EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000139767 (Gene tree)
Gene ID: 84530
Gene Symbol: SRRM4
Alias: nSR100|KIAA1853
Full Name: serine/arginine repetitive matrix 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 181,568 bases
Position: chr12:118,981,486-119,163,053
Accession: 29389
RBP type: canonical RBP
Summary: SRRM4 promotes alternative splicing and inclusion of neural-specific exons in target mRNAs (Calarco et al., 2009 [PubMed 19737518]).[supplied by OMIM, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000267260	SRRM_C	PF15230.6	1.3e-24	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
30417466	Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer.	Cancer Sci	2019 Jan	Lee AR	doi: 10.1111/cas.13869

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000267260	SRRM4-201	8477	-	ENSP00000267260	611 (aa)	-	A7MD48
ENST00000537597	SRRM4-202	561	-	-	- (aa)	-	-
ENST00000641899	SRRM4-204	682	-	ENSP00000493188	66 (aa)	-	A0A286YF08
ENST00000545224	SRRM4-203	461	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000139767's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000139767	Platelet Function Tests	2.1215831E-006	-
ENSG00000139767	Platelet Function Tests	2.1110239E-006	-
ENSG00000139767	Autosomal dominant compelling helio ophthalmic outburst syndrome	3E-12	27182965

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000139767	rs1568923	12	118981798	?	Photic sneeze reflex	27182965	[1.06-1.1]	1.0799136	EFO_0007887

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000139767's network

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000139767	SRRM4	89	83.241	ENSAMEG00000016072	SRRM4	89	89.959	Ailuropoda_melanoleuca
ENSG00000139767	SRRM4	65	53.883	ENSAPLG00000009202	SRRM4	91	53.394	Anas_platyrhynchos
ENSG00000139767	SRRM4	56	45.810	ENSACAG00000004139	SRRM4	88	49.721	Anolis_carolinensis
ENSG00000139767	SRRM4	85	90.230	ENSBTAG00000008676	SRRM4	87	90.230	Bos_taurus
ENSG00000139767	SRRM4	100	95.786	ENSCJAG00000009146	SRRM4	100	95.786	Callithrix_jacchus
ENSG00000139767	SRRM4	85	92.308	ENSCAFG00000023113	SRRM4	86	92.337	Canis_familiaris
ENSG00000139767	SRRM4	79	82.692	ENSCAFG00020018665	SRRM4	56	93.082	Canis_lupus_dingo
ENSG00000139767	SRRM4	79	84.615	ENSCHIG00000019151	SRRM4	58	92.523	Capra_hircus
ENSG00000139767	SRRM4	78	93.111	ENSTSYG00000012239	SRRM4	84	93.111	Carlito_syrichta
ENSG00000139767	SRRM4	79	82.692	ENSCAPG00000008729	SRRM4	88	90.129	Cavia_aperea
ENSG00000139767	SRRM4	85	90.996	ENSCPOG00000003544	SRRM4	86	90.996	Cavia_porcellus
ENSG00000139767	SRRM4	85	96.552	ENSCCAG00000022479	SRRM4	86	96.552	Cebus_capucinus
ENSG00000139767	SRRM4	100	97.390	ENSCATG00000036343	SRRM4	100	97.390	Cercocebus_atys
ENSG00000139767	SRRM4	85	92.131	ENSCLAG00000009764	SRRM4	85	92.146	Chinchilla_lanigera
ENSG00000139767	SRRM4	100	97.073	ENSCSAG00000002300	SRRM4	100	97.073	Chlorocebus_sabaeus
ENSG00000139767	SRRM4	85	60.662	ENSCPBG00000012293	SRRM4	88	61.243	Chrysemys_picta_bellii
ENSG00000139767	SRRM4	100	94.926	ENSCANG00000031719	SRRM4	100	94.926	Colobus_angolensis_palliatus
