EuRBPDB

Description

Ensembl ID: ENSG00000138802 (Gene tree)
Gene ID: 10427
Gene Symbol: SEC24B
Alias: N
Full Name: SEC24 homolog B, COPII coat complex component
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 107,125 bases
Position: chr4:109,433,772-109,540,896
Accession: 10704
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein is thought to be a cargo-binding component of the COPII vesicle, and is thought to be involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. Mutations in this gene have been associated with neural tube defects, and are thought to be a result of a disruption in interactions with the protein encoded by the VANGL planar cell polarity protein 2 (VANGL2) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000399100	SEC24B-202	3780	XM_011531540	ENSP00000382051	1233 (aa)	XP_011529842	O95487
ENST00000504968	SEC24B-203	4066	XM_005262688	ENSP00000428564	1298 (aa)	XP_005262745	O95487
ENST00000265175	SEC24B-201	5083	XM_011531536	ENSP00000265175	1268 (aa)	XP_011529838	O95487

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000138802	Alzheimer Disease	4E-6	27770636

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000138802	rs182972826	4	109534350	T	Late-onset Alzheimer's disease	27770636	[0.24-0.64] unit increase	0.44	EFO_1001870

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000138802	SEC24B	62	30.552	FBgn0262126	Sec24CD	70	30.707	Drosophila_melanogaster
ENSG00000138802	SEC24B	58	34.031	YIL109C	SEC24	90	32.943	Saccharomyces_cerevisiae

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000139	Golgi membrane	-	IEA	Component
GO:0001843	neural tube closure	-	IEA	Process
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	Process
GO:0003151	outflow tract morphogenesis	-	IEA	Process
GO:0005515	protein binding	19706601.24405750.27018634.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005829	cytosol	10075675.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006886	intracellular protein transport	-	IEA	Process
GO:0006888	ER to Golgi vesicle-mediated transport	20427317.	IMP	Process
GO:0006888	ER to Golgi vesicle-mediated transport	-	TAS	Process
GO:0008270	zinc ion binding	18843296.	IDA	Function
GO:0012507	ER to Golgi transport vesicle membrane	-	TAS	Component
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	-	TAS	Process
GO:0021747	cochlear nucleus development	-	IEA	Process
GO:0030127	COPII vesicle coat	10075675.17499046.	IDA	Component
GO:0035909	aorta morphogenesis	-	IEA	Process
GO:0048208	COPII vesicle coating	-	TAS	Process
GO:0060088	auditory receptor cell stereocilium organization	-	IEA	Process
GO:0060463	lung lobe morphogenesis	-	IEA	Process
GO:0060982	coronary artery morphogenesis	-	IEA	Process
GO:0061156	pulmonary artery morphogenesis	-	IEA	Process
GO:0090110	cargo loading into COPII-coated vesicle	17499046.18843296.	IDA	Process
GO:0090178	regulation of establishment of planar polarity involved in neural tube closure	-	IEA	Process
GO:1901301	regulation of cargo loading into COPII-coated vesicle	-	IEA	Process