EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000139726 (Gene tree)
Gene ID: 8562
Gene Symbol: DENR
Alias: DRP|DRP1|SMAP-3
Full Name: density regulated re-initiation and release factor
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 18,291 bases
Position: chr12:122,752,774-122,771,064
Accession: 2769
RBP type: canonical RBP
Summary: This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000280557	SUI1	PF01253.22	2.5e-16	1	1
ENSP00000413661	SUI1	PF01253.22	4.7e-08	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17878526	Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1.	Cancer Genomics Proteomics	2007 May-Jun	Mazan-Mamczarz K	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000280557	DENR-201	2769	-	ENSP00000280557	198 (aa)	-	O43583
ENST00000537955	DENR-203	699	-	-	- (aa)	-	-
ENST00000455982	DENR-202	1052	-	ENSP00000413661	160 (aa)	-	F8VVL1
ENST00000539463	DENR-204	671	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000139726's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000139726	rs117742602	12	122754512	G	Thrombin-activatable fibrinolysis inhibitor levels	29378355	[0.12-0.26] unit decrease	0.19	EFO_0008069

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000139726's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139726	DENR	100	76.768	ENSAPOG00000021065	denr	100	76.768	Acanthochromis_polyacanthus
ENSG00000139726	DENR	100	94.581	ENSAMEG00000014851	DENR	99	94.581	Ailuropoda_melanoleuca
ENSG00000139726	DENR	91	81.868	ENSACIG00000007705	denr	100	76.884	Amphilophus_citrinellus
ENSG00000139726	DENR	100	76.768	ENSAOCG00000004767	denr	100	76.768	Amphiprion_ocellaris
ENSG00000139726	DENR	100	76.768	ENSAPEG00000006323	denr	100	76.768	Amphiprion_percula
ENSG00000139726	DENR	88	81.564	ENSATEG00000004198	denr	91	81.564	Anabas_testudineus
ENSG00000139726	DENR	100	91.414	ENSAPLG00000003750	DENR	99	91.414	Anas_platyrhynchos
ENSG00000139726	DENR	97	91.192	ENSACAG00000016012	DENR	98	91.192	Anolis_carolinensis
ENSG00000139726	DENR	100	77.273	ENSANAG00000011753	-	99	77.273	Aotus_nancymaae
ENSG00000139726	DENR	100	99.495	ENSANAG00000033479	-	100	99.495	Aotus_nancymaae
ENSG00000139726	DENR	100	76.768	ENSACLG00000024786	denr	100	76.768	Astatotilapia_calliptera
ENSG00000139726	DENR	93	78.125	ENSAMXG00000019387	denr	96	81.771	Astyanax_mexicanus
ENSG00000139726	DENR	100	96.465	ENSBTAG00000049723	DENR	100	96.465	Bos_taurus
ENSG00000139726	DENR	100	96.465	ENSBTAG00000032433	DENR	100	96.465	Bos_taurus
ENSG00000139726	DENR	87	44.767	WBGene00012932	Y47D3A.21	89	45.556	Caenorhabditis_elegans
ENSG00000139726	DENR	100	84.663	ENSCJAG00000042372	-	100	84.663	Callithrix_jacchus
ENSG00000139726	DENR	100	99.495	ENSCJAG00000020488	DENR	100	99.495	Callithrix_jacchus
ENSG00000139726	DENR	100	96.465	ENSCAFG00000032380	DENR	72	96.465	Canis_familiaris
ENSG00000139726	DENR	100	96.465	ENSCAFG00020016334	DENR	100	96.465	Canis_lupus_dingo
ENSG00000139726	DENR	100	96.465	ENSCHIG00000025489	DENR	100	96.465	Capra_hircus
ENSG00000139726	DENR	100	98.485	ENSTSYG00000028003	-	100	98.485	Carlito_syrichta
