EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000138767 (Gene tree)
Gene ID: 246175
Gene Symbol: CNOT6L
Alias: DKFZp434K098|Ccr4b
Full Name: CCR4-NOT transcription complex subunit 6 like
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 106,852 bases
Position: chr4:77,713,387-77,820,238
Accession: 18042
RBP type: canonical RBP
Summary: (CCR4-NOT Transcription Complex Subunit 6 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Cycle Genes. Gene Ontology (GO) annotations related to this gene include poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000425571	Exo_endo_phos	PF03372.23	2.5e-21	1	1
ENSP00000497467	Exo_endo_phos	PF03372.23	2.5e-21	1	1
ENSP00000424896	Exo_endo_phos	PF03372.23	2.6e-21	1	1
ENSP00000423750	Exo_endo_phos	PF03372.23	5.2e-13	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30478191	CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte.	EMBO J	2018 Dec 14	Sha QQ	doi: 10.15252/embj.201899333
20628353	Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.	EMBO J	2010 Aug 4	Wang H	doi: 10.1038/emboj.2010.152

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512485	CNOT6L-206	1890	XM_011531810	ENSP00000425571	550 (aa)	XP_011530112	H0Y9Z5
ENST00000508371	CNOT6L-205	700	-	-	- (aa)	-	-
ENST00000504123	CNOT6L-201	8865	XM_011531808	ENSP00000424896	555 (aa)	XP_011530110	Q96LI5
ENST00000505983	CNOT6L-203	781	-	-	- (aa)	-	-
ENST00000649644	CNOT6L-209	8843	XM_011531806	ENSP00000497467	550 (aa)	XP_011530108	UPI0000D9B0B3
ENST00000515506	CNOT6L-208	4024	-	ENSP00000423750	435 (aa)	-	H0Y9C1
ENST00000515441	CNOT6L-207	572	-	ENSP00000426269	158 (aa)	-	D6RGK9
ENST00000504804	CNOT6L-202	1925	-	ENSP00000425836	41 (aa)	-	D6RIW9
ENST00000506166	CNOT6L-204	781	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000138767's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03018	RNA degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138767	Cholesterol	1.23278258205857E-6	17903299
ENSG00000138767	Cholesterol	9.33655690071318E-6	17903299
ENSG00000138767	Cholesterol, LDL	9.78311823159541E-6	17903299
ENSG00000138767	Cholesterol	5.81042032961757E-6	17903299

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138767's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000138767	CNOT6L	100	87.975	ENSG00000113300	CNOT6	100	89.474

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138767	CNOT6L	100	91.139	ENSAPOG00000005894	cnot6l	100	84.505	Acanthochromis_polyacanthus
ENSG00000138767	CNOT6L	100	100.000	ENSAMEG00000005570	CNOT6L	99	99.639	Ailuropoda_melanoleuca
ENSG00000138767	CNOT6L	100	92.405	ENSACIG00000002515	cnot6l	100	85.045	Amphilophus_citrinellus
ENSG00000138767	CNOT6L	99	81.651	ENSAOCG00000006705	cnot6l	100	80.901	Amphiprion_ocellaris
ENSG00000138767	CNOT6L	100	91.139	ENSAPEG00000020035	cnot6l	100	81.736	Amphiprion_percula
ENSG00000138767	CNOT6L	100	92.405	ENSATEG00000008774	cnot6l	100	85.225	Anabas_testudineus
ENSG00000138767	CNOT6L	100	97.468	ENSAPLG00000003448	CNOT6L	100	95.863	Anas_platyrhynchos
ENSG00000138767	CNOT6L	100	96.203	ENSACAG00000012099	CNOT6L	99	94.353	Anolis_carolinensis