ENSG00000139767	SRRM4	85	84.231	ENSCGRG00001000544	Srrm4	86	86.207	Cricetulus_griseus_chok1gshd
ENSG00000139767	SRRM4	85	79.310	ENSCGRG00000006973	Srrm4	85	78.544	Cricetulus_griseus_crigri
ENSG00000139767	SRRM4	85	88.462	ENSDNOG00000000260	SRRM4	88	88.506	Dasypus_novemcinctus
ENSG00000139767	SRRM4	85	81.071	ENSDORG00000015243	Srrm4	87	81.418	Dipodomys_ordii
ENSG00000139767	SRRM4	85	91.876	ENSEASG00005008759	SRRM4	87	91.954	Equus_asinus_asinus
ENSG00000139767	SRRM4	85	91.876	ENSECAG00000021729	SRRM4	87	91.954	Equus_caballus
ENSG00000139767	SRRM4	85	92.456	ENSFCAG00000010536	SRRM4	84	92.529	Felis_catus
ENSG00000139767	SRRM4	85	87.259	ENSFDAG00000007218	SRRM4	85	88.910	Fukomys_damarensis
ENSG00000139767	SRRM4	79	51.852	ENSGAGG00000017218	SRRM4	82	59.604	Gopherus_agassizii
ENSG00000139767	SRRM4	100	99.184	ENSGGOG00000005338	SRRM4	100	99.184	Gorilla_gorilla
ENSG00000139767	SRRM4	85	91.522	ENSHGLG00000007830	SRRM4	86	91.587	Heterocephalus_glaber_female
ENSG00000139767	SRRM4	77	83.019	ENSHGLG00100008549	SRRM4	62	86.154	Heterocephalus_glaber_male
ENSG00000139767	SRRM4	76	88.000	ENSSTOG00000026642	SRRM4	83	78.706	Ictidomys_tridecemlineatus
ENSG00000139767	SRRM4	82	81.028	ENSJJAG00000016448	Srrm4	82	87.318	Jaculus_jaculus
ENSG00000139767	SRRM4	85	87.645	ENSLAFG00000003731	SRRM4	85	87.548	Loxodonta_africana
ENSG00000139767	SRRM4	100	96.457	ENSMFAG00000041271	SRRM4	100	96.457	Macaca_fascicularis
ENSG00000139767	SRRM4	79	98.077	ENSMMUG00000021230	SRRM4	67	89.524	Macaca_mulatta
ENSG00000139767	SRRM4	100	96.607	ENSMNEG00000044154	SRRM4	100	96.607	Macaca_nemestrina
ENSG00000139767	SRRM4	100	97.398	ENSMLEG00000034455	SRRM4	100	97.398	Mandrillus_leucophaeus
ENSG00000139767	SRRM4	85	59.475	ENSMGAG00000009082	SRRM4	87	61.896	Meleagris_gallopavo
ENSG00000139767	SRRM4	85	83.846	ENSMAUG00000013203	Srrm4	86	85.824	Mesocricetus_auratus
ENSG00000139767	SRRM4	85	93.103	ENSMICG00000012386	SRRM4	85	93.103	Microcebus_murinus
ENSG00000139767	SRRM4	85	82.885	ENSMOCG00000006737	Srrm4	86	85.441	Microtus_ochrogaster
ENSG00000139767	SRRM4	85	57.016	ENSMODG00000015283	SRRM4	92	56.073	Monodelphis_domestica
ENSG00000139767	SRRM4	85	87.115	MGP_CAROLIEiJ_G0027638	Srrm4	85	86.398	Mus_caroli
ENSG00000139767	SRRM4	85	86.513	ENSMUSG00000063919	Srrm4	85	85.824	Mus_musculus
ENSG00000139767	SRRM4	85	85.000	MGP_PahariEiJ_G0024219	Srrm4	86	84.291	Mus_pahari
ENSG00000139767	SRRM4	85	86.731	MGP_SPRETEiJ_G0028637	Srrm4	85	86.015	Mus_spretus
ENSG00000139767	SRRM4	85	92.263	ENSMPUG00000002930	SRRM4	87	92.337	Mustela_putorius_furo
ENSG00000139767	SRRM4	85	89.101	ENSNGAG00000020807	Srrm4	87	89.101	Nannospalax_galili
ENSG00000139767	SRRM4	100	98.374	ENSNLEG00000000200	SRRM4	100	98.374	Nomascus_leucogenys
ENSG00000139767	SRRM4	85	82.286	ENSOPRG00000016981	SRRM4	77	81.698	Ochotona_princeps
ENSG00000139767	SRRM4	85	91.346	ENSODEG00000006291	SRRM4	85	91.379	Octodon_degus
ENSG00000139767	SRRM4	85	89.382	ENSOCUG00000004503	SRRM4	77	89.484	Oryctolagus_cuniculus
ENSG00000139767	SRRM4	85	92.912	ENSOGAG00000015431	SRRM4	85	92.912	Otolemur_garnettii