ENSG00000139726	DENR	100	95.455	ENSTSYG00000035451	-	100	95.455	Carlito_syrichta
ENSG00000139726	DENR	82	95.062	ENSCAPG00000002873	DENR	100	95.062	Cavia_aperea
ENSG00000139726	DENR	100	95.960	ENSCPOG00000031356	DENR	100	95.960	Cavia_porcellus
ENSG00000139726	DENR	100	82.323	ENSCCAG00000026516	-	100	82.323	Cebus_capucinus
ENSG00000139726	DENR	98	82.803	ENSCCAG00000033248	-	100	82.234	Cebus_capucinus
ENSG00000139726	DENR	100	99.495	ENSCATG00000032375	-	100	99.495	Cercocebus_atys
ENSG00000139726	DENR	100	94.444	ENSCLAG00000014586	DENR	100	94.444	Chinchilla_lanigera
ENSG00000139726	DENR	77	100.000	ENSCSAG00000002095	DENR	100	100.000	Chlorocebus_sabaeus
ENSG00000139726	DENR	100	79.397	ENSCHOG00000011505	DENR	100	79.397	Choloepus_hoffmanni
ENSG00000139726	DENR	100	91.919	ENSCPBG00000026018	DENR	100	91.919	Chrysemys_picta_bellii
ENSG00000139726	DENR	87	54.598	ENSCING00000022096	-	85	54.598	Ciona_intestinalis
ENSG00000139726	DENR	88	49.718	ENSCSAVG00000008066	-	95	45.000	Ciona_savignyi
ENSG00000139726	DENR	100	94.949	ENSCGRG00001022427	Denr	100	94.949	Cricetulus_griseus_chok1gshd
ENSG00000139726	DENR	100	94.949	ENSCGRG00000014376	Denr	100	94.949	Cricetulus_griseus_crigri
ENSG00000139726	DENR	100	77.612	ENSCSEG00000012090	denr	100	77.612	Cynoglossus_semilaevis
ENSG00000139726	DENR	100	79.104	ENSCVAG00000006732	denr	100	78.788	Cyprinodon_variegatus
ENSG00000139726	DENR	93	77.387	ENSDARG00000037229	denr	96	78.894	Danio_rerio
ENSG00000139726	DENR	100	93.434	ENSDNOG00000036413	-	100	93.434	Dasypus_novemcinctus
ENSG00000139726	DENR	77	98.684	ENSDNOG00000001447	DENR	100	98.684	Dasypus_novemcinctus
ENSG00000139726	DENR	87	50.289	FBgn0030802	DENR	87	50.289	Drosophila_melanogaster
ENSG00000139726	DENR	100	75.879	ENSETEG00000013029	DENR	100	75.879	Echinops_telfairi
ENSG00000139726	DENR	100	97.475	ENSEASG00005012513	DENR	100	97.475	Equus_asinus_asinus
ENSG00000139726	DENR	100	97.475	ENSECAG00000021824	DENR	72	97.475	Equus_caballus
ENSG00000139726	DENR	97	77.041	ENSELUG00000002656	denr	97	77.041	Esox_lucius
ENSG00000139726	DENR	100	96.465	ENSFCAG00000006126	DENR	100	96.465	Felis_catus
ENSG00000139726	DENR	100	89.000	ENSFALG00000009235	DENR	100	89.000	Ficedula_albicollis
ENSG00000139726	DENR	100	95.960	ENSFDAG00000016899	-	100	95.960	Fukomys_damarensis
ENSG00000139726	DENR	100	75.253	ENSFDAG00000018403	-	100	75.253	Fukomys_damarensis
ENSG00000139726	DENR	91	84.239	ENSFHEG00000007729	denr	93	84.783	Fundulus_heteroclitus
ENSG00000139726	DENR	97	76.410	ENSGMOG00000017892	denr	97	76.923	Gadus_morhua
ENSG00000139726	DENR	100	91.414	ENSGALG00000003795	DENR	100	91.414	Gallus_gallus
ENSG00000139726	DENR	100	76.884	ENSGAFG00000004297	denr	100	76.884	Gambusia_affinis
ENSG00000139726	DENR	100	76.119	ENSGACG00000015614	denr	100	76.617	Gasterosteus_aculeatus
ENSG00000139726	DENR	100	92.424	ENSGAGG00000023819	DENR	100	92.424	Gopherus_agassizii
ENSG00000139726	DENR	100	100.000	ENSGGOG00000005562	DENR	100	100.000	Gorilla_gorilla
ENSG00000139726	DENR	100	78.109	ENSHBUG00000011606	denr	100	78.109	Haplochromis_burtoni