ENSG00000138767	CNOT6L	100	100.000	ENSANAG00000023917	CNOT6L	100	100.000	Aotus_nancymaae
ENSG00000138767	CNOT6L	100	90.506	ENSACLG00000000879	cnot6l	100	83.243	Astatotilapia_calliptera
ENSG00000138767	CNOT6L	100	89.241	ENSAMXG00000008943	cnot6l	98	82.790	Astyanax_mexicanus
ENSG00000138767	CNOT6L	100	100.000	ENSBTAG00000049571	CNOT6L	100	100.000	Bos_taurus
ENSG00000138767	CNOT6L	100	100.000	ENSCJAG00000014846	CNOT6L	100	99.820	Callithrix_jacchus
ENSG00000138767	CNOT6L	100	100.000	ENSCAFG00000008699	CNOT6L	99	99.819	Canis_familiaris
ENSG00000138767	CNOT6L	100	100.000	ENSCAFG00020011108	CNOT6L	100	98.364	Canis_lupus_dingo
ENSG00000138767	CNOT6L	100	100.000	ENSCHIG00000006297	CNOT6L	100	100.000	Capra_hircus
ENSG00000138767	CNOT6L	100	100.000	ENSTSYG00000009068	CNOT6L	100	100.000	Carlito_syrichta
ENSG00000138767	CNOT6L	90	100.000	ENSCPOG00000010337	CNOT6L	100	100.000	Cavia_porcellus
ENSG00000138767	CNOT6L	100	100.000	ENSCCAG00000025000	CNOT6L	100	100.000	Cebus_capucinus
ENSG00000138767	CNOT6L	100	100.000	ENSCATG00000029623	CNOT6L	100	100.000	Cercocebus_atys
ENSG00000138767	CNOT6L	100	99.091	ENSCLAG00000004598	CNOT6L	100	99.096	Chinchilla_lanigera
ENSG00000138767	CNOT6L	100	100.000	ENSCSAG00000004580	CNOT6L	100	100.000	Chlorocebus_sabaeus
ENSG00000138767	CNOT6L	90	100.000	ENSCHOG00000001108	-	70	100.000	Choloepus_hoffmanni
ENSG00000138767	CNOT6L	100	96.835	ENSCPBG00000019403	CNOT6L	100	96.727	Chrysemys_picta_bellii
ENSG00000138767	CNOT6L	100	100.000	ENSCANG00000028583	CNOT6L	100	100.000	Colobus_angolensis_palliatus
ENSG00000138767	CNOT6L	100	98.018	ENSCGRG00001022099	Cnot6l	100	98.018	Cricetulus_griseus_chok1gshd
ENSG00000138767	CNOT6L	100	97.273	ENSCGRG00000000543	Cnot6l	100	97.273	Cricetulus_griseus_crigri
ENSG00000138767	CNOT6L	100	87.342	ENSCSEG00000010395	-	98	82.339	Cynoglossus_semilaevis
ENSG00000138767	CNOT6L	100	87.975	ENSCSEG00000014001	cnot6l	100	81.982	Cynoglossus_semilaevis
ENSG00000138767	CNOT6L	100	91.772	ENSCVAG00000021683	cnot6l	96	85.124	Cyprinodon_variegatus
ENSG00000138767	CNOT6L	100	89.873	ENSDARG00000054597	cnot6l	98	83.424	Danio_rerio
ENSG00000138767	CNOT6L	100	98.750	ENSDNOG00000004229	CNOT6L	99	99.065	Dasypus_novemcinctus
ENSG00000138767	CNOT6L	90	100.000	ENSDORG00000011458	Cnot6l	100	89.455	Dipodomys_ordii
ENSG00000138767	CNOT6L	100	79.747	ENSEBUG00000004849	cnot6l	100	70.515	Eptatretus_burgeri
ENSG00000138767	CNOT6L	100	100.000	ENSEASG00005016429	CNOT6L	92	100.000	Equus_asinus_asinus
ENSG00000138767	CNOT6L	100	100.000	ENSECAG00000001582	CNOT6L	88	100.000	Equus_caballus
ENSG00000138767	CNOT6L	100	90.506	ENSELUG00000013353	cnot6l	88	83.032	Esox_lucius
ENSG00000138767	CNOT6L	100	100.000	ENSFCAG00000008322	CNOT6L	100	99.820	Felis_catus
ENSG00000138767	CNOT6L	100	97.468	ENSFALG00000008515	CNOT6L	100	95.676	Ficedula_albicollis
ENSG00000138767	CNOT6L	100	99.091	ENSFDAG00000007719	CNOT6L	95	99.097	Fukomys_damarensis
ENSG00000138767	CNOT6L	100	92.405	ENSFHEG00000012364	cnot6l	100	77.020	Fundulus_heteroclitus
