EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138430 (Gene tree)
Gene ID: 29789
Gene Symbol: OLA1
Alias: PTD004|GTPBP9
Full Name: Obg like ATPase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 176,252 bases
Position: chr2:174,072,447-174,248,698
Accession: 28833
RBP type: canonical RBP
Summary: This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000410385	MMR_HSR1	PF01926.23	7.4e-23	1	1
ENSP00000284719	MMR_HSR1	PF01926.23	2.3e-22	1	1
ENSP00000386350	MMR_HSR1	PF01926.23	2.7e-22	1	1
ENSP00000414568	MMR_HSR1	PF01926.23	1.6e-19	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000497760	OLA1-209	722	-	-	- (aa)	-	-
ENST00000428402	OLA1-206	1270	-	ENSP00000410385	278 (aa)	-	Q9NTK5
ENST00000392560	OLA1-203	711	-	-	- (aa)	-	-
ENST00000429575	OLA1-207	485	-	ENSP00000404864	103 (aa)	-	C9JCJ9
ENST00000284719	OLA1-201	4417	-	ENSP00000284719	396 (aa)	-	Q9NTK5
ENST00000427472	OLA1-205	709	-	ENSP00000414568	116 (aa)	-	C9JTK6
ENST00000462000	OLA1-208	656	-	-	- (aa)	-	-
ENST00000409546	OLA1-204	2071	-	ENSP00000386350	416 (aa)	-	J3KQ32
ENST00000344357	OLA1-202	1656	-	ENSP00000340167	238 (aa)	-	Q9NTK5

Gene Model

Click here to download ENSG00000138430's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138430	Platelet Function Tests	3.6289495E-006	-
ENSG00000138430	Child Development Disorders, Pervasive	1.4147000E-005	-
ENSG00000138430	Alzheimer Disease	7E-8	26830138
ENSG00000138430	Age of Onset	7E-8	26830138

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138430	rs9679651	2	174130669	?	Clostridium difficile infection in multiple myeloma	29594489			EFO_0009130\|EFO_0001378
ENSG00000138430	rs75107833	2	174100883	?	Coronary artery calcified atherosclerotic plaque score in type 2 diabetes	29221444	[0.83-2.69] unit decrease	1.758	EFO_0004723\|EFO_0001360
ENSG00000138430	rs75107833	2	174100883	?	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes	29221444	[0.17-0.5] unit decrease	0.336	EFO_0004723\|EFO_0001360
ENSG00000138430	rs2044469	2	174096760	A	Hand grip strength	29691431	[0.0014-0.0026] unit increase	0.002	EFO_0006941
ENSG00000138430	rs4131583	2	174217580	?	Reaction time	29844566	[0.0069-0.0138] unit increase	0.010374	EFO_0008393
ENSG00000138430	rs9636259	2	174093068	?	Reaction time	29844566	[0.0061-0.0129] unit increase	0.0095128	EFO_0008393
ENSG00000138430	rs77345174	2	174112105	T	Blood protein levels	30072576	[0.18-0.31] unit decrease	0.247	EFO_0007937
ENSG00000138430	rs11694601	2	174084630	A	Systolic blood pressure	30224653	[0.13-0.25] mmHg decrease	0.1909	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138430's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138430	OLA1	100	91.379	ENSAPOG00000023705	ola1	100	85.859	Acanthochromis_polyacanthus
ENSG00000138430	OLA1	98	89.474	ENSAPOG00000015861	OLA1	99	86.548	Acanthochromis_polyacanthus
ENSG00000138430	OLA1	100	99.138	ENSAMEG00000012204	OLA1	100	96.578	Ailuropoda_melanoleuca
ENSG00000138430	OLA1	100	83.613	ENSACIG00000016766	ola1	100	73.990	Amphilophus_citrinellus
ENSG00000138430	OLA1	100	85.437	ENSACIG00000000692	OLA1	100	86.667	Amphilophus_citrinellus
ENSG00000138430	OLA1	100	91.379	ENSAOCG00000019135	ola1	100	86.364	Amphiprion_ocellaris
ENSG00000138430	OLA1	100	89.831	ENSAOCG00000012625	OLA1	100	86.935	Amphiprion_ocellaris
ENSG00000138430	OLA1	100	74.138	ENSAOCG00000008268	-	85	74.797	Amphiprion_ocellaris
ENSG00000138430	OLA1	100	89.831	ENSAPEG00000022047	OLA1	100	86.432	Amphiprion_percula
ENSG00000138430	OLA1	100	91.379	ENSAPEG00000014283	ola1	100	86.364	Amphiprion_percula
ENSG00000138430	OLA1	100	87.379	ENSATEG00000015763	OLA1	100	87.467	Anabas_testudineus
