EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000140105 (Gene tree)
Gene ID: 7453
Gene Symbol: WARS
Alias: IFP53|IFI53
Full Name: tryptophanyl-tRNA synthetase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 43,018 bases
Position: chr14:100,333,788-100,376,805
Accession: 12729
RBP type: canonical RBP
Summary: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000339485	tRNA-synt_1b	PF00579.25	1.5e-20	1	1
ENSP00000351481	tRNA-synt_1b	PF00579.25	1.5e-20	1	1
ENSP00000451887	tRNA-synt_1b	PF00579.25	1.5e-20	1	1
ENSP00000347495	tRNA-synt_1b	PF00579.25	2e-20	1	1
ENSP00000376620	tRNA-synt_1b	PF00579.25	2e-20	1	1
ENSP00000451460	tRNA-synt_1b	PF00579.25	2e-20	1	1
ENSP00000451891	tRNA-synt_1b	PF00579.25	3.9e-10	1	1
ENSP00000451490	tRNA-synt_1b	PF00579.25	6.6e-05	1	1
ENSP00000451251	tRNA-synt_1b	PF00579.25	7.2e-05	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
2161949	The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein.	J Virol	1990 Jul	Roller RJ	-
7753379	Distribution of [3H]zolpidem binding sites in relation to messenger RNA encoding the alpha 1, beta 2 and gamma 2 subunits of GABAA receptors in rat brain.	Neuroscience	1995 Feb	Duncan GE	-
12069601	Three G.C base pairs required for the efficient aminoacylation of tRNATrp by tryptophanyl-tRNA synthetase from Bacillus subtilis.	Biochemistry	2002 Jun 25	Xu F	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000627608	WARS-244	123	-	ENSP00000487316	40 (aa)	-	G3V4Q0
ENST00000554820	WARS-219	538	-	ENSP00000450563	86 (aa)	-	G3V2C0
ENST00000556338	WARS-228	547	-	ENSP00000451544	140 (aa)	-	G3V423
ENST00000355338	WARS-202	3092	XM_024449707	ENSP00000347495	471 (aa)	XP_024305475	P23381
ENST00000554950	WARS-220	1376	-	-	- (aa)	-	-
ENST00000344102	WARS-201	2690	XM_011537136	ENSP00000339485	430 (aa)	XP_011535438	P23381
ENST00000556504	WARS-230	847	-	ENSP00000451251	223 (aa)	-	G3V3H8
ENST00000556695	WARS-234	553	-	ENSP00000451777	58 (aa)	-	G3V3R3
ENST00000553934	WARS-212	530	-	ENSP00000452379	33 (aa)	-	P78534
ENST00000555031	WARS-221	658	-	ENSP00000450623	55 (aa)	-	G3V2F2
ENST00000556295	WARS-227	517	-	ENSP00000451377	58 (aa)	-	G3V3R3
ENST00000556645	WARS-232	2508	-	ENSP00000451887	430 (aa)	-	P23381
ENST00000557614	WARS-242	499	-	-	- (aa)	-	-
ENST00000555063	WARS-222	573	-	-	- (aa)	-	-
ENST00000557347	WARS-241	577	-	ENSP00000451922	40 (aa)	-	G3V4Q0
ENST00000554509	WARS-215	563	-	ENSP00000451894	105 (aa)	-	G3V4N0
ENST00000553413	WARS-206	568	-	ENSP00000452550	107 (aa)	-	G3V5W1
ENST00000555464	WARS-224	544	-	-	- (aa)	-	-
ENST00000358655	WARS-203	2466	-	ENSP00000351481	430 (aa)	-	P23381
ENST00000553769	WARS-210	560	-	ENSP00000451906	104 (aa)	-	G3V4N8
ENST00000554331	WARS-214	831	-	-	- (aa)	-	-
ENST00000392882	WARS-204	2938	XM_005268044	ENSP00000376620	471 (aa)	XP_005268101	P23381
ENST00000557297	WARS-240	821	-	ENSP00000451599	154 (aa)	-	G3V456
ENST00000555813	WARS-225	410	-	ENSP00000451953	63 (aa)	-	G3V4S4
ENST00000554084	WARS-213	866	-	-	- (aa)	-	-
ENST00000556579	WARS-231	565	-	-	- (aa)	-	-
ENST00000556783	WARS-236	567	-	ENSP00000451679	36 (aa)	-	G3V4A3
ENST00000556209	WARS-226	564	-	ENSP00000451027	70 (aa)	-	G3V339
ENST00000553808	WARS-211	1060	-	-	- (aa)	-	-
ENST00000554601	WARS-216	719	-	ENSP00000451891	185 (aa)	-	H0YJP3
ENST00000556435	WARS-229	528	-	ENSP00000452519	153 (aa)	-	G3V5U1
ENST00000554605	WARS-217	560	-	ENSP00000450978	68 (aa)	-	G3V313
ENST00000554772	WARS-218	562	-	ENSP00000451469	124 (aa)	-	G3V3X0
ENST00000553581	WARS-209	572	-	ENSP00000452358	25 (aa)	-	G3V5H5
