EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000138646 (Gene tree)
Gene ID: 51191
Gene Symbol: HERC5
Alias: CEB1
Full Name: HECT and RLD domain containing E3 ubiquitin protein ligase 5
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 49,054 bases
Position: chr4:88,457,117-88,506,170
Accession: 24368
RBP type: non-canonical RBP
Summary: This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000508695	HERC5-204	543	-	-	- (aa)	-	-
ENST00000510223	HERC5-205	2925	-	-	- (aa)	-	-
ENST00000264350	HERC5-201	3513	XM_011532022	ENSP00000264350	1024 (aa)	XP_011530324	Q9UII4
ENST00000502913	HERC5-202	1949	-	-	- (aa)	-	-
ENST00000508159	HERC5-203	2243	-	ENSP00000424129	662 (aa)	-	E9PBL0

Gene Model

Click here to download ENSG00000138646's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138646	Hypertension	2.6003624E-005	-
ENSG00000138646	Forced Expiratory Volume	9E-6	22424883

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138646	rs10516809	4	88499935	?	Pulmonary function decline	22424883	[0.17-0.44] unit increase	0.3063	EFO_0004314

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138646's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	10581175.	TAS	Process
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0004842	ubiquitin-protein transferase activity	-	TAS	Function
GO:0005515	protein binding	20133869.20308324.	IPI	Function
GO:0005829	cytosol	-	TAS	Component
GO:0032020	ISG15-protein conjugation	21873635.	IBA	Process
GO:0032020	ISG15-protein conjugation	20308324.	IDA	Process
GO:0032480	negative regulation of type I interferon production	-	TAS	Process
GO:0042296	ISG15 transferase activity	21873635.	IBA	Function
GO:0042296	ISG15 transferase activity	20308324.	IDA	Function
GO:0045087	innate immune response	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0050688	regulation of defense response to virus	21873635.	IBA	Process
GO:0050688	regulation of defense response to virus	20308324.	IDA	Process
GO:0051607	defense response to virus	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25353388	Identification of HERC5 and its potential role in NSCLC progression.	Int J Cancer	2015 May 15	Wrage M	doi: 10.1002/ijc.29298
26653219	HERC5 is a prognostic biomarker for post-liver transplant recurrent human hepatocellular carcinoma.	J Transl Med	2015 Dec 11	Xue F	doi: 10.1186/s12967-015-0743-2.

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	88469199	Missense_Mutation	NA	E393K	0.35
BLCA	chr4	88463941	Silent	NA	V289V	0.21
BLCA	chr4	88489309	Missense_Mutation	novel	E702D	0.46
BLCA	chr4	88493065	Missense_Mutation	NA	F729L	0.49
BLCA	chr4	88494235	Frame_Shift_Del	novel	*A784Pfs23**	0.27
BLCA	chr4	88494241	Missense_Mutation	novel	N785S	0.09
BLCA	chr4	88486193	Missense_Mutation	novel	E606Q	0.22
