EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000138772 (Gene tree)
Gene ID: 306
Gene Symbol: ANXA3
Alias: ANX3
Full Name: annexin A3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 58,933 bases
Position: chr4:78,551,519-78,610,451
Accession: 541
RBP type: non-canonical RBP
Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
9687075	Characterization of a cDNA encoding a novel plant poly(A) polymerase.	Plant Mol Biol	1998 Jul	Das Gupta J	-
8702692	A plant poly(A) polymerase requires a novel RNA-binding protein for activity.	J Biol Chem	1996 Aug 16	Li QS	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512542	ANXA3-208	307	-	ENSP00000426591	55 (aa)	-	D6RFJ9
ENST00000512373	ANXA3-207	545	-	ENSP00000424584	104 (aa)	-	D6RAZ8
ENST00000514171	ANXA3-210	880	-	ENSP00000421512	154 (aa)	-	D6RFG5
ENST00000508214	ANXA3-205	567	-	ENSP00000422281	134 (aa)	-	D6RCA8
ENST00000510502	ANXA3-206	571	-	-	- (aa)	-	-
ENST00000505805	ANXA3-204	832	-	-	- (aa)	-	-
ENST00000512884	ANXA3-209	1335	-	ENSP00000423068	284 (aa)	-	D6RA82
ENST00000503776	ANXA3-203	2932	-	-	- (aa)	-	-
ENST00000503570	ANXA3-202	1524	-	ENSP00000421015	284 (aa)	-	D6RA82
ENST00000264908	ANXA3-201	1657	-	ENSP00000264908	323 (aa)	-	P12429

Gene Model

Click here to download ENSG00000138772's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138772	Amyotrophic lateral sclerosis 1	5E-6	24529757
ENSG00000138772	Arthritis, Rheumatoid	1E-12	22446963

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138772	rs7679218	4	78585710	?	Amyotrophic lateral sclerosis (sporadic)	24529757			EFO_0001357
ENSG00000138772	rs11335718	4	78607389	A	Osteoarthritis (self-reported)	29559693	[1.07172-1.16949]	1.11954	EFO_0002506
ENSG00000138772	rs2867461	4	78592061	A	Rheumatoid arthritis	22446963	[1.09-1.17]	1.13	EFO_0000685
ENSG00000138772	rs10028001	4	78581818	A	Rheumatoid arthritis	30423114	[0.064-0.164] unit decrease	0.11386	EFO_0000685

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000138772's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005509	calcium ion binding	-	IEA	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005544	calcium-dependent phospholipid binding	2138016.2138632.	IDA	Function
GO:0005737	cytoplasm	17205602.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	7526843.	IDA	Component
GO:0006909	phagocytosis	21873635.	IBA	Process
GO:0006909	phagocytosis	9497492.	IDA	Process
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	21873635.	IBA	Process
GO:0010595	positive regulation of endothelial cell migration	21873635.	IBA	Process
GO:0010595	positive regulation of endothelial cell migration	16236264.	IDA	Process
GO:0016020	membrane	17205602.	IDA	Component
GO:0019834	phospholipase A2 inhibitor activity	21873635.	IBA	Function
GO:0021766	hippocampus development	-	IEA	Process
GO:0030424	axon	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0030670	phagocytic vesicle membrane	7526843.	IDA	Component
GO:0031100	animal organ regeneration	-	IEA	Process
GO:0042581	specific granule	7526843.	IDA	Component
GO:0042742	defense response to bacterium	9497492.	IDA	Process
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043086	negative regulation of catalytic activity	-	IEA	Process
GO:0043312	neutrophil degranulation	9550422.	IDA	Process
GO:0045766	positive regulation of angiogenesis	16236264.	IDA	Process
GO:0048306	calcium-dependent protein binding	21873635.	IBA	Function
GO:0048306	calcium-dependent protein binding	15226301.	IPI	Function
GO:0051054	positive regulation of DNA metabolic process	-	IEA	Process
GO:0051091	positive regulation of DNA-binding transcription factor activity	16236264.	IDA	Process
GO:0051384	response to glucocorticoid	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.23533145.	HDA	Component
GO:0070848	response to growth factor	-	IEA	Process
GO:2000310	regulation of NMDA receptor activity	21873635.	IBA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24815437	Expression of annexin A3 in gastric cancer and its correlation with proliferation and apoptosis.	Asian Pac J Cancer Prev	2014	Zhai JM	-
23631820	Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance.	Exp Mol Pathol	2013 Aug	Zeng C	doi: 10.1016/j.yexmp.2013.04.002
28703915	Self-Normalized Detection of ANXA3 from Untreated Urine of Prostate Cancer Patients without Digital Rectal Examination.	Adv Healthc Mater	2017 Sep	Jeun M	doi: 10.1002/adhm.201700449
24824926	Impact of Annexin A3 expression in gastric cancer cells.	Neoplasma	2014	Yu SY	-
21137070	Decreased annexin A3 expression correlates with tumor progression in papillary thyroid cancer.	Proteomics Clin Appl	2010 May	Jung EJ	doi: 10.1002/prca.200900063
28497041	Annexin A3 as a Prognostic Biomarker for Breast Cancer: A Retrospective Study.	Biomed Res Int	2017	Zhou T	doi: 10.1155/2017/2603685
26093083	Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target.	Oncotarget	2015 Aug 28	Zeidan B	-
21055154	[Proteomic study of gallbladder cancer, with special reference on the expression and significance of annexin A3].	Zhonghua Bing Li Xue Za Zhi	2010 Jun	Tan Y	-
20103635	Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer.	Cancer Res	2010 Feb 15	Yan X	doi: 10.1158/0008-5472.CAN-09-3215
24954692	Prostate cancer biomarker annexin A3 detected in urines obtained following digital rectal examination presents antigenic variability.	Clin Biochem	2014 Jul	Hamelin-Peyron C	doi: 10.1016/j.clinbiochem.2014.05.063
27878264	Silencing of ANXA3 expression by RNA interference inhibits the proliferation and invasion of breast cancer cells.	Oncol Rep	2017 Jan	Zhou T	doi: 10.3892/or.2016.5251
27894078	Overexpression of ANXA3 is an independent prognostic indicator in gastric cancer and its depletion suppresses cell proliferation and tumor growth.	Oncotarget	2016 Dec 27	Wang K	doi: 10.18632/oncotarget.13493.
29224019	The MiR-495/Annexin A3/P53 Axis Inhibits the Invasion and EMT of Colorectal Cancer Cells.	Cell Physiol Biochem	2017	Bai Z	doi: 10.1159/000485877