ENSG00000139767	SRRM4	85	89.655	ENSOARG00000002063	SRRM4	87	89.655	Ovis_aries
ENSG00000139767	SRRM4	93	99.473	ENSPPAG00000028134	SRRM4	100	99.473	Pan_paniscus
ENSG00000139767	SRRM4	85	92.456	ENSPPRG00000002659	SRRM4	84	92.529	Panthera_pardus
ENSG00000139767	SRRM4	79	86.538	ENSPTIG00000011414	SRRM4	62	82.704	Panthera_tigris_altaica
ENSG00000139767	SRRM4	100	99.673	ENSPTRG00000005517	SRRM4	100	99.673	Pan_troglodytes
ENSG00000139767	SRRM4	85	98.084	ENSPANG00000022544	SRRM4	99	98.039	Papio_anubis
ENSG00000139767	SRRM4	85	83.109	ENSPEMG00000001823	Srrm4	86	84.321	Peromyscus_maniculatus_bairdii
ENSG00000139767	SRRM4	78	78.870	ENSPCAG00000016401	SRRM4	69	79.498	Procavia_capensis
ENSG00000139767	SRRM4	85	93.295	ENSPCOG00000013803	SRRM4	87	93.295	Propithecus_coquereli
ENSG00000139767	SRRM4	78	91.004	ENSPVAG00000017487	SRRM4	86	91.004	Pteropus_vampyrus
ENSG00000139767	SRRM4	85	86.346	ENSRNOG00000001141	Srrm4	86	85.632	Rattus_norvegicus
ENSG00000139767	SRRM4	79	94.231	ENSRBIG00000040107	SRRM4	61	97.151	Rhinopithecus_bieti
ENSG00000139767	SRRM4	79	96.154	ENSRROG00000035868	SRRM4	62	98.291	Rhinopithecus_roxellana
ENSG00000139767	SRRM4	79	98.077	ENSSBOG00000035310	SRRM4	85	88.506	Saimiri_boliviensis_boliviensis
ENSG00000139767	SRRM4	78	66.267	ENSSHAG00000017330	SRRM4	88	64.414	Sarcophilus_harrisii
ENSG00000139767	SRRM4	52	84.858	ENSSARG00000012647	SRRM4	84	69.874	Sorex_araneus
ENSG00000139767	SRRM4	85	89.847	ENSSSCG00000009845	SRRM4	85	89.847	Sus_scrofa
ENSG00000139767	SRRM4	63	57.436	ENSTGUG00000009228	SRRM4	91	58.240	Taeniopygia_guttata
ENSG00000139767	SRRM4	85	57.824	ENSVPAG00000007937	SRRM4	67	87.500	Vicugna_pacos

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	-	ISS	Process
GO:0003729	mRNA binding	21873635.	IBA	Function
GO:0003729	mRNA binding	-	ISS	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	ISS	Component
GO:0006397	mRNA processing	21873635.	IBA	Process
GO:0006397	mRNA processing	-	ISS	Process
GO:0007399	nervous system development	-	ISS	Process
GO:0007605	sensory perception of sound	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0030154	cell differentiation	-	ISS	Process
GO:0042551	neuron maturation	21873635.	IBA	Process
GO:0043484	regulation of RNA splicing	21873635.	IBA	Process
GO:0043484	regulation of RNA splicing	-	ISS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27180064	SRRM4 Drives Neuroendocrine Transdifferentiation of Prostate Adenocarcinoma Under Androgen Receptor Pathway Inhibition.	Eur Urol	2017 Jan	Li Y	doi: 10.1016/j.eururo.2016.04.028
30155992	SRRM4 gene expression correlates with neuroendocrine prostate cancer.	Prostate	2019 Jan	Li Y	doi: 10.1002/pros.23715
23928058	The small cell lung cancer-specific isoform of RE1-silencing transcription factor (REST) is regulated by neural-specific Ser/Arg repeat-related protein of 100 kDa (nSR100).	Mol Cancer Res	2013 Oct	Shimojo M	doi: 10.1158/1541-7786.MCR-13-0269
29759485	Roles of Alternative RNA Splicing of the Bif-1 Gene by SRRM4 During the Development of Treatment-induced Neuroendocrine Prostate Cancer.	EBioMedicine	2018 May	Gan Y	doi: 10.1016/j.ebiom.2018.05.002
