EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000139131 (Gene tree)
Gene ID: 51067
Gene Symbol: YARS2
Alias: FLJ13995|CGI-04|mt-TyrRS
Full Name: tyrosyl-tRNA synthetase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 30,871 bases
Position: chr12:32,725,091-32,755,961
Accession: 24249
RBP type: canonical RBP
Summary: This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000320658	tRNA-synt_1b	PF00579.25	2.6e-71	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24003969	Pathophysiology and genetic mutations in congenital sideroblastic anemia.	Pediatr Int	2013 Dec	Fujiwara T	doi: 10.1111/ped.12217.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551673	YARS2-203	489	-	-	- (aa)	-	-
ENST00000324868	YARS2-201	2122	-	ENSP00000320658	477 (aa)	-	Q9Y2Z4
ENST00000548490	YARS2-202	1321	-	ENSP00000447710	291 (aa)	-	H0YHS6

Gene Model

Click here to download ENSG00000139131's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000139131	Hemoglobin A2	7.871e-005	-
ENSG00000139131	Platelet Function Tests	2.1100000E-006	-
ENSG00000139131	Platelet Function Tests	4.3700000E-006	-
ENSG00000139131	Platelet Function Tests	1.0425700E-005	-
ENSG00000139131	Platelet Function Tests	5.7000000E-006	-
ENSG00000139131	Platelet Function Tests	5.4105233E-006	-
ENSG00000139131	Platelet Function Tests	1.8905200E-005	-
ENSG00000139131	Platelet Function Tests	1.8905200E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000139131's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139131	YARS2	100	58.471	ENSAPOG00000008208	yars2	100	58.471	Acanthochromis_polyacanthus
ENSG00000139131	YARS2	99	90.690	ENSAMEG00000008909	YARS2	100	89.099	Ailuropoda_melanoleuca
ENSG00000139131	YARS2	97	58.658	ENSACIG00000018640	yars2	95	58.658	Amphilophus_citrinellus
ENSG00000139131	YARS2	96	60.000	ENSAOCG00000005594	yars2	91	62.443	Amphiprion_ocellaris
ENSG00000139131	YARS2	96	60.000	ENSAPEG00000006952	yars2	91	62.443	Amphiprion_percula
ENSG00000139131	YARS2	96	60.714	ENSATEG00000019778	yars2	91	61.991	Anabas_testudineus
ENSG00000139131	YARS2	56	77.358	ENSAPLG00000004982	YARS2	100	77.358	Anas_platyrhynchos
ENSG00000139131	YARS2	100	65.136	ENSACAG00000012351	YARS2	97	65.136	Anolis_carolinensis
ENSG00000139131	YARS2	99	96.552	ENSANAG00000026208	YARS2	100	95.388	Aotus_nancymaae
ENSG00000139131	YARS2	100	59.711	ENSACLG00000026295	yars2	100	59.711	Astatotilapia_calliptera
ENSG00000139131	YARS2	99	60.127	ENSAMXG00000015193	yars2	94	60.127	Astyanax_mexicanus
ENSG00000139131	YARS2	100	89.121	ENSBTAG00000011399	YARS2	100	89.121	Bos_taurus
ENSG00000139131	YARS2	84	41.434	WBGene00006968	yars-2	92	35.443	Caenorhabditis_elegans
ENSG00000139131	YARS2	100	95.807	ENSCJAG00000018129	YARS2	100	95.807	Callithrix_jacchus
ENSG00000139131	YARS2	100	87.212	ENSCAFG00000010496	YARS2	100	87.212	Canis_familiaris
ENSG00000139131	YARS2	100	87.212	ENSCAFG00020019713	YARS2	100	87.212	Canis_lupus_dingo
ENSG00000139131	YARS2	100	89.121	ENSCHIG00000002520	YARS2	100	89.121	Capra_hircus
ENSG00000139131	YARS2	99	90.722	ENSTSYG00000013725	YARS2	100	89.540	Carlito_syrichta