ENST00000556698	WARS-235	640	-	ENSP00000450427	152 (aa)	-	G3V227
ENST00000557722	WARS-243	848	-	ENSP00000450500	212 (aa)	-	G3V277
ENST00000557135	WARS-238	2080	XM_011537133	ENSP00000451460	471 (aa)	XP_011535435	P23381
ENST00000553545	WARS-208	591	-	ENSP00000451716	97 (aa)	-	G3V4C7
ENST00000557239	WARS-239	471	-	-	- (aa)	-	-
ENST00000556660	WARS-233	584	-	ENSP00000451402	114 (aa)	-	G3V3S7
ENST00000557094	WARS-237	582	-	-	- (aa)	-	-
ENST00000553395	WARS-205	801	-	ENSP00000451490	226 (aa)	-	G3V3Y5
ENST00000555410	WARS-223	677	-	ENSP00000450934	177 (aa)	-	G3V2Y7
ENST00000553524	WARS-207	707	-	ENSP00000451349	150 (aa)	-	G3V3P2

Gene Model

Click here to download ENSG00000140105's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00970	Aminoacyl-tRNA biosynthesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000140105	Platelet Count	1.706e-005	-
ENSG00000140105	Platelet Count	3.487e-005	-
ENSG00000140105	Platelet Count	3.487e-005	-
ENSG00000140105	Platelet Count	3.487e-005	-
ENSG00000140105	Platelet Function Tests	2.3611100E-005	-
ENSG00000140105	Platelet Function Tests	2.5476900E-005	-
ENSG00000140105	Platelet Function Tests	2.5476900E-005	-
ENSG00000140105	Platelet Function Tests	1.5033800E-005	-
ENSG00000140105	Platelet Function Tests	1.2048900E-005	-
ENSG00000140105	Platelet Function Tests	2.5476900E-005	-
ENSG00000140105	Platelet Function Tests	2.5476900E-005	-
ENSG00000140105	Platelet Function Tests	2.3545268E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000140105	rs941923	14	100346740	C	Blood protein levels	30072576	[0.2-0.31] unit increase	0.255	EFO_0007937
ENSG00000140105	rs7150701	14	100363922	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000140105's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000140105	WARS	58	42.623	ENSG00000196141	SPATS2L	52	42.623

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000140105	WARS	99	80.000	ENSAPOG00000014207	WARS	97	78.017	Acanthochromis_polyacanthus
ENSG00000140105	WARS	100	94.419	ENSAMEG00000011100	WARS	99	93.235	Ailuropoda_melanoleuca
ENSG00000140105	WARS	99	79.302	ENSACIG00000005371	WARS	99	76.940	Amphilophus_citrinellus
ENSG00000140105	WARS	99	80.698	ENSAOCG00000005885	WARS	97	78.664	Amphiprion_ocellaris
ENSG00000140105	WARS	99	80.698	ENSAPEG00000018449	WARS	97	78.664	Amphiprion_percula
ENSG00000140105	WARS	99	78.886	ENSATEG00000012465	WARS	97	77.419	Anabas_testudineus
ENSG00000140105	WARS	99	81.395	ENSAPLG00000002940	WARS	99	79.237	Anas_platyrhynchos
ENSG00000140105	WARS	97	85.167	ENSACAG00000013482	WARS	97	83.080	Anolis_carolinensis
ENSG00000140105	WARS	100	97.209	ENSANAG00000034744	WARS	99	95.763	Aotus_nancymaae
ENSG00000140105	WARS	99	78.372	ENSACLG00000016185	WARS	97	76.724	Astatotilapia_calliptera
ENSG00000140105	WARS	99	80.186	ENSAMXG00000020268	WARS	100	80.186	Astyanax_mexicanus
ENSG00000140105	WARS	100	95.116	ENSBTAG00000004679	WARS	99	93.023	Bos_taurus
ENSG00000140105	WARS	91	62.500	WBGene00006945	wars-1	95	61.965	Caenorhabditis_elegans
ENSG00000140105	WARS	100	96.528	ENSCJAG00000016912	WARS	99	95.148	Callithrix_jacchus
ENSG00000140105	WARS	100	94.186	ENSCAFG00000017906	WARS	99	93.235	Canis_familiaris
ENSG00000140105	WARS	100	94.186	ENSCAFG00020011171	WARS	98	93.235	Canis_lupus_dingo
ENSG00000140105	WARS	100	94.419	ENSCHIG00000023952	WARS	98	92.389	Capra_hircus
ENSG00000140105	WARS	99	85.650	ENSTSYG00000033077	-	100	79.821	Carlito_syrichta
ENSG00000140105	WARS	99	92.506	ENSTSYG00000004966	-	99	89.978	Carlito_syrichta
ENSG00000140105	WARS	100	90.000	ENSCAPG00000006805	WARS	98	88.387	Cavia_aperea
