EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138674 (Gene tree)
Gene ID: 22872
Gene Symbol: SEC31A
Alias: KIAA0905|ABP125|ABP130|SEC31L1
Full Name: SEC31 homolog A, COPII coat complex component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 82,506 bases
Position: chr4:82,818,661-82,901,166
Accession: 17052
RBP type: non-canonical RBP
Summary: The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000507340	SEC31A-221	587	-	ENSP00000422797	68 (aa)	-	D6RAB3
ENST00000513858	SEC31A-237	3687	-	ENSP00000426886	1067 (aa)	-	O94979
ENST00000509142	SEC31A-228	3861	-	ENSP00000426569	1106 (aa)	-	O94979
ENST00000507816	SEC31A-223	546	-	ENSP00000421001	92 (aa)	-	D6RHE8
ENST00000503058	SEC31A-210	706	-	ENSP00000425056	235 (aa)	-	H0Y9T9
ENST00000508502	SEC31A-227	3801	-	ENSP00000424635	1205 (aa)	-	O94979
ENST00000507676	SEC31A-222	551	-	ENSP00000475765	65 (aa)	-	U3KQC9
ENST00000506495	SEC31A-218	541	-	ENSP00000425064	26 (aa)	-	D6REC0
ENST00000355196	SEC31A-204	4104	-	ENSP00000347329	1220 (aa)	-	O94979
ENST00000505479	SEC31A-216	631	-	-	- (aa)	-	-
ENST00000510167	SEC31A-230	857	-	ENSP00000422267	285 (aa)	-	H0Y8V7
ENST00000505472	SEC31A-215	4159	-	ENSP00000421633	1251 (aa)	-	D6REX3
ENST00000515062	SEC31A-240	597	-	ENSP00000426943	181 (aa)	-	H0YAF5
ENST00000348405	SEC31A-203	4012	-	ENSP00000337602	1181 (aa)	-	O94979
ENST00000395310	SEC31A-205	4259	-	ENSP00000378721	1220 (aa)	-	O94979
ENST00000506497	SEC31A-219	926	-	-	- (aa)	-	-
ENST00000505434	SEC31A-214	569	-	ENSP00000425095	66 (aa)	-	D6REA9
ENST00000505984	SEC31A-217	3596	-	ENSP00000424451	1166 (aa)	-	O94979
ENST00000510310	SEC31A-231	584	-	-	- (aa)	-	-
ENST00000514326	SEC31A-238	847	-	ENSP00000425555	166 (aa)	-	D6RCQ9
ENST00000508479	SEC31A-226	3397	-	ENSP00000425999	877 (aa)	-	D6RHZ5
ENST00000503210	SEC31A-211	553	-	ENSP00000422563	81 (aa)	-	D6RBT0
ENST00000514362	SEC31A-239	617	-	-	- (aa)	-	-
ENST00000443462	SEC31A-207	4042	-	ENSP00000408027	1200 (aa)	-	O94979
ENST00000507051	SEC31A-220	458	-	ENSP00000476156	11 (aa)	-	U3KQR3
ENST00000448323	SEC31A-208	4255	-	ENSP00000400926	1220 (aa)	-	O94979
ENST00000311785	SEC31A-202	3909	-	ENSP00000309070	1106 (aa)	-	O94979
ENST00000511975	SEC31A-233	564	-	-	- (aa)	-	-
ENST00000264405	SEC31A-201	3447	-	ENSP00000264405	969 (aa)	-	H7BXG7
ENST00000436790	SEC31A-206	1717	-	-	- (aa)	-	-
ENST00000503226	SEC31A-212	613	-	-	- (aa)	-	-
ENST00000515749	SEC31A-241	829	-	-	- (aa)	-	-
ENST00000500777	SEC31A-209	3610	-	ENSP00000421464	1067 (aa)	-	O94979
ENST00000512732	SEC31A-235	551	-	-	- (aa)	-	-
ENST00000503937	SEC31A-213	1564	-	ENSP00000422371	383 (aa)	-	H0Y8W8
ENST00000513323	SEC31A-236	822	-	ENSP00000426950	164 (aa)	-	D6RE64
ENST00000509691	SEC31A-229	491	-	-	- (aa)	-	-
ENST00000512664	SEC31A-234	710	-	ENSP00000424336	237 (aa)	-	H0Y9K1
ENST00000511338	SEC31A-232	657	-	ENSP00000425140	219 (aa)	-	H0Y9V3
ENST00000507867	SEC31A-225	682	-	-	- (aa)	-	-
ENST00000507828	SEC31A-224	1329	-	ENSP00000426562	443 (aa)	-	H0YAB3

Gene Model

Click here to download ENSG00000138674's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138674	Asthma	3E-6	27611488

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138674	rs10022260	4	82872768	?	Adult asthma	27611488	[0.12-0.3] unit increase	0.212	EFO_0000270
ENSG00000138674	rs57960857	4	82886057	A	Neutrophil percentage of white cells	27863252	[0.014-0.028] unit increase	0.02111551	EFO_0007990
ENSG00000138674	rs4302451	4	82899017	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138674's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138674	SEC31A	100	98.485	ENSMUSG00000035325	Sec31a	100	90.754	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	Process
GO:0005198	structural molecule activity	21873635.	IBA	Function
GO:0005515	protein binding	16957052.17196169.17214967.18256029.20696395.25416956.25667979.27716508.	IPI	Function
GO:0005737	cytoplasm	17196169.	IDA	Component
GO:0005783	endoplasmic reticulum	17196169.	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	10788476.	NAS	Process
GO:0007029	endoplasmic reticulum organization	21873635.	IBA	Process
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0030120	vesicle coat	22792322.	IDA	Component
GO:0030127	COPII vesicle coat	21873635.	IBA	Component
GO:0030127	COPII vesicle coat	17499046.27716508.	IDA	Component
GO:0030127	COPII vesicle coat	10788476.	NAS	Component
GO:0030134	COPII-coated ER to Golgi transport vesicle	22358839.22802641.	IDA	Component
GO:0036498	IRE1-mediated unfolded protein response	-	TAS	Process
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0048306	calcium-dependent protein binding	16957052.17196169.	IPI	Function
GO:0048471	perinuclear region of cytoplasm	17196169.19401338.	IDA	Component
GO:0051592	response to calcium ion	17196169.	IDA	Process
GO:0070971	endoplasmic reticulum exit site	21873635.	IBA	Component
GO:0070971	endoplasmic reticulum exit site	25201882.28442536.	IDA	Component
GO:0070971	endoplasmic reticulum exit site	16957052.	IMP	Component
GO:0090110	cargo loading into COPII-coated vesicle	21873635.	IBA	Process
GO:0090110	cargo loading into COPII-coated vesicle	17499046.18843296.	IDA	Process
GO:0090114	COPII-coated vesicle budding	21873635.	IBA	Process