BRCA	chr4	88475945	Missense_Mutation	novel	M499I	0.27
BRCA	chr4	88462263	Nonsense_Mutation	novel	G199*	0.38
BRCA	chr4	88469241	Missense_Mutation	rs145240865	R407W	0.2
BRCA	chr4	88467189	Missense_Mutation	novel	E348K	0.19
BRCA	chr4	88467181	Nonsense_Mutation	NA	S345*	0.27
BRCA	chr4	88489316	Missense_Mutation	NA	D705H	0.22
BRCA	chr4	88467181	Nonsense_Mutation	NA	S345*	0.27
CESC	chr4	88505846	Missense_Mutation	rs751293985	E1015K	0.38
CESC	chr4	88479502	Missense_Mutation	novel	H578Y	0.06
CESC	chr4	88494271	Missense_Mutation	NA	K795T	0.1
CESC	chr4	88487104	Missense_Mutation	novel	F629L	0.37
CESC	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.33
CESC	chr4	88504285	Missense_Mutation	rs773827213	A879V	0.63
CESC	chr4	88504556	Missense_Mutation	NA	A943G	0.31
CESC	chr4	88504325	Silent	rs201540163	C892C	0.16
CESC	chr4	88499948	Missense_Mutation	NA	D823N	0.29
CESC	chr4	88476019	Missense_Mutation	rs766394501	S524L	0.36
CESC	chr4	88486168	Silent	NA	L597L	0.61
COAD	chr4	88475992	Missense_Mutation	NA	V515G	0.38
COAD	chr4	88494309	Nonsense_Mutation	NA	E808*	0.25
COAD	chr4	88487071	Splice_Region	rs369956338	D618D	0.16
COAD	chr4	88504283	Missense_Mutation	NA	K878N	0.26
COAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.2
COAD	chr4	88463598	Missense_Mutation	novel	G252D	0.2
COAD	chr4	88460121	Missense_Mutation	rs779976280	K139I	0.83
COAD	chr4	88487095	Silent	rs111323592	C626C	0.25
COAD	chr4	88504286	Silent	rs761284663	A879A	0.35
COAD	chr4	88469179	Missense_Mutation	NA	R386M	0.3
COAD	chr4	88504271	Silent	rs762515665	N874N	0.45
COAD	chr4	88467091	Missense_Mutation	NA	G315E	0.27
COAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.29
COAD	chr4	88467095	Missense_Mutation	novel	K316N	0.39
COAD	chr4	88486186	Missense_Mutation	NA	F603L	0.25
COAD	chr4	88470659	Frame_Shift_Del	NA	L430*	0.4
COAD	chr4	88459471	Splice_Site	NA	X130_splice	0.55
COAD	chr4	88504313	Missense_Mutation	NA	F888L	0.34
DLBC	chr4	88505851	Silent	rs756694449	A1016A	0.39
GBM	chr4	88489271	Missense_Mutation	novel	L690V	0.05
GBM	chr4	88460100	Missense_Mutation	novel	E132V	0.19
GBM	chr4	88486163	Missense_Mutation	rs369280809	E596K	0.28
GBM	chr4	88489208	Missense_Mutation	rs754363045	E669K	0.33
GBM	chr4	88494204	Missense_Mutation	novel	L773I	0.22
GBM	chr4	88469188	Missense_Mutation	novel	P389L	0.1
GBM	chr4	88469156	Splice_Site	novel	X379_splice	0.12
GBM	chr4	88505850	Missense_Mutation	novel	A1016V	0.47
GBM	chr4	88489268	Missense_Mutation	novel	H689D	0.05
HNSC	chr4	88493035	Silent	novel	G719G	0.2
HNSC	chr4	88505756	Missense_Mutation	novel	E985K	0.22
HNSC	chr4	88486192	Silent	novel	V605V	0.29
HNSC	chr4	88486225	Silent	NA	T616T	0.28
HNSC	chr4	88486226	Missense_Mutation	novel	V617L	0.26
HNSC	chr4	88499951	Missense_Mutation	novel	E824Q	0.21