ENSG00000139131	YARS2	98	89.825	ENSCPOG00000015276	YARS2	100	86.611	Cavia_porcellus
ENSG00000139131	YARS2	99	97.241	ENSCCAG00000038073	YARS2	100	96.226	Cebus_capucinus
ENSG00000139131	YARS2	100	98.532	ENSCATG00000039275	YARS2	100	98.532	Cercocebus_atys
ENSG00000139131	YARS2	100	87.683	ENSCLAG00000002000	YARS2	100	87.683	Chinchilla_lanigera
ENSG00000139131	YARS2	99	99.310	ENSCSAG00000007382	YARS2	100	98.113	Chlorocebus_sabaeus
ENSG00000139131	YARS2	100	87.474	ENSCHOG00000011749	YARS2	100	87.474	Choloepus_hoffmanni
ENSG00000139131	YARS2	100	68.191	ENSCPBG00000020392	YARS2	100	67.556	Chrysemys_picta_bellii
ENSG00000139131	YARS2	93	45.255	ENSCING00000007475	-	83	45.035	Ciona_intestinalis
ENSG00000139131	YARS2	93	45.985	ENSCSAVG00000001469	-	93	44.342	Ciona_savignyi
ENSG00000139131	YARS2	99	98.276	ENSCANG00000002599	YARS2	100	79.749	Colobus_angolensis_palliatus
ENSG00000139131	YARS2	100	83.473	ENSCGRG00001019281	Yars2	100	83.473	Cricetulus_griseus_chok1gshd
ENSG00000139131	YARS2	63	66.556	ENSCSEG00000009212	yars2	97	66.556	Cynoglossus_semilaevis
ENSG00000139131	YARS2	98	60.690	ENSCVAG00000007972	yars2	94	62.582	Cyprinodon_variegatus
ENSG00000139131	YARS2	91	63.594	ENSDARG00000077299	yars2	100	60.042	Danio_rerio
ENSG00000139131	YARS2	99	86.552	ENSDNOG00000024479	YARS2	100	85.356	Dasypus_novemcinctus
ENSG00000139131	YARS2	65	89.091	ENSDORG00000011489	Yars2	84	89.091	Dipodomys_ordii
ENSG00000139131	YARS2	99	49.153	FBgn0035064	TyrRS-m	99	47.312	Drosophila_melanogaster
ENSG00000139131	YARS2	93	57.664	ENSEBUG00000006652	yars2	91	58.391	Eptatretus_burgeri
ENSG00000139131	YARS2	100	90.795	ENSEASG00005004548	YARS2	100	90.795	Equus_asinus_asinus
ENSG00000139131	YARS2	100	90.586	ENSECAG00000011140	YARS2	100	90.586	Equus_caballus
ENSG00000139131	YARS2	98	60.351	ENSELUG00000007909	yars2	87	61.211	Esox_lucius
ENSG00000139131	YARS2	99	92.069	ENSFCAG00000005329	YARS2	100	90.776	Felis_catus
ENSG00000139131	YARS2	61	75.258	ENSFALG00000001189	YARS2	98	75.258	Ficedula_albicollis
ENSG00000139131	YARS2	100	86.192	ENSFDAG00000006499	YARS2	100	86.192	Fukomys_damarensis
ENSG00000139131	YARS2	97	61.837	ENSFHEG00000002505	yars2	82	63.371	Fundulus_heteroclitus
ENSG00000139131	YARS2	100	56.549	ENSGMOG00000001082	yars2	100	56.549	Gadus_morhua
ENSG00000139131	YARS2	100	66.053	ENSGALG00000012919	YARS2	100	66.053	Gallus_gallus
ENSG00000139131	YARS2	99	60.764	ENSGAFG00000003993	yars2	95	62.963	Gambusia_affinis
ENSG00000139131	YARS2	97	59.929	ENSGACG00000003720	yars2	93	61.400	Gasterosteus_aculeatus
ENSG00000139131	YARS2	93	71.749	ENSGAGG00000007739	YARS2	93	71.749	Gopherus_agassizii
ENSG00000139131	YARS2	99	100.000	ENSGGOG00000026482	-	98	100.000	Gorilla_gorilla
ENSG00000139131	YARS2	100	60.124	ENSHBUG00000014602	yars2	100	60.124	Haplochromis_burtoni
ENSG00000139131	YARS2	100	88.075	ENSHGLG00000009938	YARS2	97	88.075	Heterocephalus_glaber_female
ENSG00000139131	YARS2	100	87.657	ENSHGLG00100001061	YARS2	100	87.657	Heterocephalus_glaber_male
ENSG00000139131	YARS2	97	58.657	ENSHCOG00000004523	yars2	80	58.355	Hippocampus_comes