30100395	A novel mechanism of SRRM4 in promoting neuroendocrine prostate cancer development via a pluripotency gene network.	EBioMedicine	2018 Sep	Lee AR	doi: 10.1016/j.ebiom.2018.08.011

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	119117005	Missense_Mutation	rs189389386	R145H	0.48
ACC	chr12	119145464	Silent	rs201517536	Y285Y	0.4
ACC	chr12	119156528	Silent	novel	P522P	0.58
BLCA	chr12	119130716	Missense_Mutation	rs376151397	R218H	0.48
BLCA	chr12	119122072	Missense_Mutation	NA	S156Y	0.32
BLCA	chr12	119145515	Silent	NA	A302A	0.2
BLCA	chr12	119130719	Missense_Mutation	rs559217766	R219Q	0.38
BLCA	chr12	119122106	Silent	novel	K167K	0.2
BLCA	chr12	119125424	Missense_Mutation	novel	R187S	0.24
BLCA	chr12	119145682	Nonsense_Mutation	novel	S358*	0.36
BLCA	chr12	119151109	Missense_Mutation	rs767156598	S390F	0.14
BLCA	chr12	118981942	Silent	novel	F20F	0.24
BLCA	chr12	119151039	Missense_Mutation	novel	E367K	0.18
BLCA	chr12	118981919	Missense_Mutation	novel	E13Q	0.39
BRCA	chr12	119116945	Missense_Mutation	novel	S125Y	0.07
BRCA	chr12	119154289	Missense_Mutation	novel	R480S	0.14	SRRM_C
BRCA	chr12	119114349	Missense_Mutation	rs200755711	R117Q	0.71
BRCA	chr12	118981888	Silent	NA	A2A	0.29
BRCA	chr12	119156636	In_Frame_Ins	novel	R560_R561dup	0.21
BRCA	chr12	119151104	Silent	novel	G388G	0.04
BRCA	chr12	118981956	Missense_Mutation	NA	T25N	0.4
BRCA	chr12	119154332	Missense_Mutation	novel	R494K	0.18	SRRM_C
BRCA	chr12	119156627	Silent	novel	R555R	0.3
BRCA	chr12	119151178	In_Frame_Del	novel	P414_T417del	0.12
BRCA	chr12	119153612	Missense_Mutation	NA	R452C	0.4
BRCA	chr12	119145485	Silent	NA	S292S	0.39
CESC	chr12	119158089	3'UTR	novel		0.4
CESC	chr12	119156656	Missense_Mutation	novel	R565H	0.43
CESC	chr12	118981851	5'UTR	rs375818717		0.33
CESC	chr12	119125454	Missense_Mutation	NA	S197P	0.17
CESC	chr12	119156639	Silent	NA	R559R	0.35
CESC	chr12	118981947	Missense_Mutation	novel	A22V	0.38
CESC	chr12	119161780	3'UTR	novel		0.2
CESC	chr12	118981660	5'UTR	novel		0.62
CESC	chr12	119154290	Missense_Mutation	novel	R480H	0.32	SRRM_C
CESC	chr12	119102354	Missense_Mutation	NA	R84G	0.18
CESC	chr12	119154371	Missense_Mutation	rs267603332	R507Q	0.06	SRRM_C
CESC	chr12	119156639	Silent	NA	R559R	0.22
COAD	chr12	119125450	Silent	novel	S195S	0.22
COAD	chr12	119156614	Missense_Mutation	NA	R551Q	0.32
COAD	chr12	119117001	Nonsense_Mutation	NA	R144*	0.39
COAD	chr12	119125436	Missense_Mutation	rs377276368	R191W	0.22
COAD	chr12	119125447	Missense_Mutation	rs745760704	S194R	0.21
COAD	chr12	119145388	Missense_Mutation	novel	G260V	0.27
COAD	chr12	119145554	Silent	NA	G315G	0.16
COAD	chr12	119145563	Missense_Mutation	NA	K318N	0.36
COAD	chr12	118981892	Missense_Mutation	rs537292029	V4I	0.31
COAD	chr12	118981956	Frame_Shift_Del	novel	*R27Vfs74**	0.31
COAD	chr12	119145620	Silent	rs774958862	S337S	0.29
COAD	chr12	119117002	Missense_Mutation	rs771801140	R144Q	0.46
COAD	chr12	118981831	5'UTR	novel		0.47
COAD	chr12	119130684	Silent	rs763996258	R207R	0.41
