EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000139718 (Gene tree)
Gene ID: 23067
Gene Symbol: SETD1B
Alias: KIAA1076|Set1B|KMT2G
Full Name: SET domain containing 1B, histone lysine methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 29,127 bases
Position: chr12:121,803,530-121,832,656
Accession: 29187
RBP type: canonical RBP
Summary: SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000267197	RRM_1	PF00076.22	8.2e-10	1	1
ENSP00000442924	RRM_1	PF00076.22	8.2e-10	1	1
ENSP00000474253	RRM_1	PF00076.22	8.4e-10	1	1
ENSP00000481531	RRM_1	PF00076.22	8.4e-10	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000604567	SETD1B-203	5969	XM_005253858	ENSP00000474253	1966 (aa)	XP_005253915	Q9UPS6
ENST00000542440	SETD1B-202	8185	-	ENSP00000442924	1923 (aa)	-	Q9UPS6
ENST00000267197	SETD1B-201	5772	-	ENSP00000267197	1923 (aa)	-	A0A0A0MQV9
ENST00000619791	SETD1B-204	5901	XM_006719296	ENSP00000481531	1966 (aa)	XP_006719359	Q9UPS6

Gene Model

Click here to download ENSG00000139718's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00310	Lysine degradation	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000139718	Motor Activity	3E-6	23251661

