EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138385 (Gene tree)
Gene ID: 6741
Gene Symbol: SSB
Alias: LARP3|La|La/SSB
Full Name: small RNA binding exonuclease protection factor La
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 20,132 bases
Position: chr2:169,791,933-169,812,064
Accession: 11316
RBP type: canonical RBP
Summary: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000260956	RRM_1	PF00076.22	2.4e-15	1	1
ENSP00000386636	RRM_1	PF00076.22	2.4e-15	1	1
ENSP00000397029	RRM_1	PF00076.22	8.1e-12	1	1
ENSP00000396890	RRM_1	PF00076.22	4.1e-11	1	1
ENSP00000260956	RRM_3	PF08777.11	5.7e-31	1	1
ENSP00000386636	RRM_3	PF08777.11	5.7e-31	1	1
ENSP00000397029	La	PF05383.17	8.1e-22	1	1
ENSP00000260956	La	PF05383.17	1.3e-21	1	1
ENSP00000386636	La	PF05383.17	1.3e-21	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
7933082	La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA.	J Virol	1994 Nov	Svitkin YV	-
2468131	Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding.	Nucleic Acids Res	1989 Mar 25	Chan EK	-
2436670	Multiple phosphorylation of human SS-B/LA autoantigen and its effect on poly(U) and autoantibody binding.	Biochim Biophys Acta	1987 Apr 22	Pfeifle J	-
8683593	A Xenopus laevis homologue of the La autoantigen binds the pyrimidine tract of the 5' UTR of ribosomal protein mRNAs in vitro: implication of a protein factor in complex formation.	J Mol Biol	1996 Jun 28	Pellizzoni L	-
11080168	Euplotes telomerase contains an La motif protein produced by apparent translational frameshifting.	EMBO J	2000 Nov 15	Aigner S	-
27345152	The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway.	Mol Cell	2016 Jul 7	Hasler D	doi: 10.1016/j.molcel.2016.05.026
7556214	Anti-La monoclonal antibodies recognizing epitopes within the RNA-binding domain of the La protein show differential capacities to immunoprecipitate RNA-associated La protein.	Eur J Biochem	1995 Sep 1	Pruijn GJ	-
6232502	Association of an RNA polymerase III transcription factor with a ribonucleoprotein complex recognized by autoimmune sera.	Nucleic Acids Res	1984 Apr 11	Gottesfeld JM	-
8972196	The La autoantigen contains a dimerization domain that is essential for enhancing translation.	Mol Cell Biol	1997 Jan	Craig AW	-
8035794	Developmental characterization of a Drosophila RNA-binding protein homologous to the human systemic lupus erythematosus-associated La/SS-B autoantigen.	Mol Cell Biol	1994 Aug	Bai C	-
11435567	Characterization of nuclear RNases that cleave hepatitis B virus RNA near the La protein binding site.	J Virol	2001 Aug	Heise T	-
15371415	The La motif and the RNA recognition motifs of human La autoantigen contribute individually to RNA recognition and subcellular localization.	J Biol Chem	2004 Nov 26	Horke S	-
22363785	Two major autoantibody clusters in systemic lupus erythematosus.	PLoS One	2012	Ching KH	doi: 10.1371/journal.pone.0032001
2438757	Epitopes and structural domains of a RNA-binding nuclear protein, SS-B/La: similarities with adenovirus DNA-binding protein.	Scand J Rheumatol Suppl	1986	Chan EK	-
9003790	General RNA binding proteins render translation cap dependent.	EMBO J	1996 Dec 16	Svitkin YV	-
8454877	Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies.	J Immunol	1993 Apr 1	Topfer F	-
23129761	Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition.	J Biol Chem	2013 Jan 4	Liang C	doi: 10.1074/jbc.M112.401323
22207702	La autoantigen mediates oxidant induced de novo Nrf2 protein translation.	Mol Cell Proteomics	2012 Jun	Zhang J	doi: 10.1074/mcp.M111.015032
7518914	The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA.	Nucleic Acids Res	1994 Jul 11	Xiao Q	-
9971802	Intracellular redistribution of truncated La protein produced by poliovirus 3Cpro-mediated cleavage.	J Virol	1999 Mar	Shiroki K	-
2476998	Sjgren's syndrome nuclear antigen B (La): cDNA cloning, structural domains, and autoepitopes.	J Autoimmun	1989 Aug	Chan EK	-
9778034	Identification of human autoantigen La/SS-B as BC1/BC200 RNA-binding protein.	DNA Cell Biol	1998 Sep	Kremerskothen J	-
2445893	Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodies.	J Exp Med	1987 Dec 1	Chan EK	-
9237100	Phage-displayed La/SS-B antigen as a diagnostic reagent.	Immunotechnology	1997 Jun	Poon VK	-
8627683	Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity.	J Virol	1996 Mar	Das S	-
7799435	A yeast RNA binding protein that resembles the human autoantigen La.	J Mol Biol	1995 Jan 13	Lin-Marq N	-
12083808	Identification and cloning of a new protein that binds the 3(') untranslated region of alpha-striated tropomyosin.	Mol Genet Metab	2002 Jun	Fang HL	-
15016896	A peptide from autoantigen La blocks poliovirus and hepatitis C virus cap-independent translation and reveals a single tyrosine critical for La RNA binding and translation stimulation.	J Virol	2004 Apr	Izumi RE	-
17363515	From mRNA metabolism to cancer therapy: chronic myelogenous leukemia shows the way.	Clin Cancer Res	2007 Mar 15	Perrotti D	-
17346312	Specific interaction of HeLa cell proteins with coxsackievirus B3 3'UTR: La autoantigen binds the 3' and 5'UTR independently of the poly(A) tail.	Cell Microbiol	2007 Jul	Cheung P	-
22208657	Primary Sjgren's syndrome and the type I interferon system.	Curr Pharm Biotechnol	2012 Aug	Nordmark G	-
29109527	The RNA binding protein La/SS-B promotes RIG-I-mediated type I and type III IFN responses following Sendai viral infection.	Sci Rep	2017 Nov 6	Mahony R	doi: 10.1038/s41598-017-15197-9.