ENSG00000139131	YARS2	100	58.969	ENSIPUG00000011637	yars2	100	58.969	Ictalurus_punctatus
ENSG00000139131	YARS2	99	92.440	ENSSTOG00000011917	YARS2	100	91.423	Ictidomys_tridecemlineatus
ENSG00000139131	YARS2	99	84.536	ENSJJAG00000000641	Yars2	100	84.728	Jaculus_jaculus
ENSG00000139131	YARS2	100	58.921	ENSKMAG00000016962	yars2	100	58.921	Kryptolebias_marmoratus
ENSG00000139131	YARS2	100	59.298	ENSLBEG00000022576	yars2	100	59.298	Labrus_bergylta
ENSG00000139131	YARS2	99	62.414	ENSLACG00000006720	YARS2	96	58.246	Latimeria_chalumnae
ENSG00000139131	YARS2	99	62.284	ENSLOCG00000016695	yars2	94	65.556	Lepisosteus_oculatus
ENSG00000139131	YARS2	100	88.075	ENSLAFG00000017360	YARS2	100	88.075	Loxodonta_africana
ENSG00000139131	YARS2	100	98.323	ENSMFAG00000032763	YARS2	100	98.323	Macaca_fascicularis
ENSG00000139131	YARS2	100	98.113	ENSMMUG00000013654	YARS2	100	98.113	Macaca_mulatta
ENSG00000139131	YARS2	99	99.310	ENSMNEG00000033863	YARS2	98	96.594	Macaca_nemestrina
ENSG00000139131	YARS2	100	98.323	ENSMLEG00000040261	YARS2	100	98.323	Mandrillus_leucophaeus
ENSG00000139131	YARS2	96	58.719	ENSMAMG00000023144	yars2	91	60.722	Mastacembelus_armatus
ENSG00000139131	YARS2	100	60.124	ENSMZEG00005010162	yars2	100	60.124	Maylandia_zebra
ENSG00000139131	YARS2	57	77.122	ENSMGAG00000013318	YARS2	99	77.122	Meleagris_gallopavo
ENSG00000139131	YARS2	100	84.310	ENSMAUG00000012334	Yars2	100	84.310	Mesocricetus_auratus
ENSG00000139131	YARS2	100	90.586	ENSMICG00000033335	YARS2	100	90.586	Microcebus_murinus
ENSG00000139131	YARS2	100	83.054	ENSMOCG00000011433	Yars2	100	83.054	Microtus_ochrogaster
ENSG00000139131	YARS2	95	59.567	ENSMMOG00000001063	yars2	87	59.567	Mola_mola
ENSG00000139131	YARS2	100	76.349	ENSMODG00000012921	-	100	76.349	Monodelphis_domestica
ENSG00000139131	YARS2	97	60.211	ENSMALG00000013849	yars2	88	61.124	Monopterus_albus
ENSG00000139131	YARS2	100	85.616	MGP_CAROLIEiJ_G0020491	Yars2	100	84.728	Mus_caroli
ENSG00000139131	YARS2	100	85.274	ENSMUSG00000022792	Yars2	100	84.519	Mus_musculus
ENSG00000139131	YARS2	100	85.274	MGP_PahariEiJ_G0016196	Yars2	100	84.728	Mus_pahari
ENSG00000139131	YARS2	100	85.616	MGP_SPRETEiJ_G0021386	Yars2	100	84.728	Mus_spretus
ENSG00000139131	YARS2	100	90.147	ENSMPUG00000000223	YARS2	100	90.147	Mustela_putorius_furo
ENSG00000139131	YARS2	100	88.285	ENSMLUG00000001614	YARS2	100	88.285	Myotis_lucifugus
ENSG00000139131	YARS2	99	83.849	ENSNGAG00000021477	Yars2	96	87.004	Nannospalax_galili
ENSG00000139131	YARS2	100	60.124	ENSNBRG00000018713	yars2	100	60.124	Neolamprologus_brichardi
ENSG00000139131	YARS2	100	98.952	ENSNLEG00000016641	YARS2	100	98.952	Nomascus_leucogenys
ENSG00000139131	YARS2	65	92.308	ENSMEUG00000003618	-	65	92.308	Notamacropus_eugenii
ENSG00000139131	YARS2	100	85.983	ENSOPRG00000007817	-	100	85.983	Ochotona_princeps
ENSG00000139131	YARS2	99	85.223	ENSODEG00000006403	YARS2	100	75.314	Octodon_degus
ENSG00000139131	YARS2	100	60.412	ENSONIG00000008830	yars2	100	60.412	Oreochromis_niloticus
ENSG00000139131	YARS2	100	87.448	ENSOCUG00000000022	YARS2	100	87.448	Oryctolagus_cuniculus
