EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000138592 (Gene tree)
Gene ID: 9101
Gene Symbol: USP8
Alias: HumORF8|KIAA0055|UBPY|SPG59
Full Name: ubiquitin specific peptidase 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 90,043 bases
Position: chr15:50,424,377-50,514,419
Accession: 12631
RBP type: non-canonical RBP
Summary: This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17711858	The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.	J Biol Chem	2007 Oct 19	Row PE	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000560954	USP8-214	582	-	-	- (aa)	-	-
ENST00000307179	USP8-201	4243	XM_006720762	ENSP00000302239	1118 (aa)	XP_006720825	P40818
ENST00000560379	USP8-210	737	-	-	- (aa)	-	-
ENST00000560982	USP8-215	410	-	ENSP00000453427	73 (aa)	-	H0YM17
ENST00000560730	USP8-212	1449	-	ENSP00000452950	136 (aa)	-	H0YKV1
ENST00000559329	USP8-208	1917	-	ENSP00000454003	480 (aa)	-	A0A075B720
ENST00000561330	USP8-218	815	-	ENSP00000453460	125 (aa)	-	H0YM47
ENST00000558892	USP8-206	616	-	-	- (aa)	-	-
ENST00000396444	USP8-202	19026	XM_006720761	ENSP00000379721	1118 (aa)	XP_006720824	P40818
ENST00000560885	USP8-213	525	-	-	- (aa)	-	-
ENST00000625664	USP8-219	1568	-	ENSP00000485810	62 (aa)	-	H0YLS3
ENST00000560297	USP8-209	652	-	ENSP00000453206	96 (aa)	-	H0YLH2
ENST00000425032	USP8-204	3559	XM_017022721	ENSP00000412682	1012 (aa)	XP_016878210	P40818
ENST00000560527	USP8-211	535	-	-	- (aa)	-	-
ENST00000558091	USP8-205	498	-	ENSP00000454059	135 (aa)	-	H0YNL5
ENST00000419830	USP8-203	2402	-	-	- (aa)	-	-
ENST00000559242	USP8-207	432	-	ENSP00000453320	62 (aa)	-	H0YLS3
ENST00000561206	USP8-216	556	-	-	- (aa)	-	-
ENST00000561211	USP8-217	609	-	ENSP00000457345	62 (aa)	-	H0YLS3

Gene Model

Click here to download ENSG00000138592's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04137	Mitophagy - animal	KEGG
hsa04144	Endocytosis	KEGG
hsa04934	Cushing syndrome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138592	Platelet Function Tests	1.3465600E-005	-
ENSG00000138592	Platelet Function Tests	1.8377700E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138592	rs147661253	15	50495229	TTG	Osteoarthritis of the hip or knee (hospital diagnosed)	29559693	[1.0474-1.1227]	1.0845	EFO_1000786\|EFO_0004616
ENSG00000138592	rs147661253	15	50495229	TTG	Osteoarthritis of the knee (hospital diagnosed)	29559693	[1.0597-1.1561]	1.1068	EFO_0004616
ENSG00000138592	rs11854087	15	50505794	C	Granulocyte percentage of myeloid white cells	27863252	[0.042-0.085] unit decrease	0.06329888	EFO_0007997
ENSG00000138592	rs3131610	15	50507898	A	Myeloid white cell count	27863252	[0.02-0.036] unit decrease	0.02810746	EFO_0007988
ENSG00000138592	rs3131610	15	50507898	A	White blood cell count	27863252	[0.021-0.037] unit decrease	0.02910776	EFO_0004308
ENSG00000138592	rs3131610	15	50507898	A	Granulocyte count	27863252	[0.02-0.036] unit decrease	0.02778724	EFO_0007987
ENSG00000138592	rs3131610	15	50507898	A	Sum neutrophil eosinophil counts	27863252	[0.02-0.037] unit decrease	0.02853039	EFO_0004833\|EFO_0004842