COAD	chr12	119130782	Missense_Mutation	rs780069693	R240H	0.27
COAD	chr12	119154284	Missense_Mutation	rs750601249	R478Q	0.5	SRRM_C
COAD	chr12	119156755	Missense_Mutation	NA	R598Q	0.29
COAD	chr12	119117001	Nonsense_Mutation	NA	R144*	0.25
COAD	chr12	119145568	Missense_Mutation	rs201559885	R320Q	0.34
COAD	chr12	119151032	Silent	rs148793411	P364P	0.35
COAD	chr12	119114349	Missense_Mutation	rs200755711	R117Q	0.16
COAD	chr12	119151159	Frame_Shift_Ins	NA	*N409Kfs17**	0.25
COAD	chr12	118981846	5'UTR	novel		0.17
COAD	chr12	118981981	Silent	NA	V33V	0.22
COAD	chr12	119122073	Silent	NA	S156S	0.42
COAD	chr12	119156656	Missense_Mutation	novel	R565H	0.35
COAD	chr12	119145640	Missense_Mutation	novel	A344V	0.19
COAD	chr12	118981687	5'UTR	novel		0.33
COAD	chr12	119130688	Missense_Mutation	rs766052804	R209W	0.23
COAD	chr12	118981646	5'UTR	novel		0.45
COAD	chr12	119156644	Missense_Mutation	NA	R561Q	0.24
ESCA	chr12	119151186	Missense_Mutation	novel	Y416D	0.34
ESCA	chr12	119158667	3'UTR	novel		0.36
ESCA	chr12	119156683	Missense_Mutation	novel	S574I	0.35
ESCA	chr12	119158075	3'UTR	novel		0.24
ESCA	chr12	119156525	Silent	novel	R521R	0.48
GBM	chr12	119102256	Missense_Mutation	novel	P51L	0.15
GBM	chr12	119145454	Missense_Mutation	novel	S282F	0.15
GBM	chr12	119151156	Nonsense_Mutation	novel	R406*	0.15
GBM	chr12	119156506	Missense_Mutation	NA	R515H	0.14	SRRM_C
GBM	chr12	119151160	Missense_Mutation	NA	S407C	0.24
GBM	chr12	119130683	Missense_Mutation	rs532719039	R207H	0.38
HNSC	chr12	119130697	Missense_Mutation	novel	E212K	0.41
HNSC	chr12	119130705	Silent	novel	G214G	0.56
HNSC	chr12	119156631	Missense_Mutation	rs746763503	R557W	0.41
HNSC	chr12	119145447	Nonsense_Mutation	novel	G280*	0.25
HNSC	chr12	119145511	Nonsense_Mutation	novel	S301*	0.21
HNSC	chr12	119154283	Silent	novel	R478R	0.13
HNSC	chr12	119130684	Silent	rs763996258	R207R	0.15
HNSC	chr12	119145586	Missense_Mutation	novel	N326S	0.6
HNSC	chr12	119151111	Missense_Mutation	rs369698646	R391C	0.11
KIRC	chr12	118981724	5'UTR	novel		0.13
KIRC	chr12	119114348	Missense_Mutation	rs765750545	R117W	0.22
KIRP	chr12	119145424	Missense_Mutation	NA	A272D	0.26
KIRP	chr12	119130762	Frame_Shift_Del	novel	*P234Lfs24**	0.23
LGG	chr12	119154353	Missense_Mutation	NA	P501L	0.49	SRRM_C
LGG	chr12	119145430	Missense_Mutation	rs377333031	P274L	0.36
LGG	chr12	119151180	Missense_Mutation	novel	P414S	0.59
LIHC	chr12	119102243	Missense_Mutation	novel	P47T	0.32
LIHC	chr12	119125410	Missense_Mutation	rs550204730	R182H	0.35
LIHC	chr12	119156588	Missense_Mutation	novel	S542R	0.34
LIHC	chr12	119130776	Missense_Mutation	NA	S238Y	0.28
LIHC	chr12	119151071	Silent	NA	V377V	0.45
LIHC	chr12	119156586	Missense_Mutation	NA	S542C	0.47
LIHC	chr12	119116983	Missense_Mutation	NA	S138C	0.41
LIHC	chr12	119130800	Missense_Mutation	novel	L246H	0.37
LUAD	chr12	119125396	Silent	novel	P177P	0.5
LUAD	chr12	119154338	Missense_Mutation	NA	R496H	0.35	SRRM_C
LUAD	chr12	119145472	Missense_Mutation	novel	G288E	0.27
LUAD	chr12	119125461	Missense_Mutation	novel	P199H	0.39
LUAD	chr12	119145445	Missense_Mutation	novel	R279P	0.46