ENSG00000138767	CNOT6L	100	83.544	ENSGMOG00000000730	cnot6l	100	73.196	Gadus_morhua
ENSG00000138767	CNOT6L	96	62.381	ENSGMOG00000011077	-	99	62.055	Gadus_morhua
ENSG00000138767	CNOT6L	100	97.468	ENSGALG00000010333	CNOT6L	91	96.203	Gallus_gallus
ENSG00000138767	CNOT6L	100	91.139	ENSGAFG00000006105	cnot6l	98	84.962	Gambusia_affinis
ENSG00000138767	CNOT6L	99	96.083	ENSGAGG00000008605	CNOT6L	93	95.833	Gopherus_agassizii
ENSG00000138767	CNOT6L	100	100.000	ENSGGOG00000023412	CNOT6L	99	100.000	Gorilla_gorilla
ENSG00000138767	CNOT6L	100	90.506	ENSHBUG00000004755	cnot6l	95	84.855	Haplochromis_burtoni
ENSG00000138767	CNOT6L	100	99.273	ENSHGLG00000006452	CNOT6L	100	99.273	Heterocephalus_glaber_female
ENSG00000138767	CNOT6L	100	99.273	ENSHGLG00100012384	CNOT6L	98	99.273	Heterocephalus_glaber_male
ENSG00000138767	CNOT6L	100	89.241	ENSHCOG00000009512	cnot6l	94	76.525	Hippocampus_comes
ENSG00000138767	CNOT6L	100	87.342	ENSIPUG00000009879	cnot6l	100	82.246	Ictalurus_punctatus
ENSG00000138767	CNOT6L	100	99.818	ENSSTOG00000015293	CNOT6L	100	99.818	Ictidomys_tridecemlineatus
ENSG00000138767	CNOT6L	100	98.909	ENSJJAG00000020583	Cnot6l	100	98.915	Jaculus_jaculus
ENSG00000138767	CNOT6L	100	88.608	ENSKMAG00000004165	cnot6l	100	83.063	Kryptolebias_marmoratus
ENSG00000138767	CNOT6L	100	91.139	ENSLBEG00000027202	cnot6l	100	82.098	Labrus_bergylta
ENSG00000138767	CNOT6L	100	95.570	ENSLACG00000004684	CNOT6L	100	90.909	Latimeria_chalumnae
ENSG00000138767	CNOT6L	100	89.241	ENSLOCG00000007420	cnot6l	93	84.324	Lepisosteus_oculatus
ENSG00000138767	CNOT6L	100	100.000	ENSLAFG00000011449	CNOT6L	100	97.865	Loxodonta_africana
ENSG00000138767	CNOT6L	100	100.000	ENSMFAG00000044296	CNOT6L	100	100.000	Macaca_fascicularis
ENSG00000138767	CNOT6L	100	100.000	ENSMMUG00000045609	CNOT6L	99	100.000	Macaca_mulatta
ENSG00000138767	CNOT6L	100	100.000	ENSMNEG00000041259	CNOT6L	100	100.000	Macaca_nemestrina
ENSG00000138767	CNOT6L	100	100.000	ENSMLEG00000029198	CNOT6L	99	100.000	Mandrillus_leucophaeus
ENSG00000138767	CNOT6L	100	93.038	ENSMAMG00000016954	cnot6l	94	86.654	Mastacembelus_armatus
ENSG00000138767	CNOT6L	100	90.506	ENSMZEG00005020235	cnot6l	100	83.243	Maylandia_zebra
ENSG00000138767	CNOT6L	100	97.468	ENSMGAG00000005144	CNOT6L	100	96.036	Meleagris_gallopavo
ENSG00000138767	CNOT6L	100	99.459	ENSMICG00000017026	CNOT6L	100	99.459	Microcebus_murinus
ENSG00000138767	CNOT6L	100	98.018	ENSMOCG00000009451	Cnot6l	100	98.018	Microtus_ochrogaster
ENSG00000138767	CNOT6L	100	92.405	ENSMMOG00000014621	cnot6l	100	84.324	Mola_mola
ENSG00000138767	CNOT6L	100	98.000	ENSMODG00000011744	CNOT6L	75	98.000	Monodelphis_domestica
ENSG00000138767	CNOT6L	100	92.405	ENSMALG00000006354	cnot6l	96	86.090	Monopterus_albus
ENSG00000138767	CNOT6L	100	98.018	MGP_CAROLIEiJ_G0027429	Cnot6l	100	98.018	Mus_caroli
ENSG00000138767	CNOT6L	100	98.018	ENSMUSG00000034724	Cnot6l	100	98.018	Mus_musculus
ENSG00000138767	CNOT6L	100	98.018	MGP_PahariEiJ_G0017207	Cnot6l	100	98.018	Mus_pahari
ENSG00000138767	CNOT6L	100	98.018	MGP_SPRETEiJ_G0028426	Cnot6l	100	98.018	Mus_spretus
ENSG00000138767	CNOT6L	95	95.038	ENSMPUG00000003895	CNOT6L	100	95.038	Mustela_putorius_furo