ENSG00000138430	OLA1	100	90.517	ENSATEG00000009394	ola1	100	85.859	Anabas_testudineus
ENSG00000138430	OLA1	100	90.756	ENSAPLG00000008147	OLA1	100	91.436	Anas_platyrhynchos
ENSG00000138430	OLA1	100	94.828	ENSACAG00000017018	OLA1	100	91.162	Anolis_carolinensis
ENSG00000138430	OLA1	100	100.000	ENSANAG00000029072	-	100	99.281	Aotus_nancymaae
ENSG00000138430	OLA1	100	78.641	ENSANAG00000023787	-	99	73.469	Aotus_nancymaae
ENSG00000138430	OLA1	100	89.655	ENSACLG00000011067	ola1	100	85.859	Astatotilapia_calliptera
ENSG00000138430	OLA1	100	88.136	ENSACLG00000009505	OLA1	100	85.427	Astatotilapia_calliptera
ENSG00000138430	OLA1	100	93.103	ENSAMXG00000004913	ola1	100	87.374	Astyanax_mexicanus
ENSG00000138430	OLA1	91	99.048	ENSBTAG00000052586	-	67	98.113	Bos_taurus
ENSG00000138430	OLA1	100	100.000	ENSBTAG00000006970	OLA1	100	99.242	Bos_taurus
ENSG00000138430	OLA1	100	75.862	WBGene00012344	ola-1	100	67.337	Caenorhabditis_elegans
ENSG00000138430	OLA1	100	100.000	ENSCJAG00000007877	OLA1	100	99.640	Callithrix_jacchus
ENSG00000138430	OLA1	100	99.029	ENSCJAG00000046788	-	82	95.203	Callithrix_jacchus
ENSG00000138430	OLA1	100	100.000	ENSCAFG00000013178	OLA1	100	99.747	Canis_familiaris
ENSG00000138430	OLA1	100	100.000	ENSCHIG00000024019	OLA1	99	98.995	Capra_hircus
ENSG00000138430	OLA1	100	100.000	ENSTSYG00000005517	-	100	99.747	Carlito_syrichta
ENSG00000138430	OLA1	96	89.189	ENSTSYG00000030848	-	86	87.705	Carlito_syrichta
ENSG00000138430	OLA1	100	100.000	ENSCPOG00000031110	OLA1	100	99.747	Cavia_porcellus
ENSG00000138430	OLA1	100	95.690	ENSCCAG00000030871	-	94	95.968	Cebus_capucinus
ENSG00000138430	OLA1	100	100.000	ENSCCAG00000017844	-	100	100.000	Cebus_capucinus
ENSG00000138430	OLA1	100	74.359	ENSCCAG00000025532	-	98	70.213	Cebus_capucinus
ENSG00000138430	OLA1	100	96.117	ENSCCAG00000022561	-	99	92.857	Cebus_capucinus
ENSG00000138430	OLA1	100	100.000	ENSCATG00000040710	-	98	98.276	Cercocebus_atys
ENSG00000138430	OLA1	100	93.103	ENSCATG00000033646	-	94	93.233	Cercocebus_atys
ENSG00000138430	OLA1	100	100.000	ENSCATG00000038920	-	100	100.000	Cercocebus_atys
ENSG00000138430	OLA1	100	100.000	ENSCLAG00000008657	OLA1	100	99.747	Chinchilla_lanigera
ENSG00000138430	OLA1	100	100.000	ENSCSAG00000014670	OLA1	100	100.000	Chlorocebus_sabaeus
ENSG00000138430	OLA1	89	99.061	ENSCHOG00000005044	OLA1	100	82.597	Choloepus_hoffmanni
ENSG00000138430	OLA1	100	93.162	ENSCPBG00000003917	OLA1	99	91.436	Chrysemys_picta_bellii
ENSG00000138430	OLA1	88	88.235	ENSCING00000006759	-	99	72.000	Ciona_intestinalis
ENSG00000138430	OLA1	100	80.172	ENSCSAVG00000006512	-	100	70.677	Ciona_savignyi
ENSG00000138430	OLA1	100	86.207	ENSCANG00000030999	-	100	85.926	Colobus_angolensis_palliatus
ENSG00000138430	OLA1	100	100.000	ENSCANG00000039286	-	100	100.000	Colobus_angolensis_palliatus
ENSG00000138430	OLA1	84	89.691	ENSCANG00000029540	-	88	67.700	Colobus_angolensis_palliatus
ENSG00000138430	OLA1	100	94.828	ENSCANG00000035975	-	98	93.651	Colobus_angolensis_palliatus
ENSG00000138430	OLA1	100	100.000	ENSCGRG00001001469	Ola1	100	100.000	Cricetulus_griseus_chok1gshd
ENSG00000138430	OLA1	100	100.000	ENSCGRG00000017472	Ola1	100	100.000	Cricetulus_griseus_crigri
ENSG00000138430	OLA1	100	89.831	ENSCSEG00000005504	OLA1	76	84.824	Cynoglossus_semilaevis
ENSG00000138430	OLA1	100	89.655	ENSCSEG00000005434	ola1	100	83.123	Cynoglossus_semilaevis
ENSG00000138430	OLA1	100	88.793	ENSCVAG00000003966	ola1	100	85.859	Cyprinodon_variegatus
ENSG00000138430	OLA1	100	88.136	ENSCVAG00000018673	OLA1	100	85.678	Cyprinodon_variegatus
ENSG00000138430	OLA1	100	91.379	ENSDARG00000044565	ola1	98	89.474	Danio_rerio