LUAD	chr12	119125396	Silent	novel	P177P	0.21
LUAD	chr12	119154276	Silent	novel	S475S	0.33
LUAD	chr12	119130684	Silent	novel	R207R	0.17
LUAD	chr12	119130724	Missense_Mutation	novel	H221N	0.1
LUAD	chr12	119130679	Missense_Mutation	NA	H206Y	0.11
LUSC	chr12	118981958	Missense_Mutation	NA	P26T	0.19
LUSC	chr12	119151213	Missense_Mutation	novel	E425K	0.28
LUSC	chr12	119125418	Missense_Mutation	NA	H185N	0.53
LUSC	chr12	119125456	Silent	novel	S197S	0.21
LUSC	chr12	119145487	Nonsense_Mutation	novel	S293*	0.28
LUSC	chr12	119156604	Missense_Mutation	novel	S548C	0.11
LUSC	chr12	119145624	Missense_Mutation	NA	P339T	0.17
LUSC	chr12	119151046	Missense_Mutation	rs142472990	A369D	0.16
LUSC	chr12	118982003	Missense_Mutation	NA	P41T	0.44
LUSC	chr12	119145527	Silent	novel	G306G	0.73
LUSC	chr12	119130719	Missense_Mutation	rs559217766	R219Q	0.26
LUSC	chr12	119145483	Missense_Mutation	NA	S292A	0.23
LUSC	chr12	119130714	Silent	novel	S217S	0.11
LUSC	chr12	119151135	Nonsense_Mutation	novel	R399*	0.39
LUSC	chr12	118981888	Silent	NA	A2A	0.42
LUSC	chr12	119145522	Missense_Mutation	rs563549457	R305W	0.42
LUSC	chr12	119151156	Nonsense_Mutation	novel	R406*	0.21
LUSC	chr12	119130729	Silent	novel	S222S	0.39
LUSC	chr12	119151130	Missense_Mutation	novel	S397I	0.35
LUSC	chr12	119145638	Silent	NA	G343G	0.3
LUSC	chr12	119153573	Missense_Mutation	novel	S439T	0.63
LUSC	chr12	119130788	Missense_Mutation	novel	P242H	0.3
OV	chr12	119151136	Missense_Mutation	rs753604308	R399Q	0.07
OV	chr12	119154362	Missense_Mutation	NA	L504R	0.43	SRRM_C
OV	chr12	119130683	Missense_Mutation	rs532719039	R207H	0.29
PAAD	chr12	119130749	Missense_Mutation	novel	L229H	0.27
PCPG	chr12	118981818	5'UTR	novel		0.3
PRAD	chr12	119145482	Silent	rs367777055	T291T	0.31
PRAD	chr12	119125450	Silent	novel	S195S	0.27
PRAD	chr12	119145522	Missense_Mutation	rs563549457	R305W	0.27
READ	chr12	118981992	Missense_Mutation	NA	T37M	0.36
READ	chr12	119145482	Silent	NA	T291T	0.44
SARC	chr12	119156680	Missense_Mutation	novel	R573H	0.46
SARC	chr12	119130689	Missense_Mutation	rs114691929	R209Q	0.26
SARC	chr12	119154315	Silent	novel	R488R	0.3
SARC	chr12	119158145	3'UTR	novel		0.36
SKCM	chr12	119156543	Silent	novel	S527S	0.21
SKCM	chr12	119102276	Missense_Mutation	novel	G58R	0.17
SKCM	chr12	119153569	Silent	novel	S437S	0.38
SKCM	chr12	119145629	Silent	novel	Q340Q	0.37
SKCM	chr12	119154352	Missense_Mutation	NA	P501S	0.36	SRRM_C
SKCM	chr12	119102316	Missense_Mutation	NA	P71L	0.23
SKCM	chr12	119145602	Silent	NA	G331G	0.15
SKCM	chr12	119145602	Silent	NA	G331G	0.8
SKCM	chr12	119145429	Missense_Mutation	NA	P274S	0.3
SKCM	chr12	119125401	Missense_Mutation	novel	K179R	0.26
SKCM	chr12	119151098	Missense_Mutation	NA	M386I	0.39
SKCM	chr12	119154354	Silent	NA	P501P	0.37
SKCM	chr12	119154315	Silent	NA	R488R	0.24
SKCM	chr12	119156523	Missense_Mutation	NA	R521W	0.16	SRRM_C
SKCM	chr12	119145442	Missense_Mutation	rs752852674	S278L	0.64
SKCM	chr12	119151168	Missense_Mutation	NA	P410S	0.33
SKCM	chr12	118982009	Missense_Mutation	novel	P43S	0.25
SKCM	chr12	118982010	Missense_Mutation	novel	P43L	0.25