ENSG00000138767	CNOT6L	93	99.027	ENSMLUG00000000936	CNOT6L	100	99.027	Myotis_lucifugus
ENSG00000138767	CNOT6L	100	97.658	ENSNGAG00000019803	Cnot6l	100	97.658	Nannospalax_galili
ENSG00000138767	CNOT6L	87	83.421	ENSNBRG00000016345	cnot6l	80	80.723	Neolamprologus_brichardi
ENSG00000138767	CNOT6L	100	100.000	ENSNLEG00000028820	CNOT6L	100	100.000	Nomascus_leucogenys
ENSG00000138767	CNOT6L	80	84.580	ENSMEUG00000009767	-	77	84.475	Notamacropus_eugenii
ENSG00000138767	CNOT6L	100	99.273	ENSODEG00000004161	CNOT6L	99	99.278	Octodon_degus
ENSG00000138767	CNOT6L	100	90.506	ENSONIG00000013992	cnot6l	97	83.036	Oreochromis_niloticus
ENSG00000138767	CNOT6L	100	99.367	ENSOANG00000003561	CNOT6L	100	98.364	Ornithorhynchus_anatinus
ENSG00000138767	CNOT6L	100	100.000	ENSOCUG00000002497	CNOT6L	100	99.820	Oryctolagus_cuniculus
ENSG00000138767	CNOT6L	100	89.873	ENSORLG00000018874	cnot6l	100	81.917	Oryzias_latipes
ENSG00000138767	CNOT6L	100	90.506	ENSOMEG00000010026	cnot6l	100	82.162	Oryzias_melastigma
ENSG00000138767	CNOT6L	100	96.036	ENSOGAG00000012122	CNOT6L	100	95.315	Otolemur_garnettii
ENSG00000138767	CNOT6L	100	100.000	ENSOARG00000017771	CNOT6L	100	100.000	Ovis_aries
ENSG00000138767	CNOT6L	90	100.000	ENSPPAG00000034242	-	99	100.000	Pan_paniscus
ENSG00000138767	CNOT6L	100	97.091	ENSPPAG00000030178	-	100	97.091	Pan_paniscus
ENSG00000138767	CNOT6L	100	100.000	ENSPPRG00000008857	CNOT6L	100	99.820	Panthera_pardus
ENSG00000138767	CNOT6L	100	100.000	ENSPTIG00000015698	CNOT6L	100	99.820	Panthera_tigris_altaica
ENSG00000138767	CNOT6L	100	100.000	ENSPTRG00000016198	CNOT6L	100	100.000	Pan_troglodytes
ENSG00000138767	CNOT6L	90	100.000	ENSPTRG00000045291	-	99	100.000	Pan_troglodytes
ENSG00000138767	CNOT6L	100	100.000	ENSPANG00000007831	CNOT6L	100	100.000	Papio_anubis
ENSG00000138767	CNOT6L	100	91.139	ENSPKIG00000002892	cnot6l	100	84.601	Paramormyrops_kingsleyae
ENSG00000138767	CNOT6L	100	95.636	ENSPSIG00000016241	CNOT6L	100	95.315	Pelodiscus_sinensis
ENSG00000138767	CNOT6L	100	86.076	ENSPMGG00000004021	cnot6l	99	80.109	Periophthalmus_magnuspinnatus
ENSG00000138767	CNOT6L	100	98.000	ENSPEMG00000011554	Cnot6l	100	98.000	Peromyscus_maniculatus_bairdii
ENSG00000138767	CNOT6L	100	81.013	ENSPMAG00000005706	cnot6l	96	72.978	Petromyzon_marinus
ENSG00000138767	CNOT6L	100	96.909	ENSPCIG00000027504	-	100	96.909	Phascolarctos_cinereus
ENSG00000138767	CNOT6L	100	91.772	ENSPFOG00000013163	cnot6l	100	84.324	Poecilia_formosa
ENSG00000138767	CNOT6L	100	91.772	ENSPLAG00000019862	cnot6l	100	84.144	Poecilia_latipinna
ENSG00000138767	CNOT6L	100	91.772	ENSPMEG00000015834	cnot6l	100	84.144	Poecilia_mexicana
ENSG00000138767	CNOT6L	100	91.772	ENSPREG00000003561	cnot6l	100	84.324	Poecilia_reticulata
ENSG00000138767	CNOT6L	100	100.000	ENSPPYG00000014869	CNOT6L	100	100.000	Pongo_abelii
ENSG00000138767	CNOT6L	90	100.000	ENSPCAG00000016617	CNOT6L	82	100.000	Procavia_capensis
ENSG00000138767	CNOT6L	100	100.000	ENSPCOG00000014669	CNOT6L	100	100.000	Propithecus_coquereli
ENSG00000138767	CNOT6L	90	97.297	ENSPVAG00000002690	CNOT6L	79	99.525	Pteropus_vampyrus
