EuRBPDB

Description

Ensembl ID: ENSG00000138768 (Gene tree)
Gene ID: 8615
Gene Symbol: USO1
Alias: TAP|VDP|p115
Full Name: USO1 vesicle transport factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 89,768 bases
Position: chr4:75,724,522-75,814,289
Accession: 30904
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28878750	Identification of the Tolfenamic Acid Binding Pocket in PrbP from Liberibacter asiaticus.	Front Microbiol	2017 Aug 23	Pan L	doi: 10.3389/fmicb.2017.01591

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512893	USO1-203	577	-	-	- (aa)	-	-
ENST00000264904	USO1-201	4135	XM_006714396	ENSP00000264904	973 (aa)	XP_006714459	O60763
ENST00000514213	USO1-204	4034	-	ENSP00000444850	962 (aa)	-	O60763
ENST00000508454	USO1-202	365	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138768	Carotid Artery Diseases	1.42840357348611E-6	17903303
ENSG00000138768	Carotid Artery Diseases	1.05783877865331E-5	17903303
ENSG00000138768	Carotid Artery Diseases	1.5532367385506E-5	17903303
ENSG00000138768	Carotid Artery Diseases	6.33424836662398E-5	17903303
ENSG00000138768	Atrial Fibrillation	4.04314880344536E-5	17903304
ENSG00000138768	Atrial Fibrillation	9.98319329472697E-5	17903304
ENSG00000138768	Osteoporosis	3.25287542284823E-5	17903295
ENSG00000138768	Osteoporosis	7.58969308047863E-5	17903295
ENSG00000138768	Anatomy	6.1637457E-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138768	USO1	97	93.148	ENSMUSG00000029407	Uso1	98	93.184	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	TAS	Component
GO:0001650	fibrillar center	-	IDA	Component
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005794	Golgi apparatus	-	IDA	Component
GO:0005795	Golgi stack	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	21873635.	IBA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	ISS	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0007030	Golgi organization	-	IEA	Process
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0012507	ER to Golgi transport vesicle membrane	21873635.	IBA	Component
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0030133	transport vesicle	-	TAS	Component
GO:0045056	transcytosis	21873635.	IBA	Process
GO:0045296	cadherin binding	25468996.	HDA	Function
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0048211	Golgi vesicle docking	21873635.	IBA	Process
GO:0048280	vesicle fusion with Golgi apparatus	-	IEA	Process
GO:0048471	perinuclear region of cytoplasm	-	IEA	Component
GO:0061025	membrane fusion	21873635.	IBA	Process