EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138246 (Gene tree)
Gene ID: 23317
Gene Symbol: DNAJC13
Alias: RME8|KIAA0678
Full Name: DnaJ heat shock protein family (Hsp40) member C13
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 121,507 bases
Position: chr3:132,417,526-132,539,032
Accession: 30343
RBP type: non-canonical RBP
Summary: This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkinson's disease. [provided by RefSeq, Jun 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000464766	DNAJC13-203	775	-	-	- (aa)	-	-
ENST00000260818	DNAJC13-201	7730	XM_017006036	ENSP00000260818	2243 (aa)	XP_016861525	O75165
ENST00000486798	DNAJC13-205	2306	-	-	- (aa)	-	-
ENST00000471925	DNAJC13-204	1439	-	-	- (aa)	-	-
ENST00000650455	DNAJC13-209	7707	-	ENSP00000496825	631 (aa)	-	-
ENST00000509279	DNAJC13-207	673	-	ENSP00000426240	96 (aa)	-	H0YA63
ENST00000506813	DNAJC13-206	801	-	ENSP00000421735	173 (aa)	-	H0Y8Q2
ENST00000513822	DNAJC13-208	338	-	-	- (aa)	-	-
ENST00000463038	DNAJC13-202	546	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138246's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138246	Apolipoproteins B	6.98768415566437E-6	17903299
ENSG00000138246	Apolipoproteins B	1.99985286670735E-6	17903299
ENSG00000138246	Arteries	1.7040000E-005	-
ENSG00000138246	Arteries	5.4290000E-005	-
ENSG00000138246	Cholesterol, LDL	2E-9	24097068
ENSG00000138246	Cholesterol, HDL	5E-9	24097068

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138246	rs11924792	3	132521256	C	Blood protein levels	29875488	[0.53-0.69] unit decrease	0.61	EFO_0007937
ENSG00000138246	rs17404153	3	132444356	T	HDL cholesterol	24097068	[NR] unit decrease	0.028	EFO_0004612
ENSG00000138246	rs17404153	3	132444356	T	LDL cholesterol	24097068	[NR] unit decrease	0.034	EFO_0004611
ENSG00000138246	rs17412738	3	132538575	G	Blood protein levels	28240269	[0.35-0.61] unit decrease	0.4839	EFO_0008048
ENSG00000138246	rs62292953	3	132483605	A	Red cell distribution width	27863252	[0.024-0.044] unit increase	0.03380187	EFO_0005192
ENSG00000138246	rs112409831	3	132417596	C	Iron status biomarkers (total iron binding capacity)	28334935	[0.22-0.51] unit increase	0.365	EFO_0006334
ENSG00000138246	rs17345563	3	132490359	A	LDL cholesterol levels	28334899	[0.025-0.047] unit increase (EA Beta value)	0.0358	EFO_0004611
ENSG00000138246	rs577887768	3	132487560	ATTTTTTTTTTTTTTT	Red cell distribution width	28957414	[0.025-0.048] unit increase	0.0367742	EFO_0005192
ENSG00000138246	rs17404153	3	132444356	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.037	EFO_0004611
ENSG00000138246	rs17404153	3	132444356	G	Low density lipoprotein cholesterol levels	29507422	unit increase	0.035	EFO_0004611
ENSG00000138246	rs17404153	3	132444356	G	Total cholesterol levels	29507422	unit increase	0.035	EFO_0004574
ENSG00000138246	rs17404153	3	132444356	G	Total cholesterol levels	29507422	unit increase	0.032	EFO_0004574
ENSG00000138246	rs62292950	3	132479151	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000138246	rs9832919	3	132465682	?	White blood cell count	30595370			EFO_0004308
ENSG00000138246	rs79953286	3	132507256	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138246's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138246	DNAJC13	100	98.266	ENSMUSG00000032560	Dnajc13	99	98.266	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001649	osteoblast differentiation	16210410.	HDA	Process
GO:0005515	protein binding	24643499.	IPI	Function
GO:0005765	lysosomal membrane	17897319.	HDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0006898	receptor-mediated endocytosis	21873635.	IBA	Process
GO:0007032	endosome organization	24643499.	IMP	Process
GO:0010008	endosome membrane	21873635.	IBA	Component
GO:0010008	endosome membrane	24643499.	IDA	Component
GO:0015031	protein transport	-	IEA	Process
GO:0016020	membrane	16210410.19946888.	HDA	Component
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0031901	early endosome membrane	18256511.	IDA	Component
GO:0035577	azurophil granule membrane	-	TAS	Component
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0070062	extracellular exosome	19056867.	HDA	Component
GO:0071203	WASH complex	24643499.	IDA	Component
GO:1902954	regulation of early endosome to recycling endosome transport	18256511.	IMP	Process
GO:2000641	regulation of early endosome to late endosome transport	18256511.	IMP	Process