ENSG00000138430	OLA1	100	91.379	ENSDARG00000114210	CABZ01035356.1	77	88.976	Danio_rerio
ENSG00000138430	OLA1	100	100.000	ENSDNOG00000010630	OLA1	100	99.495	Dasypus_novemcinctus
ENSG00000138430	OLA1	100	100.000	ENSDORG00000008681	-	100	99.495	Dipodomys_ordii
ENSG00000138430	OLA1	100	88.655	ENSDORG00000024064	-	100	82.751	Dipodomys_ordii
ENSG00000138430	OLA1	100	78.448	FBgn0030151	CG1354	97	73.779	Drosophila_melanogaster
ENSG00000138430	OLA1	100	98.276	ENSETEG00000012453	OLA1	69	97.934	Echinops_telfairi
ENSG00000138430	OLA1	100	85.345	ENSEBUG00000006035	ola1	100	82.071	Eptatretus_burgeri
ENSG00000138430	OLA1	100	100.000	ENSEASG00005022603	OLA1	94	94.344	Equus_asinus_asinus
ENSG00000138430	OLA1	100	100.000	ENSECAG00000016353	OLA1	100	99.747	Equus_caballus
ENSG00000138430	OLA1	100	84.874	ENSEEUG00000015203	OLA1	100	90.055	Erinaceus_europaeus
ENSG00000138430	OLA1	99	80.738	ENSELUG00000010548	ola1	99	73.201	Esox_lucius
ENSG00000138430	OLA1	99	89.565	ENSELUG00000022548	OLA1	89	84.530	Esox_lucius
ENSG00000138430	OLA1	100	84.874	ENSFCAG00000022771	-	80	88.798	Felis_catus
ENSG00000138430	OLA1	100	100.000	ENSFCAG00000036661	-	100	100.000	Felis_catus
ENSG00000138430	OLA1	100	91.379	ENSFALG00000002944	OLA1	100	91.162	Ficedula_albicollis
ENSG00000138430	OLA1	100	100.000	ENSFDAG00000011277	OLA1	100	99.496	Fukomys_damarensis
ENSG00000138430	OLA1	100	88.983	ENSFHEG00000000700	OLA1	100	85.930	Fundulus_heteroclitus
ENSG00000138430	OLA1	100	89.655	ENSFHEG00000009030	ola1	100	85.606	Fundulus_heteroclitus
ENSG00000138430	OLA1	100	84.483	ENSGMOG00000000608	ola1	99	81.218	Gadus_morhua
ENSG00000138430	OLA1	100	91.597	ENSGALG00000009325	OLA1	100	91.162	Gallus_gallus
ENSG00000138430	OLA1	100	88.793	ENSGAFG00000019733	ola1	100	85.101	Gambusia_affinis
ENSG00000138430	OLA1	100	84.466	ENSGAFG00000003776	OLA1	100	73.737	Gambusia_affinis
ENSG00000138430	OLA1	100	87.931	ENSGACG00000010083	ola1	100	83.081	Gasterosteus_aculeatus
ENSG00000138430	OLA1	100	93.162	ENSGAGG00000015089	-	98	91.406	Gopherus_agassizii
ENSG00000138430	OLA1	100	98.276	ENSGGOG00000005816	-	95	97.656	Gorilla_gorilla
ENSG00000138430	OLA1	100	100.000	ENSGGOG00000022215	OLA1	100	99.747	Gorilla_gorilla
ENSG00000138430	OLA1	80	90.323	ENSGGOG00000038364	-	86	90.323	Gorilla_gorilla
ENSG00000138430	OLA1	100	88.136	ENSHBUG00000019432	OLA1	100	85.427	Haplochromis_burtoni
ENSG00000138430	OLA1	100	89.655	ENSHBUG00000006078	ola1	100	85.859	Haplochromis_burtoni
ENSG00000138430	OLA1	100	84.483	ENSHGLG00000007643	-	100	73.869	Heterocephalus_glaber_female
ENSG00000138430	OLA1	100	100.000	ENSHGLG00000006618	-	100	99.747	Heterocephalus_glaber_female
ENSG00000138430	OLA1	100	91.379	ENSHGLG00000012199	-	100	87.282	Heterocephalus_glaber_female
ENSG00000138430	OLA1	100	82.323	ENSHGLG00000003777	-	100	82.323	Heterocephalus_glaber_female
ENSG00000138430	OLA1	100	100.000	ENSHGLG00100004206	-	97	100.000	Heterocephalus_glaber_male
ENSG00000138430	OLA1	100	84.483	ENSHGLG00100008457	-	100	73.869	Heterocephalus_glaber_male
ENSG00000138430	OLA1	100	91.379	ENSHGLG00100009225	-	100	87.282	Heterocephalus_glaber_male
ENSG00000138430	OLA1	100	90.517	ENSHCOG00000020085	ola1	100	84.848	Hippocampus_comes
ENSG00000138430	OLA1	100	93.103	ENSIPUG00000019139	ola1	100	87.374	Ictalurus_punctatus
ENSG00000138430	OLA1	100	100.000	ENSSTOG00000015547	OLA1	100	99.747	Ictidomys_tridecemlineatus
ENSG00000138430	OLA1	100	85.294	ENSJJAG00000018538	-	100	83.249	Jaculus_jaculus
ENSG00000138430	OLA1	100	100.000	ENSJJAG00000022958	-	100	100.000	Jaculus_jaculus