ENSG00000138592	rs28840973	15	50468713	C	Heel bone mineral density	30598549	[0.027-0.043] unit decrease	0.0352912	EFO_0009270
ENSG00000138592	rs35912128	15	50438935	AT	Knee osteoarthritis	30664745	[1.05-1.11]	1.08	EFO_0004616
ENSG00000138592	rs7164347	15	50426364	?	Lung function (FEV1/FVC)	30595370			EFO_0004713

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138592's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000281	mitotic cytokinesis	18388320.	IMP	Process
GO:0004197	cysteine-type endopeptidase activity	9827704.	TAS	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	21873635.	IBA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	16520378.18388320.	IDA	Function
GO:0004843	thiol-dependent ubiquitin-specific protease activity	-	TAS	Function
GO:0005515	protein binding	17711858.18329369.19302785.19427866.24378640.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005737	cytoplasm	18388320.	IDA	Component
GO:0005769	early endosome	16520378.	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	16520378.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	-	IEA	Process
GO:0007032	endosome organization	21873635.	IBA	Process
GO:0007032	endosome organization	16520378.	IMP	Process
GO:0007265	Ras protein signal transduction	21873635.	IBA	Process
GO:0008283	cell proliferation	9628861.	TAS	Process
GO:0014069	postsynaptic density	21873635.	IBA	Component
GO:0016579	protein deubiquitination	21873635.	IBA	Process
GO:0016579	protein deubiquitination	18388320.27302062.	IMP	Process
GO:0016579	protein deubiquitination	-	TAS	Process
GO:0017124	SH3 domain binding	-	IEA	Function
GO:0019897	extrinsic component of plasma membrane	21873635.	IBA	Component
GO:0019897	extrinsic component of plasma membrane	16520378.	IDA	Component
GO:0030496	midbody	21873635.	IBA	Component
GO:0030496	midbody	18388320.	IDA	Component
GO:0031313	extrinsic component of endosome membrane	21873635.	IBA	Component
GO:0031647	regulation of protein stability	27302062.	IMP	Process
GO:0032880	regulation of protein localization	27302062.	IMP	Process
GO:0043197	dendritic spine	21873635.	IBA	Component
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0070536	protein K63-linked deubiquitination	21873635.	IBA	Process
GO:0070536	protein K63-linked deubiquitination	16520378.	IDA	Process
GO:0071108	protein K48-linked deubiquitination	21873635.	IBA	Process
GO:0071108	protein K48-linked deubiquitination	16520378.	IDA	Process
GO:0071549	cellular response to dexamethasone stimulus	-	IEA	Process
GO:0090263	positive regulation of canonical Wnt signaling pathway	20495530.	IMP	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0099576	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	-	IEA	Process
GO:1990090	cellular response to nerve growth factor stimulus	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25675982	Recurrent gain-of-function USP8 mutations in Cushing's disease.	Cell Res	2015 Mar	Ma ZY	doi: 10.1038/cr.2015.20
28544031	Ubiquitin-specific protease 8 is a novel prognostic marker in early-stage lung adenocarcinoma.	Pathol Int	2017 Jun	Kim Y	doi: 10.1111/pin.12546