SKCM	chr12	119151098	Missense_Mutation	NA	M386I	0.24
SKCM	chr12	119130823	Missense_Mutation	NA	A254T	0.27
SKCM	chr12	118982013	Missense_Mutation	NA	R44K	0.32
SKCM	chr12	119102308	Silent	NA	A68A	0.72
SKCM	chr12	119116976	Silent	NA	K135K	0.09
SKCM	chr12	119145645	Silent	NA	L346L	0.53
SKCM	chr12	119102316	Missense_Mutation	NA	P71L	0.88
SKCM	chr12	119102285	Missense_Mutation	novel	E61K	0.15
SKCM	chr12	119154255	Silent	novel	P468P	0.3
SKCM	chr12	119151086	Silent	rs749346406	R382R	0.18
SKCM	chr12	119102272	Silent	NA	Q56Q	0.39
SKCM	chr12	119102335	Nonsense_Mutation	NA	W77*	0.5
SKCM	chr12	119114310	Missense_Mutation	rs759272320	P104L	0.27
SKCM	chr12	119130801	Silent	NA	L246L	0.52
SKCM	chr12	119125450	Silent	novel	S195S	0.51
SKCM	chr12	119151179	Silent	novel	S413S	0.55
SKCM	chr12	119154305	Missense_Mutation	novel	R485Q	0.18	SRRM_C
SKCM	chr12	119125480	Splice_Site	novel	X205_splice	0.32
STAD	chr12	118981905	Missense_Mutation	NA	E8G	0.24
STAD	chr12	119125415	Missense_Mutation	rs769083054	R184C	0.24
STAD	chr12	119151032	Silent	rs148793411	P364P	0.12
STAD	chr12	119156636	Missense_Mutation	rs750188540	S558R	0.43
STAD	chr12	119102279	Missense_Mutation	NA	P59T	0.34
STAD	chr12	119125398	Missense_Mutation	rs775854693	R178Q	0.15
STAD	chr12	119156543	Silent	novel	S527S	0.43
STAD	chr12	118981977	Missense_Mutation	rs773727086	I32N	0.18
STAD	chr12	119130731	Missense_Mutation	rs199609864	R223H	0.26
STAD	chr12	118981892	Missense_Mutation	rs537292029	V4I	0.17
STAD	chr12	118981812	5'UTR	novel		0.29
STAD	chr12	119154314	Missense_Mutation	NA	R488Q	0.24	SRRM_C
STAD	chr12	119154295	Nonsense_Mutation	NA	R482*	0.24	SRRM_C
STAD	chr12	119102346	Missense_Mutation	novel	K81T	0.34
STAD	chr12	119125435	Silent	rs373113033	S190S	0.16
STAD	chr12	118982015	Splice_Site	novel	X44_splice	0.33
STAD	chr12	119151140	Silent	NA	S400S	0.48
STAD	chr12	119156596	Missense_Mutation	NA	A545G	0.4
STAD	chr12	119145488	Silent	rs771655871	S293S	0.2
STAD	chr12	119151175	Missense_Mutation	rs56390632	A412D	0.28
UCEC	chr12	119156788	Missense_Mutation	novel	T609M	0.5
UCEC	chr12	118981992	Missense_Mutation	NA	T37M	0.26
UCEC	chr12	119154299	Missense_Mutation	NA	A483V	0.4	SRRM_C
UCEC	chr12	119151208	Missense_Mutation	novel	S423Y	0.1
UCEC	chr12	119145464	Silent	rs201517536	Y285Y	0.21
UCEC	chr12	119114345	Missense_Mutation	novel	T116A	0.48
UCEC	chr12	119156650	Missense_Mutation	rs780766753	R563Q	0.42
UCEC	chr12	119125476	Missense_Mutation	novel	S204N	0.1
UCEC	chr12	119151118	Missense_Mutation	NA	S393F	0.26
UCEC	chr12	119158905	3'UTR	novel		0.5
UCEC	chr12	119161862	3'UTR	novel		0.71
UCEC	chr12	119130731	Missense_Mutation	rs199609864	R223H	0.42
UCEC	chr12	118981812	5'UTR	novel		0.24
UCEC	chr12	119117001	Nonsense_Mutation	NA	R144*	0.23
UCEC	chr12	119154290	Missense_Mutation	novel	R480H	0.17	SRRM_C
UCEC	chr12	119117001	Nonsense_Mutation	NA	R144*	0.2
UCEC	chr12	119151135	Nonsense_Mutation	novel	R399*	0.04
UCEC	chr12	119130827	Missense_Mutation	novel	R255K	0.18
UCEC	chr12	119145403	Missense_Mutation	novel	A265V	0.08
UCEC	chr12	119120265	Missense_Mutation	NA	K151N	0.24