19299548	A comprehensive analysis of the La-motif protein superfamily.	RNA	2009 May	Bousquet-Antonelli C	doi: 10.1261/rna.1478709
17888216	Ribosomal P protein P0 as a candidate for the target antigen of anti-endothelial cell antibodies in mixed connective tissue disease.	Clin Exp Rheumatol	2007 Jul-Aug	Naniwa T	-
2411763	Immunologic and structural studies of the lupus/Sjgren's syndrome autoantigen, La/SSB, with a monoclonal antibody.	J Clin Invest	1985 Aug	Harley JB	-
9601606	New nuclear functions for calmodulin.	Cell Calcium	1998 Feb-Mar	Agell N	-
9409781	La autoantigen binding to a 5' cis-element of rubella virus RNA correlates with element function in vivo.	Gene	1997 Nov 12	Duncan RC	-
8709254	Autoantigens interact with cis-acting elements of rubella virus RNA.	J Virol	1996 Sep	Pogue GP	-
11342556	Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.	J Biol Chem	2001 Jul 20	Ohndorf UM	-
11125164	Binding of the La autoantigen to the hepatitis C virus 3' untranslated region protects the RNA from rapid degradation in vitro.	J Gen Virol	2001 Jan	Spangberg K	-
27436793	Hydrogen peroxide induces La cytoplasmic shuttling and increases hepatitis C virus internal ribosome entry site-dependent translation.	J Gen Virol	2016 Sep	Chan SW	doi: 10.1099/jgv.0.000556

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000474273	SSB-210	735	-	-	- (aa)	-	-
ENST00000490914	SSB-211	754	-	-	- (aa)	-	-
ENST00000470621	SSB-209	440	-	-	- (aa)	-	-
ENST00000494051	SSB-212	392	-	-	- (aa)	-	-
ENST00000409333	SSB-202	1782	-	ENSP00000386636	408 (aa)	-	P05455
ENST00000417292	SSB-204	545	-	ENSP00000396890	120 (aa)	-	E9PGX9
ENST00000422006	SSB-205	2463	-	ENSP00000397029	184 (aa)	-	E7ERC4
ENST00000468600	SSB-208	290	-	-	- (aa)	-	-
ENST00000461708	SSB-206	619	-	-	- (aa)	-	-
ENST00000260956	SSB-201	1709	-	ENSP00000260956	408 (aa)	-	P05455
ENST00000413002	SSB-203	674	-	ENSP00000395758	134 (aa)	-	E9PFL9
ENST00000465871	SSB-207	421	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138385's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05322	Systemic lupus erythematosus	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138385's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000138385	SSB	98	31.092	ENSG00000174720	LARP7	73	39.216

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138385	SSB	98	63.559	ENSAPOG00000003448	ssb	100	54.768	Acanthochromis_polyacanthus
ENSG00000138385	SSB	100	97.283	ENSAMEG00000010507	SSB	100	90.544	Ailuropoda_melanoleuca
ENSG00000138385	SSB	98	64.407	ENSACIG00000001738	ssb	97	57.754	Amphilophus_citrinellus
ENSG00000138385	SSB	98	65.254	ENSAOCG00000020398	ssb	100	55.012	Amphiprion_ocellaris
ENSG00000138385	SSB	98	66.102	ENSAPEG00000020395	ssb	100	55.501	Amphiprion_percula
ENSG00000138385	SSB	98	63.559	ENSATEG00000016884	ssb	100	57.213	Anabas_testudineus
ENSG00000138385	SSB	100	79.167	ENSAPLG00000006109	SSB	100	71.429	Anas_platyrhynchos
ENSG00000138385	SSB	100	73.333	ENSACAG00000017008	SSB	99	66.829	Anolis_carolinensis
ENSG00000138385	SSB	100	92.935	ENSANAG00000027195	-	100	88.480	Aotus_nancymaae
ENSG00000138385	SSB	98	65.254	ENSACLG00000010798	ssb	100	54.054	Astatotilapia_calliptera
ENSG00000138385	SSB	98	58.120	ENSAMXG00000012606	ssb	100	55.932	Astyanax_mexicanus
ENSG00000138385	SSB	100	98.370	ENSBTAG00000008716	SSB	100	93.627	Bos_taurus
ENSG00000138385	SSB	89	41.284	WBGene00016653	C44E4.4	91	33.967	Caenorhabditis_elegans