ENSG00000138767	CNOT6L	89	83.204	ENSPNYG00000006717	cnot6l	92	81.225	Pundamilia_nyererei
ENSG00000138767	CNOT6L	100	89.241	ENSPNAG00000003537	cnot6l	98	83.333	Pygocentrus_nattereri
ENSG00000138767	CNOT6L	100	98.000	ENSRNOG00000002075	Cnot6l	100	98.000	Rattus_norvegicus
ENSG00000138767	CNOT6L	100	99.636	ENSRBIG00000027644	CNOT6L	100	99.638	Rhinopithecus_bieti
ENSG00000138767	CNOT6L	100	100.000	ENSRROG00000031003	CNOT6L	100	99.818	Rhinopithecus_roxellana
ENSG00000138767	CNOT6L	100	100.000	ENSSBOG00000028521	CNOT6L	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000138767	CNOT6L	100	98.000	ENSSHAG00000006072	CNOT6L	100	97.658	Sarcophilus_harrisii
ENSG00000138767	CNOT6L	100	91.139	ENSSFOG00015019044	cnot6l	100	83.877	Scleropages_formosus
ENSG00000138767	CNOT6L	100	91.139	ENSSMAG00000015568	cnot6l	100	82.342	Scophthalmus_maximus
ENSG00000138767	CNOT6L	100	93.038	ENSSDUG00000018426	cnot6l	100	85.225	Seriola_dumerili
ENSG00000138767	CNOT6L	100	92.405	ENSSLDG00000000335	cnot6l	100	85.045	Seriola_lalandi_dorsalis
ENSG00000138767	CNOT6L	100	98.101	ENSSPUG00000002016	CNOT6L	100	96.182	Sphenodon_punctatus
ENSG00000138767	CNOT6L	100	92.405	ENSSPAG00000022932	cnot6l	100	85.045	Stegastes_partitus
ENSG00000138767	CNOT6L	100	100.000	ENSSSCG00000008989	CNOT6L	100	99.820	Sus_scrofa
ENSG00000138767	CNOT6L	100	97.468	ENSTGUG00000001737	-	100	96.036	Taeniopygia_guttata
ENSG00000138767	CNOT6L	100	89.873	ENSTRUG00000004332	cnot6l	100	83.604	Takifugu_rubripes
ENSG00000138767	CNOT6L	100	89.241	ENSTNIG00000016717	cnot6l	100	82.523	Tetraodon_nigroviridis
ENSG00000138767	CNOT6L	99	93.779	ENSTBEG00000016519	CNOT6L	97	94.410	Tupaia_belangeri
ENSG00000138767	CNOT6L	100	100.000	ENSTTRG00000005606	CNOT6L	100	99.379	Tursiops_truncatus
ENSG00000138767	CNOT6L	100	100.000	ENSUAMG00000026982	CNOT6L	100	99.636	Ursus_americanus
ENSG00000138767	CNOT6L	100	100.000	ENSUMAG00000007955	CNOT6L	100	99.640	Ursus_maritimus
ENSG00000138767	CNOT6L	100	100.000	ENSVPAG00000010892	CNOT6L	100	95.298	Vicugna_pacos
ENSG00000138767	CNOT6L	100	100.000	ENSVVUG00000024858	CNOT6L	100	99.820	Vulpes_vulpes
ENSG00000138767	CNOT6L	100	91.139	ENSXETG00000000372	cnot6l	100	90.235	Xenopus_tropicalis
ENSG00000138767	CNOT6L	100	89.873	ENSXMAG00000002900	cnot6l	100	83.784	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	-	TAS	Process
GO:0004535	poly(A)-specific ribonuclease activity	-	TAS	Function
GO:0005515	protein binding	17452450.18377426.21981923.21984185.22977175.26496610.	IPI	Function
GO:0005634	nucleus	21233283.	IDA	Component
GO:0005737	cytoplasm	21233283.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-	TAS	Process
GO:0008284	positive regulation of cell proliferation	21233283.	IMP	Process
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly	21233283.	IMP	Process
GO:0030014	CCR4-NOT complex	19558367.	IDA	Component
GO:0031047	gene silencing by RNA	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0061157	mRNA destabilization	-	IEA	Process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	-	IEA	Process