30010158	High Expression of Ubiquitin-Specific Protease 8 (USP8) Is Associated with Poor Prognosis in Patients with Cervical Squamous Cell Carcinoma.	Med Sci Monit	2018 Jul 16	Yan M	doi: 10.12659/MSM.909235.
24344018	Clinical and prognostic importance of XIAP and USP8 in advanced stages of non-small cell lung cancer.	J BUON	2013 Oct-Dec	Baykara M	-
23748694	USP8 is a novel target for overcoming gefitinib resistance in lung cancer.	Clin Cancer Res	2013 Jul 15	Byun S	doi: 10.1158/1078-0432.CCR-12-3696

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr15	50492747	Missense_Mutation	NA	Q761E	0.25
BLCA	chr15	50465102	Missense_Mutation	novel	L199F	0.53
BLCA	chr15	50476987	Missense_Mutation	rs373961591	I330V	0.09
BLCA	chr15	50484330	Missense_Mutation	NA	R620K	0.16
BLCA	chr15	50476950	Silent	novel	V317V	0.3
BLCA	chr15	50484311	Missense_Mutation	novel	L614I	0.42
BLCA	chr15	50498657	Missense_Mutation	novel	N1034Y	0.49
BLCA	chr15	50499186	3'UTR	novel		0.38
BLCA	chr15	50493581	Intron	novel		0.27
BLCA	chr15	50481957	Missense_Mutation	novel	K565N	0.46
BLCA	chr15	50481481	Missense_Mutation	novel	I407F	0.5
BLCA	chr15	50477487	Silent	NA	K402K	0.2
BLCA	chr15	50490450	Missense_Mutation	NA	P720Q	0.05
BLCA	chr15	50481664	Missense_Mutation	novel	E468K	0.32
BLCA	chr15	50465172	Missense_Mutation	rs772324296	E223K	0.28
BLCA	chr15	50490281	Missense_Mutation	novel	G664R	0.41
BLCA	chr15	50471724	Missense_Mutation	novel	D260H	0.11
BLCA	chr15	50481627	Silent	rs139912757	L455L	0.41
BLCA	chr15	50497206	Missense_Mutation	novel	P1005S	0.32
BRCA	chr15	50449420	Silent	NA	L90L	0.45
BRCA	chr15	50498988	Missense_Mutation	novel	H1086L	0.17
BRCA	chr15	50459088	Missense_Mutation	NA	G142R	0.22
BRCA	chr15	50476941	Silent	NA	N314N	0.28
BRCA	chr15	50494233	Missense_Mutation	NA	E871Q	0.34
BRCA	chr15	50493874	Intron	novel		0.08
CESC	chr15	50495855	Missense_Mutation	NA	N889T	0.19
CESC	chr15	50449435	Missense_Mutation	novel	I95M	0.33
CESC	chr15	50497051	Intron	rs748537198		0.19
CESC	chr15	50459139	Missense_Mutation	NA	D159H	0.6
CESC	chr15	50490450	Missense_Mutation	NA	P720Q	0.13
CESC	chr15	50494080	Silent	novel	L820L	0.31
CESC	chr15	50482011	Silent	novel	K583K	0.23
CESC	chr15	50476980	Silent	novel	E327E	0.2
CESC	chr15	50494124	Missense_Mutation	NA	M834I	0.37
CESC	chr15	50484316	Silent	NA	R615R	0.45
CHOL	chr15	50500940	3'Flank	novel		0.41
COAD	chr15	50481683	Frame_Shift_Del	novel	*N476Tfs19**	0.31
COAD	chr15	50481757	Nonsense_Mutation	NA	Q499*	0.39
COAD	chr15	50459070	Frame_Shift_Ins	novel	*R138Kfs14**	0.27
COAD	chr15	50489828	Nonsense_Mutation	NA	R640*	0.41
COAD	chr15	50497125	Missense_Mutation	NA	T978P	0.42
COAD	chr15	50477334	Silent	NA	T351T	0.06
COAD	chr15	50497178	Frame_Shift_Del	NA	*K997Rfs2**	0.11
COAD	chr15	50441463	Frame_Shift_Ins	NA	*R76Kfs3**	0.54
COAD	chr15	50481592	Missense_Mutation	rs148244041	R444C	0.09
COAD	chr15	50471718	Missense_Mutation	NA	L258F	0.14
COAD	chr15	50476977	Missense_Mutation	novel	E326D	0.25
COAD	chr15	50489837	Missense_Mutation	novel	E643K	0.17
COAD	chr15	50500906	3'Flank	novel		0.11