ENSG00000138430	OLA1	100	88.136	ENSKMAG00000015578	OLA1	100	84.422	Kryptolebias_marmoratus
ENSG00000138430	OLA1	100	91.379	ENSKMAG00000012576	ola1	100	85.859	Kryptolebias_marmoratus
ENSG00000138430	OLA1	100	89.655	ENSLBEG00000018929	ola1	99	84.383	Labrus_bergylta
ENSG00000138430	OLA1	100	88.136	ENSLBEG00000016137	OLA1	100	85.176	Labrus_bergylta
ENSG00000138430	OLA1	100	88.384	ENSLACG00000007258	OLA1	100	88.384	Latimeria_chalumnae
ENSG00000138430	OLA1	100	88.793	ENSLOCG00000007399	ola1	99	86.111	Lepisosteus_oculatus
ENSG00000138430	OLA1	100	100.000	ENSLAFG00000002706	OLA1	100	99.495	Loxodonta_africana
ENSG00000138430	OLA1	100	100.000	ENSMFAG00000044124	OLA1	100	100.000	Macaca_fascicularis
ENSG00000138430	OLA1	94	88.991	ENSMFAG00000046141	-	96	86.087	Macaca_fascicularis
ENSG00000138430	OLA1	100	86.207	ENSMFAG00000030771	-	98	87.681	Macaca_fascicularis
ENSG00000138430	OLA1	100	86.207	ENSMMUG00000008743	-	94	84.496	Macaca_mulatta
ENSG00000138430	OLA1	100	100.000	ENSMMUG00000007092	OLA1	100	100.000	Macaca_mulatta
ENSG00000138430	OLA1	100	89.655	ENSMNEG00000023330	-	98	89.916	Macaca_nemestrina
ENSG00000138430	OLA1	89	92.233	ENSMNEG00000034412	-	92	88.991	Macaca_nemestrina
ENSG00000138430	OLA1	100	100.000	ENSMNEG00000040767	OLA1	100	100.000	Macaca_nemestrina
ENSG00000138430	OLA1	100	91.379	ENSMLEG00000040122	-	96	91.935	Mandrillus_leucophaeus
ENSG00000138430	OLA1	100	100.000	ENSMLEG00000040175	OLA1	100	100.000	Mandrillus_leucophaeus
ENSG00000138430	OLA1	100	88.350	ENSMAMG00000003717	ola1	100	75.000	Mastacembelus_armatus
ENSG00000138430	OLA1	100	88.136	ENSMAMG00000005934	OLA1	100	85.427	Mastacembelus_armatus
ENSG00000138430	OLA1	100	89.655	ENSMZEG00005001203	ola1	100	85.859	Maylandia_zebra
ENSG00000138430	OLA1	100	88.136	ENSMZEG00005005008	OLA1	100	85.427	Maylandia_zebra
ENSG00000138430	OLA1	100	87.379	ENSMGAG00000009826	OLA1	99	90.141	Meleagris_gallopavo
ENSG00000138430	OLA1	100	100.000	ENSMAUG00000019168	Ola1	100	100.000	Mesocricetus_auratus
ENSG00000138430	OLA1	100	100.000	ENSMICG00000000354	OLA1	100	99.747	Microcebus_murinus
ENSG00000138430	OLA1	100	100.000	ENSMOCG00000003125	-	100	99.495	Microtus_ochrogaster
ENSG00000138430	OLA1	100	96.639	ENSMOCG00000011603	-	100	91.667	Microtus_ochrogaster
ENSG00000138430	OLA1	100	81.553	ENSMMOG00000008941	ola1	99	72.475	Mola_mola
ENSG00000138430	OLA1	100	87.379	ENSMMOG00000001661	OLA1	100	72.980	Mola_mola
ENSG00000138430	OLA1	100	93.966	ENSMODG00000009296	OLA1	100	89.394	Monodelphis_domestica
ENSG00000138430	OLA1	100	90.517	ENSMALG00000017692	ola1	93	84.848	Monopterus_albus
ENSG00000138430	OLA1	97	90.179	ENSMALG00000009196	OLA1	100	74.811	Monopterus_albus
ENSG00000138430	OLA1	100	100.000	MGP_CAROLIEiJ_G0023655	Ola1	100	99.242	Mus_caroli
ENSG00000138430	OLA1	100	100.000	ENSMUSG00000027108	Ola1	100	99.495	Mus_musculus
ENSG00000138430	OLA1	100	100.000	MGP_PahariEiJ_G0025107	Ola1	100	99.495	Mus_pahari
ENSG00000138430	OLA1	100	100.000	MGP_SPRETEiJ_G0024578	Ola1	100	99.495	Mus_spretus
ENSG00000138430	OLA1	100	100.000	ENSMPUG00000013906	OLA1	100	100.000	Mustela_putorius_furo
ENSG00000138430	OLA1	99	80.932	ENSNGAG00000017257	-	99	73.105	Nannospalax_galili
ENSG00000138430	OLA1	100	100.000	ENSNGAG00000017639	Ola1	100	99.747	Nannospalax_galili
ENSG00000138430	OLA1	100	84.466	ENSNBRG00000011698	OLA1	100	86.170	Neolamprologus_brichardi
ENSG00000138430	OLA1	100	84.466	ENSNBRG00000022738	ola1	100	74.242	Neolamprologus_brichardi
ENSG00000138430	OLA1	100	98.058	ENSNLEG00000015824	-	100	94.697	Nomascus_leucogenys
ENSG00000138430	OLA1	100	100.000	ENSNLEG00000005817	OLA1	100	99.760	Nomascus_leucogenys
