EuRBPDB

Description

Ensembl ID: ENSG00000139641 (Gene tree)
Gene ID: 23344
Gene Symbol: ESYT1
Alias: MBC2|KIAA0747|FAM62A
Full Name: extended synaptotagmin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 26,427 bases
Position: chr12:56,118,250-56,144,676
Accession: 29534
RBP type: non-canonical RBP
Summary: (Extended Synaptotagmin 1) is a Protein Coding gene. Among its related pathways are Metabolism and Sphingolipid metabolism. Gene Ontology (GO) annotations related to this gene include lipid binding and phospholipid binding. An important paralog of this gene is ESYT2.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000550878	ESYT1-207	646	-	-	- (aa)	-	-
ENST00000551112	ESYT1-209	548	-	-	- (aa)	-	-
ENST00000551790	ESYT1-210	540	-	ENSP00000447756	88 (aa)	-	F8VZB1
ENST00000550986	ESYT1-208	543	-	-	- (aa)	-	-
ENST00000394048	ESYT1-202	4388	-	ENSP00000377612	1104 (aa)	-	Q9BSJ8
ENST00000267113	ESYT1-201	3577	-	ENSP00000267113	1114 (aa)	-	Q9BSJ8
ENST00000550179	ESYT1-205	576	-	-	- (aa)	-	-
ENST00000550515	ESYT1-206	716	-	-	- (aa)	-	-
ENST00000547667	ESYT1-203	594	-	-	- (aa)	-	-
ENST00000548142	ESYT1-204	563	-	-	- (aa)	-	-

Gene Model

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000139641	rs11171747	12	56124624	?	Systemic sclerosis	21779181	[1.14-1.33]	1.23	EFO_0000717

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139641	ESYT1	100	96.591	ENSMUSG00000025366	Esyt1	100	86.890	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005509	calcium ion binding	21873635.	IBA	Function
GO:0005515	protein binding	23791178.27065097.	IPI	Function
GO:0005544	calcium-dependent phospholipid binding	21873635.	IBA	Function
GO:0005783	endoplasmic reticulum	-	IDA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0006687	glycosphingolipid metabolic process	-	TAS	Process
GO:0006869	lipid transport	-	IEA	Process
GO:0008429	phosphatidylethanolamine binding	21873635.	IBA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0030176	integral component of endoplasmic reticulum membrane	23791178.	IDA	Component
GO:0031210	phosphatidylcholine binding	21873635.	IBA	Function
GO:0031227	intrinsic component of endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	21873635.	IBA	Component
GO:0035091	phosphatidylinositol binding	21873635.	IBA	Function
GO:0042802	identical protein binding	23791178.27065097.	IPI	Function
GO:0061817	endoplasmic reticulum-plasma membrane tethering	-	IEA	Process