ENSG00000140105	WARS	100	90.000	ENSCPOG00000004263	WARS	98	88.387	Cavia_porcellus
ENSG00000140105	WARS	100	96.744	ENSCCAG00000037259	WARS	98	96.583	Cebus_capucinus
ENSG00000140105	WARS	100	97.788	ENSCATG00000026382	WARS	100	97.674	Cercocebus_atys
ENSG00000140105	WARS	100	90.698	ENSCLAG00000017151	WARS	99	88.747	Chinchilla_lanigera
ENSG00000140105	WARS	100	97.788	ENSCSAG00000010343	WARS	99	97.246	Chlorocebus_sabaeus
ENSG00000140105	WARS	100	89.823	ENSCHOG00000008425	WARS	100	86.986	Choloepus_hoffmanni
ENSG00000140105	WARS	100	85.398	ENSCPBG00000006626	WARS	99	83.761	Chrysemys_picta_bellii
ENSG00000140105	WARS	100	98.230	ENSCANG00000015012	WARS	99	97.669	Colobus_angolensis_palliatus
ENSG00000140105	WARS	100	91.628	ENSCGRG00001019667	Wars	98	91.379	Cricetulus_griseus_chok1gshd
ENSG00000140105	WARS	100	91.628	ENSCGRG00000000720	-	96	91.379	Cricetulus_griseus_crigri
ENSG00000140105	WARS	99	79.439	ENSCSEG00000002340	WARS	97	76.739	Cynoglossus_semilaevis
ENSG00000140105	WARS	99	80.186	ENSCVAG00000015644	WARS	97	77.922	Cyprinodon_variegatus
ENSG00000140105	WARS	58	93.519	ENSDARG00000104659	CABZ01109604.1	100	87.059	Danio_rerio
ENSG00000140105	WARS	100	91.860	ENSDNOG00000036125	WARS	98	90.678	Dasypus_novemcinctus
ENSG00000140105	WARS	100	93.503	ENSDORG00000008281	Wars	97	89.700	Dipodomys_ordii
ENSG00000140105	WARS	95	62.439	FBgn0010803	TrpRS	95	62.439	Drosophila_melanogaster
ENSG00000140105	WARS	100	87.442	ENSETEG00000011009	WARS	99	85.000	Echinops_telfairi
ENSG00000140105	WARS	84	74.309	ENSEBUG00000001760	-	85	74.309	Eptatretus_burgeri
ENSG00000140105	WARS	99	90.676	ENSEASG00005021610	WARS	99	87.527	Equus_asinus_asinus
ENSG00000140105	WARS	99	90.676	ENSECAG00000011037	WARS	99	87.527	Equus_caballus
ENSG00000140105	WARS	100	90.265	ENSEEUG00000002199	WARS	100	77.143	Erinaceus_europaeus
ENSG00000140105	WARS	99	79.021	ENSELUG00000015824	WARS	97	76.890	Esox_lucius
ENSG00000140105	WARS	100	94.419	ENSFCAG00000010002	WARS	99	92.389	Felis_catus
ENSG00000140105	WARS	99	81.352	ENSFALG00000002696	WARS	99	79.193	Ficedula_albicollis
ENSG00000140105	WARS	99	88.811	ENSFDAG00000009856	WARS	97	86.229	Fukomys_damarensis
ENSG00000140105	WARS	99	79.487	ENSFHEG00000005785	WARS	97	77.223	Fundulus_heteroclitus
ENSG00000140105	WARS	99	78.089	ENSGMOG00000001899	WARS	98	75.216	Gadus_morhua
ENSG00000140105	WARS	97	80.769	ENSGALG00000011228	WARS	99	77.919	Gallus_gallus
ENSG00000140105	WARS	67	91.935	ENSGAFG00000007515	WARS	99	87.097	Gambusia_affinis
ENSG00000140105	WARS	99	79.070	ENSGACG00000009413	WARS	97	76.724	Gasterosteus_aculeatus
ENSG00000140105	WARS	99	84.615	ENSGAGG00000013941	WARS	100	84.615	Gopherus_agassizii
ENSG00000140105	WARS	100	100.000	ENSGGOG00000010170	WARS	100	99.575	Gorilla_gorilla
ENSG00000140105	WARS	99	78.372	ENSHBUG00000023805	WARS	97	76.724	Haplochromis_burtoni
ENSG00000140105	WARS	99	90.909	ENSHGLG00000018963	WARS	99	88.136	Heterocephalus_glaber_female
ENSG00000140105	WARS	99	90.909	ENSHGLG00100011536	WARS	98	88.136	Heterocephalus_glaber_male
ENSG00000140105	WARS	99	78.704	ENSHCOG00000013824	WARS	98	77.039	Hippocampus_comes
ENSG00000140105	WARS	99	82.051	ENSIPUG00000014705	wars	97	79.393	Ictalurus_punctatus
ENSG00000140105	WARS	100	93.953	ENSSTOG00000013601	WARS	99	92.781	Ictidomys_tridecemlineatus
ENSG00000140105	WARS	100	91.395	ENSJJAG00000021942	Wars	99	90.890	Jaculus_jaculus
ENSG00000140105	WARS	99	79.535	ENSKMAG00000009281	WARS	97	77.056	Kryptolebias_marmoratus
ENSG00000140105	WARS	99	76.798	ENSLBEG00000005142	WARS	100	73.729	Labrus_bergylta