COAD	chr15	50500907	3'Flank	novel		0.11
COAD	chr15	50497168	Missense_Mutation	rs752820652	R992Q	0.19
GBM	chr15	50493917	Intron	novel		0.14
GBM	chr15	50493919	Intron	novel		0.14
GBM	chr15	50459082	Missense_Mutation	novel	E140Q	0.16
GBM	chr15	50496046	Missense_Mutation	novel	S953P	0.34
GBM	chr15	50495901	Silent	NA	F904F	0.29
GBM	chr15	50498919	Missense_Mutation	novel	L1063R	0.08
HNSC	chr15	50481769	Missense_Mutation	novel	A503P	0.57
HNSC	chr15	50493353	Intron	novel		0.05
HNSC	chr15	50481970	Missense_Mutation	novel	D570H	0.24
HNSC	chr15	50499065	Nonsense_Mutation	rs142928952	R1112*	0.24
HNSC	chr15	50499130	3'UTR	novel		0.17
HNSC	chr15	50477441	Missense_Mutation	NA	S387C	0.38
HNSC	chr15	50492752	Silent	novel	I762I	0.25
HNSC	chr15	50471770	Missense_Mutation	rs376852674	R275Q	0.06
HNSC	chr15	50481488	Missense_Mutation	novel	R409L	0.37
HNSC	chr15	50484248	Splice_Site	novel	X602_splice	0.3
HNSC	chr15	50498637	Missense_Mutation	novel	S1027C	0.07
HNSC	chr15	50441422	Missense_Mutation	novel	Y60D	0.37
HNSC	chr15	50495846	Splice_Site	novel	X887_splice	0.48
HNSC	chr15	50494141	Missense_Mutation	novel	G840E	0.17
HNSC	chr15	50495859	Silent	novel	R890R	0.31
HNSC	chr15	50476971	Silent	novel	Q324Q	0.62
KIRC	chr15	50471654	Silent	NA	E236E	0.33
LGG	chr15	50476869	Silent	NA	L290L	0.31
LGG	chr15	50493595	Intron	novel		0.35
LIHC	chr15	50465120	Silent	novel	R205R	0.08
LIHC	chr15	50459113	Missense_Mutation	novel	A150V	0.23
LIHC	chr15	50490413	Missense_Mutation	NA	R708G	0.3
LUAD	chr15	50489823	Missense_Mutation	novel	R638T	0.13
LUAD	chr15	50499028	Silent	novel	S1099S	0.13
LUAD	chr15	50497196	Nonsense_Mutation	NA	W1001*	0.31
LUAD	chr15	50489823	Missense_Mutation	NA	R638K	0.15
LUAD	chr15	50490261	Splice_Site	novel	X658_splice	0.06
LUAD	chr15	50499006	Missense_Mutation	NA	S1092C	0.08
LUAD	chr15	50449422	Missense_Mutation	NA	G91V	0.22
LUAD	chr15	50490378	Missense_Mutation	NA	H696P	0.17
LUAD	chr15	50482009	Nonsense_Mutation	NA	K583*	0.33
LUAD	chr15	50476919	Missense_Mutation	NA	C307F	0.21
LUAD	chr15	50476970	Missense_Mutation	NA	Q324R	0.27
LUAD	chr15	50481527	Missense_Mutation	NA	R422T	0.25
LUAD	chr15	50493377	Intron	novel		0.24
LUAD	chr15	50477442	Silent	NA	S387S	0.25
LUSC	chr15	50477332	Missense_Mutation	novel	T351A	0.22
LUSC	chr15	50500724	3'Flank	novel		0.89
LUSC	chr15	50441381	Missense_Mutation	novel	T46K	0.48
LUSC	chr15	50441412	Silent	NA	E56E	0.23
LUSC	chr15	50494107	Missense_Mutation	NA	E829Q	0.24
LUSC	chr15	50476927	Nonsense_Mutation	NA	Q310*	0.42
LUSC	chr15	50465189	Splice_Region	novel	P228P	0.27
LUSC	chr15	50465136	Missense_Mutation	NA	Q211E	0.19
LUSC	chr15	50490342	Missense_Mutation	novel	A684G	0.15
MESO	chr15	50465169	Missense_Mutation	novel	P222S	0.35
MESO	chr15	50497169	Silent	novel	R992R	0.45
OV	chr15	50477333	Missense_Mutation	novel	T351K	0.21
OV	chr15	50477406	Silent	NA	L375L	0.27
PAAD	chr15	50481755	Frame_Shift_Ins	novel	*Q499Lfs53**	0.09
PAAD	chr15	50449422	Missense_Mutation	NA	G91V	0.05
PAAD	chr15	50481757	In_Frame_Ins	novel	Q499delinsLFHSE	0.04
PAAD	chr15	50449448	Frame_Shift_Del	novel	*E100Kfs12**	0.1