HNSC	chr4	88479481	Missense_Mutation	novel	L571V	0.23
HNSC	chr4	88479402	Silent	novel	Q544Q	0.1
KICH	chr4	88487071	Splice_Region	rs369956338	D618D	0.4
KIRC	chr4	88504340	Silent	NA	I897I	0.08
KIRC	chr4	88462353	Missense_Mutation	NA	E229K	0.33
KIRC	chr4	88505852	Missense_Mutation	novel	I1017V	0.27
KIRC	chr4	88463869	Missense_Mutation	NA	F265L	0.26
KIRP	chr4	88489258	Silent	NA	V685V	0.45
LGG	chr4	88489229	Missense_Mutation	rs376568622	A676T	0.42
LGG	chr4	88504501	Missense_Mutation	novel	R925C	0.36
LUAD	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.38
LUAD	chr4	88467089	Frame_Shift_Del	novel	*G315Efs23**	0.28
LUAD	chr4	88459467	In_Frame_Ins	novel	L129_R130insGKIS	0.07
LUAD	chr4	88489167	Missense_Mutation	NA	S655T	0.32
LUAD	chr4	88472406	Splice_Region	novel		0.27
LUAD	chr4	88462236	Missense_Mutation	NA	G190R	0.21
LUAD	chr4	88494316	Missense_Mutation	NA	S810T	0.61
LUAD	chr4	88505986	3'UTR	novel		1
LUAD	chr4	88489164	Splice_Site	NA	X655_splice	0.24
LUAD	chr4	88459449	Missense_Mutation	rs533028212	N123S	0.31
LUAD	chr4	88493010	Splice_Site	novel	X712_splice	0.12
LUAD	chr4	88504272	Missense_Mutation	novel	D875H	0.13
LUAD	chr4	88462239	Missense_Mutation	novel	V191L	0.42
LUSC	chr4	88479416	Missense_Mutation	novel	A549V	0.29
LUSC	chr4	88463540	Missense_Mutation	novel	D233Y	0.21
LUSC	chr4	88463853	Splice_Site	NA	X261_splice	0.23
LUSC	chr4	88463560	Silent	novel	G239G	0.11
LUSC	chr4	88504332	Missense_Mutation	NA	D895H	0.06
LUSC	chr4	88479426	Nonsense_Mutation	NA	C552*	0.23
LUSC	chr4	88505877	Nonstop_Mutation	NA	1025Lext30	0.24
LUSC	chr4	88463540	Missense_Mutation	novel	D233Y	0.1
LUSC	chr4	88462338	Missense_Mutation	NA	G224S	0.29
LUSC	chr4	88476027	Missense_Mutation	NA	L527M	0.49
LUSC	chr4	88479364	Missense_Mutation	NA	A532T	0.32
LUSC	chr4	88460160	Missense_Mutation	novel	A152V	0.67
OV	chr4	88486225	Silent	NA	T616T	0.88
OV	chr4	88504302	Missense_Mutation	NA	R885W	0.23
OV	chr4	88463973	Missense_Mutation	novel	I300T	0.04
PAAD	chr4	88493098	Silent	rs781638920	P740P	0.09
PAAD	chr4	88504303	Missense_Mutation	rs375430185	R885Q	0.18
READ	chr4	88504302	Missense_Mutation	NA	R885W	0.29
READ	chr4	88504285	Missense_Mutation	rs773827213	A879V	0.25
READ	chr4	88504371	Missense_Mutation	NA	V908L	0.4
READ	chr4	88479376	Nonsense_Mutation	novel	E536*	0.43
READ	chr4	88486168	Silent	rs774593839	L597L	0.36
READ	chr4	88487114	Missense_Mutation	novel	P633S	0.37
READ	chr4	88489326	Missense_Mutation	NA	K708T	0.31
SARC	chr4	88504332	Missense_Mutation	NA	D895H	0.06
SARC	chr4	88463882	Missense_Mutation	novel	G270R	0.39
SKCM	chr4	88463547	Missense_Mutation	rs756900772	S235F	0.19
SKCM	chr4	88494162	Splice_Region	novel		0.65
SKCM	chr4	88494300	Missense_Mutation	NA	D805N	0.11
SKCM	chr4	88499940	Missense_Mutation	NA	L820H	0.41
