EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138758 (Gene tree)
Gene ID: 55752
Gene Symbol: SEPT11
Alias: FLJ10849
Full Name: septin 11
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 90,682 bases
Position: chr4:76,949,703-77,040,384
Accession: 25589
RBP type: canonical RBP
Summary: SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking (Hanai et al., 2004 [PubMed 15196925]; Nagata et al., 2004 [PubMed 15485874]).[supplied by OMIM, Jul 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000420839	MMR_HSR1	PF01926.23	1.1e-06	1	1
ENSP00000422047	MMR_HSR1	PF01926.23	1.5e-06	1	1
ENSP00000425262	MMR_HSR1	PF01926.23	2.1e-06	1	1
ENSP00000426344	MMR_HSR1	PF01926.23	4.4e-06	1	1
ENSP00000264893	MMR_HSR1	PF01926.23	4.5e-06	1	1
ENSP00000424925	MMR_HSR1	PF01926.23	4.5e-06	1	1
ENSP00000422896	MMR_HSR1	PF01926.23	4.7e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000515671	SEPT11-216	507	-	-	- (aa)	-	-
ENST00000513697	SEPT11-215	328	-	-	- (aa)	-	-
ENST00000510641	SEPT11-210	1870	-	ENSP00000420839	372 (aa)	-	D6RDU5
ENST00000264893	SEPT11-201	5593	XM_006714259	ENSP00000264893	429 (aa)	XP_006714322	Q9NVA2
ENST00000506731	SEPT11-208	659	-	ENSP00000423103	160 (aa)	-	H0Y961
ENST00000512333	SEPT11-211	579	-	-	- (aa)	-	-
ENST00000512575	SEPT11-212	587	-	-	- (aa)	-	-
ENST00000506047	SEPT11-207	1382	-	-	- (aa)	-	-
ENST00000504460	SEPT11-204	557	-	-	- (aa)	-	-
ENST00000502401	SEPT11-202	276	-	ENSP00000424122	82 (aa)	-	H0Y9G8
ENST00000505788	SEPT11-206	2079	-	ENSP00000424925	432 (aa)	-	D6RER5
ENST00000513373	SEPT11-214	546	-	-	- (aa)	-	-
ENST00000510515	SEPT11-209	1886	XM_017008400	ENSP00000422896	439 (aa)	XP_016863889	Q9NVA2
ENST00000502584	SEPT11-203	2615	XM_017008403	ENSP00000426344	425 (aa)	XP_016863892	D6RGI3
ENST00000504637	SEPT11-205	548	-	ENSP00000425262	126 (aa)	-	D6RDP1
ENST00000512778	SEPT11-213	610	-	ENSP00000422047	136 (aa)	-	D6R9Y6

Gene Model

Click here to download ENSG00000138758's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05100	Bacterial invasion of epithelial cells	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138758	Eating	2E-7	27106561
ENSG00000138758	Mental Health	2E-7	27106561
ENSG00000138758	Waist-Hip Ratio	9E-6	23192594
ENSG00000138758	Eating	9E-6	27106561
ENSG00000138758	Mental Health	9E-6	27106561

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138758	rs1135642	4	77031856	A	Food addiction	27106561	unit increase	0.13	EFO_0007829\|EFO_0007830
ENSG00000138758	rs1135642	4	77031856	A	Food addiction	27106561		1.62	EFO_0007829\|EFO_0007830
ENSG00000138758	rs17002342	4	77034052	T	Waist-to-hip circumference ratio (alcohol intake interaction)	23192594	[0.34-0.88] unit increase	0.61	EFO_0007878\|EFO_0004343
ENSG00000138758	rs11930058	4	76983157	?	Heel bone mineral density	30048462	[0.02-0.031] unit increase	0.0251604	EFO_0009270
ENSG00000138758	rs62302300	4	76988404	C	Heel bone mineral density	30598549	[0.02-0.029] unit increase	0.0244496	EFO_0009270
ENSG00000138758	rs62302300	4	76988404	?	Heel bone mineral density	30595370			EFO_0009270