ENSG00000140105	WARS	99	77.156	ENSLACG00000003262	WARS	99	74.894	Latimeria_chalumnae
ENSG00000140105	WARS	99	82.028	ENSLOCG00000011600	WARS	97	80.300	Lepisosteus_oculatus
ENSG00000140105	WARS	100	92.807	ENSLAFG00000010505	WARS	98	91.006	Loxodonta_africana
ENSG00000140105	WARS	100	97.788	ENSMFAG00000031367	WARS	100	97.442	Macaca_fascicularis
ENSG00000140105	WARS	100	97.788	ENSMMUG00000013865	WARS	99	97.034	Macaca_mulatta
ENSG00000140105	WARS	100	97.788	ENSMNEG00000039856	WARS	99	97.458	Macaca_nemestrina
ENSG00000140105	WARS	100	97.788	ENSMLEG00000034858	WARS	99	97.246	Mandrillus_leucophaeus
ENSG00000140105	WARS	99	81.119	ENSMAMG00000007146	WARS	97	78.525	Mastacembelus_armatus
ENSG00000140105	WARS	99	78.372	ENSMZEG00005004767	WARS	97	76.724	Maylandia_zebra
ENSG00000140105	WARS	99	80.186	ENSMGAG00000013314	WARS	99	78.132	Meleagris_gallopavo
ENSG00000140105	WARS	100	94.651	ENSMICG00000006708	WARS	100	93.856	Microcebus_murinus
ENSG00000140105	WARS	100	89.767	ENSMOCG00000021997	Wars	98	88.771	Microtus_ochrogaster
ENSG00000140105	WARS	99	74.473	ENSMMOG00000010226	WARS	94	74.424	Mola_mola
ENSG00000140105	WARS	99	87.879	ENSMODG00000013146	WARS	98	86.266	Monodelphis_domestica
ENSG00000140105	WARS	100	75.771	ENSMALG00000013123	WARS	94	75.973	Monopterus_albus
ENSG00000140105	WARS	100	90.698	MGP_CAROLIEiJ_G0018108	Wars	99	90.042	Mus_caroli
ENSG00000140105	WARS	100	90.698	ENSMUSG00000021266	Wars	99	90.042	Mus_musculus
ENSG00000140105	WARS	100	90.698	MGP_PahariEiJ_G0029865	Wars	99	90.042	Mus_pahari
ENSG00000140105	WARS	100	90.465	MGP_SPRETEiJ_G0018958	Wars	99	89.831	Mus_spretus
ENSG00000140105	WARS	100	94.651	ENSMPUG00000002916	WARS	98	93.023	Mustela_putorius_furo
ENSG00000140105	WARS	99	95.338	ENSMLUG00000011737	-	98	94.194	Myotis_lucifugus
ENSG00000140105	WARS	68	96.000	ENSMLUG00000027714	-	100	96.797	Myotis_lucifugus
ENSG00000140105	WARS	100	91.163	ENSNGAG00000005928	Wars	98	90.733	Nannospalax_galili
ENSG00000140105	WARS	99	78.140	ENSNBRG00000024110	WARS	97	76.509	Neolamprologus_brichardi
ENSG00000140105	WARS	100	98.372	ENSNLEG00000001035	WARS	99	98.093	Nomascus_leucogenys
ENSG00000140105	WARS	99	77.855	ENSMEUG00000002229	-	100	78.082	Notamacropus_eugenii
ENSG00000140105	WARS	100	90.233	ENSOPRG00000005132	WARS	100	88.960	Ochotona_princeps
ENSG00000140105	WARS	99	91.375	ENSODEG00000010853	WARS	99	89.574	Octodon_degus
ENSG00000140105	WARS	99	79.070	ENSONIG00000003539	WARS	97	77.371	Oreochromis_niloticus
ENSG00000140105	WARS	100	88.837	ENSOANG00000005727	WARS	99	86.994	Ornithorhynchus_anatinus
ENSG00000140105	WARS	100	90.233	ENSOCUG00000015789	WARS	98	88.817	Oryctolagus_cuniculus
ENSG00000140105	WARS	99	78.555	ENSORLG00000014524	WARS	93	76.573	Oryzias_latipes
ENSG00000140105	WARS	99	78.555	ENSORLG00020013405	WARS	97	76.573	Oryzias_latipes_hni
ENSG00000140105	WARS	99	78.788	ENSORLG00015011977	WARS	93	76.790	Oryzias_latipes_hsok
ENSG00000140105	WARS	99	79.254	ENSOMEG00000010613	WARS	97	77.440	Oryzias_melastigma
ENSG00000140105	WARS	100	90.714	ENSOGAG00000032196	WARS	99	88.372	Otolemur_garnettii
ENSG00000140105	WARS	100	94.419	ENSOARG00000002035	WARS	98	92.600	Ovis_aries
ENSG00000140105	WARS	100	100.000	ENSPPAG00000041582	WARS	100	100.000	Pan_paniscus
ENSG00000140105	WARS	100	94.651	ENSPPRG00000023504	WARS	100	92.600	Panthera_pardus
ENSG00000140105	WARS	100	94.651	ENSPTIG00000015754	WARS	99	92.389	Panthera_tigris_altaica
ENSG00000140105	WARS	100	100.000	ENSPTRG00000006720	WARS	100	100.000	Pan_troglodytes
ENSG00000140105	WARS	100	97.788	ENSPANG00000004815	WARS	99	97.458	Papio_anubis