ENSG00000138385	SSB	100	99.167	ENSCJAG00000045073	SSB	100	97.304	Callithrix_jacchus
ENSG00000138385	SSB	100	97.500	ENSCAFG00000012418	SSB	100	93.888	Canis_familiaris
ENSG00000138385	SSB	100	97.500	ENSCAFG00020002900	SSB	100	93.888	Canis_lupus_dingo
ENSG00000138385	SSB	100	98.370	ENSCHIG00000022624	-	100	93.627	Capra_hircus
ENSG00000138385	SSB	100	95.109	ENSCHIG00000022196	-	100	87.990	Capra_hircus
ENSG00000138385	SSB	100	99.167	ENSTSYG00000000097	SSB	100	95.098	Carlito_syrichta
ENSG00000138385	SSB	100	98.370	ENSCPOG00000003338	SSB	100	95.588	Cavia_porcellus
ENSG00000138385	SSB	100	100.000	ENSCCAG00000035147	SSB	100	98.039	Cebus_capucinus
ENSG00000138385	SSB	100	72.549	ENSCATG00000042909	-	100	72.549	Cercocebus_atys
ENSG00000138385	SSB	100	76.961	ENSCATG00000036701	SSB	100	76.961	Cercocebus_atys
ENSG00000138385	SSB	100	97.826	ENSCLAG00000015617	-	100	94.853	Chinchilla_lanigera
ENSG00000138385	SSB	86	99.130	ENSCLAG00000004563	-	98	97.436	Chinchilla_lanigera
ENSG00000138385	SSB	100	100.000	ENSCSAG00000015200	SSB	89	98.775	Chlorocebus_sabaeus
ENSG00000138385	SSB	100	90.833	ENSCSAG00000018390	-	100	89.500	Chlorocebus_sabaeus
ENSG00000138385	SSB	100	98.370	ENSCHOG00000007763	SSB	100	94.118	Choloepus_hoffmanni
ENSG00000138385	SSB	100	84.167	ENSCPBG00000006519	SSB	100	79.462	Chrysemys_picta_bellii
ENSG00000138385	SSB	100	83.333	ENSCANG00000033240	-	100	83.088	Colobus_angolensis_palliatus
ENSG00000138385	SSB	100	100.000	ENSCANG00000027695	SSB	100	98.775	Colobus_angolensis_palliatus
ENSG00000138385	SSB	98	76.368	ENSCANG00000028838	-	95	76.368	Colobus_angolensis_palliatus
ENSG00000138385	SSB	100	92.391	ENSCGRG00001024831	Ssb	100	80.145	Cricetulus_griseus_chok1gshd
ENSG00000138385	SSB	100	92.391	ENSCGRG00000005387	Ssb	100	80.145	Cricetulus_griseus_crigri
ENSG00000138385	SSB	98	62.712	ENSCSEG00000011599	ssb	99	56.576	Cynoglossus_semilaevis
ENSG00000138385	SSB	98	64.407	ENSCVAG00000021558	ssb	100	57.073	Cyprinodon_variegatus
ENSG00000138385	SSB	98	60.169	ENSDARG00000029252	ssb	99	56.576	Danio_rerio
ENSG00000138385	SSB	100	97.283	ENSDNOG00000013450	SSB	100	93.627	Dasypus_novemcinctus
ENSG00000138385	SSB	100	94.565	ENSDORG00000005543	Ssb	100	84.783	Dipodomys_ordii
ENSG00000138385	SSB	98	39.837	FBgn0011638	La	92	34.555	Drosophila_melanogaster
ENSG00000138385	SSB	100	92.500	ENSETEG00000004614	-	61	94.030	Echinops_telfairi
ENSG00000138385	SSB	100	54.167	ENSEBUG00000001237	ssb	96	48.346	Eptatretus_burgeri
ENSG00000138385	SSB	100	99.167	ENSEASG00005022835	SSB	100	95.588	Equus_asinus_asinus
ENSG00000138385	SSB	100	99.167	ENSECAG00000018495	SSB	100	95.833	Equus_caballus
ENSG00000138385	SSB	100	97.500	ENSEEUG00000008077	SSB	86	89.286	Erinaceus_europaeus
ENSG00000138385	SSB	100	64.167	ENSELUG00000020929	ssb	100	59.512	Esox_lucius
ENSG00000138385	SSB	100	98.370	ENSFCAG00000011601	SSB	100	94.621	Felis_catus
ENSG00000138385	SSB	100	78.333	ENSFALG00000000930	SSB	100	74.817	Ficedula_albicollis
ENSG00000138385	SSB	100	98.333	ENSFDAG00000000598	SSB	100	94.608	Fukomys_damarensis
ENSG00000138385	SSB	68	67.073	ENSFHEG00000003268	ssb	96	54.369	Fundulus_heteroclitus
ENSG00000138385	SSB	86	68.696	ENSFHEG00000003003	-	100	67.797	Fundulus_heteroclitus
ENSG00000138385	SSB	98	61.538	ENSGMOG00000002664	ssb	99	54.902	Gadus_morhua
ENSG00000138385	SSB	100	79.167	ENSGALG00000009677	SSB	100	74.265	Gallus_gallus
ENSG00000138385	SSB	98	62.712	ENSGAFG00000002749	ssb	100	55.501	Gambusia_affinis
ENSG00000138385	SSB	98	63.559	ENSGACG00000005107	ssb	100	53.735	Gasterosteus_aculeatus
