EuRBPDB

Description

Ensembl ID: ENSG00000138801 (Gene tree)
Gene ID: 9061
Gene Symbol: PAPSS1
Alias: ATPSK1|PAPSS
Full Name: 3'-phosphoadenosine 5'-phosphosulfate synthase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 130,177 bases
Position: chr4:107,590,276-107,720,452
Accession: 8603
RBP type: non-canonical RBP
Summary: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS) is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the sulfate conjugation of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by OMIM, Mar 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000512641	PAPSS1-206	466	-	-	- (aa)	-	-
ENST00000506544	PAPSS1-204	577	-	-	- (aa)	-	-
ENST00000265174	PAPSS1-201	2731	XM_011532400	ENSP00000265174	624 (aa)	XP_011530702	O43252
ENST00000502431	PAPSS1-202	903	-	-	- (aa)	-	-
ENST00000514815	PAPSS1-208	296	-	-	- (aa)	-	-
ENST00000514489	PAPSS1-207	579	-	-	- (aa)	-	-
ENST00000511304	PAPSS1-205	927	-	-	- (aa)	-	-
ENST00000504987	PAPSS1-203	492	-	-	- (aa)	-	-

Gene Model

Pathways

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138801	Stroke	8.9481673E-004	-
ENSG00000138801	Erythrocyte Indices	3.768e-005	-
ENSG00000138801	Arteries	9.3540000E-005	-
ENSG00000138801	Coronary Disease	5.1690000E-005	-
ENSG00000138801	Coronary Disease	3.2850000E-005	-
ENSG00000138801	Coronary Disease	2.3540000E-006	-
ENSG00000138801	Coronary Disease	2.3540000E-006	-
ENSG00000138801	Coronary Disease	3.0240000E-005	-
ENSG00000138801	Coronary Disease	1.7980000E-005	-
ENSG00000138801	Coronary Disease	2.0630000E-006	-
ENSG00000138801	Coronary Disease	1.5070000E-006	-
ENSG00000138801	Coronary Disease	8.6170000E-005	-

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138801	PAPSS1	96	78.369	ENSG00000198682	PAPSS2	98	78.369	Homo_sapiens

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000103	sulfate assimilation	21873635.	IBA	Process
GO:0000103	sulfate assimilation	14747722.	IDA	Process
GO:0000103	sulfate assimilation	-	IEA	Process
GO:0001501	skeletal system development	9771708.	TAS	Process
GO:0004020	adenylylsulfate kinase activity	21873635.	IBA	Function
GO:0004020	adenylylsulfate kinase activity	14747722.23207770.	IDA	Function
GO:0004781	sulfate adenylyltransferase (ATP) activity	14747722.	IDA	Function
GO:0004781	sulfate adenylyltransferase (ATP) activity	-	ISS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005829	cytosol	-	TAS	Component
GO:0016310	phosphorylation	-	IEA	Process
GO:0016779	nucleotidyltransferase activity	-	ISS	Function
GO:0042803	protein homodimerization activity	14747722.	IPI	Function
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	21873635.	IBA	Process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	14747722.23207770.	IDA	Process
GO:0050428	3'-phosphoadenosine 5'-phosphosulfate biosynthetic process	-	TAS	Process