PAAD	chr15	50490516	Missense_Mutation	NA	R742Q	0.09
PAAD	chr15	50494085	Silent	novel	G821G	0.11
PAAD	chr15	50495898	Silent	novel	D903D	0.16
PRAD	chr15	50495908	Missense_Mutation	NA	A907S	0.49
PRAD	chr15	50489822	Missense_Mutation	novel	R638G	0.3
READ	chr15	50490450	Missense_Mutation	NA	P720Q	0.47
READ	chr15	50481756	Silent	novel	E498E	0.42
READ	chr15	50493461	Intron	novel		0.42
READ	chr15	50494175	Missense_Mutation	novel	K851N	0.39
SKCM	chr15	50499024	Missense_Mutation	NA	S1098F	0.44
SKCM	chr15	50494157	Silent	NA	I845I	0.38
SKCM	chr15	50489865	Missense_Mutation	NA	P652L	0.27
SKCM	chr15	50489851	Silent	rs747926929	I647I	0.29
SKCM	chr15	50481966	Silent	rs769218734	V568V	1
SKCM	chr15	50481967	Missense_Mutation	novel	E569K	0.95
SKCM	chr15	50494033	Intron	novel		0.56
SKCM	chr15	50481510	Missense_Mutation	novel	K416N	0.39
SKCM	chr15	50490398	Missense_Mutation	NA	P703S	0.42
SKCM	chr15	50496072	Missense_Mutation	novel	K961N	0.17
SKCM	chr15	50441430	Silent	novel	L62L	0.4
SKCM	chr15	50490438	Missense_Mutation	rs753615462	S716F	0.26
SKCM	chr15	50449408	Silent	NA	F86F	0.42
SKCM	chr15	50495979	Silent	NA	F930F	0.22
SKCM	chr15	50441470	Nonsense_Mutation	NA	R76*	0.29
SKCM	chr15	50494095	Missense_Mutation	NA	E825K	0.84
STAD	chr15	50498990	Missense_Mutation	NA	E1087Q	0.09
STAD	chr15	50489851	Silent	rs747926929	I647I	0.24
STAD	chr15	50493911	Intron	novel		0.29
STAD	chr15	50441464	Frame_Shift_Del	novel	*R76Dfs36**	0.26
STAD	chr15	50476874	Missense_Mutation	NA	N292S	0.12
STAD	chr15	50484344	Missense_Mutation	rs768514589	D625N	0.42
STAD	chr15	50490434	Missense_Mutation	NA	R715C	0.38
STAD	chr15	50481682	Frame_Shift_Ins	novel	*N476Kfs35**	0.15
STAD	chr15	50476967	Missense_Mutation	rs759611314	R323H	0.15
STAD	chr15	50471694	Frame_Shift_Ins	novel	*N252Efs9**	0.44
STAD	chr15	50494054	Intron	novel		0.24
STAD	chr15	50441464	Frame_Shift_Del	novel	*R76Dfs36**	0.37
THCA	chr15	50493538	Intron	novel		0.1
THCA	chr15	50493540	Intron	novel		0.1
THCA	chr15	50481757	In_Frame_Ins	novel	Q499delinsLFHSE	0.17
THCA	chr15	50481759	Silent	novel	Q499Q	0.09
UCEC	chr15	50439101	Nonsense_Mutation	NA	E10*	0.3
UCEC	chr15	50500664	3'Flank	novel		0.31
UCEC	chr15	50471690	Silent	novel	K248K	0.79
UCEC	chr15	50499209	3'UTR	novel		0.44
UCEC	chr15	50481648	Missense_Mutation	novel	K462N	0.24
UCEC	chr15	50482050	Missense_Mutation	novel	D596E	0.3
UCEC	chr15	50495870	Missense_Mutation	novel	K894T	0.1
UCEC	chr15	50496051	Silent	novel	L954L	0.2
UCEC	chr15	50439013	5'UTR	novel		0.46
UCEC	chr15	50481709	Missense_Mutation	NA	R483W	0.39
UCEC	chr15	50489829	Missense_Mutation	rs374126671	R640Q	0.45
UCEC	chr15	50495875	Nonsense_Mutation	NA	E896*	0.14
UCEC	chr15	50476859	Missense_Mutation	novel	K287T	0.38
UCEC	chr15	50476964	Missense_Mutation	rs148200969	R322Q	0.45
UCEC	chr15	50493402	Intron	novel		0.43
UCEC	chr15	50449448	Missense_Mutation	novel	E100K	0.5
UCEC	chr15	50439128	Missense_Mutation	novel	D19Y	0.43
UCEC	chr15	50481962	Missense_Mutation	novel	S567Y	0.42
UCEC	chr15	50492871	Missense_Mutation	novel	A802D	0.44
UCEC	chr15	50498606	Missense_Mutation	novel	D1017N	0.13