ENSG00000138430	OLA1	100	86.555	ENSMEUG00000009973	OLA1	100	77.778	Notamacropus_eugenii
ENSG00000138430	OLA1	100	100.000	ENSOPRG00000005569	OLA1	100	83.471	Ochotona_princeps
ENSG00000138430	OLA1	100	100.000	ENSODEG00000009011	OLA1	100	99.747	Octodon_degus
ENSG00000138430	OLA1	100	89.655	ENSONIG00000001265	ola1	100	85.859	Oreochromis_niloticus
ENSG00000138430	OLA1	100	88.136	ENSONIG00000008658	OLA1	100	85.678	Oreochromis_niloticus
ENSG00000138430	OLA1	100	94.958	ENSOANG00000008601	OLA1	100	94.192	Ornithorhynchus_anatinus
ENSG00000138430	OLA1	100	100.000	ENSOCUG00000003574	OLA1	100	100.000	Oryctolagus_cuniculus
ENSG00000138430	OLA1	100	87.379	ENSORLG00000013788	ola1	100	74.495	Oryzias_latipes
ENSG00000138430	OLA1	100	88.034	ENSORLG00000017489	OLA1	99	85.385	Oryzias_latipes
ENSG00000138430	OLA1	100	88.793	ENSORLG00020021173	OLA1	100	84.848	Oryzias_latipes_hni
ENSG00000138430	OLA1	100	87.379	ENSORLG00020015238	ola1	100	74.495	Oryzias_latipes_hni
ENSG00000138430	OLA1	100	88.034	ENSORLG00015015230	OLA1	100	84.887	Oryzias_latipes_hsok
ENSG00000138430	OLA1	100	89.655	ENSORLG00015013782	ola1	94	84.932	Oryzias_latipes_hsok
ENSG00000138430	OLA1	100	87.179	ENSOMEG00000004469	OLA1	100	84.887	Oryzias_melastigma
ENSG00000138430	OLA1	100	90.517	ENSOMEG00000012796	ola1	100	85.354	Oryzias_melastigma
ENSG00000138430	OLA1	100	100.000	ENSOGAG00000016557	OLA1	100	99.497	Otolemur_garnettii
ENSG00000138430	OLA1	100	100.000	ENSOARG00000000451	-	99	97.590	Ovis_aries
ENSG00000138430	OLA1	100	100.000	ENSOARG00000000967	-	100	98.616	Ovis_aries
ENSG00000138430	OLA1	100	92.241	ENSPPAG00000037463	-	99	87.335	Pan_paniscus
ENSG00000138430	OLA1	80	90.323	ENSPPAG00000008602	-	86	90.323	Pan_paniscus
ENSG00000138430	OLA1	100	100.000	ENSPPAG00000035004	OLA1	100	99.747	Pan_paniscus
ENSG00000138430	OLA1	100	100.000	ENSPPRG00000004233	-	100	100.000	Panthera_pardus
ENSG00000138430	OLA1	100	97.414	ENSPPRG00000003845	-	98	92.424	Panthera_pardus
ENSG00000138430	OLA1	100	96.552	ENSPTIG00000021823	-	98	92.424	Panthera_tigris_altaica
ENSG00000138430	OLA1	100	100.000	ENSPTIG00000011872	-	100	100.000	Panthera_tigris_altaica
ENSG00000138430	OLA1	100	100.000	ENSPTRG00000012650	OLA1	100	100.000	Pan_troglodytes
ENSG00000138430	OLA1	100	92.241	ENSPTRG00000048207	-	99	87.071	Pan_troglodytes
ENSG00000138430	OLA1	80	90.323	ENSPTRG00000051545	-	86	90.323	Pan_troglodytes
ENSG00000138430	OLA1	100	93.103	ENSPANG00000035095	-	94	93.233	Papio_anubis
ENSG00000138430	OLA1	100	100.000	ENSPANG00000020854	OLA1	100	100.000	Papio_anubis
ENSG00000138430	OLA1	100	91.379	ENSPKIG00000004546	OLA1	100	87.121	Paramormyrops_kingsleyae
ENSG00000138430	OLA1	100	92.241	ENSPSIG00000017495	OLA1	100	91.162	Pelodiscus_sinensis
ENSG00000138430	OLA1	100	83.193	ENSPMGG00000001339	ola1	100	84.848	Periophthalmus_magnuspinnatus
ENSG00000138430	OLA1	100	89.744	ENSPMGG00000000277	OLA1	100	85.390	Periophthalmus_magnuspinnatus
ENSG00000138430	OLA1	100	100.000	ENSPEMG00000021970	Ola1	100	99.747	Peromyscus_maniculatus_bairdii
ENSG00000138430	OLA1	69	87.500	ENSPMAG00000004552	-	100	87.500	Petromyzon_marinus
ENSG00000138430	OLA1	100	88.793	ENSPFOG00000016213	ola1	100	85.354	Poecilia_formosa
ENSG00000138430	OLA1	98	88.596	ENSPLAG00000017971	OLA1	99	85.533	Poecilia_latipinna
ENSG00000138430	OLA1	100	88.793	ENSPLAG00000016640	ola1	100	85.101	Poecilia_latipinna
ENSG00000138430	OLA1	98	88.596	ENSPMEG00000002033	OLA1	99	85.025	Poecilia_mexicana
ENSG00000138430	OLA1	100	88.793	ENSPMEG00000015915	ola1	100	85.354	Poecilia_mexicana
ENSG00000138430	OLA1	100	84.466	ENSPREG00000005840	ola1	100	73.485	Poecilia_reticulata