ENSG00000138385	SSB	100	82.500	ENSGAGG00000007807	SSB	100	78.240	Gopherus_agassizii
ENSG00000138385	SSB	83	100.000	ENSGGOG00000011507	-	88	99.231	Gorilla_gorilla
ENSG00000138385	SSB	100	81.618	ENSGGOG00000024891	-	100	81.618	Gorilla_gorilla
ENSG00000138385	SSB	65	96.552	ENSGGOG00000023471	-	100	96.552	Gorilla_gorilla
ENSG00000138385	SSB	98	65.254	ENSHBUG00000006584	ssb	100	53.563	Haplochromis_burtoni
ENSG00000138385	SSB	100	91.667	ENSHGLG00000005832	-	100	85.539	Heterocephalus_glaber_female
ENSG00000138385	SSB	100	88.333	ENSHGLG00000004478	-	100	86.585	Heterocephalus_glaber_female
ENSG00000138385	SSB	100	95.000	ENSHGLG00000001810	-	85	90.217	Heterocephalus_glaber_female
ENSG00000138385	SSB	100	97.500	ENSHGLG00000017580	-	100	93.494	Heterocephalus_glaber_female
ENSG00000138385	SSB	89	94.393	ENSHGLG00000018387	-	100	94.068	Heterocephalus_glaber_female
ENSG00000138385	SSB	97	86.923	ENSHGLG00000011331	-	98	92.949	Heterocephalus_glaber_female
ENSG00000138385	SSB	100	84.328	ENSHGLG00100013137	-	75	95.082	Heterocephalus_glaber_male
ENSG00000138385	SSB	100	97.500	ENSHGLG00100003084	-	100	93.494	Heterocephalus_glaber_male
ENSG00000138385	SSB	86	96.522	ENSHGLG00100014205	-	85	95.425	Heterocephalus_glaber_male
ENSG00000138385	SSB	98	87.179	ENSHGLG00100008767	-	100	81.618	Heterocephalus_glaber_male
ENSG00000138385	SSB	96	89.565	ENSHGLG00100007213	-	86	91.566	Heterocephalus_glaber_male
ENSG00000138385	SSB	96	87.500	ENSHGLG00100006391	-	97	88.372	Heterocephalus_glaber_male
ENSG00000138385	SSB	77	83.696	ENSHGLG00100008353	-	65	75.497	Heterocephalus_glaber_male
ENSG00000138385	SSB	86	93.913	ENSHGLG00100003175	-	99	93.162	Heterocephalus_glaber_male
ENSG00000138385	SSB	98	61.864	ENSHCOG00000019011	ssb	99	55.000	Hippocampus_comes
ENSG00000138385	SSB	98	65.812	ENSIPUG00000003681	SSB	99	57.960	Ictalurus_punctatus
ENSG00000138385	SSB	100	98.370	ENSSTOG00000008416	SSB	100	95.343	Ictidomys_tridecemlineatus
ENSG00000138385	SSB	100	94.565	ENSJJAG00000023158	-	100	80.282	Jaculus_jaculus
ENSG00000138385	SSB	99	91.597	ENSJJAG00000016250	-	99	68.642	Jaculus_jaculus
ENSG00000138385	SSB	98	66.102	ENSKMAG00000017317	ssb	100	56.235	Kryptolebias_marmoratus
ENSG00000138385	SSB	98	61.017	ENSLBEG00000017345	ssb	100	53.790	Labrus_bergylta
ENSG00000138385	SSB	100	75.000	ENSLACG00000014056	SSB	99	69.363	Latimeria_chalumnae
ENSG00000138385	SSB	100	72.500	ENSLOCG00000007933	ssb	99	66.749	Lepisosteus_oculatus
ENSG00000138385	SSB	100	98.333	ENSLAFG00000000867	-	100	88.471	Loxodonta_africana
ENSG00000138385	SSB	100	87.500	ENSLAFG00000028909	-	100	79.167	Loxodonta_africana
ENSG00000138385	SSB	99	72.269	ENSLAFG00000026721	-	99	69.536	Loxodonta_africana
ENSG00000138385	SSB	100	88.043	ENSMFAG00000041478	-	100	84.314	Macaca_fascicularis
ENSG00000138385	SSB	100	100.000	ENSMFAG00000039066	SSB	100	99.020	Macaca_fascicularis
ENSG00000138385	SSB	100	88.333	ENSMMUG00000011724	-	97	83.088	Macaca_mulatta
ENSG00000138385	SSB	99	68.719	ENSMMUG00000039889	-	100	68.966	Macaca_mulatta
ENSG00000138385	SSB	100	100.000	ENSMMUG00000023051	SSB	100	99.020	Macaca_mulatta
ENSG00000138385	SSB	100	100.000	ENSMNEG00000028321	SSB	100	97.059	Macaca_nemestrina
ENSG00000138385	SSB	100	88.043	ENSMNEG00000034698	-	100	84.314	Macaca_nemestrina
ENSG00000138385	SSB	100	70.343	ENSMLEG00000042644	-	100	70.343	Mandrillus_leucophaeus
ENSG00000138385	SSB	100	100.000	ENSMLEG00000035717	SSB	100	99.020	Mandrillus_leucophaeus