UCEC	chr15	50489829	Missense_Mutation	rs374126671	R640Q	0.53
UCEC	chr15	50481668	Missense_Mutation	novel	T469N	0.04
UCEC	chr15	50497207	Missense_Mutation	NA	P1005L	0.33
UCEC	chr15	50500739	3'Flank	rs535476757		0.1
UCEC	chr15	50496003	Silent	NA	T938T	0.42
UCEC	chr15	50494231	Frame_Shift_Ins	novel	*Q870Hfs14**	0.04
UCEC	chr15	50498637	Missense_Mutation	novel	S1027Y	0.16
UCEC	chr15	50449448	Missense_Mutation	novel	E100K	0.63
UCEC	chr15	50477302	Missense_Mutation	novel	E341K	0.17
UCEC	chr15	50459078	Silent	rs773781112	R138R	0.37
UCEC	chr15	50481488	Missense_Mutation	rs114434131	R409H	0.38
UCEC	chr15	50498623	Missense_Mutation	NA	Q1022H	0.43
UCEC	chr15	50459000	Missense_Mutation	NA	R112S	0.22
UCEC	chr15	50459158	Frame_Shift_Del	novel	*K166Rfs26**	0.39
UCEC	chr15	50490516	Missense_Mutation	NA	R742Q	0.47
UCEC	chr15	50494176	Missense_Mutation	novel	I852F	0.46
UCEC	chr15	50498997	Missense_Mutation	novel	S1089Y	0.08
UCEC	chr15	50481709	Missense_Mutation	NA	R483W	0.33
UCEC	chr15	50490449	Missense_Mutation	novel	P720S	0.26
UCEC	chr15	50449428	Missense_Mutation	novel	G93E	0.23
UCEC	chr15	50493912	Intron	novel		0.39
UCEC	chr15	50482042	Missense_Mutation	novel	T594A	0.45
UCEC	chr15	50477487	Missense_Mutation	novel	K402N	0.52
UCEC	chr15	50490351	Missense_Mutation	novel	S687Y	0.34
UCEC	chr15	50481709	Missense_Mutation	NA	R483W	0.45
UCEC	chr15	50441389	Missense_Mutation	NA	E49K	0.05
UCEC	chr15	50441389	Nonsense_Mutation	novel	E49*	0.57
UCEC	chr15	50477483	Missense_Mutation	novel	I401T	0.32
UCEC	chr15	50494085	Silent	novel	G821G	0.44
UCEC	chr15	50476929	Silent	novel	Q310Q	0.13
UCEC	chr15	50441464	Frame_Shift_Del	novel	*R76Dfs36**	0.59
UCEC	chr15	50481738	Missense_Mutation	NA	E492D	0.26
UCEC	chr15	50493905	Intron	novel		0.38
UCEC	chr15	50498605	Silent	rs145863722	Y1016Y	0.19
UCEC	chr15	50477346	Silent	NA	S355S	0.48
UCEC	chr15	50498660	Missense_Mutation	NA	L1035I	0.47
UCEC	chr15	50500901	3'Flank	rs3803374		0.52
UCEC	chr15	50481592	Missense_Mutation	rs148244041	R444C	0.32
UCEC	chr15	50441472	Silent	rs778043652	R76R	0.25
UCEC	chr15	50490291	Missense_Mutation	NA	R667H	0.23
UCEC	chr15	50493687	Intron	novel		0.25
UCEC	chr15	50495892	Silent	rs751144521	L901L	0.42
UCEC	chr15	50498723	Missense_Mutation	novel	V1056I	0.41
UCEC	chr15	50496046	Missense_Mutation	novel	S953P	0.47
UCEC	chr15	50477334	Silent	NA	T351T	0.3
UCEC	chr15	50490279	Missense_Mutation	novel	T663I	0.55
UCEC	chr15	50498725	Silent	novel	V1056V	0.43
UCEC	chr15	50493373	Intron	novel		0.35
UCEC	chr15	50493541	Intron	novel		0.6
UCS	chr15	50477487	Missense_Mutation	novel	K402N	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2	0.079424
CESC	DEL	0.1797	0.00049652
KICH	AMP	0.2727	0.21756
KIRP	DEL	0.1007	0.2062
PAAD	DEL	0.1087	0.13216
READ	DEL	0.4364	0.025797

Survival Analysis

Cancer	P-value	Q-value
ACC	0.0067	Kaplan-Meier Survival Analysis
SKCM	0.017	Kaplan-Meier Survival Analysis
READ	0.0092	Kaplan-Meier Survival Analysis
GBM	0.023	Kaplan-Meier Survival Analysis
DLBC	0.038	Kaplan-Meier Survival Analysis
OV	0.042	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742