ENSG00000139726	DENR	100	95.960	ENSHGLG00000009606	DENR	100	95.960	Heterocephalus_glaber_female
ENSG00000139726	DENR	100	95.960	ENSHGLG00100019201	DENR	100	95.960	Heterocephalus_glaber_male
ENSG00000139726	DENR	88	81.667	ENSHCOG00000003310	denr	92	81.667	Hippocampus_comes
ENSG00000139726	DENR	100	76.667	ENSIPUG00000016199	denr	100	76.667	Ictalurus_punctatus
ENSG00000139726	DENR	100	97.980	ENSSTOG00000014128	DENR	100	97.980	Ictidomys_tridecemlineatus
ENSG00000139726	DENR	100	89.899	ENSJJAG00000008721	-	100	89.899	Jaculus_jaculus
ENSG00000139726	DENR	97	91.083	ENSJJAG00000013822	-	92	91.083	Jaculus_jaculus
ENSG00000139726	DENR	100	95.960	ENSJJAG00000012558	-	100	95.960	Jaculus_jaculus
ENSG00000139726	DENR	91	83.516	ENSKMAG00000008452	denr	94	84.066	Kryptolebias_marmoratus
ENSG00000139726	DENR	88	83.708	ENSLBEG00000021674	denr	100	76.617	Labrus_bergylta
ENSG00000139726	DENR	65	86.719	ENSLACG00000022178	DENR	96	86.719	Latimeria_chalumnae
ENSG00000139726	DENR	97	83.938	ENSLOCG00000005501	denr	97	84.456	Lepisosteus_oculatus
ENSG00000139726	DENR	100	94.000	ENSLAFG00000031728	DENR	100	94.000	Loxodonta_africana
ENSG00000139726	DENR	100	99.495	ENSMFAG00000038312	DENR	100	99.495	Macaca_fascicularis
ENSG00000139726	DENR	100	99.495	ENSMMUG00000046801	DENR	100	99.495	Macaca_mulatta
ENSG00000139726	DENR	100	99.495	ENSMNEG00000034844	-	100	99.495	Macaca_nemestrina
ENSG00000139726	DENR	98	77.070	ENSMNEG00000030944	-	99	72.589	Macaca_nemestrina
ENSG00000139726	DENR	100	99.495	ENSMLEG00000032214	DENR	100	99.495	Mandrillus_leucophaeus
ENSG00000139726	DENR	91	81.768	ENSMAMG00000011386	denr	100	76.768	Mastacembelus_armatus
ENSG00000139726	DENR	100	76.768	ENSMZEG00005007982	denr	100	76.768	Maylandia_zebra
ENSG00000139726	DENR	100	91.414	ENSMGAG00000003720	DENR	99	91.414	Meleagris_gallopavo
ENSG00000139726	DENR	100	82.828	ENSMAUG00000020940	Denr	100	82.828	Mesocricetus_auratus
ENSG00000139726	DENR	100	97.980	ENSMICG00000046263	DENR	100	97.980	Microcebus_murinus
ENSG00000139726	DENR	100	97.475	ENSMOCG00000019231	Denr	100	97.475	Microtus_ochrogaster
ENSG00000139726	DENR	80	86.164	ENSMMOG00000009357	denr	87	86.164	Mola_mola
ENSG00000139726	DENR	100	92.424	ENSMODG00000012302	DENR	100	92.424	Monodelphis_domestica
ENSG00000139726	DENR	91	84.530	ENSMALG00000018416	denr	100	79.293	Monopterus_albus
ENSG00000139726	DENR	100	96.465	MGP_CAROLIEiJ_G0027737	Denr	100	96.465	Mus_caroli
ENSG00000139726	DENR	100	96.465	ENSMUSG00000023106	Denr	100	96.465	Mus_musculus
ENSG00000139726	DENR	100	96.465	MGP_PahariEiJ_G0024317	Denr	100	96.465	Mus_pahari
ENSG00000139726	DENR	100	96.465	MGP_SPRETEiJ_G0028735	Denr	100	96.465	Mus_spretus
ENSG00000139726	DENR	100	95.500	ENSMPUG00000001826	DENR	73	95.500	Mustela_putorius_furo
ENSG00000139726	DENR	100	94.500	ENSMLUG00000002088	DENR	100	94.500	Myotis_lucifugus
ENSG00000139726	DENR	100	96.970	ENSNGAG00000013775	Denr	100	96.970	Nannospalax_galili
ENSG00000139726	DENR	100	79.293	ENSNBRG00000018898	denr	100	79.293	Neolamprologus_brichardi
ENSG00000139726	DENR	100	100.000	ENSNLEG00000029880	DENR	100	100.000	Nomascus_leucogenys