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138758's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000138758	SEPT11	79	42.857	ENSG00000184640	SEPT9	88	47.027

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138758	SEPT11	96	100.000	ENSAMEG00000013821	SEPT11	98	98.454	Ailuropoda_melanoleuca
ENSG00000138758	SEPT11	99	98.383	ENSAPLG00000010395	SEPT11	99	96.905	Anas_platyrhynchos
ENSG00000138758	SEPT11	99	98.383	ENSACAG00000012255	SEPT11	100	97.203	Anolis_carolinensis
ENSG00000138758	SEPT11	100	100.000	ENSANAG00000029750	SEPT11	100	100.000	Aotus_nancymaae
ENSG00000138758	SEPT11	100	100.000	ENSBTAG00000021372	SEPT11	100	100.000	Bos_taurus
ENSG00000138758	SEPT11	100	100.000	ENSCJAG00000014744	SEPT11	100	100.000	Callithrix_jacchus
ENSG00000138758	SEPT11	99	100.000	ENSCAFG00020011148	SEPT11	99	100.000	Canis_lupus_dingo
ENSG00000138758	SEPT11	100	100.000	ENSCHIG00000021075	SEPT11	100	100.000	Capra_hircus
ENSG00000138758	SEPT11	100	99.537	ENSTSYG00000013404	-	100	99.537	Carlito_syrichta
ENSG00000138758	SEPT11	97	97.436	ENSCAPG00000015684	SEPT11	98	90.780	Cavia_aperea
ENSG00000138758	SEPT11	100	99.301	ENSCPOG00000009037	SEPT11	100	99.301	Cavia_porcellus
ENSG00000138758	SEPT11	100	100.000	ENSCCAG00000022420	SEPT11	100	100.000	Cebus_capucinus
ENSG00000138758	SEPT11	100	100.000	ENSCATG00000027299	SEPT11	100	100.000	Cercocebus_atys
ENSG00000138758	SEPT11	99	99.461	ENSCLAG00000006114	SEPT11	99	99.519	Chinchilla_lanigera
ENSG00000138758	SEPT11	100	100.000	ENSCSAG00000004591	SEPT11	100	100.000	Chlorocebus_sabaeus
ENSG00000138758	SEPT11	99	98.652	ENSCPBG00000019417	SEPT11	100	97.222	Chrysemys_picta_bellii
ENSG00000138758	SEPT11	100	100.000	ENSCANG00000032458	SEPT11	100	100.000	Colobus_angolensis_palliatus
ENSG00000138758	SEPT11	100	99.074	ENSCGRG00001000184	Sept11	100	99.074	Cricetulus_griseus_chok1gshd
ENSG00000138758	SEPT11	100	98.834	ENSCGRG00000002281	Sept11	100	98.834	Cricetulus_griseus_crigri
ENSG00000138758	SEPT11	100	99.769	ENSDNOG00000003551	SEPT11	100	99.769	Dasypus_novemcinctus
ENSG00000138758	SEPT11	100	100.000	ENSDORG00000015527	Sept11	100	100.000	Dipodomys_ordii
ENSG00000138758	SEPT11	96	91.503	ENSETEG00000000950	SEPT11	85	100.000	Echinops_telfairi
ENSG00000138758	SEPT11	99	87.871	ENSEBUG00000003985	SEPT11	87	87.871	Eptatretus_burgeri
ENSG00000138758	SEPT11	100	100.000	ENSEASG00005016442	SEPT11	100	99.306	Equus_asinus_asinus
ENSG00000138758	SEPT11	100	100.000	ENSECAG00000005768	SEPT11	100	99.767	Equus_caballus
ENSG00000138758	SEPT11	100	100.000	ENSFCAG00000027412	SEPT11	100	100.000	Felis_catus
ENSG00000138758	SEPT11	99	98.383	ENSFALG00000008500	SEPT11	94	97.596	Ficedula_albicollis
ENSG00000138758	SEPT11	99	99.461	ENSFDAG00000020305	SEPT11	100	99.527	Fukomys_damarensis
ENSG00000138758	SEPT11	100	97.436	ENSGALG00000011476	SEPT11	97	97.436	Gallus_gallus
ENSG00000138758	SEPT11	99	98.652	ENSGAGG00000025821	SEPT11	100	97.454	Gopherus_agassizii
ENSG00000138758	SEPT11	100	100.000	ENSGGOG00000015115	SEPT11	100	100.000	Gorilla_gorilla