ENSG00000138385	SSB	98	65.254	ENSMAMG00000004800	ssb	100	57.702	Mastacembelus_armatus
ENSG00000138385	SSB	98	65.254	ENSMZEG00005005749	ssb	100	54.054	Maylandia_zebra
ENSG00000138385	SSB	100	79.167	ENSMGAG00000010328	SSB	99	75.610	Meleagris_gallopavo
ENSG00000138385	SSB	86	93.913	ENSMAUG00000019529	-	99	93.377	Mesocricetus_auratus
ENSG00000138385	SSB	100	99.167	ENSMICG00000028252	-	99	96.059	Microcebus_murinus
ENSG00000138385	SSB	100	99.167	ENSMICG00000033304	-	95	90.617	Microcebus_murinus
ENSG00000138385	SSB	86	93.043	ENSMOCG00000001823	-	99	92.715	Microtus_ochrogaster
ENSG00000138385	SSB	97	62.308	ENSMMOG00000002088	-	95	62.308	Mola_mola
ENSG00000138385	SSB	90	84.259	ENSMODG00000019271	-	100	67.402	Monodelphis_domestica
ENSG00000138385	SSB	100	86.667	ENSMODG00000008227	-	100	78.469	Monodelphis_domestica
ENSG00000138385	SSB	90	83.333	ENSMODG00000007027	-	100	81.761	Monodelphis_domestica
ENSG00000138385	SSB	98	65.254	ENSMALG00000008045	ssb	90	58.400	Monopterus_albus
ENSG00000138385	SSB	100	91.848	MGP_CAROLIEiJ_G0023629	-	100	91.848	Mus_caroli
ENSG00000138385	SSB	100	91.848	ENSMUSG00000068882	Ssb	100	91.848	Mus_musculus
ENSG00000138385	SSB	100	91.848	MGP_PahariEiJ_G0025081	-	100	91.848	Mus_pahari
ENSG00000138385	SSB	100	91.848	MGP_SPRETEiJ_G0024551	Ssb	100	91.848	Mus_spretus
ENSG00000138385	SSB	100	98.333	ENSMPUG00000000785	SSB	100	94.608	Mustela_putorius_furo
ENSG00000138385	SSB	100	98.333	ENSMLUG00000016316	SSB	100	89.362	Myotis_lucifugus
ENSG00000138385	SSB	91	92.683	ENSNGAG00000012920	-	88	92.683	Nannospalax_galili
ENSG00000138385	SSB	98	65.254	ENSNBRG00000012661	ssb	100	54.054	Neolamprologus_brichardi
ENSG00000138385	SSB	100	100.000	ENSNLEG00000004958	SSB	100	100.000	Nomascus_leucogenys
ENSG00000138385	SSB	100	73.913	ENSNLEG00000028754	-	100	70.416	Nomascus_leucogenys
ENSG00000138385	SSB	100	85.833	ENSMEUG00000001650	-	100	87.097	Notamacropus_eugenii
ENSG00000138385	SSB	63	98.333	ENSOPRG00000008479	-	70	96.429	Ochotona_princeps
ENSG00000138385	SSB	72	75.768	ENSOPRG00000008475	-	100	75.768	Ochotona_princeps
ENSG00000138385	SSB	88	88.571	ENSODEG00000006639	-	100	72.527	Octodon_degus
ENSG00000138385	SSB	100	96.667	ENSODEG00000004202	-	100	88.976	Octodon_degus
ENSG00000138385	SSB	100	97.826	ENSODEG00000010185	-	100	97.838	Octodon_degus
ENSG00000138385	SSB	88	91.509	ENSODEG00000010041	-	99	88.406	Octodon_degus
ENSG00000138385	SSB	98	64.407	ENSONIG00000008776	ssb	100	53.563	Oreochromis_niloticus
ENSG00000138385	SSB	100	90.000	ENSOANG00000008543	SSB	100	83.824	Ornithorhynchus_anatinus
ENSG00000138385	SSB	100	100.000	ENSOCUG00000010396	SSB	100	94.853	Oryctolagus_cuniculus
ENSG00000138385	SSB	98	69.492	ENSORLG00000017208	ssb	100	57.702	Oryzias_latipes
ENSG00000138385	SSB	98	69.492	ENSORLG00020022574	ssb	100	57.702	Oryzias_latipes_hni
ENSG00000138385	SSB	98	68.644	ENSORLG00015016592	ssb	100	57.457	Oryzias_latipes_hsok
ENSG00000138385	SSB	98	66.949	ENSOMEG00000003193	ssb	100	58.578	Oryzias_melastigma
ENSG00000138385	SSB	100	98.333	ENSOGAG00000029768	SSB	100	89.647	Otolemur_garnettii
ENSG00000138385	SSB	100	98.370	ENSOARG00000002906	SSB	100	93.137	Ovis_aries
ENSG00000138385	SSB	100	80.392	ENSPPAG00000032427	-	100	87.597	Pan_paniscus
ENSG00000138385	SSB	100	100.000	ENSPPAG00000042673	SSB	100	100.000	Pan_paniscus
ENSG00000138385	SSB	96	94.783	ENSPPAG00000006189	-	96	80.800	Pan_paniscus
ENSG00000138385	SSB	100	98.370	ENSPPRG00000006599	SSB	100	94.621	Panthera_pardus