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr4	78573235	Missense_Mutation	novel	A24G	0.22
BLCA	chr4	78579062	Missense_Mutation	NA	E47Q	0.06
BLCA	chr4	78595828	Missense_Mutation	rs539172460	T192M	0.17
BRCA	chr4	78601565	Missense_Mutation	NA	L262F	0.24
BRCA	chr4	78579027	Missense_Mutation	NA	G35A	0.36
BRCA	chr4	78604350	Missense_Mutation	rs73828045	R288Q	0.33
BRCA	chr4	78595402	Missense_Mutation	NA	K169E	0.17
BRCA	chr4	78579080	Missense_Mutation	rs181568024	R53W	0.09
CESC	chr4	78554464	5'UTR	novel		0.42
CESC	chr4	78579035	Missense_Mutation	NA	E38K	0.4
CESC	chr4	78554481	Missense_Mutation	NA	S3C	0.51
CESC	chr4	78610124	3'UTR	rs373519447		0.37
COAD	chr4	78554444	5'UTR	novel		0.48
COAD	chr4	78582231	Missense_Mutation	novel	V85M	0.06
COAD	chr4	78597387	Missense_Mutation	NA	H235Y	0.35
COAD	chr4	78582278	Missense_Mutation	NA	K100N	0.2
COAD	chr4	78604288	Silent	novel	T267T	0.15
COAD	chr4	78595844	Missense_Mutation	NA	F197L	0.29
COAD	chr4	78604286	Missense_Mutation	NA	T267A	0.36
COAD	chr4	78610121	3'UTR	novel		0.22
COAD	chr4	78610144	3'UTR	rs375307482		0.25
GBM	chr4	78586274	Silent	rs144437584	N109N	0.39
GBM	chr4	78591545	Splice_Region	novel	V135V	0.09
GBM	chr4	78604349	Nonsense_Mutation	rs377732793	R288*	0.23
GBM	chr4	78582216	Missense_Mutation	NA	F80I	0.24
GBM	chr4	78579044	Missense_Mutation	novel	L41F	0.09
HNSC	chr4	78601533	Missense_Mutation	novel	A252T	0.32
KICH	chr4	78610286	3'UTR	novel		0.23
KIRC	chr4	78601549	Missense_Mutation	novel	R257I	0.41
KIRC	chr4	78597402	Missense_Mutation	NA	L240M	0.12
KIRP	chr4	78610106	Silent	NA	G321G	0.48
KIRP	chr4	78595395	Silent	NA	E166E	0.35
KIRP	chr4	78591597	Missense_Mutation	rs762300727	R153W	0.39
LGG	chr4	78610100	Silent	rs772590143	C319C	0.11
LGG	chr4	78601554	Missense_Mutation	rs376086128	H259Y	0.35
LGG	chr4	78591556	Missense_Mutation	NA	S139I	0.05
LIHC	chr4	78610116	3'UTR	novel		0.49
LIHC	chr4	78573234	Missense_Mutation	NA	A24S	0.52
LIHC	chr4	78582230	Missense_Mutation	NA	M84I	0.07
LIHC	chr4	78582230	Missense_Mutation	NA	M84I	0.43
LIHC	chr4	78554488	Missense_Mutation	novel	W5C	0.06
LUAD	chr4	78595411	Missense_Mutation	NA	E172K	0.26
LUAD	chr4	78591586	Missense_Mutation	NA	S149C	0.14
LUAD	chr4	78601523	Missense_Mutation	novel	R248S	0.11
LUAD	chr4	78586312	Missense_Mutation	novel	S122I	0.43
LUAD	chr4	78604355	Missense_Mutation	novel	E290Q	0.06
LUAD	chr4	78582233	Silent	NA	V85V	0.13
LUAD	chr4	78601542	Missense_Mutation	rs762302189	A255T	0.4
LUSC	chr4	78595828	Missense_Mutation	rs539172460	T192K	0.17
LUSC	chr4	78604384	Silent	NA	L299L	0.3
