EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000139323 (Gene tree)
Gene ID: 282809
Gene Symbol: POC1B
Alias: TUWD12|FLJ14923|WDR51B
Full Name: POC1 centriolar protein B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 106,545 bases
Position: chr12:89,419,718-89,526,262
Accession: 30836
RBP type: canonical RBP
Summary: POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutation in this gene result in autosomal-recessive cone-rod dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000323302	eIF2A	PF08662.11	4.3e-09	1	1
ENSP00000447916	eIF2A	PF08662.11	5.9e-09	1	1
ENSP00000376877	eIF2A	PF08662.11	1.2e-05	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000551819	POC1B-213	364	-	-	- (aa)	-	-
ENST00000549504	POC1B-211	581	-	ENSP00000450118	93 (aa)	-	F8VPF1
ENST00000547496	POC1B-207	1392	-	ENSP00000447437	50 (aa)	-	F8VV91
ENST00000546740	POC1B-204	911	-	-	- (aa)	-	-
ENST00000549035	POC1B-209	2038	-	ENSP00000447916	436 (aa)	-	Q8TC44
ENST00000548715	POC1B-208	829	-	ENSP00000449945	50 (aa)	-	F8VV91
ENST00000539190	POC1B-203	1727	-	-	- (aa)	-	-
ENST00000552563	POC1B-214	700	-	-	- (aa)	-	-
ENST00000547274	POC1B-206	473	-	ENSP00000449648	50 (aa)	-	F8VV91
ENST00000546830	POC1B-205	550	-	ENSP00000449256	91 (aa)	-	F8VX21
ENST00000549591	POC1B-212	5840	-	-	- (aa)	-	-
ENST00000549304	POC1B-210	766	-	-	- (aa)	-	-
ENST00000393179	POC1B-202	3096	-	ENSP00000376877	348 (aa)	-	Q8IU52
ENST00000313546	POC1B-201	3001	-	ENSP00000323302	478 (aa)	-	Q8TC44

Gene Model

Click here to download ENSG00000139323's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000139323	Pancreatic Neoplasms	5.3E-05	22523087
ENSG00000139323	Cardiovascular Diseases	1E-16	26908625
ENSG00000139323	Schizophrenia	7E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000139323	rs11105298	12	89482366	C	B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio	29237677	[0.17-0.25] Unit increase	0.21	EFO_0008469
ENSG00000139323	rs35761782	12	89504601	AT	Monocyte count	27863252	[0.018-0.033] unit increase	0.02575606	EFO_0005091
ENSG00000139323	rs10535587	12	89459427	T	Blood protein levels	29875488	[0.3-0.42] unit decrease	0.36	EFO_0007937
ENSG00000139323	rs11105306	12	89503611	T	NT-proBNP levels in acute coronary syndrome	26908625	[0.14-0.23] ng/L decrease	0.187	EFO_0005278
ENSG00000139323	rs10777165	12	89447088	C	Schizophrenia	26198764	[NR]	1.0526316	EFO_0000692
ENSG00000139323	rs10858881	12	89497697	G	Blood protein levels	28240269	[0.4-0.6] unit decrease	0.501	EFO_0008086
ENSG00000139323	rs61378614	12	89509877	C	B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio	29237677	[0.037-0.165] Unit increase	0.101	EFO_0008469
ENSG00000139323	rs35761782	12	89504601	AT	Granulocyte percentage of myeloid white cells	27863252	[0.017-0.032] unit decrease	0.02457922	EFO_0007997
ENSG00000139323	rs145485557	12	89445110	T	Systolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006335\|EFO_0004329
ENSG00000139323	rs145485557	12	89445110	T	Diastolic blood pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006336\|EFO_0004329
ENSG00000139323	rs145485557	12	89445110	T	Mean arterial pressure x alcohol consumption interaction (2df test)	29912962			EFO_0006340\|EFO_0004329
ENSG00000139323	rs7299139	12	89455093	?	Hair color	30595370			EFO_0007822