ENSG00000138758	SEPT11	100	99.534	ENSHGLG00000015983	SEPT11	100	99.534	Heterocephalus_glaber_female
ENSG00000138758	SEPT11	99	99.461	ENSHGLG00100018878	SEPT11	98	99.518	Heterocephalus_glaber_male
ENSG00000138758	SEPT11	100	99.537	ENSSTOG00000008117	SEPT11	100	99.537	Ictidomys_tridecemlineatus
ENSG00000138758	SEPT11	100	100.000	ENSJJAG00000007698	Sept11	100	100.000	Jaculus_jaculus
ENSG00000138758	SEPT11	98	95.868	ENSLACG00000006461	SEPT11	93	94.574	Latimeria_chalumnae
ENSG00000138758	SEPT11	100	99.769	ENSLAFG00000016488	SEPT11	100	99.769	Loxodonta_africana
ENSG00000138758	SEPT11	100	100.000	ENSMFAG00000042066	SEPT11	100	100.000	Macaca_fascicularis
ENSG00000138758	SEPT11	100	100.000	ENSMMUG00000019901	SEPT11	100	100.000	Macaca_mulatta
ENSG00000138758	SEPT11	100	100.000	ENSMNEG00000044831	SEPT11	100	100.000	Macaca_nemestrina
ENSG00000138758	SEPT11	100	100.000	ENSMLEG00000041438	SEPT11	100	100.000	Mandrillus_leucophaeus
ENSG00000138758	SEPT11	99	98.113	ENSMGAG00000009422	SEPT11	98	96.675	Meleagris_gallopavo
ENSG00000138758	SEPT11	100	99.301	ENSMAUG00000008193	Sept11	100	99.301	Mesocricetus_auratus
ENSG00000138758	SEPT11	100	96.759	ENSMICG00000033844	SEPT11	100	96.759	Microcebus_murinus
ENSG00000138758	SEPT11	100	99.767	ENSMOCG00000014932	Sept11	100	99.767	Microtus_ochrogaster
ENSG00000138758	SEPT11	100	98.368	ENSMODG00000011825	SEPT11	100	98.368	Monodelphis_domestica
ENSG00000138758	SEPT11	100	99.769	MGP_CAROLIEiJ_G0027424	Sept11	100	99.769	Mus_caroli
ENSG00000138758	SEPT11	100	99.769	ENSMUSG00000058013	Sept11	100	99.769	Mus_musculus
ENSG00000138758	SEPT11	100	99.529	MGP_PahariEiJ_G0017202	Sept11	100	99.529	Mus_pahari
ENSG00000138758	SEPT11	100	99.769	MGP_SPRETEiJ_G0028421	Sept11	100	99.769	Mus_spretus
ENSG00000138758	SEPT11	99	97.574	ENSMPUG00000008207	SEPT11	98	96.927	Mustela_putorius_furo
ENSG00000138758	SEPT11	88	99.160	ENSMLUG00000024451	-	97	99.103	Myotis_lucifugus
ENSG00000138758	SEPT11	100	99.306	ENSNGAG00000000462	Sept11	100	99.306	Nannospalax_galili
ENSG00000138758	SEPT11	100	100.000	ENSNLEG00000032040	SEPT11	100	100.000	Nomascus_leucogenys
ENSG00000138758	SEPT11	96	96.732	ENSMEUG00000013950	-	100	87.413	Notamacropus_eugenii
ENSG00000138758	SEPT11	96	99.346	ENSOPRG00000000156	SEPT11	80	100.000	Ochotona_princeps
ENSG00000138758	SEPT11	100	99.074	ENSODEG00000000877	SEPT11	100	99.074	Octodon_degus
ENSG00000138758	SEPT11	99	96.765	ENSOANG00000013643	SEPT11	99	91.784	Ornithorhynchus_anatinus
ENSG00000138758	SEPT11	99	99.730	ENSOCUG00000001289	SEPT11	90	99.294	Oryctolagus_cuniculus
ENSG00000138758	SEPT11	99	99.461	ENSOGAG00000005210	SEPT11	100	98.605	Otolemur_garnettii
ENSG00000138758	SEPT11	99	100.000	ENSOARG00000017493	SEPT11	97	97.248	Ovis_aries
ENSG00000138758	SEPT11	100	100.000	ENSPPAG00000041700	SEPT11	100	100.000	Pan_paniscus
ENSG00000138758	SEPT11	100	100.000	ENSPPRG00000007487	SEPT11	100	100.000	Panthera_pardus
ENSG00000138758	SEPT11	100	100.000	ENSPTIG00000017796	SEPT11	100	100.000	Panthera_tigris_altaica