ENSG00000139131	YARS2	99	59.516	ENSORLG00000002424	yars2	95	60.976	Oryzias_latipes
ENSG00000139131	YARS2	99	59.862	ENSORLG00020019938	yars2	95	61.641	Oryzias_latipes_hni
ENSG00000139131	YARS2	97	53.169	ENSORLG00015012856	yars2	100	45.625	Oryzias_latipes_hsok
ENSG00000139131	YARS2	100	58.958	ENSOMEG00000007611	yars2	100	58.958	Oryzias_melastigma
ENSG00000139131	YARS2	100	80.962	ENSOGAG00000011505	YARS2	100	80.962	Otolemur_garnettii
ENSG00000139131	YARS2	100	87.810	ENSOARG00000019327	-	100	87.810	Ovis_aries
ENSG00000139131	YARS2	99	53.691	ENSOARG00000008982	-	94	56.010	Ovis_aries
ENSG00000139131	YARS2	100	99.790	ENSPPAG00000036590	YARS2	100	99.790	Pan_paniscus
ENSG00000139131	YARS2	99	92.414	ENSPPRG00000011306	YARS2	100	90.985	Panthera_pardus
ENSG00000139131	YARS2	99	92.414	ENSPTIG00000020214	YARS2	100	90.985	Panthera_tigris_altaica
ENSG00000139131	YARS2	100	99.581	ENSPTRG00000004819	YARS2	100	99.581	Pan_troglodytes
ENSG00000139131	YARS2	100	98.532	ENSPANG00000015833	YARS2	100	98.532	Papio_anubis
ENSG00000139131	YARS2	99	60.481	ENSPKIG00000022142	YARS2	85	63.053	Paramormyrops_kingsleyae
ENSG00000139131	YARS2	99	53.608	ENSPKIG00000021759	yars2	99	52.990	Paramormyrops_kingsleyae
ENSG00000139131	YARS2	55	77.273	ENSPSIG00000007855	YARS2	100	77.273	Pelodiscus_sinensis
ENSG00000139131	YARS2	100	56.936	ENSPMGG00000005934	yars2	100	56.936	Periophthalmus_magnuspinnatus
ENSG00000139131	YARS2	96	86.022	ENSPEMG00000007655	Yars2	93	87.727	Peromyscus_maniculatus_bairdii
ENSG00000139131	YARS2	94	60.284	ENSPMAG00000002536	yars2	91	59.142	Petromyzon_marinus
ENSG00000139131	YARS2	99	61.111	ENSPFOG00000012264	yars2	93	63.474	Poecilia_formosa
ENSG00000139131	YARS2	99	61.111	ENSPLAG00000003699	yars2	93	63.474	Poecilia_latipinna
ENSG00000139131	YARS2	99	61.111	ENSPMEG00000024102	yars2	95	62.745	Poecilia_mexicana
ENSG00000139131	YARS2	99	61.111	ENSPREG00000011521	yars2	93	63.474	Poecilia_reticulata
ENSG00000139131	YARS2	100	98.952	ENSPPYG00000004406	YARS2	100	98.952	Pongo_abelii
ENSG00000139131	YARS2	99	87.889	ENSPCAG00000006086	YARS2	77	98.148	Procavia_capensis
ENSG00000139131	YARS2	100	89.749	ENSPCOG00000026397	YARS2	100	89.749	Propithecus_coquereli
ENSG00000139131	YARS2	100	88.494	ENSPVAG00000000520	YARS2	100	88.494	Pteropus_vampyrus
ENSG00000139131	YARS2	100	60.331	ENSPNYG00000007346	yars2	100	60.331	Pundamilia_nyererei
ENSG00000139131	YARS2	100	59.465	ENSPNAG00000004766	yars2	100	59.465	Pygocentrus_nattereri
ENSG00000139131	YARS2	100	84.067	ENSRNOG00000025252	Yars2	100	84.067	Rattus_norvegicus
ENSG00000139131	YARS2	100	98.532	ENSRBIG00000041046	-	100	98.532	Rhinopithecus_bieti
ENSG00000139131	YARS2	99	88.276	ENSRBIG00000038155	-	91	87.879	Rhinopithecus_bieti
ENSG00000139131	YARS2	99	88.276	ENSRBIG00000037050	-	91	87.879	Rhinopithecus_bieti
ENSG00000139131	YARS2	100	98.532	ENSRROG00000037913	-	100	98.532	Rhinopithecus_roxellana
ENSG00000139131	YARS2	99	96.897	ENSRROG00000030036	-	89	89.499	Rhinopithecus_roxellana
ENSG00000139131	YARS2	98	37.248	YPL097W	-	90	33.626	Saccharomyces_cerevisiae