ENSG00000138430	OLA1	100	85.437	ENSPREG00000005171	OLA1	100	86.702	Poecilia_reticulata
ENSG00000138430	OLA1	100	100.000	ENSPPYG00000012943	OLA1	100	99.747	Pongo_abelii
ENSG00000138430	OLA1	100	100.000	ENSPCOG00000017353	-	100	99.747	Propithecus_coquereli
ENSG00000138430	OLA1	100	87.069	ENSPCOG00000022010	-	96	78.697	Propithecus_coquereli
ENSG00000138430	OLA1	89	100.000	ENSPVAG00000000982	OLA1	100	92.818	Pteropus_vampyrus
ENSG00000138430	OLA1	100	89.655	ENSPNYG00000014943	ola1	100	85.859	Pundamilia_nyererei
ENSG00000138430	OLA1	100	88.136	ENSPNYG00000007912	OLA1	100	85.427	Pundamilia_nyererei
ENSG00000138430	OLA1	100	94.828	ENSPNAG00000012638	ola1	91	86.301	Pygocentrus_nattereri
ENSG00000138430	OLA1	100	98.276	ENSRNOG00000019047	Ola1	100	98.232	Rattus_norvegicus
ENSG00000138430	OLA1	100	100.000	ENSRBIG00000006151	OLA1	100	95.813	Rhinopithecus_bieti
ENSG00000138430	OLA1	100	92.241	ENSRBIG00000018330	-	94	91.270	Rhinopithecus_bieti
ENSG00000138430	OLA1	100	87.931	ENSRBIG00000013930	-	98	87.302	Rhinopithecus_bieti
ENSG00000138430	OLA1	100	100.000	ENSRROG00000038551	OLA1	100	100.000	Rhinopithecus_roxellana
ENSG00000138430	OLA1	100	88.793	ENSRROG00000026608	-	98	88.095	Rhinopithecus_roxellana
ENSG00000138430	OLA1	95	89.091	ENSRROG00000032626	-	90	89.091	Rhinopithecus_roxellana
ENSG00000138430	OLA1	78	43.564	YGR210C	-	62	30.000	Saccharomyces_cerevisiae
ENSG00000138430	OLA1	100	58.475	YBR025C	-	98	53.827	Saccharomyces_cerevisiae
ENSG00000138430	OLA1	94	40.103	YHL014C	YLF2	96	40.103	Saccharomyces_cerevisiae
ENSG00000138430	OLA1	100	94.872	ENSSBOG00000031656	-	89	93.548	Saimiri_boliviensis_boliviensis
ENSG00000138430	OLA1	100	99.160	ENSSBOG00000002999	OLA1	100	98.737	Saimiri_boliviensis_boliviensis
ENSG00000138430	OLA1	100	95.798	ENSSHAG00000014637	OLA1	99	94.444	Sarcophilus_harrisii
ENSG00000138430	OLA1	100	91.379	ENSSFOG00015018477	ola1	100	87.374	Scleropages_formosus
ENSG00000138430	OLA1	100	88.136	ENSSMAG00000014909	OLA1	100	86.181	Scophthalmus_maximus
ENSG00000138430	OLA1	100	90.517	ENSSMAG00000017661	ola1	100	85.139	Scophthalmus_maximus
ENSG00000138430	OLA1	100	84.874	ENSSDUG00000021482	OLA1	99	85.677	Seriola_dumerili
ENSG00000138430	OLA1	100	90.517	ENSSDUG00000013714	ola1	100	86.146	Seriola_dumerili
ENSG00000138430	OLA1	100	88.983	ENSSLDG00000018580	OLA1	100	85.176	Seriola_lalandi_dorsalis
ENSG00000138430	OLA1	100	90.517	ENSSLDG00000014654	ola1	100	85.894	Seriola_lalandi_dorsalis
ENSG00000138430	OLA1	100	99.580	ENSSARG00000010743	OLA1	100	98.990	Sorex_araneus
ENSG00000138430	OLA1	100	92.857	ENSSPUG00000002409	OLA1	100	92.424	Sphenodon_punctatus
ENSG00000138430	OLA1	100	88.136	ENSSPAG00000000415	OLA1	100	86.683	Stegastes_partitus
ENSG00000138430	OLA1	100	90.517	ENSSPAG00000021138	ola1	100	85.606	Stegastes_partitus
ENSG00000138430	OLA1	100	99.580	ENSSSCG00000015963	OLA1	100	99.495	Sus_scrofa
ENSG00000138430	OLA1	100	91.379	ENSTGUG00000008710	-	100	91.162	Taeniopygia_guttata
ENSG00000138430	OLA1	100	89.655	ENSTRUG00000015215	ola1	99	85.101	Takifugu_rubripes
ENSG00000138430	OLA1	100	86.408	ENSTRUG00000017614	OLA1	100	74.933	Takifugu_rubripes
ENSG00000138430	OLA1	100	89.655	ENSTNIG00000017209	ola1	100	82.492	Tetraodon_nigroviridis
ENSG00000138430	OLA1	100	100.000	ENSTBEG00000007574	OLA1	100	82.675	Tupaia_belangeri
ENSG00000138430	OLA1	100	99.138	ENSTTRG00000016999	OLA1	100	98.232	Tursiops_truncatus
ENSG00000138430	OLA1	100	99.138	ENSUAMG00000025620	-	97	96.875	Ursus_americanus
ENSG00000138430	OLA1	100	100.000	ENSUMAG00000015410	OLA1	95	99.747	Ursus_maritimus
ENSG00000138430	OLA1	100	99.138	ENSVPAG00000009660	OLA1	100	93.687	Vicugna_pacos