SKCM	chr4	88494219	Silent	novel	L778L	0.42
SKCM	chr4	88493038	Nonsense_Mutation	NA	Y720*	0.7
SKCM	chr4	88469199	Missense_Mutation	NA	E393K	0.28
SKCM	chr4	88468370	Nonsense_Mutation	NA	L361*	0.62
SKCM	chr4	88463549	Missense_Mutation	NA	L236F	0.17
SKCM	chr4	88463548	Silent	NA	S235S	0.14
SKCM	chr4	88457471	Missense_Mutation	NA	R68C	0.31
SKCM	chr4	88469161	Missense_Mutation	NA	S380L	0.59
SKCM	chr4	88469187	Missense_Mutation	NA	P389S	0.34
SKCM	chr4	88487136	Missense_Mutation	rs772009697	S640L	0.31
SKCM	chr4	88472452	Missense_Mutation	novel	A448T	0.59
STAD	chr4	88459362	Frame_Shift_Ins	novel	*N96Kfs25**	0.23
STAD	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.26
STAD	chr4	88489260	Missense_Mutation	novel	R686I	0.12
STAD	chr4	88463961	Missense_Mutation	NA	R296K	0.41
STAD	chr4	88494288	Missense_Mutation	NA	P801S	0.13
STAD	chr4	88487071	Splice_Region	rs369956338	D618D	0.19
STAD	chr4	88467164	Silent	rs778841083	P339P	0.33
STAD	chr4	88459415	Missense_Mutation	NA	L112I	0.31
STAD	chr4	88469161	Nonsense_Mutation	NA	S380*	0.25
STAD	chr4	88463614	Silent	NA	L257L	0.08
STAD	chr4	88467181	Missense_Mutation	NA	S345L	0.21
STAD	chr4	88494285	Missense_Mutation	NA	M800V	0.31
STAD	chr4	88459373	Missense_Mutation	NA	K98E	0.21
STAD	chr4	88504374	Missense_Mutation	novel	I909V	0.44
STAD	chr4	88504306	Missense_Mutation	novel	R886I	0.46
STAD	chr4	88493097	Missense_Mutation	rs189534383	P740L	0.27
STAD	chr4	88460115	Frame_Shift_Del	rs770854785	I140*	0.38
STAD	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.39
STAD	chr4	88504355	Silent	rs771189296	P902P	0.29
STAD	chr4	88504273	Missense_Mutation	NA	D875G	0.16
TGCT	chr4	88467085	Missense_Mutation	novel	D313G	0.07
THCA	chr4	88470648	In_Frame_Ins	novel	L425_T426insLSVCIL	0.06
UCEC	chr4	88462195	Missense_Mutation	NA	F176C	0.45
UCEC	chr4	88505839	Silent	rs376617022	A1012A	0.27
UCEC	chr4	88463967	Missense_Mutation	novel	T298N	0.43
UCEC	chr4	88472490	Missense_Mutation	novel	W460C	0.44
UCEC	chr4	88504371	Missense_Mutation	novel	V908M	0.4
UCEC	chr4	88486168	Silent	rs774593839	L597L	0.09
UCEC	chr4	88487132	Missense_Mutation	NA	L639M	0.41
UCEC	chr4	88494311	Silent	NA	E808E	0.41
UCEC	chr4	88475973	Missense_Mutation	novel	V509M	0.46
UCEC	chr4	88505971	3'UTR	novel		0.34
UCEC	chr4	88463543	Missense_Mutation	novel	P234T	0.25
UCEC	chr4	88462341	Missense_Mutation	NA	L225M	0.28
UCEC	chr4	88470640	Missense_Mutation	NA	P422H	0.13
UCEC	chr4	88472419	Missense_Mutation	novel	E437K	0.05
UCEC	chr4	88486210	Silent	NA	Y611Y	0.24
UCEC	chr4	88487132	Missense_Mutation	NA	L639M	0.04
UCEC	chr4	88505838	Missense_Mutation	rs752546199	A1012V	0.19
UCEC	chr4	88487086	Silent	NA	V623V	0.36
UCEC	chr4	88504302	Missense_Mutation	NA	R885W	0.28
UCEC	chr4	88504325	Silent	rs201540163	C892C	0.27