ENSG00000139726	DENR	100	78.788	ENSODEG00000005378	-	100	82.828	Octodon_degus
ENSG00000139726	DENR	98	95.541	ENSODEG00000009408	-	97	92.347	Octodon_degus
ENSG00000139726	DENR	100	69.192	ENSODEG00000006563	-	100	69.192	Octodon_degus
ENSG00000139726	DENR	91	83.152	ENSONIG00000015319	denr	100	77.612	Oreochromis_niloticus
ENSG00000139726	DENR	100	93.000	ENSOANG00000011417	-	100	93.000	Ornithorhynchus_anatinus
ENSG00000139726	DENR	100	97.475	ENSOCUG00000008150	-	100	97.475	Oryctolagus_cuniculus
ENSG00000139726	DENR	96	84.211	ENSOCUG00000027291	-	100	82.632	Oryctolagus_cuniculus
ENSG00000139726	DENR	93	79.348	ENSORLG00000001495	denr	96	79.891	Oryzias_latipes
ENSG00000139726	DENR	93	79.348	ENSORLG00020015485	denr	96	79.891	Oryzias_latipes_hni
ENSG00000139726	DENR	93	78.919	ENSORLG00015002890	denr	96	79.459	Oryzias_latipes_hsok
ENSG00000139726	DENR	93	79.348	ENSOMEG00000021836	denr	96	79.891	Oryzias_melastigma
ENSG00000139726	DENR	100	99.495	ENSOGAG00000012426	DENR	100	99.495	Otolemur_garnettii
ENSG00000139726	DENR	100	94.089	ENSOARG00000008511	DENR	99	94.089	Ovis_aries
ENSG00000139726	DENR	100	94.175	ENSPPAG00000031425	DENR	100	94.175	Pan_paniscus
ENSG00000139726	DENR	100	64.851	ENSPPRG00000020005	-	100	67.172	Panthera_pardus
ENSG00000139726	DENR	100	96.465	ENSPPRG00000009664	-	100	96.465	Panthera_pardus
ENSG00000139726	DENR	100	95.960	ENSPTIG00000014761	-	100	95.960	Panthera_tigris_altaica
ENSG00000139726	DENR	93	73.514	ENSPTIG00000021643	-	90	80.473	Panthera_tigris_altaica
ENSG00000139726	DENR	100	100.000	ENSPTRG00000005584	DENR	100	100.000	Pan_troglodytes
ENSG00000139726	DENR	100	99.495	ENSPANG00000030074	-	100	99.495	Papio_anubis
ENSG00000139726	DENR	82	100.000	ENSPANG00000035364	-	100	100.000	Papio_anubis
ENSG00000139726	DENR	100	78.283	ENSPKIG00000001107	denr	100	75.879	Paramormyrops_kingsleyae
ENSG00000139726	DENR	100	92.929	ENSPSIG00000008249	DENR	95	92.929	Pelodiscus_sinensis
ENSG00000139726	DENR	74	81.507	ENSPMGG00000017214	denr	61	81.507	Periophthalmus_magnuspinnatus
ENSG00000139726	DENR	100	97.980	ENSPEMG00000006521	-	100	97.980	Peromyscus_maniculatus_bairdii
ENSG00000139726	DENR	86	69.286	ENSPMAG00000008589	denr	88	71.429	Petromyzon_marinus
ENSG00000139726	DENR	100	92.424	ENSPCIG00000022523	DENR	100	92.424	Phascolarctos_cinereus
ENSG00000139726	DENR	100	80.808	ENSPFOG00000023419	denr	100	80.808	Poecilia_formosa
ENSG00000139726	DENR	100	80.808	ENSPLAG00000014807	denr	100	80.808	Poecilia_latipinna
ENSG00000139726	DENR	100	75.490	ENSPMEG00000020699	denr	100	75.490	Poecilia_mexicana
ENSG00000139726	DENR	100	80.808	ENSPREG00000016795	denr	100	80.808	Poecilia_reticulata
ENSG00000139726	DENR	100	90.955	ENSPCAG00000012039	DENR	100	90.955	Procavia_capensis
ENSG00000139726	DENR	100	98.485	ENSPCOG00000015933	DENR	100	98.485	Propithecus_coquereli
ENSG00000139726	DENR	100	94.975	ENSPVAG00000001291	DENR	100	94.975	Pteropus_vampyrus
ENSG00000139726	DENR	100	79.293	ENSPNYG00000003833	denr	100	79.293	Pundamilia_nyererei
ENSG00000139726	DENR	93	80.105	ENSPNAG00000021662	denr	96	80.105	Pygocentrus_nattereri