ENSG00000139323	rs10777163	12	89436943	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000139323's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139323	POC1B	100	91.525	ENSAMEG00000001812	POC1B	100	88.591	Ailuropoda_melanoleuca
ENSG00000139323	POC1B	100	97.477	ENSANAG00000023816	POC1B	100	96.862	Aotus_nancymaae
ENSG00000139323	POC1B	99	90.490	ENSBTAG00000000687	POC1B	99	90.490	Bos_taurus
ENSG00000139323	POC1B	100	97.248	ENSCJAG00000019637	POC1B	100	96.653	Callithrix_jacchus
ENSG00000139323	POC1B	100	91.860	ENSCAFG00000006105	POC1B	99	90.275	Canis_familiaris
ENSG00000139323	POC1B	100	91.837	ENSCAFG00020016403	POC1B	100	90.138	Canis_lupus_dingo
ENSG00000139323	POC1B	99	90.202	ENSCHIG00000026402	POC1B	99	89.831	Capra_hircus
ENSG00000139323	POC1B	100	92.593	ENSTSYG00000010732	POC1B	99	84.767	Carlito_syrichta
ENSG00000139323	POC1B	86	91.837	ENSCAPG00000015652	POC1B	100	73.624	Cavia_aperea
ENSG00000139323	POC1B	100	86.239	ENSCPOG00000015525	POC1B	100	84.937	Cavia_porcellus
ENSG00000139323	POC1B	100	98.901	ENSCATG00000036201	POC1B	100	98.326	Cercocebus_atys
ENSG00000139323	POC1B	100	88.532	ENSCLAG00000006831	POC1B	100	88.739	Chinchilla_lanigera
ENSG00000139323	POC1B	100	98.901	ENSCSAG00000003775	POC1B	100	93.096	Chlorocebus_sabaeus
ENSG00000139323	POC1B	98	72.340	ENSCPBG00000000137	POC1B	99	62.838	Chrysemys_picta_bellii
ENSG00000139323	POC1B	100	98.394	ENSCANG00000043354	POC1B	100	98.117	Colobus_angolensis_palliatus
ENSG00000139323	POC1B	100	92.982	ENSDNOG00000011916	POC1B	100	89.414	Dasypus_novemcinctus
ENSG00000139323	POC1B	100	90.110	ENSDORG00000013903	Poc1b	100	86.639	Dipodomys_ordii
ENSG00000139323	POC1B	100	91.284	ENSEASG00005019319	POC1B	100	91.004	Equus_asinus_asinus
ENSG00000139323	POC1B	100	91.209	ENSECAG00000013326	POC1B	100	90.795	Equus_caballus
ENSG00000139323	POC1B	100	91.209	ENSFCAG00000007623	POC1B	100	89.540	Felis_catus
ENSG00000139323	POC1B	98	56.177	ENSFALG00000010636	POC1B	93	54.202	Ficedula_albicollis
ENSG00000139323	POC1B	100	96.491	ENSFDAG00000020160	POC1B	100	89.865	Fukomys_damarensis
ENSG00000139323	POC1B	98	65.169	ENSGAGG00000013124	POC1B	99	67.797	Gopherus_agassizii
ENSG00000139323	POC1B	100	100.000	ENSGGOG00000008572	POC1B	100	99.582	Gorilla_gorilla
ENSG00000139323	POC1B	100	93.878	ENSHGLG00000014556	POC1B	100	90.367	Heterocephalus_glaber_female
ENSG00000139323	POC1B	100	94.737	ENSHGLG00100000295	POC1B	100	85.135	Heterocephalus_glaber_male
ENSG00000139323	POC1B	100	90.698	ENSSTOG00000006306	POC1B	100	87.949	Ictidomys_tridecemlineatus
ENSG00000139323	POC1B	100	92.308	ENSJJAG00000013503	Poc1b	100	81.381	Jaculus_jaculus
ENSG00000139323	POC1B	98	71.910	ENSLOCG00000016379	POC1B	97	57.322	Lepisosteus_oculatus
ENSG00000139323	POC1B	100	89.220	ENSLAFG00000017550	POC1B	100	89.429	Loxodonta_africana
ENSG00000139323	POC1B	100	98.901	ENSMFAG00000043490	POC1B	100	98.536	Macaca_fascicularis
ENSG00000139323	POC1B	100	98.901	ENSMNEG00000040128	POC1B	100	98.536	Macaca_nemestrina
ENSG00000139323	POC1B	100	98.901	ENSMLEG00000031700	POC1B	100	98.536	Mandrillus_leucophaeus
ENSG00000139323	POC1B	100	87.209	ENSMOCG00000015822	Poc1b	100	83.264	Microtus_ochrogaster
ENSG00000139323	POC1B	100	80.220	ENSMODG00000009882	POC1B	99	71.203	Monodelphis_domestica
ENSG00000139323	POC1B	100	85.714	MGP_PahariEiJ_G0031323	Poc1b	100	81.651	Mus_pahari