ENSG00000140105	WARS	99	80.653	ENSPKIG00000000766	WARS	97	78.091	Paramormyrops_kingsleyae
ENSG00000140105	WARS	99	84.149	ENSPSIG00000016332	WARS	98	82.759	Pelodiscus_sinensis
ENSG00000140105	WARS	99	79.767	ENSPMGG00000010821	WARS	100	79.767	Periophthalmus_magnuspinnatus
ENSG00000140105	WARS	100	91.395	ENSPEMG00000009239	Wars	98	90.234	Peromyscus_maniculatus_bairdii
ENSG00000140105	WARS	99	76.995	ENSPMAG00000000111	wars	99	74.359	Petromyzon_marinus
ENSG00000140105	WARS	99	87.413	ENSPCIG00000030371	WARS	98	85.837	Phascolarctos_cinereus
ENSG00000140105	WARS	99	79.582	ENSPFOG00000001753	WARS	97	77.106	Poecilia_formosa
ENSG00000140105	WARS	99	79.767	ENSPLAG00000014196	WARS	97	77.489	Poecilia_latipinna
ENSG00000140105	WARS	99	80.000	ENSPMEG00000010793	WARS	97	77.489	Poecilia_mexicana
ENSG00000140105	WARS	99	79.767	ENSPREG00000019907	WARS	97	77.706	Poecilia_reticulata
ENSG00000140105	WARS	100	98.230	ENSPPYG00000006142	WARS	100	97.674	Pongo_abelii
ENSG00000140105	WARS	100	88.312	ENSPCAG00000008095	WARS	99	88.378	Procavia_capensis
ENSG00000140105	WARS	100	92.035	ENSPCOG00000017332	WARS	100	93.079	Propithecus_coquereli
ENSG00000140105	WARS	100	93.506	ENSPVAG00000000727	WARS	98	87.284	Pteropus_vampyrus
ENSG00000140105	WARS	99	78.372	ENSPNYG00000018861	WARS	97	76.724	Pundamilia_nyererei
ENSG00000140105	WARS	99	80.186	ENSPNAG00000006589	WARS	97	78.091	Pygocentrus_nattereri
ENSG00000140105	WARS	100	90.000	ENSRNOG00000004359	Wars	99	90.716	Rattus_norvegicus
ENSG00000140105	WARS	100	98.230	ENSRBIG00000041632	WARS	99	97.669	Rhinopithecus_bieti
ENSG00000140105	WARS	100	98.230	ENSRROG00000021348	WARS	99	97.669	Rhinopithecus_roxellana
ENSG00000140105	WARS	91	54.798	YOL097C	WRS1	91	54.798	Saccharomyces_cerevisiae
ENSG00000140105	WARS	100	97.403	ENSSBOG00000024797	WARS	98	97.039	Saimiri_boliviensis_boliviensis
ENSG00000140105	WARS	99	87.179	ENSSHAG00000013829	WARS	98	85.622	Sarcophilus_harrisii
ENSG00000140105	WARS	99	79.953	ENSSFOG00015018023	wars	97	79.587	Scleropages_formosus
ENSG00000140105	WARS	99	79.118	ENSSMAG00000019972	WARS	99	76.068	Scophthalmus_maximus
ENSG00000140105	WARS	99	79.907	ENSSDUG00000016837	WARS	97	77.056	Seriola_dumerili
ENSG00000140105	WARS	67	94.355	ENSSDUG00000016951	WARS	81	88.710	Seriola_dumerili
ENSG00000140105	WARS	68	93.600	ENSSLDG00000003513	WARS	62	84.899	Seriola_lalandi_dorsalis
ENSG00000140105	WARS	83	87.744	ENSSARG00000009725	WARS	78	87.744	Sorex_araneus
ENSG00000140105	WARS	99	83.178	ENSSPUG00000007838	WARS	97	82.213	Sphenodon_punctatus
ENSG00000140105	WARS	99	79.767	ENSSPAG00000022395	WARS	97	77.802	Stegastes_partitus
ENSG00000140105	WARS	100	94.186	ENSSSCG00000002516	WARS	99	92.389	Sus_scrofa
ENSG00000140105	WARS	54	88.889	ENSTGUG00000015396	-	100	72.961	Taeniopygia_guttata
ENSG00000140105	WARS	99	81.818	ENSTGUG00000012762	WARS	99	80.346	Taeniopygia_guttata
ENSG00000140105	WARS	99	79.439	ENSTRUG00000009413	WARS	97	77.056	Takifugu_rubripes
ENSG00000140105	WARS	99	80.140	ENSTNIG00000017279	WARS	99	76.972	Tetraodon_nigroviridis
ENSG00000140105	WARS	91	84.211	ENSTBEG00000010600	WARS	80	92.827	Tupaia_belangeri
ENSG00000140105	WARS	99	89.928	ENSTTRG00000015974	WARS	86	95.964	Tursiops_truncatus
ENSG00000140105	WARS	100	94.419	ENSUAMG00000016352	WARS	99	93.235	Ursus_americanus
ENSG00000140105	WARS	100	94.419	ENSUMAG00000000473	WARS	99	93.235	Ursus_maritimus
ENSG00000140105	WARS	100	93.953	ENSVVUG00000028415	WARS	99	93.023	Vulpes_vulpes
ENSG00000140105	WARS	99	80.886	ENSXETG00000002524	wars	97	78.959	Xenopus_tropicalis
ENSG00000140105	WARS	67	93.548	ENSXCOG00000004848	WARS	99	88.172	Xiphophorus_couchianus