UCEC	chr12	119130748	Missense_Mutation	novel	L229I	0.52
UCEC	chr12	119156499	Missense_Mutation	novel	R513W	0.36	SRRM_C
UCEC	chr12	119158394	3'UTR	novel		0.57
UCEC	chr12	119145458	Missense_Mutation	novel	Q283H	0.37
UCEC	chr12	118981881	5'UTR	rs377146881		0.34
UCEC	chr12	119156505	Missense_Mutation	novel	R515C	0.38	SRRM_C
UCEC	chr12	119157928	3'UTR	novel		0.4
UCEC	chr12	119125386	Missense_Mutation	rs375268699	R174Q	0.32
UCEC	chr12	119158098	3'UTR	novel		0.36
UCEC	chr12	119158261	3'UTR	novel		0.59
UCEC	chr12	119156504	Silent	novel	K514K	0.55
UCEC	chr12	119156644	Missense_Mutation	NA	R561Q	0.25
UCEC	chr12	118981631	5'UTR	novel		0.33
UCEC	chr12	119153565	Missense_Mutation	novel	S436Y	0.4
UCEC	chr12	118981662	5'UTR	novel		0.26
UCEC	chr12	119102379	Missense_Mutation	novel	H92R	0.28
UCEC	chr12	119145488	Silent	rs771655871	S293S	0.39
UCEC	chr12	119154336	Silent	novel	K495K	0.4
UCEC	chr12	119130682	Missense_Mutation	rs368516977	R207C	0.31
UCEC	chr12	119161674	3'UTR	novel		0.28
UCEC	chr12	119130731	Missense_Mutation	rs199609864	R223H	0.47
UCEC	chr12	119117005	Missense_Mutation	novel	R145L	0.26
UCEC	chr12	119156652	Missense_Mutation	novel	T564A	0.33
UCEC	chr12	119154296	Missense_Mutation	novel	R482Q	0.48	SRRM_C
UCEC	chr12	118981752	5'UTR	novel		0.17
UCEC	chr12	119158254	3'UTR	novel		0.21
UCEC	chr12	119125441	Silent	NA	S192S	0.3
UCEC	chr12	119158359	3'UTR	novel		0.33
UCEC	chr12	119117001	Nonsense_Mutation	NA	R144*	0.3
UCEC	chr12	119145508	Missense_Mutation	novel	S300N	0.5
UCEC	chr12	119153596	Silent	NA	S446S	0.16
UCEC	chr12	118981916	Missense_Mutation	NA	F12L	0.25
UCEC	chr12	119125437	Missense_Mutation	rs370817014	R191Q	0.36
UCEC	chr12	119153615	Missense_Mutation	novel	R453C	0.48
UCEC	chr12	119145522	Missense_Mutation	rs563549457	R305W	0.29
UCEC	chr12	119156809	3'UTR	novel		0.33
UCEC	chr12	119130799	Missense_Mutation	novel	L246I	0.24
UCEC	chr12	118981935	Missense_Mutation	novel	G18E	0.39
UCEC	chr12	119116996	Missense_Mutation	novel	H142R	0.43
UCEC	chr12	119151083	Silent	novel	A381A	0.57
UCEC	chr12	119156643	Missense_Mutation	NA	R561W	0.44
UCEC	chr12	119156759	Silent	rs754682419	S599S	0.29
UCEC	chr12	118981947	Missense_Mutation	novel	A22V	0.29
UCEC	chr12	119151198	Nonsense_Mutation	rs763862350	R420*	0.44
UCS	chr12	119154302	Missense_Mutation	rs755901947	R484H	0.31	SRRM_C
UCS	chr12	119145464	Silent	rs201517536	Y285Y	0.5
UCS	chr12	119151039	Missense_Mutation	novel	E367K	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.1602	6.3933e-07
CHOL	DEL	0.2222	0.067545
HNSC	DEL	0.0536	0.22646
LUAD	DEL	0.1376	0.0059643
LUSC	DEL	0.1098	0.038823
PAAD	DEL	0.1848	0.0030251
PRAD	AMP	0.0569	0.016187
SKCM	DEL	0.1798	0.00079981

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0052	Kaplan-Meier Survival Analysis
SARC	0.016	Kaplan-Meier Survival Analysis
LUSC	0.011	Kaplan-Meier Survival Analysis
PAAD	0.00011	Kaplan-Meier Survival Analysis
READ	0.036	Kaplan-Meier Survival Analysis
KICH	0.045	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
UVM	0.0016	Kaplan-Meier Survival Analysis