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	EFO ID
ENSG00000139718	rs895953	12	121811142	T	Coronary artery disease and HDL cholesterol levels (multivariate analysis)	30525989	EFO_0004612\|EFO_0000378
ENSG00000139718	rs895953	12	121811142	T	Coronary artery disease and triglyceride levels (multivariate analysis)	30525989	EFO_0004530\|EFO_0000378
ENSG00000139718	rs7974348	12	121816807	?	White blood cell count	30595370	EFO_0004308
ENSG00000139718	rs895953	12	121811142	?	Lipid traits (pleiotropy) (HIPO component 1)	30289880	EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000139718's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139718	SETD1B	66	82.595	ENSAMEG00000014455	SETD1B	61	85.188	Ailuropoda_melanoleuca
ENSG00000139718	SETD1B	71	61.300	ENSACIG00000016453	setd1ba	54	48.187	Amphilophus_citrinellus
ENSG00000139718	SETD1B	71	80.805	ENSATEG00000021563	setd1ba	55	80.675	Anabas_testudineus
ENSG00000139718	SETD1B	50	73.898	ENSAPLG00000005217	SETD1B	70	75.000	Anas_platyrhynchos
ENSG00000139718	SETD1B	76	97.037	ENSANAG00000027480	SETD1B	61	91.702	Aotus_nancymaae
ENSG00000139718	SETD1B	100	95.688	ENSCJAG00000016930	SETD1B	100	95.688	Callithrix_jacchus
ENSG00000139718	SETD1B	58	85.784	ENSCAFG00020016619	SETD1B	57	97.153	Canis_lupus_dingo
ENSG00000139718	SETD1B	72	86.769	ENSCHIG00000013406	SETD1B	55	96.479	Capra_hircus
ENSG00000139718	SETD1B	85	94.828	ENSTSYG00000033777	SETD1B	68	97.727	Carlito_syrichta
ENSG00000139718	SETD1B	100	96.156	ENSCCAG00000031928	SETD1B	100	96.156	Cebus_capucinus
ENSG00000139718	SETD1B	100	94.718	ENSCATG00000035803	SETD1B	100	94.718	Cercocebus_atys
ENSG00000139718	SETD1B	89	94.292	ENSCSAG00000002187	SETD1B	98	93.265	Chlorocebus_sabaeus
ENSG00000139718	SETD1B	88	96.496	ENSCANG00000023445	SETD1B	100	96.496	Colobus_angolensis_palliatus
ENSG00000139718	SETD1B	59	96.804	ENSCGRG00000018075	Setd1b	80	96.379	Cricetulus_griseus_crigri
ENSG00000139718	SETD1B	74	83.093	ENSDNOG00000035084	SETD1B	98	81.568	Dasypus_novemcinctus
ENSG00000139718	SETD1B	96	94.690	ENSEASG00005012369	SETD1B	99	94.690	Equus_asinus_asinus
ENSG00000139718	SETD1B	79	94.838	ENSECAG00000006549	SETD1B	77	94.838	Equus_caballus
ENSG00000139718	SETD1B	84	91.973	ENSFDAG00000015120	SETD1B	62	92.540	Fukomys_damarensis
ENSG00000139718	SETD1B	75	62.682	ENSGALG00000004324	SETD1B	54	74.090	Gallus_gallus
ENSG00000139718	SETD1B	86	56.162	ENSGAFG00000008712	setd1ba	58	81.056	Gambusia_affinis
ENSG00000139718	SETD1B	93	99.179	ENSGGOG00000006715	SETD1B	100	92.223	Gorilla_gorilla
ENSG00000139718	SETD1B	63	92.739	ENSHGLG00000012063	SETD1B	70	91.883	Heterocephalus_glaber_female
ENSG00000139718	SETD1B	83	57.302	ENSKMAG00000007804	setd1ba	55	63.596	Kryptolebias_marmoratus
ENSG00000139718	SETD1B	92	62.273	ENSLACG00000018379	SETD1B	54	70.108	Latimeria_chalumnae
ENSG00000139718	SETD1B	87	94.671	ENSLAFG00000026518	SETD1B	95	94.671	Loxodonta_africana
ENSG00000139718	SETD1B	100	93.601	ENSMFAG00000030930	SETD1B	100	93.601	Macaca_fascicularis
ENSG00000139718	SETD1B	100	94.806	ENSMMUG00000012842	SETD1B	100	94.806	Macaca_mulatta
ENSG00000139718	SETD1B	100	93.855	ENSMNEG00000014228	SETD1B	100	93.855	Macaca_nemestrina
ENSG00000139718	SETD1B	62	94.802	ENSMLEG00000039573	SETD1B	63	95.215	Mandrillus_leucophaeus
ENSG00000139718	SETD1B	63	62.285	ENSMGAG00000004421	SETD1B	53	72.377	Meleagris_gallopavo
ENSG00000139718	SETD1B	91	51.575	ENSMMOG00000008190	setd1ba	50	81.505	Mola_mola
ENSG00000139718	SETD1B	82	99.185	ENSNLEG00000001254	SETD1B	53	99.178	Nomascus_leucogenys
ENSG00000139718	SETD1B	76	93.064	ENSODEG00000010155	SETD1B	82	93.931	Octodon_degus
ENSG00000139718	SETD1B	95	86.381	ENSOCUG00000017708	SETD1B	98	94.539	Oryctolagus_cuniculus
ENSG00000139718	SETD1B	71	79.448	ENSORLG00000008435	setd1ba	52	80.878	Oryzias_latipes
ENSG00000139718	SETD1B	87	55.099	ENSORLG00020017079	setd1ba	51	80.878	Oryzias_latipes_hni
ENSG00000139718	SETD1B	67	79.077	ENSOMEG00000002270	setd1ba	52	81.013	Oryzias_melastigma
ENSG00000139718	SETD1B	62	84.811	ENSOARG00000012777	SETD1B	63	84.799	Ovis_aries
ENSG00000139718	SETD1B	100	96.748	ENSPPAG00000043308	SETD1B	100	96.748	Pan_paniscus
ENSG00000139718	SETD1B	89	95.568	ENSPPRG00000021041	SETD1B	98	95.616	Panthera_pardus
ENSG00000139718	SETD1B	100	99.339	ENSPTRG00000005567	SETD1B	100	99.339	Pan_troglodytes
ENSG00000139718	SETD1B	100	98.629	ENSPANG00000014784	SETD1B	100	98.629	Papio_anubis
ENSG00000139718	SETD1B	89	52.670	ENSPMGG00000011527	setd1ba	50	72.554	Periophthalmus_magnuspinnatus
ENSG00000139718	SETD1B	86	53.748	ENSPFOG00000019768	setd1ba	50	82.019	Poecilia_formosa
ENSG00000139718	SETD1B	91	52.304	ENSPLAG00000023459	setd1ba	50	83.228	Poecilia_latipinna
ENSG00000139718	SETD1B	90	53.352	ENSPREG00000011589	setd1ba	50	83.228	Poecilia_reticulata
ENSG00000139718	SETD1B	100	95.023	ENSRBIG00000034516	SETD1B	100	95.023	Rhinopithecus_bieti
ENSG00000139718	SETD1B	100	94.258	ENSRROG00000011844	SETD1B	100	94.258	Rhinopithecus_roxellana
ENSG00000139718	SETD1B	72	96.631	ENSSBOG00000033322	SETD1B	100	96.631	Saimiri_boliviensis_boliviensis
ENSG00000139718	SETD1B	70	95.265	ENSSSCG00000009806	SETD1B	79	95.265	Sus_scrofa
ENSG00000139718	SETD1B	57	91.349	ENSUAMG00000008729	SETD1B	52	92.545	Ursus_americanus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	-	IEA	Function
GO:0005515	protein binding	17998332.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005694	chromosome	-	IEA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0035097	histone methyltransferase complex	17355966.	IDA	Component
GO:0042800	histone methyltransferase activity (H3-K4 specific)	17355966.	IDA	Function
GO:0048188	Set1C/COMPASS complex	17998332.18838538.	IDA	Component
GO:0051568	histone H3-K4 methylation	17355966.	IDA	Process