ENSG00000138385	SSB	100	98.333	ENSPTIG00000011021	SSB	97	94.377	Panthera_tigris_altaica
ENSG00000138385	SSB	100	100.000	ENSPTRG00000012620	SSB	100	100.000	Pan_troglodytes
ENSG00000138385	SSB	100	76.225	ENSPTRG00000042880	-	100	76.225	Pan_troglodytes
ENSG00000138385	SSB	100	100.000	ENSPANG00000007440	SSB	100	99.020	Papio_anubis
ENSG00000138385	SSB	100	69.118	ENSPANG00000034126	-	100	69.608	Papio_anubis
ENSG00000138385	SSB	100	70.109	ENSPANG00000031877	-	95	68.905	Papio_anubis
ENSG00000138385	SSB	100	68.333	ENSPKIG00000019325	ssb	99	62.010	Paramormyrops_kingsleyae
ENSG00000138385	SSB	100	79.167	ENSPSIG00000002265	SSB	93	75.795	Pelodiscus_sinensis
ENSG00000138385	SSB	96	60.000	ENSPMGG00000020075	ssb	91	55.014	Periophthalmus_magnuspinnatus
ENSG00000138385	SSB	86	94.783	ENSPEMG00000021746	-	99	94.040	Peromyscus_maniculatus_bairdii
ENSG00000138385	SSB	99	51.351	ENSPMAG00000002982	ssb	100	45.602	Petromyzon_marinus
ENSG00000138385	SSB	86	80.870	ENSPCIG00000016333	-	92	82.946	Phascolarctos_cinereus
ENSG00000138385	SSB	100	85.870	ENSPCIG00000028591	-	100	82.641	Phascolarctos_cinereus
ENSG00000138385	SSB	98	64.407	ENSPFOG00000009650	ssb	100	56.479	Poecilia_formosa
ENSG00000138385	SSB	98	64.407	ENSPLAG00000020498	ssb	100	55.990	Poecilia_latipinna
ENSG00000138385	SSB	98	63.559	ENSPMEG00000001051	ssb	100	55.990	Poecilia_mexicana
ENSG00000138385	SSB	98	61.864	ENSPREG00000003708	ssb	99	56.955	Poecilia_reticulata
ENSG00000138385	SSB	100	100.000	ENSPPYG00000012919	SSB	100	99.265	Pongo_abelii
ENSG00000138385	SSB	100	98.333	ENSPCAG00000010276	SSB	100	89.119	Procavia_capensis
ENSG00000138385	SSB	100	95.833	ENSPCOG00000015741	-	100	92.157	Propithecus_coquereli
ENSG00000138385	SSB	86	100.000	ENSPCOG00000023189	-	100	84.804	Propithecus_coquereli
ENSG00000138385	SSB	100	98.333	ENSPVAG00000006615	SSB	100	93.838	Pteropus_vampyrus
ENSG00000138385	SSB	98	65.254	ENSPNYG00000006444	ssb	100	54.054	Pundamilia_nyererei
ENSG00000138385	SSB	98	63.248	ENSPNAG00000011708	ssb	100	57.561	Pygocentrus_nattereri
ENSG00000138385	SSB	100	90.217	ENSRNOG00000011606	AABR07061825.1	100	77.859	Rattus_norvegicus
ENSG00000138385	SSB	100	92.391	ENSRNOG00000007998	Ssb	100	77.358	Rattus_norvegicus
ENSG00000138385	SSB	100	70.905	ENSRBIG00000029918	-	100	70.905	Rhinopithecus_bieti
ENSG00000138385	SSB	100	97.059	ENSRBIG00000041972	SSB	100	97.059	Rhinopithecus_bieti
ENSG00000138385	SSB	99	84.034	ENSRBIG00000041232	-	98	81.675	Rhinopithecus_bieti
ENSG00000138385	SSB	96	100.000	ENSRBIG00000041608	-	98	90.685	Rhinopithecus_bieti
ENSG00000138385	SSB	96	100.000	ENSRROG00000034102	-	98	89.027	Rhinopithecus_roxellana
ENSG00000138385	SSB	99	84.034	ENSRROG00000031684	-	100	82.707	Rhinopithecus_roxellana
ENSG00000138385	SSB	100	80.685	ENSRROG00000007149	-	100	80.685	Rhinopithecus_roxellana
ENSG00000138385	SSB	100	100.000	ENSRROG00000040346	SSB	100	98.775	Rhinopithecus_roxellana
ENSG00000138385	SSB	100	100.000	ENSSBOG00000027204	SSB	100	98.529	Saimiri_boliviensis_boliviensis
ENSG00000138385	SSB	100	86.667	ENSSHAG00000018062	SSB	100	82.927	Sarcophilus_harrisii
ENSG00000138385	SSB	100	70.833	ENSSFOG00015000550	ssb	100	64.407	Scleropages_formosus
ENSG00000138385	SSB	98	62.712	ENSSMAG00000013885	ssb	99	56.952	Scophthalmus_maximus
ENSG00000138385	SSB	98	63.559	ENSSDUG00000020117	ssb	100	56.479	Seriola_dumerili
ENSG00000138385	SSB	98	62.712	ENSSLDG00000002525	ssb	100	54.926	Seriola_lalandi_dorsalis
ENSG00000138385	SSB	87	94.231	ENSSARG00000007747	SSB	100	84.715	Sorex_araneus