OV	chr4	78573227	Silent	novel	S21S	0.07
SARC	chr4	78586290	Missense_Mutation	novel	E115K	0.59
SKCM	chr4	78582199	Missense_Mutation	NA	G74D	0.34
SKCM	chr4	78591599	Silent	novel	R153R	0.22
SKCM	chr4	78586275	Missense_Mutation	rs144530066	E110K	0.36
SKCM	chr4	78595865	Silent	novel	R204R	0.3
SKCM	chr4	78586275	Missense_Mutation	rs144530066	E110K	0.22
SKCM	chr4	78610091	Missense_Mutation	novel	L316F	0.43
SKCM	chr4	78586283	Silent	novel	A112A	0.37
SKCM	chr4	78597341	Silent	NA	I219I	0.24
SKCM	chr4	78586333	Missense_Mutation	NA	S129F	0.25
SKCM	chr4	78604307	Nonsense_Mutation	rs764726341	R274*	0.59
SKCM	chr4	78586275	Missense_Mutation	rs144530066	E110K	0.29
STAD	chr4	78573227	Silent	novel	S21S	0.2
THCA	chr4	78604368	Frame_Shift_Ins	novel	*H294Qfs27**	0.05
THCA	chr4	78595856	Silent	NA	L201L	0.09
UCEC	chr4	78610213	3'UTR	novel		0.27
UCEC	chr4	78597369	Missense_Mutation	novel	K229Q	0.43
UCEC	chr4	78604290	Missense_Mutation	novel	D268G	0.24
UCEC	chr4	78595881	Missense_Mutation	novel	K210Q	0.39
UCEC	chr4	78595385	Missense_Mutation	novel	R163K	0.07
UCEC	chr4	78601532	Silent	rs373810532	P251P	0.23
UCEC	chr4	78604307	Nonsense_Mutation	rs764726341	R274*	0.17
UCEC	chr4	78604350	Missense_Mutation	rs73828045	R288Q	0.6
UCEC	chr4	78586262	Splice_Region	rs746083634	G105G	0.43
UCEC	chr4	78586262	Splice_Region	rs746083634	G105G	0.31
UCEC	chr4	78597391	Missense_Mutation	novel	F236S	0.06
UCEC	chr4	78604338	Missense_Mutation	NA	L284P	0.15
UCEC	chr4	78610377	3'UTR	novel		0.2
UCEC	chr4	78595875	Missense_Mutation	novel	Q208K	0.19
UCEC	chr4	78595842	Missense_Mutation	novel	F197V	0.28
UCEC	chr4	78579080	Missense_Mutation	rs181568024	R53W	0.37
UCEC	chr4	78604349	Nonsense_Mutation	rs377732793	R288*	0.24
UCEC	chr4	78591554	Silent	novel	K138K	0.28
UCEC	chr4	78610058	Splice_Region	rs746463276	S305S	0.3
UCEC	chr4	78601525	Missense_Mutation	novel	N249S	0.4

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
LIHC	DEL	0.4	3.0903e-07
LUAD	DEL	0.1647	0.050802
MESO	DEL	0.3793	0.075661

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.031	Kaplan-Meier Survival Analysis
SARC	0.015	Kaplan-Meier Survival Analysis
MESO	0.011	Kaplan-Meier Survival Analysis
UCS	0.048	Kaplan-Meier Survival Analysis
HNSC	0.02	Kaplan-Meier Survival Analysis
ESCA	0.045	Kaplan-Meier Survival Analysis
KIRP	0.024	Kaplan-Meier Survival Analysis
COAD	0.016	Kaplan-Meier Survival Analysis
PAAD	0.0001	Kaplan-Meier Survival Analysis
CESC	0.0014	Kaplan-Meier Survival Analysis
OV	0.01	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742