EuRBPDB

Description

Ensembl ID: ENSG00000138663 (Gene tree)
Gene ID: 51138
Gene Symbol: COPS4
Alias: CSN4
Full Name: COP9 signalosome subunit 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 41,372 bases
Position: chr4:83,034,447-83,075,818
Accession: 16702
RBP type: non-canonical RBP
Summary: This gene encodes one of eight subunits composing COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000509317	COPS4-207	878	-	ENSP00000425486	275 (aa)	-	D6RD63
ENST00000506443	COPS4-204	578	-	-	- (aa)	-	-
ENST00000504274	COPS4-203	457	-	-	- (aa)	-	-
ENST00000511891	COPS4-211	558	-	-	- (aa)	-	-
ENST00000509093	COPS4-206	2273	-	ENSP00000425976	352 (aa)	-	Q9BT78
ENST00000511653	COPS4-209	1695	-	ENSP00000424655	420 (aa)	-	D6RAX7
ENST00000264389	COPS4-201	1744	-	ENSP00000264389	406 (aa)	-	Q9BT78
ENST00000507376	COPS4-205	438	-	ENSP00000426788	51 (aa)	-	D6REK7
ENST00000510801	COPS4-208	381	-	-	- (aa)	-	-
ENST00000511708	COPS4-210	824	-	-	- (aa)	-	-
ENST00000503682	COPS4-202	1702	-	ENSP00000424791	438 (aa)	-	D6RFN0

Gene Model

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000338	protein deneddylation	19141280.	IDA	Process
GO:0000338	protein deneddylation	21102408.	IMP	Process
GO:0000715	nucleotide-excision repair, DNA damage recognition	-	TAS	Process
GO:0005515	protein binding	16189514.19615732.20195357.21102408.25043011.25416956.25852190.26871637.	IPI	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	Process
GO:0008021	synaptic vesicle	21102408.	IDA	Component
GO:0008180	COP9 signalosome	21873635.	IBA	Component
GO:0008180	COP9 signalosome	18850735.	IDA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0019784	NEDD8-specific protease activity	21873635.	IBA	Function
GO:0019784	NEDD8-specific protease activity	-	TAS	Function
GO:0030054	cell junction	-	IDA	Component
GO:0043687	post-translational protein modification	-	TAS	Process