ENSG00000139726	DENR	100	92.424	ENSRNOG00000001106	Denr	100	92.424	Rattus_norvegicus
ENSG00000139726	DENR	100	79.798	ENSRBIG00000041357	DENR	100	79.293	Rhinopithecus_bieti
ENSG00000139726	DENR	100	99.495	ENSRROG00000044446	DENR	100	99.495	Rhinopithecus_roxellana
ENSG00000139726	DENR	81	35.000	YJR014W	TMA22	82	34.356	Saccharomyces_cerevisiae
ENSG00000139726	DENR	96	98.052	ENSSBOG00000030149	-	87	98.052	Saimiri_boliviensis_boliviensis
ENSG00000139726	DENR	99	68.528	ENSSBOG00000024171	-	100	68.500	Saimiri_boliviensis_boliviensis
ENSG00000139726	DENR	99	90.909	ENSSHAG00000012064	DENR	99	90.909	Sarcophilus_harrisii
ENSG00000139726	DENR	100	80.808	ENSSFOG00015018494	denr	100	80.808	Scleropages_formosus
ENSG00000139726	DENR	93	80.435	ENSSMAG00000010563	denr	96	76.768	Scophthalmus_maximus
ENSG00000139726	DENR	100	77.612	ENSSDUG00000023551	denr	100	77.612	Seriola_dumerili
ENSG00000139726	DENR	100	77.114	ENSSLDG00000011430	denr	100	77.114	Seriola_lalandi_dorsalis
ENSG00000139726	DENR	79	99.359	ENSSARG00000004446	DENR	100	99.359	Sorex_araneus
ENSG00000139726	DENR	100	92.929	ENSSPUG00000012205	DENR	100	92.929	Sphenodon_punctatus
ENSG00000139726	DENR	100	78.607	ENSSPAG00000019529	denr	100	78.607	Stegastes_partitus
ENSG00000139726	DENR	100	95.960	ENSSSCG00000009788	-	100	95.960	Sus_scrofa
ENSG00000139726	DENR	100	83.838	ENSTGUG00000005674	DENR	100	83.838	Taeniopygia_guttata
ENSG00000139726	DENR	80	86.792	ENSTRUG00000020621	denr	86	86.792	Takifugu_rubripes
ENSG00000139726	DENR	91	83.425	ENSTNIG00000013510	denr	91	83.425	Tetraodon_nigroviridis
ENSG00000139726	DENR	100	78.894	ENSTTRG00000015856	DENR	100	78.894	Tursiops_truncatus
ENSG00000139726	DENR	100	57.789	ENSUAMG00000011200	-	100	57.789	Ursus_americanus
ENSG00000139726	DENR	100	96.970	ENSUAMG00000003667	-	100	96.970	Ursus_americanus
ENSG00000139726	DENR	100	96.970	ENSUMAG00000005166	-	100	96.970	Ursus_maritimus
ENSG00000139726	DENR	100	57.789	ENSUMAG00000023866	-	100	57.789	Ursus_maritimus
ENSG00000139726	DENR	100	74.634	ENSVPAG00000011472	DENR	100	74.634	Vicugna_pacos
ENSG00000139726	DENR	100	96.465	ENSVVUG00000028097	DENR	72	96.465	Vulpes_vulpes
ENSG00000139726	DENR	100	85.354	ENSXETG00000005791	denr	99	85.354	Xenopus_tropicalis
ENSG00000139726	DENR	100	74.242	ENSXCOG00000017611	denr	100	74.242	Xiphophorus_couchianus
ENSG00000139726	DENR	100	80.303	ENSXMAG00000019247	denr	100	80.303	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001731	formation of translation preinitiation complex	21873635.	IBA	Process
GO:0001731	formation of translation preinitiation complex	20713520.	IDA	Process
GO:0002188	translation reinitiation	21873635.	IBA	Process
GO:0003674	molecular_function	-	ND	Function
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	-	IEA	Function
GO:0005515	protein binding	16169070.16874301.16936636.20195357.21516116.	IPI	Function
GO:0005575	cellular_component	-	ND	Component
GO:0032790	ribosome disassembly	20713520.	IDA	Process
GO:0075522	IRES-dependent viral translational initiation	20713520.	IDA	Process