ENSG00000139323	POC1B	100	91.209	ENSMPUG00000007581	POC1B	100	88.309	Mustela_putorius_furo
ENSG00000139323	POC1B	100	93.220	ENSMLUG00000002893	POC1B	99	88.090	Myotis_lucifugus
ENSG00000139323	POC1B	100	90.110	ENSNGAG00000019321	Poc1b	100	85.146	Nannospalax_galili
ENSG00000139323	POC1B	100	98.901	ENSNLEG00000034847	POC1B	100	98.117	Nomascus_leucogenys
ENSG00000139323	POC1B	100	87.209	ENSODEG00000009236	POC1B	99	87.261	Octodon_degus
ENSG00000139323	POC1B	99	66.819	ENSOANG00000006637	POC1B	99	66.819	Ornithorhynchus_anatinus
ENSG00000139323	POC1B	100	92.308	ENSOCUG00000008219	POC1B	100	91.213	Oryctolagus_cuniculus
ENSG00000139323	POC1B	99	90.202	ENSOARG00000015648	POC1B	99	89.727	Ovis_aries
ENSG00000139323	POC1B	100	100.000	ENSPPAG00000030897	POC1B	100	99.791	Pan_paniscus
ENSG00000139323	POC1B	100	91.209	ENSPPRG00000006168	POC1B	100	89.331	Panthera_pardus
ENSG00000139323	POC1B	100	88.991	ENSPTIG00000019536	POC1B	100	88.991	Panthera_tigris_altaica
ENSG00000139323	POC1B	100	100.000	ENSPTRG00000005284	POC1B	100	99.791	Pan_troglodytes
ENSG00000139323	POC1B	100	98.901	ENSPANG00000015875	POC1B	100	98.326	Papio_anubis
ENSG00000139323	POC1B	98	65.476	ENSPSIG00000004298	POC1B	99	62.447	Pelodiscus_sinensis
ENSG00000139323	POC1B	62	85.976	ENSPCIG00000014731	-	84	85.976	Phascolarctos_cinereus
ENSG00000139323	POC1B	100	100.000	ENSPPYG00000004819	POC1B	100	98.954	Pongo_abelii
ENSG00000139323	POC1B	94	80.428	ENSPCAG00000002158	POC1B	100	68.410	Procavia_capensis
ENSG00000139323	POC1B	100	92.308	ENSPVAG00000011562	POC1B	100	89.958	Pteropus_vampyrus
ENSG00000139323	POC1B	99	65.556	ENSPNAG00000026557	POC1B	97	55.761	Pygocentrus_nattereri
ENSG00000139323	POC1B	100	97.802	ENSRBIG00000001080	POC1B	100	90.167	Rhinopithecus_bieti
ENSG00000139323	POC1B	100	98.394	ENSRROG00000044376	POC1B	100	98.117	Rhinopithecus_roxellana
ENSG00000139323	POC1B	100	97.477	ENSSBOG00000023395	POC1B	100	97.071	Saimiri_boliviensis_boliviensis
ENSG00000139323	POC1B	100	89.011	ENSSARG00000010807	POC1B	100	76.987	Sorex_araneus
ENSG00000139323	POC1B	100	91.209	ENSSSCG00000000920	POC1B	100	90.167	Sus_scrofa
ENSG00000139323	POC1B	99	56.196	ENSTGUG00000008063	POC1B	99	55.439	Taeniopygia_guttata
ENSG00000139323	POC1B	98	87.324	ENSTBEG00000014216	POC1B	100	87.558	Tupaia_belangeri
ENSG00000139323	POC1B	100	90.138	ENSTTRG00000002513	POC1B	100	89.540	Tursiops_truncatus
ENSG00000139323	POC1B	100	91.209	ENSUAMG00000006889	POC1B	100	89.562	Ursus_americanus
ENSG00000139323	POC1B	100	91.837	ENSUMAG00000002434	POC1B	100	89.474	Ursus_maritimus
ENSG00000139323	POC1B	100	91.860	ENSVPAG00000001441	POC1B	84	87.500	Vicugna_pacos
ENSG00000139323	POC1B	69	91.237	ENSVVUG00000011627	-	96	91.237	Vulpes_vulpes
ENSG00000139323	POC1B	99	65.556	ENSXETG00000021865	poc1b	96	64.011	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000922	spindle pole	23015594.	IDA	Component
GO:0001895	retina homeostasis	25044745.	IMP	Process
GO:0005515	protein binding	23015594.25018096.25036637.26638075.	IPI	Function
GO:0005813	centrosome	21399614.	IDA	Component
GO:0005814	centriole	20008567.23015594.	IDA	Component
GO:0008283	cell proliferation	23015594.	IMP	Process
GO:0036064	ciliary basal body	20008567.	IDA	Component
GO:0060271	cilium assembly	20008567.	IMP	Process