UCEC	chr4	88504328	Silent	rs750432822	D893D	0.46
UCEC	chr4	88472419	Nonsense_Mutation	novel	E437*	0.28
UCEC	chr4	88486168	Silent	rs774593839	L597L	0.14
UCEC	chr4	88463875	Silent	rs111923801	F267F	0.44
UCEC	chr4	88504302	Missense_Mutation	NA	R885W	0.38
UCEC	chr4	88459362	Frame_Shift_Ins	novel	*N96Kfs25**	0.44
UCEC	chr4	88487095	Silent	rs111323592	C626C	0.19
UCEC	chr4	88499962	Silent	rs376687144	N827N	0.4
UCEC	chr4	88486183	Frame_Shift_Del	NA	*F604Lfs2**	0.48
UCEC	chr4	88486163	Missense_Mutation	rs369280809	E596K	0.37
UCEC	chr4	88462143	Missense_Mutation	novel	L159I	0.38
UCEC	chr4	88475915	Missense_Mutation	novel	I489M	0.31
UCEC	chr4	88499988	Missense_Mutation	novel	F836C	0.4
UCEC	chr4	88468366	Missense_Mutation	novel	E360K	0.42
UCEC	chr4	88462162	Missense_Mutation	novel	N165S	0.15
UCEC	chr4	88499942	Missense_Mutation	novel	L821M	0.11
UCEC	chr4	88504246	Missense_Mutation	novel	S866Y	0.12
UCEC	chr4	88469183	Silent	novel	T387T	0.29
UCEC	chr4	88487122	Silent	novel	I635I	0.44
UCEC	chr4	88486187	Missense_Mutation	novel	F604V	0.48
UCEC	chr4	88489228	Silent	rs758486816	F675F	0.42
UCEC	chr4	88475890	Missense_Mutation	novel	S481Y	0.44
UCEC	chr4	88468350	Silent	NA	S354S	0.42
UCEC	chr4	88494191	Missense_Mutation	novel	F768L	0.06
UCEC	chr4	88487137	Silent	rs182842130	S640S	0.24
UCEC	chr4	88463970	Missense_Mutation	novel	Q299R	0.35
UCEC	chr4	88494212	Silent	NA	G775G	0.28
UCEC	chr4	88504414	Missense_Mutation	novel	K922R	0.14
UCEC	chr4	88475878	Missense_Mutation	NA	L477R	0.44
UCEC	chr4	88499942	Silent	NA	L821L	0.39
UCEC	chr4	88494184	Missense_Mutation	NA	R766I	0.27
UCEC	chr4	88470626	Missense_Mutation	novel	E417D	0.05
UCEC	chr4	88459415	Missense_Mutation	NA	L112I	0.26
UCEC	chr4	88462247	Silent	novel	L193L	0.1
UCEC	chr4	88472434	Missense_Mutation	novel	Y442H	0.23
UCEC	chr4	88487096	Missense_Mutation	rs148569726	V627I	0.26
UCEC	chr4	88504515	Silent	novel	G929G	0.22
UCEC	chr4	88493065	Missense_Mutation	NA	F729L	0.4
UCEC	chr4	88489228	Silent	rs758486816	F675F	0.24
UCEC	chr4	88504325	Silent	rs201540163	C892C	0.38
UCEC	chr4	88505742	Missense_Mutation	novel	P980H	0.27
UCEC	chr4	88479361	Missense_Mutation	novel	W531R	0.4
UCEC	chr4	88489229	Missense_Mutation	rs376568622	A676T	0.35

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.4216	3.0903e-07
LUAD	DEL	0.188	0.050802
MESO	DEL	0.4023	0.075661

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0026	Kaplan-Meier Survival Analysis
STAD	0.021	Kaplan-Meier Survival Analysis
MESO	0.00027	Kaplan-Meier Survival Analysis
SKCM	0.037	Kaplan-Meier Survival Analysis
PRAD	0.034	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
CESC	0.0065	Kaplan-Meier Survival Analysis
UCEC	0.0001	Kaplan-Meier Survival Analysis
THCA	0.046	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742