ENSG00000140105	WARS	99	79.767	ENSXMAG00000029086	WARS	100	79.767	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001525	angiogenesis	-	IEA	Process
GO:0001933	negative regulation of protein phosphorylation	22504299.	IDA	Process
GO:0004830	tryptophan-tRNA ligase activity	21873635.	IBA	Function
GO:0004830	tryptophan-tRNA ligase activity	28369220.	IMP	Function
GO:0004830	tryptophan-tRNA ligase activity	8496617.	NAS	Function
GO:0005515	protein binding	15628863.20010843.21044950.22504299.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	22504299.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	16130169.	TAS	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006412	translation	1761529.	TAS	Process
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	Process
GO:0006436	tryptophanyl-tRNA aminoacylation	21873635.	IBA	Process
GO:0006436	tryptophanyl-tRNA aminoacylation	8496617.	NAS	Process
GO:0006469	negative regulation of protein kinase activity	22504299.	IDA	Process
GO:0008285	negative regulation of cell proliferation	1761529.	TAS	Process
GO:0010628	positive regulation of gene expression	22504299.	IDA	Process
GO:0010835	regulation of protein ADP-ribosylation	22504299.	IDA	Process
GO:0019210	kinase inhibitor activity	22504299.	IDA	Function
GO:0019901	protein kinase binding	22504299.	IPI	Function
GO:0019904	protein domain specific binding	22504299.	IPI	Function
GO:0031334	positive regulation of protein complex assembly	22504299.	IMP	Process
GO:0032991	protein-containing complex	22504299.	IMP	Component
GO:0042803	protein homodimerization activity	22504299.28369220.	IDA	Function
GO:0045765	regulation of angiogenesis	11773625.11773626.	IDA	Process
GO:0070062	extracellular exosome	20458337.23533145.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
19900940	The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.	Cancer Epidemiol Biomarkers Prev	2009 Nov	Ghanipour A	doi: 10.1158/1055-9965.EPI-09-0456.
26209610	Prediction of Recurrence and Survival for Triple-Negative Breast Cancer (TNBC) by a Protein Signature in Tissue Samples.	Mol Cell Proteomics	2015 Nov	Campone M	doi: 10.1074/mcp.M115.048967

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	100361780	Missense_Mutation	novel	E81K	0.13
BLCA	chr14	100369212	5'UTR	novel		0.48
BLCA	chr14	100360575	Missense_Mutation	novel	R134K	0.12	tRNA-synt_1b
BLCA	chr14	100369091	Nonsense_Mutation	novel	S32*	0.14
BLCA	chr14	100337094	Missense_Mutation	rs758076089	E408K	0.28
BLCA	chr14	100346753	Silent	novel	D273D	0.25
BLCA	chr14	100334848	3'UTR	novel		0.09
BRCA	chr14	100342506	Silent	novel	L335L	0.2
BRCA	chr14	100360635	Missense_Mutation	novel	K114R	0.27	tRNA-synt_1b
BRCA	chr14	100354409	Intron	novel		0.53
BRCA	chr14	100343377	Frame_Shift_Ins	novel	*F280Pfs45**	0.23
BRCA	chr14	100333930	3'UTR	novel		0.12
CESC	chr14	100337151	Missense_Mutation	novel	Q389K	0.16
CESC	chr14	100353827	Missense_Mutation	NA	M195I	0.43	tRNA-synt_1b
CESC	chr14	100334864	3'UTR	novel		0.56
CESC	chr14	100369094	Missense_Mutation	rs370081524	A31V	0.58
CESC	chr14	100334197	3'UTR	novel		0.27
CESC	chr14	100334948	Missense_Mutation	rs751453486	R448Q	0.2
COAD	chr14	100334869	3'UTR	rs368813835		0.4
COAD	chr14	100369094	Missense_Mutation	rs370081524	A31V	0.15
COAD	chr14	100354450	Missense_Mutation	NA	T180K	0.49	tRNA-synt_1b
COAD	chr14	100342550	Missense_Mutation	novel	R321W	0.13
COAD	chr14	100337143	Silent	NA	G391G	0.5
ESCA	chr14	100334537	3'UTR	novel		0.25
ESCA	chr14	100334421	3'UTR	novel		0.57
ESCA	chr14	100334916	Missense_Mutation	novel	E459Q	0.21