ENSG00000139131	YARS2	99	97.241	ENSSBOG00000023473	YARS2	100	96.017	Saimiri_boliviensis_boliviensis
ENSG00000139131	YARS2	100	78.586	ENSSHAG00000004495	YARS2	100	78.586	Sarcophilus_harrisii
ENSG00000139131	YARS2	98	58.596	ENSSFOG00015002490	yars2	91	61.435	Scleropages_formosus
ENSG00000139131	YARS2	100	59.711	ENSSMAG00000006844	yars2	97	59.711	Scophthalmus_maximus
ENSG00000139131	YARS2	100	59.711	ENSSDUG00000023361	yars2	100	59.711	Seriola_dumerili
ENSG00000139131	YARS2	100	59.504	ENSSLDG00000023865	yars2	100	59.504	Seriola_lalandi_dorsalis
ENSG00000139131	YARS2	99	62.585	ENSSPUG00000000061	YARS2	90	66.813	Sphenodon_punctatus
ENSG00000139131	YARS2	100	58.678	ENSSPAG00000020638	yars2	100	58.678	Stegastes_partitus
ENSG00000139131	YARS2	100	89.958	ENSSSCG00000027429	-	100	89.958	Sus_scrofa
ENSG00000139131	YARS2	65	73.397	ENSTGUG00000011510	YARS2	96	73.397	Taeniopygia_guttata
ENSG00000139131	YARS2	93	60.806	ENSTRUG00000016475	yars2	91	61.538	Takifugu_rubripes
ENSG00000139131	YARS2	100	56.818	ENSTNIG00000006253	yars2	100	56.818	Tetraodon_nigroviridis
ENSG00000139131	YARS2	78	94.631	ENSTBEG00000008274	YARS2	78	94.631	Tupaia_belangeri
ENSG00000139131	YARS2	100	89.958	ENSTTRG00000013823	YARS2	100	89.958	Tursiops_truncatus
ENSG00000139131	YARS2	99	91.349	ENSUAMG00000014358	YARS2	100	89.937	Ursus_americanus
ENSG00000139131	YARS2	99	91.349	ENSUMAG00000003011	YARS2	100	89.937	Ursus_maritimus
ENSG00000139131	YARS2	100	88.912	ENSVPAG00000004767	YARS2	100	88.912	Vicugna_pacos
ENSG00000139131	YARS2	100	87.421	ENSVVUG00000012736	YARS2	100	87.421	Vulpes_vulpes
ENSG00000139131	YARS2	62	58.915	ENSXETG00000012271	yars2	78	58.915	Xenopus_tropicalis
ENSG00000139131	YARS2	96	62.057	ENSXCOG00000020889	yars2	91	63.883	Xiphophorus_couchianus
ENSG00000139131	YARS2	99	61.246	ENSXMAG00000009650	yars2	93	63.333	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000049	tRNA binding	20598274.	IDA	Function
GO:0000049	tRNA binding	15779907.	TAS	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0004831	tyrosine-tRNA ligase activity	21873635.	IBA	Function
GO:0004831	tyrosine-tRNA ligase activity	15779907.15840810.17997975.20598274.	IDA	Function
GO:0004831	tyrosine-tRNA ligase activity	10810093.	NAS	Function
GO:0005515	protein binding	25416956.	IPI	Function
GO:0005524	ATP binding	15779907.	TAS	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	20598274.	IC	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005739	mitochondrion	10810093.	NAS	Component
GO:0005739	mitochondrion	15779907.	TAS	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0006412	translation	10810093.	NAS	Process
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0042803	protein homodimerization activity	15779907.17997975.	IPI	Function
GO:0043039	tRNA aminoacylation	21873635.	IBA	Process
GO:0043039	tRNA aminoacylation	15779907.15840810.17997975.	IDA	Process
GO:0070184	mitochondrial tyrosyl-tRNA aminoacylation	15779907.	IC	Process
GO:0070184	mitochondrial tyrosyl-tRNA aminoacylation	20598274.	IMP	Process
GO:0072545	tyrosine binding	17997975.	IDA	Function