ENSG00000138430	OLA1	100	100.000	ENSVVUG00000014108	-	95	98.630	Vulpes_vulpes
ENSG00000138430	OLA1	100	100.000	ENSVVUG00000012991	-	98	100.000	Vulpes_vulpes
ENSG00000138430	OLA1	100	87.931	ENSXETG00000008500	ola1	100	85.606	Xenopus_tropicalis
ENSG00000138430	OLA1	100	84.466	ENSXCOG00000014121	ola1	100	73.990	Xiphophorus_couchianus
ENSG00000138430	OLA1	100	88.793	ENSXCOG00000019180	OLA1	100	75.000	Xiphophorus_couchianus
ENSG00000138430	OLA1	100	88.793	ENSXMAG00000009840	ola1	100	85.101	Xiphophorus_maculatus
ENSG00000138430	OLA1	100	88.136	ENSXMAG00000005330	OLA1	100	85.427	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002576	platelet degranulation	-	TAS	Process
GO:0005515	protein binding	22190034.	IPI	Function
GO:0005524	ATP binding	17430889.	IDA	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	IDA	Component
GO:0005813	centrosome	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016887	ATPase activity	21873635.	IBA	Function
GO:0016887	ATPase activity	17430889.	IDA	Function
GO:0031093	platelet alpha granule lumen	-	TAS	Component
GO:0043022	ribosome binding	-	IEA	Function
GO:0043023	ribosomal large subunit binding	-	IEA	Function
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0046034	ATP metabolic process	17430889.	IDA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
20053727	DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies.	Mol Cancer Res	2010 Jan	Sun H	doi: 10.1158/1541-7786.MCR-09-0278
26863455	OLA1 contributes to epithelial-mesenchymal transition in lung cancer by modulating the GSK3β/snail/E-cadherin signaling.	Oncotarget	2016 Mar 1	Bai L	doi: 10.18632/oncotarget.7224.
27271530	OLA1 gene sequencing in patients with BRCA1/2 mutation-negative suspected hereditary breast and ovarian cancer.	Breast Cancer	2017 Mar	Takahashi M	doi: 10.1007/s12282-016-0709-0
26283179	OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.	Sci Rep	2015 Aug 18	Chen H	doi: 10.1038/srep13241.
19882753	Knockdown of OLA1, a regulator of oxidative stress response, inhibits motility and invasion of breast cancer cells.	J Zhejiang Univ Sci B	2009 Nov	Zhang JW	doi: 10.1631/jzus.B0910009.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr2	174081943	Missense_Mutation	novel	E284K	0.39
BLCA	chr2	174081944	Silent	novel	L283L	0.38
BLCA	chr2	174141872	Missense_Mutation	NA	E168Q	0.29
BLCA	chr2	174075316	3'UTR	novel		0.6
BRCA	chr2	174079013	Missense_Mutation	rs781608678	M348I	0.11
BRCA	chr2	174081169	Missense_Mutation	rs375033952	R317C	0.13
BRCA	chr2	174081994	Missense_Mutation	novel	L267M	0.05
BRCA	chr2	174223105	Missense_Mutation	NA	H101D	0.17	MMR_HSR1
BRCA	chr2	174075367	3'UTR	novel		0.05
CESC	chr2	174229446	Missense_Mutation	NA	S36C	0.16	MMR_HSR1
CESC	chr2	174229348	Missense_Mutation	novel	E69K	0.44	MMR_HSR1
CESC	chr2	174074913	3'UTR	novel		0.24
CESC	chr2	174123274	Missense_Mutation	NA	E212K	0.31
COAD	chr2	174123184	Missense_Mutation	novel	K242E	0.27
COAD	chr2	174229342	Missense_Mutation	rs748811959	F71V	0.24	MMR_HSR1
COAD	chr2	174075372	3'UTR	novel		0.4
COAD	chr2	174123261	Missense_Mutation	novel	K216R	0.09
COAD	chr2	174075316	3'UTR	novel		0.6
COAD	chr2	174079006	Missense_Mutation	novel	E351K	0.37
COAD	chr2	174078994	Nonsense_Mutation	NA	E355*	0.27
COAD	chr2	174075351	3'UTR	novel		0.31
COAD	chr2	174246802	Frame_Shift_Del	NA	*K5Rfs19**	0.26
ESCA	chr2	174075476	Missense_Mutation	rs761407656	D381N	0.44
ESCA	chr2	174223080	Missense_Mutation	novel	A109V	0.22	MMR_HSR1
ESCA	chr2	174223081	Missense_Mutation	novel	A109S	0.19	MMR_HSR1
ESCA	chr2	174141930	Missense_Mutation	novel	I148M	0.57
ESCA	chr2	174074766	3'UTR	novel		0.39