ENSG00000138758	SEPT11	100	100.000	ENSPTRG00000016192	SEPT11	100	100.000	Pan_troglodytes
ENSG00000138758	SEPT11	100	100.000	ENSPANG00000021634	SEPT11	100	100.000	Papio_anubis
ENSG00000138758	SEPT11	99	98.652	ENSPSIG00000017552	SEPT11	99	95.571	Pelodiscus_sinensis
ENSG00000138758	SEPT11	100	99.769	ENSPEMG00000016338	Sept11	100	99.769	Peromyscus_maniculatus_bairdii
ENSG00000138758	SEPT11	100	99.068	ENSPCIG00000028014	SEPT11	100	99.068	Phascolarctos_cinereus
ENSG00000138758	SEPT11	100	100.000	ENSPPYG00000014864	SEPT11	98	100.000	Pongo_abelii
ENSG00000138758	SEPT11	99	97.531	ENSPCAG00000004069	SEPT11	85	100.000	Procavia_capensis
ENSG00000138758	SEPT11	100	99.306	ENSPCOG00000014774	SEPT11	100	99.306	Propithecus_coquereli
ENSG00000138758	SEPT11	100	99.769	ENSRNOG00000002182	Sept11	100	99.769	Rattus_norvegicus
ENSG00000138758	SEPT11	100	100.000	ENSRBIG00000024343	SEPT11	100	100.000	Rhinopithecus_bieti
ENSG00000138758	SEPT11	100	100.000	ENSRROG00000038768	SEPT11	100	100.000	Rhinopithecus_roxellana
ENSG00000138758	SEPT11	100	100.000	ENSSBOG00000020488	SEPT11	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000138758	SEPT11	100	99.068	ENSSHAG00000006125	SEPT11	100	99.068	Sarcophilus_harrisii
ENSG00000138758	SEPT11	99	98.652	ENSSPUG00000006377	SEPT11	99	96.897	Sphenodon_punctatus
ENSG00000138758	SEPT11	100	99.769	ENSSSCG00000008986	SEPT11	100	99.769	Sus_scrofa
ENSG00000138758	SEPT11	60	96.341	ENSTGUG00000014234	-	100	94.819	Taeniopygia_guttata
ENSG00000138758	SEPT11	99	96.185	ENSTGUG00000001707	-	83	96.114	Taeniopygia_guttata
ENSG00000138758	SEPT11	99	96.296	ENSTBEG00000012851	SEPT11	79	99.545	Tupaia_belangeri
ENSG00000138758	SEPT11	99	97.531	ENSTTRG00000014833	SEPT11	85	100.000	Tursiops_truncatus
ENSG00000138758	SEPT11	100	100.000	ENSUAMG00000017287	SEPT11	100	100.000	Ursus_americanus
ENSG00000138758	SEPT11	99	100.000	ENSUMAG00000007904	SEPT11	95	98.824	Ursus_maritimus
ENSG00000138758	SEPT11	99	100.000	ENSVVUG00000023346	SEPT11	99	100.000	Vulpes_vulpes
ENSG00000138758	SEPT11	100	93.039	ENSXETG00000006404	sept11	100	93.039	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001725	stress fiber	15485874.	IDA	Component
GO:0003924	GTPase activity	21873635.	IBA	Function
GO:0005515	protein binding	15485874.16767699.18330356.18443421.	IPI	Function
GO:0005525	GTP binding	-	IEA	Function
GO:0005940	septin ring	21873635.	IBA	Component
GO:0015630	microtubule cytoskeleton	21873635.	IBA	Component
GO:0030054	cell junction	-	IEA	Component
GO:0030424	axon	-	IEA	Component
GO:0031105	septin complex	21873635.	IBA	Component
GO:0031105	septin complex	-	ISS	Component
GO:0043197	dendritic spine	-	IEA	Component
GO:0050807	regulation of synapse organization	-	IEA	Process
GO:0051291	protein heterooligomerization	15485874.	IDA	Process
GO:0060090	molecular adaptor activity	21873635.	IBA	Function
GO:0061640	cytoskeleton-dependent cytokinesis	21873635.	IBA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component
GO:0098982	GABA-ergic synapse	-	IEA	Component
GO:0099629	postsynaptic specialization of symmetric synapse	-	IEA	Component