ENSG00000138385	SSB	100	83.333	ENSSPUG00000012112	SSB	100	76.225	Sphenodon_punctatus
ENSG00000138385	SSB	98	64.407	ENSSPAG00000005696	ssb	100	55.257	Stegastes_partitus
ENSG00000138385	SSB	100	94.022	ENSSSCG00000015938	SSB	98	77.307	Sus_scrofa
ENSG00000138385	SSB	100	78.333	ENSTGUG00000007942	SSB	100	74.572	Taeniopygia_guttata
ENSG00000138385	SSB	98	63.559	ENSTRUG00000017839	ssb	100	56.618	Takifugu_rubripes
ENSG00000138385	SSB	98	65.254	ENSTNIG00000000915	ssb	100	59.239	Tetraodon_nigroviridis
ENSG00000138385	SSB	86	100.000	ENSTBEG00000009056	SSB	82	100.000	Tupaia_belangeri
ENSG00000138385	SSB	100	96.739	ENSTTRG00000002152	SSB	100	93.888	Tursiops_truncatus
ENSG00000138385	SSB	100	97.826	ENSUAMG00000027833	SSB	99	95.000	Ursus_americanus
ENSG00000138385	SSB	100	97.826	ENSUMAG00000013907	SSB	100	94.377	Ursus_maritimus
ENSG00000138385	SSB	100	98.333	ENSVPAG00000007183	SSB	100	93.627	Vicugna_pacos
ENSG00000138385	SSB	100	97.500	ENSVVUG00000016573	SSB	78	93.888	Vulpes_vulpes
ENSG00000138385	SSB	98	71.186	ENSXETG00000025402	ssb	100	60.140	Xenopus_tropicalis
ENSG00000138385	SSB	98	61.017	ENSXCOG00000019109	ssb	93	61.719	Xiphophorus_couchianus
ENSG00000138385	SSB	98	61.864	ENSXMAG00000004888	ssb	100	55.257	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	10983981.	IMP	Function
GO:0000784	nuclear chromosome, telomeric region	19135898.	HDA	Component
GO:0001682	tRNA 5'-leader removal	10983981.	IGI	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	3192525.	IMP	Function
GO:0003729	mRNA binding	9154801.	TAS	Function
GO:0005515	protein binding	23552417.24965446.25616068.	IPI	Function
GO:0005634	nucleus	17308035.24965446.	IDA	Component
GO:0005737	cytoplasm	17308035.	IDA	Component
GO:0006400	tRNA modification	10983981.	TAS	Process
GO:0006409	tRNA export from nucleus	17308035.	IMP	Process
GO:0008033	tRNA processing	17308035.	IMP	Process
GO:0008266	poly(U) RNA binding	12842046.15004549.16387655.	IMP	Function
GO:0008334	histone mRNA metabolic process	9154801.	TAS	Process
GO:0042780	tRNA 3'-end processing	10983981.	IGI	Process
GO:0042803	protein homodimerization activity	12842046.	IMP	Function
GO:0071045	nuclear histone mRNA catabolic process	9154801.	IMP	Process
GO:0075522	IRES-dependent viral translational initiation	12384597.	IDA	Process
GO:1903608	protein localization to cytoplasmic stress granule	24965446.	IDA	Process
GO:1990825	sequence-specific mRNA binding	9154801.	IMP	Function
GO:1990904	ribonucleoprotein complex	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20856207	The RNA-binding protein La contributes to cell proliferation and CCND1 expression.	Oncogene	2011 Jan 27	Sommer G	doi: 10.1038/onc.2010.425
22016766	Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.	PLoS One	2011	Sommer G	doi: 10.1371/journal.pone.0025402
27105491	The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.	Oncotarget	2016 May 17	Heise T	doi: 10.18632/oncotarget.8819.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr2	169811282	In_Frame_Del	novel	S366_D367delinsN	0.44
BLCA	chr2	169808544	Missense_Mutation	novel	R206T	0.26
BLCA	chr2	169810295	Nonsense_Mutation	novel	E228*	0.32
BLCA	chr2	169808867	Missense_Mutation	novel	E212K	0.24
BLCA	chr2	169810317	Missense_Mutation	NA	K235T	0.23
BRCA	chr2	169810972	Missense_Mutation	novel	E309K	0.05
BRCA	chr2	169808871	Missense_Mutation	novel	A213E	0.14
BRCA	chr2	169807039	Silent	NA	K174K	0.34
BRCA	chr2	169810282	Splice_Site	NA	X224_splice	0.13
