENSG00000138231	DBR1	99	90.833	ENSPEMG00000020602	Dbr1	97	86.891	Peromyscus_maniculatus_bairdii
ENSG00000138231	DBR1	94	74.775	ENSPMAG00000008620	dbr1	100	61.053	Petromyzon_marinus
ENSG00000138231	DBR1	94	91.892	ENSPCIG00000006494	DBR1	98	77.737	Phascolarctos_cinereus
ENSG00000138231	DBR1	94	80.180	ENSPLAG00000011665	dbr1	98	55.390	Poecilia_latipinna
ENSG00000138231	DBR1	69	45.000	ENSPLAG00000002421	-	97	45.040	Poecilia_latipinna
ENSG00000138231	DBR1	70	44.588	ENSPMEG00000020884	-	92	45.144	Poecilia_mexicana
ENSG00000138231	DBR1	94	80.180	ENSPMEG00000010080	dbr1	98	55.351	Poecilia_mexicana
ENSG00000138231	DBR1	94	80.180	ENSPREG00000020157	dbr1	98	55.027	Poecilia_reticulata
ENSG00000138231	DBR1	99	99.079	ENSPPYG00000014139	DBR1	99	99.079	Pongo_abelii
ENSG00000138231	DBR1	93	96.364	ENSPCAG00000012956	DBR1	99	92.288	Procavia_capensis
ENSG00000138231	DBR1	98	92.897	ENSPCOG00000016894	DBR1	98	93.271	Propithecus_coquereli
ENSG00000138231	DBR1	98	82.243	ENSPVAG00000007713	DBR1	98	82.430	Pteropus_vampyrus
ENSG00000138231	DBR1	94	79.279	ENSPNYG00000015453	dbr1	98	56.475	Pundamilia_nyererei
ENSG00000138231	DBR1	94	80.180	ENSPNAG00000025595	dbr1	99	56.106	Pygocentrus_nattereri
ENSG00000138231	DBR1	94	96.396	ENSRNOG00000014588	Dbr1	98	85.206	Rattus_norvegicus
ENSG00000138231	DBR1	100	97.982	ENSRBIG00000045002	DBR1	100	97.982	Rhinopithecus_bieti
ENSG00000138231	DBR1	100	98.165	ENSRROG00000044819	DBR1	100	98.165	Rhinopithecus_roxellana
ENSG00000138231	DBR1	92	48.148	YKL149C	DBR1	79	40.308	Saccharomyces_cerevisiae
ENSG00000138231	DBR1	98	94.934	ENSSBOG00000032048	DBR1	98	94.934	Saimiri_boliviensis_boliviensis
ENSG00000138231	DBR1	94	93.694	ENSSHAG00000006752	DBR1	98	76.623	Sarcophilus_harrisii
ENSG00000138231	DBR1	94	81.081	ENSSFOG00015011410	dbr1	98	57.587	Scleropages_formosus
ENSG00000138231	DBR1	94	78.378	ENSSMAG00000016078	dbr1	98	55.335	Scophthalmus_maximus
ENSG00000138231	DBR1	94	79.279	ENSSDUG00000017849	dbr1	98	55.694	Seriola_dumerili
ENSG00000138231	DBR1	94	77.477	ENSSLDG00000019891	dbr1	98	55.536	Seriola_lalandi_dorsalis
ENSG00000138231	DBR1	52	96.000	ENSSARG00000003148	-	73	96.000	Sorex_araneus
ENSG00000138231	DBR1	94	94.595	ENSSARG00000009558	-	97	75.746	Sorex_araneus
ENSG00000138231	DBR1	88	66.392	ENSSPUG00000004724	DBR1	91	66.944	Sphenodon_punctatus
ENSG00000138231	DBR1	94	78.378	ENSSPAG00000016892	dbr1	98	57.692	Stegastes_partitus
ENSG00000138231	DBR1	94	95.495	ENSSSCG00000031098	DBR1	98	89.326	Sus_scrofa
ENSG00000138231	DBR1	93	72.461	ENSTGUG00000007073	DBR1	95	72.908	Taeniopygia_guttata
ENSG00000138231	DBR1	94	79.279	ENSTRUG00000021594	dbr1	97	55.135	Takifugu_rubripes
ENSG00000138231	DBR1	92	79.630	ENSTNIG00000006710	dbr1	98	55.877	Tetraodon_nigroviridis
ENSG00000138231	DBR1	94	95.495	ENSTTRG00000004020	DBR1	98	90.467	Tursiops_truncatus
ENSG00000138231	DBR1	99	90.221	ENSUAMG00000004639	DBR1	98	90.467	Ursus_americanus
ENSG00000138231	DBR1	98	90.654	ENSUMAG00000015012	DBR1	98	90.841	Ursus_maritimus
ENSG00000138231	DBR1	94	93.694	ENSVPAG00000011711	DBR1	98	84.299	Vicugna_pacos
ENSG00000138231	DBR1	93	96.364	ENSVVUG00000026604	DBR1	98	89.720	Vulpes_vulpes
ENSG00000138231	DBR1	94	75.676	ENSXETG00000027491	dbr1	99	64.860	Xenopus_tropicalis
ENSG00000138231	DBR1	94	80.180	ENSXCOG00000018078	dbr1	98	55.801	Xiphophorus_couchianus
ENSG00000138231	DBR1	94	80.180	ENSXMAG00000007311	dbr1	98	55.904	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000375	RNA splicing, via transesterification reactions	10982890.	IMP	Process
GO:0000398	mRNA splicing, via spliceosome	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	10982890.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0008419	RNA lariat debranching enzyme activity	21873635.	IBA	Function
GO:0008419	RNA lariat debranching enzyme activity	10982890.	IMP	Function
GO:0046872	metal ion binding	-	IEA	Function
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process