GBM	chr14	100337095	Silent	novel	L407L	0.04
HNSC	chr14	100369199	5'UTR	novel		0.26
HNSC	chr14	100360583	Silent	novel	F131F	0.36
HNSC	chr14	100353883	Intron	rs770665343		0.37
HNSC	chr14	100334911	Missense_Mutation	novel	F460L	0.22
HNSC	chr14	100353803	Missense_Mutation	novel	W203C	0.16
KIRP	chr14	100334823	3'UTR	novel		0.22
LAML	chr14	100369131	Nonsense_Mutation	novel	Q19*	0.05
LAML	chr14	100354335	Intron	novel		0.54
LGG	chr14	100334895	Silent	rs187196177	L466L	0.34
LUAD	chr14	100334920	Silent	novel	V457V	0.04
LUAD	chr14	100346761	Missense_Mutation	novel	D271H	0.29
LUAD	chr14	100354517	Missense_Mutation	novel	L158V	0.08	tRNA-synt_1b
LUAD	chr14	100334945	Missense_Mutation	novel	R449L	0.34
LUAD	chr14	100337066	Missense_Mutation	rs772254998	R417M	0.13
LUAD	chr14	100354399	Intron	novel		0.31
LUAD	chr14	100334937	Missense_Mutation	rs764466208	V452I	0.09
LUAD	chr14	100353794	Silent	rs369360306	L206L	0.14
LUAD	chr14	100354537	Missense_Mutation	NA	E151A	0.13	tRNA-synt_1b
LUSC	chr14	100354543	Missense_Mutation	novel	A149V	0.09	tRNA-synt_1b
LUSC	chr14	100334870	3'UTR	novel		0.17
LUSC	chr14	100337135	Missense_Mutation	NA	C394Y	0.21
LUSC	chr14	100343291	Missense_Mutation	novel	P308L	0.25
LUSC	chr14	100369119	Missense_Mutation	rs146689917	V23I	0.25
LUSC	chr14	100334713	3'UTR	novel		0.75
LUSC	chr14	100334997	Missense_Mutation	novel	K432E	0.48
LUSC	chr14	100369119	Missense_Mutation	novel	V23L	0.16
LUSC	chr14	100361787	Silent	NA	T78T	0.25
LUSC	chr14	100343300	Missense_Mutation	novel	C305Y	0.15
OV	chr14	100337088	Missense_Mutation	novel	D410N	0.13
OV	chr14	100343299	Nonsense_Mutation	NA	C305*	0.24
OV	chr14	100361842	Frame_Shift_Ins	novel	*A60Vfs8**	0.04
OV	chr14	100354520	Missense_Mutation	novel	Y157H	0.05	tRNA-synt_1b
OV	chr14	100354369	Intron	novel		0.64
OV	chr14	100335002	Missense_Mutation	novel	L430P	0.1
OV	chr14	100337079	Missense_Mutation	novel	L413V	0.13
OV	chr14	100334934	Missense_Mutation	NA	T453A	0.52
PAAD	chr14	100346756	Silent	rs141490520	S272S	0.17
PAAD	chr14	100360660	Missense_Mutation	NA	R106W	0.2
PAAD	chr14	100361819	Missense_Mutation	novel	A68S	0.19
PRAD	chr14	100354546	Frame_Shift_Del	novel	*D148Cfs3**	0.06	tRNA-synt_1b
READ	chr14	100337189	Missense_Mutation	rs760155915	A376V	0.25
READ	chr14	100361914	Missense_Mutation	NA	I36S	0.26
SARC	chr14	100361739	Missense_Mutation	novel	S94R	0.34
SKCM	chr14	100343355	Missense_Mutation	rs745562069	P287S	0.24
SKCM	chr14	100353875	Splice_Region	novel		0.45
SKCM	chr14	100353688	Missense_Mutation	NA	G242R	0.45
SKCM	chr14	100346771	Silent	rs150850583	F267F	0.35
SKCM	chr14	100346792	Silent	NA	F260F	0.13
SKCM	chr14	100354291	Intron	novel		0.36
SKCM	chr14	100361833	Missense_Mutation	NA	P63H	0.48
SKCM	chr14	100354395	Intron	novel		0.56
SKCM	chr14	100354365	Intron	novel		0.35
SKCM	chr14	100334985	Missense_Mutation	novel	E436K	0.79
SKCM	chr14	100342558	Missense_Mutation	novel	R318K	0.23
SKCM	chr14	100353832	Nonsense_Mutation	NA	Q194*	0.29	tRNA-synt_1b
SKCM	chr14	100361804	Missense_Mutation	NA	H73Y	0.37
SKCM	chr14	100354470	Silent	NA	H173H	0.39
STAD	chr14	100335009	Missense_Mutation	rs773270850	G428S	0.11
STAD	chr14	100334900	Missense_Mutation	NA	R464L	0.12
STAD	chr14	100353818	Silent	rs751522726	D198D	0.11
STAD	chr14	100342545	Silent	NA	D322D	0.2
STAD	chr14	100335009	Missense_Mutation	rs773270850	G428S	0.14
STAD	chr14	100334856	3'UTR	novel		0.29
STAD	chr14	100369093	Silent	rs774738389	A31A	0.25
STAD	chr14	100354501	Frame_Shift_Del	novel	*G163Afs9**	0.3	tRNA-synt_1b
STAD	chr14	100369101	Missense_Mutation	novel	G29R	0.2