CESC	chr2	169810282	Splice_Site	NA	X224_splice	0.42
COAD	chr2	169811875	3'UTR	novel		0.27
COAD	chr2	169811871	3'UTR	rs770808439		0.39
COAD	chr2	169810400	Missense_Mutation	NA	D263Y	0.13
COAD	chr2	169805784	Missense_Mutation	NA	L97P	0.09
GBM	chr2	169800979	Missense_Mutation	novel	N7Y	0.08
HNSC	chr2	169811025	Silent	rs779625970	L326L	0.34
KIRC	chr2	169805531	Frame_Shift_Ins	novel	*D43Kfs11**	0.04	RRM_1
KIRC	chr2	169805533	Nonsense_Mutation	novel	*D43Sfs7**	0.04	RRM_1
KIRP	chr2	169810985	Missense_Mutation	rs777853278	E313A	0.31
LGG	chr2	169810867	Silent	NA	L274L	0.32
LGG	chr2	169808506	Missense_Mutation	NA	N193K	0.17
LIHC	chr2	169811815	3'UTR	novel		0.23
LUAD	chr2	169808539	Missense_Mutation	novel	K204N	0.39
LUAD	chr2	169800980	Missense_Mutation	NA	N7I	0.28
LUSC	chr2	169810334	Missense_Mutation	novel	D241H	0.15
PRAD	chr2	169805527	In_Frame_Ins	novel	K41_L42dup	0.59	RRM_1
PRAD	chr2	169811021	Frame_Shift_Del	novel	L326*	0.74
READ	chr2	169811224	Missense_Mutation	novel	Q347K	0.21
READ	chr2	169806891	Missense_Mutation	novel	K151T	0.16
SKCM	chr2	169805503	Silent	NA	R32R	0.27
SKCM	chr2	169801027	Splice_Site	novel	X22_splice	0.15
STAD	chr2	169808498	Frame_Shift_Del	rs753297385	*N193Mfs13**	0.36
STAD	chr2	169801008	Missense_Mutation	novel	K16N	0.08
STAD	chr2	169808498	Frame_Shift_Del	rs753297385	*N193Mfs13**	0.44
STAD	chr2	169811876	3'UTR	rs759336570		0.31
UCEC	chr2	169805502	Missense_Mutation	NA	R32Q	0.24	RRM_1
UCEC	chr2	169808500	Missense_Mutation	NA	K191N	0.32
UCEC	chr2	169811271	Silent	rs555917812	T362T	0.35
UCEC	chr2	169811817	3'UTR	novel		0.54
UCEC	chr2	169805673	Missense_Mutation	NA	R60H	0.42	RRM_1
UCEC	chr2	169812044	3'UTR	novel		0.4
UCEC	chr2	169806894	Splice_Site	NA	X151_splice	0.09
UCEC	chr2	169806788	Missense_Mutation	novel	G117C	0.38
UCEC	chr2	169811271	Silent	rs555917812	T362T	0.43
UCEC	chr2	169807017	Missense_Mutation	novel	F167C	0.23
UCEC	chr2	169805775	Missense_Mutation	novel	S94N	0.09
UCEC	chr2	169811875	3'UTR	novel		0.35
UCEC	chr2	169811800	3'UTR	novel		0.47
UCEC	chr2	169808534	Missense_Mutation	novel	A203T	0.21
UCEC	chr2	169800958	5'UTR	rs373968666		0.22
UCEC	chr2	169810421	Missense_Mutation	novel	E270K	0.29
UCEC	chr2	169806869	Missense_Mutation	novel	R144G	0.17
UCEC	chr2	169808514	Missense_Mutation	novel	R196I	0.34
UCEC	chr2	169811956	3'UTR	novel		0.43
UCEC	chr2	169811874	3'UTR	novel		0.07
UCEC	chr2	169806876	Missense_Mutation	novel	L146S	0.3
UCEC	chr2	169806829	Nonsense_Mutation	novel	W130*	0.38
UCEC	chr2	169805514	Missense_Mutation	NA	L36P	0.22	RRM_1
UCEC	chr2	169807046	Nonsense_Mutation	NA	E177*	0.4
UCEC	chr2	169805841	Splice_Site	novel	X115_splice	0.4
UCEC	chr2	169812043	3'UTR	rs567349632		0.35
UCEC	chr2	169808498	Frame_Shift_Del	rs753297385	*N193Mfs13**	0.54

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	AMP	0.0652	0.1091
PAAD	DEL	0.0326	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.034	Kaplan-Meier Survival Analysis
ACC	0.0019	Kaplan-Meier Survival Analysis
HNSC	0.00026	Kaplan-Meier Survival Analysis
SKCM	0.00071	Kaplan-Meier Survival Analysis
KIRP	0.00011	Kaplan-Meier Survival Analysis
PAAD	0.0052	Kaplan-Meier Survival Analysis
KICH	0.031	Kaplan-Meier Survival Analysis
UCEC	0.0055	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LGG	0.015	Kaplan-Meier Survival Analysis
THCA	0.031	Kaplan-Meier Survival Analysis
LUAD	0.0068	Kaplan-Meier Survival Analysis
OV	0.02	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742