GBM	chr2	174223098	Missense_Mutation	novel	G103E	0.23	MMR_HSR1
GBM	chr2	174141981	Missense_Mutation	novel	D131E	0.05
HNSC	chr2	174141858	Silent	novel	V172V	0.18
HNSC	chr2	174079048	Missense_Mutation	novel	D337H	0.26
HNSC	chr2	174141897	Missense_Mutation	novel	M159I	0.16
KIRP	chr2	174123253	Missense_Mutation	novel	F219V	0.25
LIHC	chr2	174246794	Missense_Mutation	novel	D8N	0.1
LIHC	chr2	174075295	3'UTR	novel		0.24
LUAD	chr2	174246739	Missense_Mutation	NA	G26V	0.22	MMR_HSR1
LUAD	chr2	174123655	Missense_Mutation	novel	K190N	0.15
LUAD	chr2	174223069	Missense_Mutation	novel	H113Y	0.11	MMR_HSR1
LUAD	chr2	174079049	Silent	NA	T336T	0.29
LUSC	chr2	174081169	Missense_Mutation	rs375033952	R317C	0.09
LUSC	chr2	174123191	Silent	NA	K239K	0.2
OV	chr2	174123666	Missense_Mutation	novel	C187S	0.07
OV	chr2	174141863	Missense_Mutation	NA	A171P	0.26
PRAD	chr2	174081246	Missense_Mutation	novel	A291D	0.4
PRAD	chr2	174229359	Missense_Mutation	novel	P65H	0.36	MMR_HSR1
READ	chr2	174081199	Missense_Mutation	NA	Y307H	0.29
SARC	chr2	174141861	Frame_Shift_Del	novel	E168*	0.26
SKCM	chr2	174223057	Frame_Shift_Del	novel	*F110Vfs7**	0.2	MMR_HSR1
SKCM	chr2	174141873	Silent	NA	L167L	0.22
SKCM	chr2	174229386	Missense_Mutation	novel	T56I	0.37	MMR_HSR1
SKCM	chr2	174229387	Missense_Mutation	novel	T56S	0.37	MMR_HSR1
SKCM	chr2	174229396	Missense_Mutation	novel	P53S	0.46	MMR_HSR1
SKCM	chr2	174123615	Missense_Mutation	NA	H204Y	0.44
STAD	chr2	174081939	Missense_Mutation	novel	A285V	0.1
STAD	chr2	174123210	Missense_Mutation	NA	E233G	0.25
UCEC	chr2	174075499	Missense_Mutation	NA	R373I	0.26
UCEC	chr2	174123624	Missense_Mutation	NA	R201C	0.27
UCEC	chr2	174141841	Missense_Mutation	novel	K178T	0.35
UCEC	chr2	174082033	Missense_Mutation	novel	Y254H	0.43
UCEC	chr2	174081182	Silent	novel	G312G	0.45
UCEC	chr2	174081169	Missense_Mutation	rs375033952	R317C	0.22
UCEC	chr2	174081982	Silent	rs138590546	L271L	0.13
UCEC	chr2	174082056	Missense_Mutation	novel	K246T	0.17
UCEC	chr2	174229381	Missense_Mutation	novel	D58Y	0.52	MMR_HSR1
UCEC	chr2	174223097	Silent	rs766330169	G103G	0.21
UCEC	chr2	174082005	Missense_Mutation	novel	F263C	0.41
UCEC	chr2	174081225	Missense_Mutation	novel	A298V	0.52
UCEC	chr2	174075344	3'UTR	rs556506955		0.2
UCEC	chr2	174075296	3'UTR	novel		0.47
UCEC	chr2	174141930	Missense_Mutation	novel	I148M	0.15
UCEC	chr2	174074913	3'UTR	novel		0.58
UCEC	chr2	174075344	3'UTR	rs556506955		0.38
UCEC	chr2	174075339	3'UTR	novel		0.38
UCEC	chr2	174141971	Missense_Mutation	rs549904049	V135I	0.37
UCEC	chr2	174123619	Silent	novel	F202F	0.21
UCEC	chr2	174078999	Missense_Mutation	NA	F353C	0.39
UCEC	chr2	174078967	Splice_Site	novel	X363_splice	0.19
UCEC	chr2	174246770	Missense_Mutation	novel	I16V	0.16
UCEC	chr2	174074954	3'UTR	novel		0.38
UCS	chr2	174123234	Frame_Shift_Ins	novel	*M225Nfs6**	0.47

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	AMP	0.1186	0.012962
PAAD	AMP	0.0707	0.1091
PAAD	DEL	0.0272	0.2014

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.026	Kaplan-Meier Survival Analysis
MESO	0.00056	Kaplan-Meier Survival Analysis
ACC	0.00088	Kaplan-Meier Survival Analysis
HNSC	0.0012	Kaplan-Meier Survival Analysis
KIRP	0.00057	Kaplan-Meier Survival Analysis
COAD	0.033	Kaplan-Meier Survival Analysis
PAAD	0.00089	Kaplan-Meier Survival Analysis
LAML	0.027	Kaplan-Meier Survival Analysis
KICH	0.012	Kaplan-Meier Survival Analysis
UCEC	0.014	Kaplan-Meier Survival Analysis
LIHC	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.0047	Kaplan-Meier Survival Analysis
UVM	0.026	Kaplan-Meier Survival Analysis
OV	0.027	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742