STAD	chr14	100334711	3'UTR	novel		0.19
THCA	chr14	100343348	Frame_Shift_Ins	novel	*F289Cfs36**	0.12
THYM	chr14	100342536	Frame_Shift_Del	novel	*R326Gfs25**	0.32
UCEC	chr14	100354560	Missense_Mutation	NA	M143I	0.25	tRNA-synt_1b
UCEC	chr14	100354505	Missense_Mutation	NA	R162W	0.31	tRNA-synt_1b
UCEC	chr14	100343326	Silent	NA	I296I	0.35
UCEC	chr14	100334695	3'UTR	novel		0.2
UCEC	chr14	100334077	3'UTR	novel		0.19
UCEC	chr14	100334589	3'UTR	novel		0.21
UCEC	chr14	100360585	Missense_Mutation	novel	F131V	0.39	tRNA-synt_1b
UCEC	chr14	100369136	Missense_Mutation	rs746009234	A17V	0.36
UCEC	chr14	100354363	Intron	novel		0.41
UCEC	chr14	100360660	Missense_Mutation	NA	R106W	0.35
UCEC	chr14	100333855	3'UTR	novel		0.08
UCEC	chr14	100360578	Missense_Mutation	novel	R133H	0.28	tRNA-synt_1b
UCEC	chr14	100361850	Silent	novel	D57D	0.39
UCEC	chr14	100369094	Missense_Mutation	rs370081524	A31V	0.45
UCEC	chr14	100334695	3'UTR	novel		0.3
UCEC	chr14	100342494	Silent	novel	F339F	0.23
UCEC	chr14	100361872	Missense_Mutation	NA	Y50C	0.26
UCEC	chr14	100334783	3'UTR	novel		0.21
UCEC	chr14	100342425	Silent	novel	T362T	0.2
UCEC	chr14	100361753	Missense_Mutation	novel	V90L	0.21
UCEC	chr14	100354550	Missense_Mutation	novel	L147I	0.44	tRNA-synt_1b
UCEC	chr14	100354550	Missense_Mutation	novel	L147I	0.3	tRNA-synt_1b
UCEC	chr14	100334185	3'UTR	rs536024717		0.09
UCEC	chr14	100342419	Silent	novel	T364T	0.28
UCEC	chr14	100334186	3'UTR	novel		0.4
UCEC	chr14	100354319	Intron	novel		0.44
UCEC	chr14	100369094	Missense_Mutation	rs370081524	A31V	0.37
UCEC	chr14	100334870	3'UTR	novel		0.41
UCEC	chr14	100354504	Missense_Mutation	NA	R162Q	0.21	tRNA-synt_1b
UCEC	chr14	100334096	3'UTR	novel		0.21
UCEC	chr14	100333974	3'UTR	novel		0.5
UCEC	chr14	100334347	3'UTR	novel		0.36
UCEC	chr14	100369163	Missense_Mutation	novel	S8Y	0.2
UCEC	chr14	100337089	Silent	rs752358226	D409D	0.24
UCEC	chr14	100369096	Silent	novel	N30N	0.11
UCEC	chr14	100337153	Missense_Mutation	novel	R388M	0.16
UCEC	chr14	100361850	Missense_Mutation	novel	D57E	0.24
UCEC	chr14	100354466	Missense_Mutation	rs199806688	I175V	0.32	tRNA-synt_1b
UCEC	chr14	100337076	Missense_Mutation	NA	E414K	0.47
UCEC	chr14	100334818	3'UTR	novel		0.3
UCEC	chr14	100337101	Missense_Mutation	novel	F405L	0.24
UCEC	chr14	100353695	Silent	rs760211416	D239D	0.4
UCEC	chr14	100369103	Missense_Mutation	rs576407869	A28V	0.43
UCEC	chr14	100333836	3'UTR	novel		0.31
UCEC	chr14	100360609	Missense_Mutation	novel	A123T	0.4	tRNA-synt_1b
UCS	chr14	100354229	Intron	novel		0.43
UCS	chr14	100360660	Missense_Mutation	NA	R106W	0.46

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2361	1.4717e-06
CESC	DEL	0.1424	0.00086239
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2838	0.050084
DLBC	AMP	0.0417	0.16999
GBM	DEL	0.2496	5.7274e-07
HNSC	DEL	0.113	0.0057325
KIRC	DEL	0.3826	0.0074281
KIRP	DEL	0.1701	0.085174
LIHC	DEL	0.3216	8.4799e-08
LUAD	DEL	0.2016	0.0018747
LUSC	AMP	0.2335	0.064655
MESO	DEL	0.4138	0.088547
PAAD	DEL	0.0707	0.11332
READ	DEL	0.3818	0.189
SKCM	DEL	0.2861	0.10277
STAD	DEL	0.2222	0.0031145

Survival Analysis

Cancer	P-value	Q-value
THYM	0.019	Kaplan-Meier Survival Analysis
KIRC	0.029	Kaplan-Meier Survival Analysis
SKCM	0.0001	Kaplan-Meier Survival Analysis
KIRP	0.0015	Kaplan-Meier Survival Analysis
CESC	0.043	Kaplan-Meier Survival Analysis
LAML	0.00074	Kaplan-Meier Survival Analysis
LIHC	0.0061	Kaplan-Meier Survival Analysis
LGG	0.00067	Kaplan-Meier Survival Analysis
UVM	0.00016	Kaplan-Meier Survival Analysis
OV	0.0006	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742